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EPHB2 (EPH receptor B2)

Identity

Alias (NCBI)BDPLT22
CAPB
DRT
EK5
EPHT3
ERK
Hek5
PCBC
Tyro5
HGNC (Hugo) EPHB2
HGNC Alias symbHek5
Tyro5
HGNC Previous nameDRT
 ERK
 EPHT3
HGNC Previous nameEphB2
LocusID (NCBI) 2048
Atlas_Id 40468
Location 1p36.12  [Link to chromosome band 1p36]
Location_base_pair Starts at 22710838 and ends at 22921500 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EPHB2 (1p36.12) / CPSF3L (1p36.33)EPHB2 (1p36.12) / EPHB2 (1p36.12)EPHB2 (1p36.12) / LYPLA2 (1p36.11)
H6PD (1p36.22) / EPHB2 (1p36.12)MAML2 (11q21) / EPHB2 (1p36.12)NBPF3 (1p36.12) / EPHB2 (1p36.12)
NBPF3 1p36.12 / EPHB2 1p36.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)EPHB2   3393
LRG (Locus Reference Genomic)LRG_780
Cards
Entrez_Gene (NCBI)EPHB2    EPH receptor B2
AliasesBDPLT22; CAPB; DRT; EK5; 
EPHT3; ERK; Hek5; PCBC; Tyro5
GeneCards (Weizmann)EPHB2
Ensembl hg19 (Hinxton)ENSG00000133216 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133216 [Gene_View]  ENSG00000133216 [Sequence]  chr1:22710838-22921500 [Contig_View]  EPHB2 [Vega]
ICGC DataPortalENSG00000133216
TCGA cBioPortalEPHB2
AceView (NCBI)EPHB2
Genatlas (Paris)EPHB2
SOURCE (Princeton)EPHB2
Genetics Home Reference (NIH)EPHB2
Genomic and cartography
GoldenPath hg38 (UCSC)EPHB2  -     chr1:22710838-22921500 +  1p36.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EPHB2  -     1p36.12   [Description]    (hg19-Feb_2009)
GoldenPathEPHB2 - 1p36.12 [CytoView hg19]  EPHB2 - 1p36.12 [CytoView hg38]
ImmunoBaseENSG00000133216
Genome Data Viewer NCBIEPHB2 [Mapview hg19]  
OMIM600997   603688   618462   
Gene and transcription
Genbank (Entrez)AB210018 AF025304 AK025975 AK125423 AK298898
RefSeq transcript (Entrez)NM_001309192 NM_001309193 NM_004442 NM_017449
Consensus coding sequences : CCDS (NCBI)EPHB2
Gene ExpressionEPHB2 [ NCBI-GEO ]   EPHB2 [ EBI - ARRAY_EXPRESS ]   EPHB2 [ SEEK ]   EPHB2 [ MEM ]
Gene Expression Viewer (FireBrowse)EPHB2 [ Firebrowse - Broad ]
GenevisibleExpression of EPHB2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2048
GTEX Portal (Tissue expression)EPHB2
Human Protein AtlasENSG00000133216-EPHB2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP29323   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP29323  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP29323
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP29323
Domaine pattern : Prosite (Expaxy)EPH_LBD (PS51550)    FN3 (PS50853)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_V_1 (PS00790)    RECEPTOR_TYR_KIN_V_2 (PS00791)    SAM_DOMAIN (PS50105)   
Domains : Interpro (EBI)Eph_TM    EphB2_rcpt_lig-bd    Ephrin_rcpt_lig-bd_dom    FN3_dom    FN3_sf    Galactose-bd-like_sf    Growth_fac_rcpt_cys_sf    Ig-like_fold    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    SAM    SAM/pointed_sf    Ser-Thr/Tyr_kinase_cat_dom    Tyr-kin_ephrin_A/B_rcpt-like    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_ephrin_rcpt    Tyr_kinase_rcpt_V_CS   
Domain families : Pfam (Sanger)EphA2_TM (PF14575)    Ephrin_lbd (PF01404)    Ephrin_rec_like (PF07699)    fn3 (PF00041)    PK_Tyr_Ser-Thr (PF07714)    SAM_1 (PF00536)   
Domain families : Pfam (NCBI)pfam14575    pfam01404    pfam07699    pfam00041    pfam07714    pfam00536   
Domain families : Smart (EMBL)EPH_lbd (SM00615)  Ephrin_rec_like (SM01411)  FN3 (SM00060)  SAM (SM00454)  TyrKc (SM00219)  
Conserved Domain (NCBI)EPHB2
PDB (RSDB)1B4F    1F0M    2QBX    3ZFM   
PDB Europe1B4F    1F0M    2QBX    3ZFM   
PDB (PDBSum)1B4F    1F0M    2QBX    3ZFM   
PDB (IMB)1B4F    1F0M    2QBX    3ZFM   
Structural Biology KnowledgeBase1B4F    1F0M    2QBX    3ZFM   
SCOP (Structural Classification of Proteins)1B4F    1F0M    2QBX    3ZFM   
