EPHB2 (EPH receptor B2)

2003-05-01  

Identity

HGNC
LOCATION
1p36.12
LOCUSID
ALIAS
BDPLT22,CAPB,DRT,EK5,EPHT3,ERK,Hek5,PCBC,Tyro5
FUSION GENES

Other Information

Locus ID:

NCBI: 2048
MIM: 600997
HGNC: 3393
Ensembl: ENSG00000133216

Variants:

dbSNP: 2048
ClinVar: 2048
TCGA: ENSG00000133216
COSMIC: EPHB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133216ENST00000374627B1AKC9
ENSG00000133216ENST00000374630P29323
ENSG00000133216ENST00000374632P29323
ENSG00000133216ENST00000400191P29323
ENSG00000133216ENST00000544305Q6NVW1

Expression (GTEx)

0
1
2
3
4
5
6
7
8

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHB-mediated forward signalingREACTOMER-HSA-3928662
Ephrin signalingREACTOMER-HSA-3928664
EPH-ephrin mediated repulsion of cellsREACTOMER-HSA-3928665

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
159734142005EphB receptor activity suppresses colorectal cancer progression.134
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
157223422005EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity.57
153002512004Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer.56
151263572004The phosphorylation of EphB2 receptor regulates migration and invasion of human glioma cells.52
187137442008Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion.50
193668062009Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progression.49
172349652007Notch ligand Delta-like 1 is essential for postnatal arteriogenesis.44
202338472010Ephrin-B2 regulates endothelial cell morphology and motility independently of Eph-receptor binding.38
162721702006Reduced expression of EphB2 that parallels invasion and metastasis in colorectal tumours.37

Citation

Dessen P

EPHB2 (EPH receptor B2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40468/ephb2