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EPHB3 (EPH receptor B3)

Identity

Alias_namesETK2
EphB3
Alias_symbol (synonym)Hek2
Tyro6
Other aliasEK2
HEK2
TYRO6
HGNC (Hugo) EPHB3
LocusID (NCBI) 2049
Atlas_Id 40469
Location 3q27.1  [Link to chromosome band 3q27]
Location_base_pair Starts at 184561799 and ends at 184582408 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NF1 (17q11.2) / EPHB3 (3q27.1)PIGZ (3q29) / EPHB3 (3q27.1)PIGZ 3q29 / EPHB3 3q27.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EPHB3   3394
Cards
Entrez_Gene (NCBI)EPHB3  2049  EPH receptor B3
AliasesEK2; ETK2; HEK2; TYRO6
GeneCards (Weizmann)EPHB3
Ensembl hg19 (Hinxton)ENSG00000182580 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182580 [Gene_View]  chr3:184561799-184582408 [Contig_View]  EPHB3 [Vega]
ICGC DataPortalENSG00000182580
TCGA cBioPortalEPHB3
AceView (NCBI)EPHB3
Genatlas (Paris)EPHB3
WikiGenes2049
SOURCE (Princeton)EPHB3
Genetics Home Reference (NIH)EPHB3
Genomic and cartography
GoldenPath hg38 (UCSC)EPHB3  -     chr3:184561799-184582408 +  3q27.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EPHB3  -     3q27.1   [Description]    (hg19-Feb_2009)
EnsemblEPHB3 - 3q27.1 [CytoView hg19]  EPHB3 - 3q27.1 [CytoView hg38]
Mapping of homologs : NCBIEPHB3 [Mapview hg19]  EPHB3 [Mapview hg38]
OMIM601839   
Gene and transcription
Genbank (Entrez)BC052968 CB993133 X75208
RefSeq transcript (Entrez)NM_004443
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EPHB3
Cluster EST : UnigeneHs.2913 [ NCBI ]
CGAP (NCI)Hs.2913
Alternative Splicing GalleryENSG00000182580
Gene ExpressionEPHB3 [ NCBI-GEO ]   EPHB3 [ EBI - ARRAY_EXPRESS ]   EPHB3 [ SEEK ]   EPHB3 [ MEM ]
Gene Expression Viewer (FireBrowse)EPHB3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2049
GTEX Portal (Tissue expression)EPHB3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP54753   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP54753  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP54753
Splice isoforms : SwissVarP54753
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
PhosPhoSitePlusP54753
Domaine pattern : Prosite (Expaxy)EPH_LBD (PS51550)    FN3 (PS50853)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_V_1 (PS00790)    RECEPTOR_TYR_KIN_V_2 (PS00791)    SAM_DOMAIN (PS50105)   
Domains : Interpro (EBI)###############################################################################################################################################################################################################################################################                                                                   
Domain families : Pfam (Sanger)EphA2_TM (PF14575)    Ephrin_lbd (PF01404)    Ephrin_rec_like (PF07699)    fn3 (PF00041)    Pkinase_Tyr (PF07714)    SAM_1 (PF00536)   
Domain families : Pfam (NCBI)pfam14575    pfam01404    pfam07699    pfam00041    pfam07714    pfam00536   
Domain families : Smart (EMBL)EPH_lbd (SM00615)  Ephrin_rec_like (SM01411)  FN3 (SM00060)  SAM (SM00454)  TyrKc (SM00219)  
Conserved Domain (NCBI)EPHB3
DMDM Disease mutations2049
Blocks (Seattle)EPHB3
PDB (SRS)3P1I    3ZFY    5L6O    5L6P   
PDB (PDBSum)3P1I    3ZFY    5L6O    5L6P   
PDB (IMB)3P1I    3ZFY    5L6O    5L6P   
PDB (RSDB)3P1I    3ZFY    5L6O    5L6P   
Structural Biology KnowledgeBase3P1I    3ZFY    5L6O    5L6P   
SCOP (Structural Classification of Proteins)3P1I    3ZFY    5L6O    5L6P   
CATH (Classification of proteins structures)3P1I    3ZFY    5L6O    5L6P   
SuperfamilyP54753
Human Protein AtlasENSG00000182580
Peptide AtlasP54753
HPRD03502
IPIIPI00289329   
Protein Interaction databases
DIP (DOE-UCLA)P54753
IntAct (EBI)P54753
FunCoupENSG00000182580
BioGRIDEPHB3