CATH (Classification of proteins structures)1B4F    1F0M    2QBX    3ZFM   
SuperfamilyP29323
AlphaFold pdb e-kbP29323   
Human Protein Atlas [tissue]ENSG00000133216-EPHB2 [tissue]
HPRD02997
Protein Interaction databases
DIP (DOE-UCLA)P29323
IntAct (EBI)P29323
BioGRIDEPHB2
STRING (EMBL)EPHB2
ZODIACEPHB2
Ontologies - Pathways
QuickGOP29323
Ontology : AmiGOangiogenesis  amyloid-beta binding  amyloid-beta binding  urogenital system development  negative regulation of protein phosphorylation  positive regulation of immunoglobulin production  protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  transmembrane-ephrin receptor activity  transmembrane-ephrin receptor activity  transmembrane-ephrin receptor activity  signaling receptor binding  protein binding  ATP binding  extracellular region  nucleoplasm  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  negative regulation of cell adhesion  transmembrane receptor protein tyrosine kinase signaling pathway  multicellular organism development  nervous system development  axon guidance  axon guidance  axonal fasciculation  learning or memory  learning  axon guidance receptor activity  positive regulation of gene expression  phosphorylation  peptidyl-tyrosine phosphorylation  optic nerve morphogenesis  central nervous system projection neuron axonogenesis  corpus callosum development  regulation of blood coagulation  positive regulation of cell migration  axon  dendrite  positive regulation of B cell proliferation  retinal ganglion cell axon guidance  positive regulation of synaptic plasticity  positive regulation of tumor necrosis factor production  positive regulation of kinase activity  B cell activation  inner ear morphogenesis  identical protein binding  neuron projection  neuronal cell body  receptor complex  protein-containing complex binding  negative regulation of Ras protein signal transduction  ephrin receptor signaling pathway  ephrin receptor signaling pathway  regulation of neuronal synaptic plasticity  positive regulation of long-term neuronal synaptic plasticity  camera-type eye morphogenesis  negative regulation of axonogenesis  regulation of body fluid levels  inactivation of MAPKK activity  positive regulation of synapse assembly  roof of mouth development  dendritic spine development  dendritic spine morphogenesis  negative regulation of ERK1 and ERK2 cascade  commissural neuron axon guidance  postsynaptic membrane assembly  postsynapse  glutamatergic synapse  integral component of postsynaptic membrane  integral component of presynaptic membrane  trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission  neuron projection retraction  positive regulation of long-term synaptic potentiation  positive regulation of protein localization to plasma membrane  negative regulation of NMDA glutamate receptor activity  positive regulation of NMDA glutamate receptor activity  
Ontology : EGO-EBIangiogenesis  amyloid-beta binding  amyloid-beta binding  urogenital system development  negative regulation of protein phosphorylation  positive regulation of immunoglobulin production  protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  transmembrane-ephrin receptor activity  transmembrane-ephrin receptor activity  transmembrane-ephrin receptor activity  signaling receptor binding  protein binding  ATP binding  extracellular region  nucleoplasm  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  negative regulation of cell adhesion  transmembrane receptor protein tyrosine kinase signaling pathway  multicellular organism development  nervous system development  axon guidance  axon guidance  axonal fasciculation  learning or memory  learning  axon guidance receptor activity  positive