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EPHA8 (EPH receptor A8)

Identity

Alias_namesEEK
EphA8
Alias_symbol (synonym)Hek3
Other aliasEK3
HEK3
HGNC (Hugo) EPHA8
LocusID (NCBI) 2046
Atlas_Id 40467
Location 1p36.12  [Link to chromosome band 1p36]
Location_base_pair Starts at 22563502 and ends at 22589619 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EPHA8   3391
Cards
Entrez_Gene (NCBI)EPHA8  2046  EPH receptor A8
AliasesEEK; EK3; HEK3
GeneCards (Weizmann)EPHA8
Ensembl hg19 (Hinxton)ENSG00000070886 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000070886 [Gene_View]  chr1:22563502-22589619 [Contig_View]  EPHA8 [Vega]
ICGC DataPortalENSG00000070886
TCGA cBioPortalEPHA8
AceView (NCBI)EPHA8
Genatlas (Paris)EPHA8
WikiGenes2046
SOURCE (Princeton)EPHA8
Genetics Home Reference (NIH)EPHA8
Genomic and cartography
GoldenPath hg38 (UCSC)EPHA8  -     chr1:22563502-22589619 +  1p36.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EPHA8  -     1p36.12   [Description]    (hg19-Feb_2009)
EnsemblEPHA8 - 1p36.12 [CytoView hg19]  EPHA8 - 1p36.12 [CytoView hg38]
Mapping of homologs : NCBIEPHA8 [Mapview hg19]  EPHA8 [Mapview hg38]
OMIM176945   
Gene and transcription
Genbank (Entrez)AB040892 BC038796 BC072417 BC141436 DR007053
RefSeq transcript (Entrez)NM_001006943 NM_020526
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EPHA8
Cluster EST : UnigeneHs.283613 [ NCBI ]
CGAP (NCI)Hs.283613
Alternative Splicing GalleryENSG00000070886
Gene ExpressionEPHA8 [ NCBI-GEO ]   EPHA8 [ EBI - ARRAY_EXPRESS ]   EPHA8 [ SEEK ]   EPHA8 [ MEM ]
Gene Expression Viewer (FireBrowse)EPHA8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2046
GTEX Portal (Tissue expression)EPHA8
Human Protein AtlasENSG00000070886-EPHA8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP29322   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP29322  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP29322
Splice isoforms : SwissVarP29322
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
PhosPhoSitePlusP29322
Domaine pattern : Prosite (Expaxy)EGF_2 (PS01186)    EPH_LBD (PS51550)    FN3 (PS50853)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_V_1 (PS00790)    RECEPTOR_TYR_KIN_V_2 (PS00791)    SAM_DOMAIN (PS50105)   
Domains : Interpro (EBI)###############################################################################################################################################################################################################################################################                                                                   
Domain families : Pfam (Sanger)EphA2_TM (PF14575)    Ephrin_lbd (PF01404)    fn3 (PF00041)    Pkinase_Tyr (PF07714)    SAM_1 (PF00536)   
Domain families : Pfam (NCBI)pfam14575    pfam01404    pfam00041    pfam07714    pfam00536   
Domain families : Smart (EMBL)EPH_lbd (SM00615)  Ephrin_rec_like (SM01411)  FN3 (SM00060)  SAM (SM00454)  TyrKc (SM00219)  
Conserved Domain (NCBI)EPHA8
DMDM Disease mutations2046
Blocks (Seattle)EPHA8
PDB (SRS)1UCV    1X5L    3KUL   
PDB (PDBSum)1UCV    1X5L    3KUL   
PDB (IMB)1UCV    1X5L    3KUL   
PDB (RSDB)1UCV    1X5L    3KUL   
Structural Biology KnowledgeBase1UCV    1X5L    3KUL   
SCOP (Structural Classification of Proteins)1UCV    1X5L    3KUL   
CATH (Classification of proteins structures)1UCV    1X5L    3KUL   
SuperfamilyP29322
Human Protein Atlas [tissue]ENSG00000070886-EPHA8 [tissue]