STRING (EMBL)EPHB3
ZODIACEPHB3
Ontologies - Pathways
QuickGOP54753
Ontology : AmiGOangiogenesis  urogenital system development  ephrin receptor activity  ATP binding  extracellular region  cytosol  plasma membrane  integral component of plasma membrane  axon guidance  axonal fasciculation  axon guidance receptor activity  cell migration  peptidyl-tyrosine phosphorylation  central nervous system projection neuron axonogenesis  corpus callosum development  regulation of cell-cell adhesion  dendrite  retinal ganglion cell axon guidance  substrate adhesion-dependent cell spreading  regulation of GTPase activity  protein autophosphorylation  ephrin receptor signaling pathway  ephrin receptor signaling pathway  thymus development  digestive tract morphogenesis  regulation of axonogenesis  positive regulation of synapse assembly  palate development  dendritic spine development  dendritic spine morphogenesis  
Ontology : EGO-EBIangiogenesis  urogenital system development  ephrin receptor activity  ATP binding  extracellular region  cytosol  plasma membrane  integral component of plasma membrane  axon guidance  axonal fasciculation  axon guidance receptor activity  cell migration  peptidyl-tyrosine phosphorylation  central nervous system projection neuron axonogenesis  corpus callosum development  regulation of cell-cell adhesion  dendrite  retinal ganglion cell axon guidance  substrate adhesion-dependent cell spreading  regulation of GTPase activity  protein autophosphorylation  ephrin receptor signaling pathway  ephrin receptor signaling pathway  thymus development  digestive tract morphogenesis  regulation of axonogenesis  positive regulation of synapse assembly  palate development  dendritic spine development  dendritic spine morphogenesis  
Pathways : KEGGAxon guidance   
NDEx NetworkEPHB3
Atlas of Cancer Signalling NetworkEPHB3
Wikipedia pathwaysEPHB3
Orthology - Evolution
OrthoDB2049
GeneTree (enSembl)ENSG00000182580
Phylogenetic Trees/Animal Genes : TreeFamEPHB3
HOVERGENP54753
HOGENOMP54753
Homologs : HomoloGeneEPHB3
Homology/Alignments : Family Browser (UCSC)EPHB3
Gene fusions - Rearrangements
Fusion : MitelmanPIGZ/EPHB3 [3q29/3q27.1]  [t(3;3)(q27;q29)]  
Fusion: TCGAPIGZ 3q29 EPHB3 3q27.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEPHB3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EPHB3
dbVarEPHB3
ClinVarEPHB3
1000_GenomesEPHB3 
Exome Variant ServerEPHB3
ExAC (Exome Aggregation Consortium)EPHB3 (select the gene name)
Genetic variants : HAPMAP2049
Genomic Variants (DGV)EPHB3 [DGVbeta]
DECIPHEREPHB3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEPHB3 
Mutations
ICGC Data PortalEPHB3 
TCGA Data PortalEPHB3 
Broad Tumor PortalEPHB3
OASIS PortalEPHB3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEPHB3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEPHB3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EPHB3
DgiDB (Drug Gene Interaction Database)EPHB3
DoCM (Curated mutations)EPHB3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EPHB3 (select a term)
intoGenEPHB3
Cancer3DEPHB3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601839   
Orphanet
MedgenEPHB3
Genetic Testing Registry EPHB3
NextProtP54753 [Medical]
TSGene2049
GENETestsEPHB3
Target ValidationEPHB3
Huge Navigator EPHB3 [HugePedia]
snp3D : Map Gene to Disease2049
BioCentury BCIQEPHB3
ClinGenEPHB3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2049
Chemical/Pharm GKB GenePA27826
Clinical trialEPHB3
Miscellaneous
canSAR (ICR)EPHB3 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEPHB3
EVEXEPHB3
GoPubMedEPHB3
iHOPEPHB3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:07:05 CEST 2017

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