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EPHA5 (EPH receptor A5)

Identity

Other namesCEK7
EHK1
HEK7
TYRO4
HGNC (Hugo) EPHA5
LocusID (NCBI) 2044
Location 4q13.1
Location_base_pair Starts at 66185281 and ends at 66535653 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)EPHA5   3389
Entrez_Gene (NCBI)EPHA5  2044  EPH receptor A5
Cards
GeneCards (Weizmann)EPHA5
Ensembl (Hinxton)ENSG00000145242 [Gene_View]  chr4:66185281-66535653 [Contig_View]  EPHA5 [Vega]
AceView (NCBI)EPHA5
Genatlas (Paris)EPHA5
SOURCE (Stanford)NM_004439 NM_182472
Genomic and cartography
GoldenPath (UCSC)EPHA5  -  4q13.1   chr4:66185281-66535653 -  4q13.1   [Description]    (hg19-Feb_2009)
EnsemblEPHA5 - 4q13.1 [CytoView]
Mapping of homologs : NCBIEPHA5 [Mapview]
OMIM600004   
Gene and transcription
Genbank (Entrez)AB209375 AK307826 AM393049 AM393488 BC136257
RefSeq transcript (SRS)NM_004439 NM_182472
RefSeq transcript (Entrez)NM_004439 NM_182472
RefSeq genomic (SRS)AC_000136 NC_000004 NC_018915 NT_022778 NW_001838914 NW_004078021
RefSeq genomic (Entrez)AC_000136 NC_000004 NC_018915 NT_022778 NW_001838914 NW_004078021
Consensus coding sequences : CCDS (NCBI)EPHA5
Cluster EST : UnigeneHs.654492 [ SRS ] Hs.654492 [ NCBI ]
CGAP (NCI)Hs.654492
Alternative Splicing : Fast-db (Paris)GSHG0023279
Alternative Splicing GalleryENSG00000145242
Gene ExpressionEPHA5 [ NCBI-GEO ]   EPHA5 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP54756 (SRS) P54756 (Uniprot)
NextProtP54756
With graphics : InterProP54756
Splice isoforms : SwissVarP54756(Swissvar)
Domaine pattern : Prosite (SRS)EGF_2 (PS01186)    EPH_LBD (PS51550)    FN3 (PS50853)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_V_1 (PS00790)    RECEPTOR_TYR_KIN_V_2 (PS00791)    SAM_DOMAIN (PS50105)   
Domaine pattern : Prosite (Expaxy)EGF_2 (PS01186)    EPH_LBD (PS51550)    FN3 (PS50853)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_V_1 (PS00790)    RECEPTOR_TYR_KIN_V_2 (PS00791)    SAM_DOMAIN (PS50105)   
Domains : Interpro (SRS)Ephrin_rcpt_lig-bd_dom    Fibronectin_type3    Galactose-bd-like    Ig-like_fold    Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    SAM    SAM/pointed    SAM_type1    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_ephrin_rcpt    Tyr_kinase_rcpt_V_CS   
Domains : Interpro (EBI)Ephrin_rcpt_lig-bd_dom    Fibronectin_type3    Galactose-bd-like    Ig-like_fold    Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    SAM    SAM/pointed    SAM_type1    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_ephrin_rcpt    Tyr_kinase_rcpt_V_CS   
Related proteins : CluSTrP54756
Domain families : Pfam (SRS)Ephrin_lbd (PF01404)    fn3 (PF00041)    Pkinase_Tyr (PF07714)    SAM_1 (PF00536)   
Domain families : Pfam (Sanger)Ephrin_lbd (PF01404)    fn3 (PF00041)    Pkinase_Tyr (PF07714)    SAM_1 (PF00536)   
Domain families : Pfam (NCBI)pfam01404    pfam00041    pfam07714    pfam00536   
Domain families : Smart (EMBL)EPH_lbd (SM00615)  FN3 (SM00060)  SAM (SM00454)  TyrKc (SM00219)  
DMDM2044
Blocks (Seattle)P54756
PDB (SRS)2R2P   
PDB (PDBSum)2R2P   
PDB (IMB)2R2P   
PDB (RSDB)2R2P   
Human Protein AtlasENSG00000145242
HPRD02474
IPIIPI00215945   IPI00964566   IPI00008290   IPI00964344   IPI00964051   
Protein Interaction databases
DIP (DOE-UCLA)P54756
IntAct (EBI)P54756
FunCoupENSG00000145242
REACTOMEEPHA5
Protein Interaction Database2044
BioGRIDEPHA5
InParanoidP54756
Interologous Interaction database P54756
IntegromeDBEPHA5
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)EPHA5
SNP (GeneSNP Utah)EPHA5
SNP : HGBaseEPHA5
Genetic variants : HAPMAPEPHA5
Somatic Mutations in Cancer : COSMICEPHA5 
CONAN: Copy Number AnalysisEPHA5 
Mutations and Diseases : HGMDEPHA5
OMIM600004   
GENETests600004   
Disease Genetic AssociationEPHA5
Huge Navigator EPHA5 [HugePedia]  EPHA5 [HugeCancerGEM]
Genomic VariantsEPHA5  EPHA5 [DGVbeta]
snp3D : Map Gene to Disease2044
General knowledge
Homologs : HomoloGeneEPHA5
Homology/Alignments : Family Browser (UCSC)EPHA5
Phylogenetic Trees/Animal Genes : TreeFamEPHA5
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.1 [ Enzyme-SRS ]   2.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
Chemical/Protein Interactions : CTD2044
Chemical/Pharm GKB GenePA27821
Clinical trialEPHA5
Cancer Resource (Charite)ENSG00000145242
Ontology : AmiGOephrin receptor activity  GPI-linked ephrin receptor activity  transmembrane-ephrin receptor activity  ATP binding  rough endoplasmic reticulum  plasma membrane  integral to plasma membrane  axon guidance  external side of plasma membrane  cAMP-mediated signaling  hippocampus development  axon  dendrite  regulation of Rac GTPase activity  positive regulation of CREB transcription factor activity  regulation of actin cytoskeleton organization  neuronal cell body  ephrin receptor signaling pathway  perinuclear region of cytoplasm  neuron development  dendritic spine morphogenesis  regulation of insulin secretion involved in cellular response to glucose stimulus  
Ontology : EGO-EBIephrin receptor activity  GPI-linked ephrin receptor activity  transmembrane-ephrin receptor activity  ATP binding  rough endoplasmic reticulum  plasma membrane  integral to plasma membrane  axon guidance  external side of plasma membrane  cAMP-mediated signaling  hippocampus development  axon  dendrite  regulation of Rac GTPase activity  positive regulation of CREB transcription factor activity  regulation of actin cytoskeleton organization  neuronal cell body  ephrin receptor signaling pathway  perinuclear region of cytoplasm  neuron development  dendritic spine morphogenesis  regulation of insulin secretion involved in cellular response to glucose stimulus  
Pathways : KEGGAxon guidance
Other databases
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
PubGeneEPHA5
iHOPEPHA5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:18:34 CEST 2013
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