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EPHB2 (EPH receptor B2)

Identity

Alias_namesDRT
ERK
EPHT3
EphB2
Alias_symbol (synonym)Hek5
Tyro5
Other aliasCAPB
EK5
PCBC
HGNC (Hugo) EPHB2
LocusID (NCBI) 2048
Atlas_Id 40468
Location 1p36.12  [Link to chromosome band 1p36]
Location_base_pair Starts at 22710838 and ends at 22921500 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EPHB2 (1p36.12) / CPSF3L (1p36.33)EPHB2 (1p36.12) / EPHB2 (1p36.12)EPHB2 (1p36.12) / LYPLA2 (1p36.11)
H6PD (1p36.22) / EPHB2 (1p36.12)MAML2 (11q21) / EPHB2 (1p36.12)NBPF3 (1p36.12) / EPHB2 (1p36.12)
NBPF3 1p36.12 / EPHB2 1p36.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EPHB2   3393
LRG (Locus Reference Genomic)LRG_780
Cards
Entrez_Gene (NCBI)EPHB2  2048  EPH receptor B2
AliasesCAPB; DRT; EK5; EPHT3; 
ERK; Hek5; PCBC; Tyro5
GeneCards (Weizmann)EPHB2
Ensembl hg19 (Hinxton)ENSG00000133216 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133216 [Gene_View]  chr1:22710838-22921500 [Contig_View]  EPHB2 [Vega]
ICGC DataPortalENSG00000133216
TCGA cBioPortalEPHB2
AceView (NCBI)EPHB2
Genatlas (Paris)EPHB2
WikiGenes2048
SOURCE (Princeton)EPHB2
Genetics Home Reference (NIH)EPHB2
Genomic and cartography
GoldenPath hg38 (UCSC)EPHB2  -     chr1:22710838-22921500 +  1p36.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EPHB2  -     1p36.12   [Description]    (hg19-Feb_2009)
EnsemblEPHB2 - 1p36.12 [CytoView hg19]  EPHB2 - 1p36.12 [CytoView hg38]
Mapping of homologs : NCBIEPHB2 [Mapview hg19]  EPHB2 [Mapview hg38]
OMIM600997   603688   
Gene and transcription
Genbank (Entrez)AB210018 AF025304 AK025975 AK125423 AK298898
RefSeq transcript (Entrez)NM_001309192 NM_001309193 NM_004442 NM_017449
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EPHB2
Cluster EST : UnigeneHs.523329 [ NCBI ]
CGAP (NCI)Hs.523329
Alternative Splicing GalleryENSG00000133216
Gene ExpressionEPHB2 [ NCBI-GEO ]   EPHB2 [ EBI - ARRAY_EXPRESS ]   EPHB2 [ SEEK ]   EPHB2 [ MEM ]
Gene Expression Viewer (FireBrowse)EPHB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2048
GTEX Portal (Tissue expression)EPHB2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP29323   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP29323  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP29323
Splice isoforms : SwissVarP29323
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
PhosPhoSitePlusP29323
Domaine pattern : Prosite (Expaxy)EPH_LBD (PS51550)    FN3 (PS50853)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_V_1 (PS00790)    RECEPTOR_TYR_KIN_V_2 (PS00791)    SAM_DOMAIN (PS50105)   
Domains : Interpro (EBI)###############################################################################################################################################################################################################################################################                                                                       
Domain families : Pfam (Sanger)EphA2_TM (PF14575)    Ephrin_lbd (PF01404)    Ephrin_rec_like (PF07699)    fn3 (PF00041)    Pkinase_Tyr (PF07714)    SAM_1 (PF00536)   
Domain families : Pfam (NCBI)pfam14575    pfam01404    pfam07699    pfam00041    pfam07714    pfam00536   
Domain families : Smart (EMBL)EPH_lbd (SM00615)  Ephrin_rec_like (SM01411)  FN3 (SM00060)  SAM (SM00454)  TyrKc (SM00219)  
Conserved Domain (NCBI)EPHB2
DMDM Disease mutations2048
Blocks (Seattle)EPHB2
PDB (SRS)1B4F    1F0M    2QBX    3ZFM   
PDB (PDBSum)1B4F    1F0M    2QBX    3ZFM   
PDB (IMB)1B4F    1F0M    2QBX    3ZFM   
PDB (RSDB)1B4F    1F0M    2QBX    3ZFM   
Structural Biology KnowledgeBase1B4F    1F0M    2QBX    3ZFM   
SCOP (Structural Classification of Proteins)1B4F    1F0M    2QBX    3ZFM   
CATH (Classification of proteins structures)1B4F    1F0M    2QBX    3ZFM   
SuperfamilyP29323
Human Protein AtlasENSG00000133216
Peptide AtlasP29323
HPRD02997
IPIIPI00021275   IPI00219421   IPI00252979   IPI01015477   IPI01011584   IPI00644408   
Protein Interaction databases
DIP (DOE-UCLA)P29323
IntAct (EBI)P29323
FunCoupENSG00000133216
BioGRIDEPHB2
STRING (EMBL)EPHB2
ZODIACEPHB2
Ontologies - Pathways
QuickGOP29323
