Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

EPHA5 (EPH receptor A5)

Identity

Other namesCEK7
EHK-1
EHK1
EK7
HEK7
TYRO4
HGNC (Hugo) EPHA5
LocusID (NCBI) 2044
Location 4q13.1
Location_base_pair Starts at 66185281 and ends at 66536213 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)EPHA5   3389
Cards
Entrez_Gene (NCBI)EPHA5  2044  EPH receptor A5
GeneCards (Weizmann)EPHA5
Ensembl (Hinxton)ENSG00000145242 [Gene_View]  chr4:66185281-66536213 [Contig_View]  EPHA5 [Vega]
ICGC DataPortalENSG00000145242
AceView (NCBI)EPHA5
Genatlas (Paris)EPHA5
WikiGenes2044
SOURCE (Princeton)NM_001281765 NM_001281766 NM_001281767 NM_004439 NM_182472
Genomic and cartography
GoldenPath (UCSC)EPHA5  -  4q13.1   chr4:66185281-66536213 -  4q13.1   [Description]    (hg19-Feb_2009)
EnsemblEPHA5 - 4q13.1 [CytoView]
Mapping of homologs : NCBIEPHA5 [Mapview]
OMIM600004   
Gene and transcription
Genbank (Entrez)AB209375 AK307826 AM393049 AM393488 BC136257
RefSeq transcript (Entrez)NM_001281765 NM_001281766 NM_001281767 NM_004439 NM_182472
RefSeq genomic (Entrez)AC_000136 NC_000004 NC_018915 NT_016354 NW_001838914 NW_004929320
Consensus coding sequences : CCDS (NCBI)EPHA5
Cluster EST : UnigeneHs.654492 [ NCBI ]
CGAP (NCI)Hs.654492
Alternative Splicing : Fast-db (Paris)GSHG0023279
Alternative Splicing GalleryENSG00000145242
Gene ExpressionEPHA5 [ NCBI-GEO ]     EPHA5 [ SEEK ]   EPHA5 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP54756 (Uniprot)
NextProtP54756  [Medical]
With graphics : InterProP54756
Splice isoforms : SwissVarP54756 (Swissvar)
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)EGF_2 (PS01186)    EPH_LBD (PS51550)    FN3 (PS50853)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_V_1 (PS00790)    RECEPTOR_TYR_KIN_V_2 (PS00791)    SAM_DOMAIN (PS50105)   
Domains : Interpro (EBI)Eph_TM    Ephrin_rcpt_lig-bd_dom    Fibronectin_type3    Galactose-bd-like    Ig-like_fold    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    SAM    SAM/pointed    SAM_type1    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_ephrin_rcpt    Tyr_kinase_rcpt_V_CS   
Related proteins : CluSTrP54756
Domain families : Pfam (Sanger)EphA2_TM (PF14575)    Ephrin_lbd (PF01404)    fn3 (PF00041)    Pkinase_Tyr (PF07714)    SAM_1 (PF00536)   
Domain families : Pfam (NCBI)pfam14575    pfam01404    pfam00041    pfam07714    pfam00536   
Domain families : Smart (EMBL)EPH_lbd (SM00615)  FN3 (SM00060)  SAM (SM00454)  TyrKc (SM00219)  
DMDM Disease mutations2044
Blocks (Seattle)P54756
PDB (SRS)2R2P    4ET7   
PDB (PDBSum)2R2P    4ET7   
PDB (IMB)2R2P    4ET7   
PDB (RSDB)2R2P    4ET7   
Human Protein AtlasENSG00000145242
Peptide AtlasP54756
HPRD02474
IPIIPI00215945   IPI00964566   IPI00008290   IPI00964344   IPI00964051   
Protein Interaction databases
DIP (DOE-UCLA)P54756
IntAct (EBI)P54756
FunCoupENSG00000145242
BioGRIDEPHA5
InParanoidP54756
Interologous Interaction database P54756
IntegromeDBEPHA5
STRING (EMBL)EPHA5
Ontologies - Pathways
Ontology : AmiGOephrin receptor activity  GPI-linked ephrin receptor activity  transmembrane-ephrin receptor activity  ATP binding  rough endoplasmic reticulum  plasma membrane  integral component of plasma membrane  axon guidance  external side of plasma membrane  peptidyl-tyrosine phosphorylation  cAMP-mediated signaling  hippocampus development  axon  dendrite  regulation of Rac GTPase activity  positive regulation of CREB transcription factor activity  regulation of actin cytoskeleton organization  neuronal cell body  ephrin receptor signaling pathway  perinuclear region of cytoplasm  neuron development  negative regulation of synapse assembly  regulation of insulin secretion involved in cellular response to glucose stimulus  
Ontology : EGO-EBIephrin receptor activity  GPI-linked ephrin receptor activity  transmembrane-ephrin receptor activity  ATP binding  rough endoplasmic reticulum  plasma membrane  integral component of plasma membrane  axon guidance  external side of plasma membrane  peptidyl-tyrosine phosphorylation  cAMP-mediated signaling  hippocampus development  axon  dendrite  regulation of Rac GTPase activity  positive regulation of CREB transcription factor activity  regulation of actin cytoskeleton organization  neuronal cell body  ephrin receptor signaling pathway  perinuclear region of cytoplasm  neuron development  negative regulation of synapse assembly  regulation of insulin secretion involved in cellular response to glucose stimulus  
Pathways : KEGGAxon guidance   
Protein Interaction DatabaseEPHA5
Wikipedia pathwaysEPHA5
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)EPHA5
SNP (GeneSNP Utah)EPHA5
SNP : HGBaseEPHA5
Genetic variants : HAPMAPEPHA5
1000_GenomesEPHA5 
ICGC programENSG00000145242 
CONAN: Copy Number AnalysisEPHA5 
Somatic Mutations in Cancer : COSMICEPHA5 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Mutations and Diseases : HGMDEPHA5
OMIM600004   
MedgenEPHA5
GENETestsEPHA5
Disease Genetic AssociationEPHA5
Huge Navigator EPHA5 [HugePedia]  EPHA5 [HugeCancerGEM]
Genomic VariantsEPHA5  EPHA5 [DGVbeta]
Exome VariantEPHA5
dbVarEPHA5
ClinVarEPHA5
snp3D : Map Gene to Disease2044
General knowledge
Homologs : HomoloGeneEPHA5
Homology/Alignments : Family Browser (UCSC)EPHA5
Phylogenetic Trees/Animal Genes : TreeFamEPHA5
Chemical/Protein Interactions : CTD2044
Chemical/Pharm GKB GenePA27821
Clinical trialEPHA5
Cancer Resource (Charite)ENSG00000145242
Other databases
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
CoreMineEPHA5
iHOPEPHA5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 12:44:46 CEST 2014

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.