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EPHA5 (EPH receptor A5)

Identity

Other namesCEK7
EHK-1
EHK1
EK7
HEK7
TYRO4
HGNC (Hugo) EPHA5
LocusID (NCBI) 2044
Atlas_Id 40465
Location 4q13.1  [Link to chromosome band 4q13]
Location_base_pair Starts at 66185281 and ends at 66536213 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
BCL11A (2p16.1) / EPHA5 (4q13.1)EPHA5 (4q13.1) / KPNA4 (3q25.33)EPHA5 (4q13.1) / MALAT1 (11q13.1)
EPHA5 (4q13.1) / RUFY3 (4q13.3)RPL31 (2q11.2) / EPHA5 (4q13.1)EPHA5 4q13.1 / RUFY3 4q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Lung: Translocations in Squamous Cell Carcinoma

External links

Nomenclature
HGNC (Hugo)EPHA5   3389
Cards
Entrez_Gene (NCBI)EPHA5  2044  EPH receptor A5
AliasesCEK7; EHK-1; EHK1; EK7; 
HEK7; TYRO4
GeneCards (Weizmann)EPHA5
Ensembl hg19 (Hinxton)ENSG00000145242 [Gene_View]  chr4:66185281-66536213 [Contig_View]  EPHA5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000145242 [Gene_View]  chr4:66185281-66536213 [Contig_View]  EPHA5 [Vega]
ICGC DataPortalENSG00000145242
TCGA cBioPortalEPHA5
AceView (NCBI)EPHA5
Genatlas (Paris)EPHA5
WikiGenes2044
SOURCE (Princeton)EPHA5
Genomic and cartography
GoldenPath hg19 (UCSC)EPHA5  -     chr4:66185281-66536213 -  4q13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)EPHA5  -     4q13.1   [Description]    (hg38-Dec_2013)
EnsemblEPHA5 - 4q13.1 [CytoView hg19]  EPHA5 - 4q13.1 [CytoView hg38]
Mapping of homologs : NCBIEPHA5 [Mapview hg19]  EPHA5 [Mapview hg38]
OMIM600004   
Gene and transcription
Genbank (Entrez)AB209375 AK307826 AM393049 AM393488 BC136257
RefSeq transcript (Entrez)NM_001281765 NM_001281766 NM_001281767 NM_001318761 NM_004439 NM_182472
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)EPHA5
Cluster EST : UnigeneHs.654492 [ NCBI ]
CGAP (NCI)Hs.654492
Alternative Splicing GalleryENSG00000145242
Gene ExpressionEPHA5 [ NCBI-GEO ]   EPHA5 [ EBI - ARRAY_EXPRESS ]   EPHA5 [ SEEK ]   EPHA5 [ MEM ]
Gene Expression Viewer (FireBrowse)EPHA5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2044
GTEX Portal (Tissue expression)EPHA5
Protein : pattern, domain, 3D structure
UniProt/SwissProtP54756 (Uniprot)
NextProtP54756  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP54756
Splice isoforms : SwissVarP54756 (Swissvar)
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
PhosPhoSitePlusP54756
Domaine pattern : Prosite (Expaxy)EGF_2 (PS01186)    EPH_LBD (PS51550)    FN3 (PS50853)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_V_1 (PS00790)    RECEPTOR_TYR_KIN_V_2 (PS00791)    SAM_DOMAIN (PS50105)   
Domains : Interpro (EBI)Eph_TM    Ephrin_rcpt_lig-bd_dom    FN3_dom    Galactose-bd-like    Ig-like_fold    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    SAM    SAM/pointed    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_ephrin_rcpt    Tyr_kinase_rcpt_V_CS   
Domain families : Pfam (Sanger)EphA2_TM (PF14575)    Ephrin_lbd (PF01404)    fn3 (PF00041)    Pkinase_Tyr (PF07714)    SAM_1 (PF00536)   
Domain families : Pfam (NCBI)pfam14575    pfam01404    pfam00041    pfam07714    pfam00536   
Domain families : Smart (EMBL)EPH_lbd (SM00615)  FN3 (SM00060)  SAM (SM00454)  TyrKc (SM00219)  
DMDM Disease mutations2044
Blocks (Seattle)EPHA5
PDB (SRS)2R2P    4ET7   
PDB (PDBSum)2R2P    4ET7   
PDB (IMB)2R2P    4ET7   
PDB (RSDB)2R2P    4ET7   
Structural Biology KnowledgeBase2R2P    4ET7   
SCOP (Structural Classification of Proteins)2R2P    4ET7   
CATH (Classification of proteins structures)2R2P    4ET7   
SuperfamilyP54756
Human Protein AtlasENSG00000145242