regulation of gene expression  phosphorylation  peptidyl-tyrosine phosphorylation  optic nerve morphogenesis  central nervous system projection neuron axonogenesis  corpus callosum development  regulation of blood coagulation  positive regulation of cell migration  axon  dendrite  positive regulation of B cell proliferation  retinal ganglion cell axon guidance  positive regulation of synaptic plasticity  positive regulation of tumor necrosis factor production  positive regulation of kinase activity  B cell activation  inner ear morphogenesis  identical protein binding  neuron projection  neuronal cell body  receptor complex  protein-containing complex binding  negative regulation of Ras protein signal transduction  ephrin receptor signaling pathway  ephrin receptor signaling pathway  regulation of neuronal synaptic plasticity  positive regulation of long-term neuronal synaptic plasticity  camera-type eye morphogenesis  negative regulation of axonogenesis  regulation of body fluid levels  inactivation of MAPKK activity  positive regulation of synapse assembly  roof of mouth development  dendritic spine development  dendritic spine morphogenesis  negative regulation of ERK1 and ERK2 cascade  commissural neuron axon guidance  postsynaptic membrane assembly  postsynapse  glutamatergic synapse  integral component of postsynaptic membrane  integral component of presynaptic membrane  trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission  neuron projection retraction  positive regulation of long-term synaptic potentiation  positive regulation of protein localization to plasma membrane  negative regulation of NMDA glutamate receptor activity  positive regulation of NMDA glutamate receptor activity  
Pathways : KEGGAxon guidance   
NDEx NetworkEPHB2
Atlas of Cancer Signalling NetworkEPHB2
Wikipedia pathwaysEPHB2
Orthology - Evolution
OrthoDB2048
GeneTree (enSembl)ENSG00000133216
Phylogenetic Trees/Animal Genes : TreeFamEPHB2
Homologs : HomoloGeneEPHB2
Homology/Alignments : Family Browser (UCSC)EPHB2
Gene fusions - Rearrangements
Fusion : MitelmanEPHB2/CPSF3L [1p36.12/1p36.33]  
Fusion : MitelmanNBPF3/EPHB2 [1p36.12/1p36.12]  
Fusion : QuiverEPHB2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEPHB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EPHB2
dbVarEPHB2
ClinVarEPHB2
MonarchEPHB2
1000_GenomesEPHB2 
Exome Variant ServerEPHB2
GNOMAD BrowserENSG00000133216
Varsome BrowserEPHB2
ACMGEPHB2 variants
VarityP29323
Genomic Variants (DGV)EPHB2 [DGVbeta]
DECIPHEREPHB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEPHB2 
Mutations
ICGC Data PortalEPHB2 
TCGA Data PortalEPHB2 
Broad Tumor PortalEPHB2
OASIS PortalEPHB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEPHB2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEPHB2
Mutations and Diseases : HGMDEPHB2
intOGen PortalEPHB2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaEPHB2
DgiDB (Drug Gene Interaction Database)EPHB2
DoCM (Curated mutations)EPHB2
CIViC (Clinical Interpretations of Variants in Cancer)EPHB2
Cancer3DEPHB2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600997    603688    618462   
Orphanet903   
DisGeNETEPHB2
MedgenEPHB2
Genetic Testing Registry EPHB2
NextProtP29323 [Medical]
GENETestsEPHB2
Target ValidationEPHB2
Huge Navigator EPHB2 [HugePedia]
ClinGenEPHB2
Clinical trials, drugs, therapy
MyCancerGenomeEPHB2
Protein Interactions : CTDEPHB2
Pharm GKB GenePA27825
PharosP29323
Clinical trialEPHB2
Miscellaneous
canSAR (ICR)EPHB2
HarmonizomeEPHB2
DataMed IndexEPHB2
Probes
Litterature
PubMed175 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXEPHB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:08:18 CEST 2021

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