Ontology : AmiGOangiogenesis  urogenital system development  protein tyrosine kinase activity  transmembrane-ephrin receptor activity  transmembrane-ephrin receptor activity  receptor binding  protein binding  ATP binding  extracellular region  nucleus  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  nervous system development  axon guidance  axonal fasciculation  learning  axon guidance receptor activity  phosphorylation  peptidyl-tyrosine phosphorylation  optic nerve morphogenesis  central nervous system projection neuron axonogenesis  corpus callosum development  axon  dendrite  retinal ganglion cell axon guidance  inner ear morphogenesis  identical protein binding  neuronal cell body  ephrin receptor signaling pathway  ephrin receptor signaling pathway  positive regulation of long-term neuronal synaptic plasticity  camera-type eye morphogenesis  negative regulation of axonogenesis  regulation of body fluid levels  positive regulation of synapse assembly  palate development  dendritic spine development  dendritic spine morphogenesis  commissural neuron axon guidance  postsynapse  trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission  
Ontology : EGO-EBIangiogenesis  urogenital system development  protein tyrosine kinase activity  transmembrane-ephrin receptor activity  transmembrane-ephrin receptor activity  receptor binding  protein binding  ATP binding  extracellular region  nucleus  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  nervous system development  axon guidance  axonal fasciculation  learning  axon guidance receptor activity  phosphorylation  peptidyl-tyrosine phosphorylation  optic nerve morphogenesis  central nervous system projection neuron axonogenesis  corpus callosum development  axon  dendrite  retinal ganglion cell axon guidance  inner ear morphogenesis  identical protein binding  neuronal cell body  ephrin receptor signaling pathway  ephrin receptor signaling pathway  positive regulation of long-term neuronal synaptic plasticity  camera-type eye morphogenesis  negative regulation of axonogenesis  regulation of body fluid levels  positive regulation of synapse assembly  palate development  dendritic spine development  dendritic spine morphogenesis  commissural neuron axon guidance  postsynapse  trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission  
Pathways : KEGGAxon guidance   
NDEx NetworkEPHB2
Atlas of Cancer Signalling NetworkEPHB2
Wikipedia pathwaysEPHB2
Orthology - Evolution
OrthoDB2048
GeneTree (enSembl)ENSG00000133216
Phylogenetic Trees/Animal Genes : TreeFamEPHB2
HOVERGENP29323
HOGENOMP29323
Homologs : HomoloGeneEPHB2
Homology/Alignments : Family Browser (UCSC)EPHB2
Gene fusions - Rearrangements
Fusion : MitelmanEPHB2/CPSF3L [1p36.12/1p36.33]  
Fusion : MitelmanNBPF3/EPHB2 [1p36.12/1p36.12]  [t(1;1)(p36;p36)]  
Fusion: TCGANBPF3 1p36.12 EPHB2 1p36.12 GBM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEPHB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EPHB2
dbVarEPHB2
ClinVarEPHB2
1000_GenomesEPHB2 
Exome Variant ServerEPHB2
ExAC (Exome Aggregation Consortium)EPHB2 (select the gene name)
Genetic variants : HAPMAP2048
Genomic Variants (DGV)EPHB2 [DGVbeta]
DECIPHEREPHB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEPHB2 
Mutations
ICGC Data PortalEPHB2 
TCGA Data PortalEPHB2 
Broad Tumor PortalEPHB2
OASIS PortalEPHB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEPHB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEPHB2
intOGen PortalEPHB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EPHB2
DgiDB (Drug Gene Interaction Database)EPHB2
DoCM (Curated mutations)EPHB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EPHB2 (select a term)
intoGenEPHB2
Cancer3DEPHB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600997    603688   
Orphanet903   
MedgenEPHB2
Genetic Testing Registry EPHB2
NextProtP29323 [Medical]
TSGene2048
GENETestsEPHB2
Target ValidationEPHB2
Huge Navigator EPHB2 [HugePedia]
snp3D : Map Gene to Disease2048
BioCentury BCIQEPHB2
ClinGenEPHB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2048
Chemical/Pharm GKB GenePA27825
Clinical trialEPHB2
Miscellaneous
canSAR (ICR)EPHB2 (select the gene name)
Probes
Litterature
PubMed140 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEPHB2
EVEXEPHB2
GoPubMedEPHB2
iHOPEPHB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 13:52:40 CEST 2017

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