Peptide AtlasP54756
HPRD02474
IPIIPI00215945   IPI00964566   IPI00008290   IPI00964344   IPI00964051   
Protein Interaction databases
DIP (DOE-UCLA)P54756
IntAct (EBI)P54756
FunCoupENSG00000145242
BioGRIDEPHA5
STRING (EMBL)EPHA5
ZODIACEPHA5
Ontologies - Pathways
QuickGOP54756
Ontology : AmiGOephrin receptor activity  GPI-linked ephrin receptor activity  transmembrane-ephrin receptor activity  ATP binding  rough endoplasmic reticulum  plasma membrane  plasma membrane  integral component of plasma membrane  axon guidance  external side of plasma membrane  peptidyl-tyrosine phosphorylation  cAMP-mediated signaling  hippocampus development  axon  dendrite  positive regulation of CREB transcription factor activity  regulation of actin cytoskeleton organization  neuronal cell body  regulation of GTPase activity  ephrin receptor signaling pathway  ephrin receptor signaling pathway  perinuclear region of cytoplasm  neuron development  regulation of insulin secretion involved in cellular response to glucose stimulus  
Ontology : EGO-EBIephrin receptor activity  GPI-linked ephrin receptor activity  transmembrane-ephrin receptor activity  ATP binding  rough endoplasmic reticulum  plasma membrane  plasma membrane  integral component of plasma membrane  axon guidance  external side of plasma membrane  peptidyl-tyrosine phosphorylation  cAMP-mediated signaling  hippocampus development  axon  dendrite  positive regulation of CREB transcription factor activity  regulation of actin cytoskeleton organization  neuronal cell body  regulation of GTPase activity  ephrin receptor signaling pathway  ephrin receptor signaling pathway  perinuclear region of cytoplasm  neuron development  regulation of insulin secretion involved in cellular response to glucose stimulus  
Pathways : KEGGAxon guidance   
NDEx Network
Atlas of Cancer Signalling NetworkEPHA5
Wikipedia pathwaysEPHA5
Orthology - Evolution
OrthoDB2044
GeneTree (enSembl)ENSG00000145242
Phylogenetic Trees/Animal Genes : TreeFamEPHA5
Homologs : HomoloGeneEPHA5
Homology/Alignments : Family Browser (UCSC)EPHA5
Gene fusions - Rearrangements
Fusion: TCGAEPHA5 4q13.1 RUFY3 4q13.3 LUAD
Polymorphisms : SNP, variants
NCBI Variation ViewerEPHA5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EPHA5
dbVarEPHA5
ClinVarEPHA5
1000_GenomesEPHA5 
Exome Variant ServerEPHA5
ExAC (Exome Aggregation Consortium)EPHA5 (select the gene name)
Genetic variants : HAPMAP2044
Genomic Variants (DGV)EPHA5 [DGVbeta]
Mutations
ICGC Data PortalEPHA5 
TCGA Data PortalEPHA5 
Broad Tumor PortalEPHA5
OASIS PortalEPHA5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEPHA5 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EPHA5
DgiDB (Drug Gene Interaction Database)EPHA5
DoCM (Curated mutations)EPHA5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EPHA5 (select a term)
intoGenEPHA5
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)4:66185281-66536213  ENSG00000145242
CONAN: Copy Number AnalysisEPHA5 
Mutations and Diseases : HGMDEPHA5
OMIM600004   
MedgenEPHA5
Genetic Testing Registry EPHA5
NextProtP54756 [Medical]
TSGene2044
GENETestsEPHA5
Huge Navigator EPHA5 [HugePedia]
snp3D : Map Gene to Disease2044
BioCentury BCIQEPHA5
ClinGenEPHA5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2044
Chemical/Pharm GKB GenePA27821
Clinical trialEPHA5
Miscellaneous
canSAR (ICR)EPHA5 (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEPHA5
EVEXEPHA5
GoPubMedEPHA5
iHOPEPHA5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 19:02:15 CEST 2016

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