EPHB3 (EPH receptor B3)

2003-11-01  

Identity

HGNC
LOCATION
3q27.1
LOCUSID
ALIAS
EK2,ETK2,HEK2,TYRO6
FUSION GENES

Other Information

Locus ID:

NCBI: 2049
MIM: 601839
HGNC: 3394
Ensembl: ENSG00000182580

Variants:

dbSNP: 2049
ClinVar: 2049
TCGA: ENSG00000182580
COSMIC: EPHB3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182580ENST00000330394P54753

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHB-mediated forward signalingREACTOMER-HSA-3928662
Ephrin signalingREACTOMER-HSA-3928664
EPH-ephrin mediated repulsion of cellsREACTOMER-HSA-3928665

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
218045452011Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling.66
155360742005Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases.45
194831902009Over-expression of EphB3 enhances cell-cell contacts and suppresses tumor growth in HT-29 human colon cancer cells.39
223143632012EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex.37
212663522011EphB3 is overexpressed in non-small-cell lung cancer and promotes tumor metastasis by enhancing cell survival and migration.36
211068402010EphrinBs regulate D-serine synthesis and release in astrocytes.31
196077272009Identification of novel candidate target genes, including EPHB3, MASP1 and SST at 3q26.2-q29 in squamous cell carcinoma of the lung.25
189786782008Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.21
206348912010Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.18
252777752015SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer.16

Citation

Dessen P

EPHB3 (EPH receptor B3)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40469/ephb3