Peptide AtlasP29322
HPRD01493
IPIIPI00021274   IPI00450298   
Protein Interaction databases
DIP (DOE-UCLA)P29322
IntAct (EBI)P29322
FunCoupENSG00000070886
BioGRIDEPHA8
STRING (EMBL)EPHA8
ZODIACEPHA8
Ontologies - Pathways
QuickGOP29322
Ontology : AmiGOGPI-linked ephrin receptor activity  ATP binding  plasma membrane  integral component of plasma membrane  substrate-dependent cell migration  cell adhesion  axon guidance  neuron remodeling  peptidyl-tyrosine phosphorylation  regulation of cell adhesion  neuron projection development  early endosome membrane  regulation of cell adhesion mediated by integrin  neuron projection  positive regulation of MAPK cascade  positive regulation of phosphatidylinositol 3-kinase activity  protein autophosphorylation  ephrin receptor signaling pathway  ephrin receptor signaling pathway  cellular response to follicle-stimulating hormone stimulus  
Ontology : EGO-EBIGPI-linked ephrin receptor activity  ATP binding  plasma membrane  integral component of plasma membrane  substrate-dependent cell migration  cell adhesion  axon guidance  neuron remodeling  peptidyl-tyrosine phosphorylation  regulation of cell adhesion  neuron projection development  early endosome membrane  regulation of cell adhesion mediated by integrin  neuron projection  positive regulation of MAPK cascade  positive regulation of phosphatidylinositol 3-kinase activity  protein autophosphorylation  ephrin receptor signaling pathway  ephrin receptor signaling pathway  cellular response to follicle-stimulating hormone stimulus  
Pathways : KEGGAxon guidance   
NDEx NetworkEPHA8
Atlas of Cancer Signalling NetworkEPHA8
Wikipedia pathwaysEPHA8
Orthology - Evolution
OrthoDB2046
GeneTree (enSembl)ENSG00000070886
Phylogenetic Trees/Animal Genes : TreeFamEPHA8
HOVERGENP29322
HOGENOMP29322
Homologs : HomoloGeneEPHA8
Homology/Alignments : Family Browser (UCSC)EPHA8
Gene fusions - Rearrangements
Tumor Fusion PortalEPHA8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEPHA8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EPHA8
dbVarEPHA8
ClinVarEPHA8
1000_GenomesEPHA8 
Exome Variant ServerEPHA8
ExAC (Exome Aggregation Consortium)ENSG00000070886
GNOMAD BrowserENSG00000070886
Genetic variants : HAPMAP2046
Genomic Variants (DGV)EPHA8 [DGVbeta]
DECIPHEREPHA8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEPHA8 
Mutations
ICGC Data PortalEPHA8 
TCGA Data PortalEPHA8 
Broad Tumor PortalEPHA8
OASIS PortalEPHA8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEPHA8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEPHA8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EPHA8
DgiDB (Drug Gene Interaction Database)EPHA8
DoCM (Curated mutations)EPHA8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EPHA8 (select a term)
intoGenEPHA8
Cancer3DEPHA8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176945   
Orphanet
DisGeNETEPHA8
MedgenEPHA8
Genetic Testing Registry EPHA8
NextProtP29322 [Medical]
TSGene2046
GENETestsEPHA8
Target ValidationEPHA8
Huge Navigator EPHA8 [HugePedia]
snp3D : Map Gene to Disease2046
BioCentury BCIQEPHA8
ClinGenEPHA8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2046
Chemical/Pharm GKB GenePA27823
Clinical trialEPHA8
Miscellaneous
canSAR (ICR)EPHA8 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEPHA8
EVEXEPHA8
GoPubMedEPHA8
iHOPEPHA8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:12:08 CET 2017

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