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EPHB4 (EPH receptor B4)

Identity

Other namesHTK
MYK1
TYRO11
HGNC (Hugo) EPHB4
LocusID (NCBI) 2050
Location 7q22.1
Location_base_pair Starts at 100400187 and ends at 100425143 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)EPHB4   3395
Cards
Entrez_Gene (NCBI)EPHB4  2050  EPH receptor B4
GeneCards (Weizmann)EPHB4
Ensembl (Hinxton)ENSG00000196411 [Gene_View]  chr7:100400187-100425143 [Contig_View]  EPHB4 [Vega]
AceView (NCBI)EPHB4
Genatlas (Paris)EPHB4
WikiGenes2050
SOURCE (Princeton)NM_004444
Genomic and cartography
GoldenPath (UCSC)EPHB4  -  7q22.1   chr7:100400187-100425143 -  7q22.1   [Description]    (hg19-Feb_2009)
EnsemblEPHB4 - 7q22.1 [CytoView]
Mapping of homologs : NCBIEPHB4 [Mapview]
OMIM600011   
Gene and transcription
Genbank (Entrez)AB209644 AK301224 AY056048 BC004264 BC052804
RefSeq transcript (Entrez)NM_004444
RefSeq genomic (Entrez)AC_000068 AC_000139 NC_000007 NC_018918 NT_007933 NT_079595 NW_001839065 NW_004929332
Consensus coding sequences : CCDS (NCBI)EPHB4
Cluster EST : UnigeneHs.437008 [ NCBI ]
CGAP (NCI)Hs.437008
Alternative Splicing : Fast-db (Paris)GSHG0028421
Alternative Splicing GalleryENSG00000196411
Gene ExpressionEPHB4 [ NCBI-GEO ]     EPHB4 [ SEEK ]   EPHB4 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP54760 (Uniprot)
NextProtP54760  [Medical]
With graphics : InterProP54760
Splice isoforms : SwissVarP54760 (Swissvar)
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)EGF_2 (PS01186)    EPH_LBD (PS51550)    FN3 (PS50853)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_V_1 (PS00790)    RECEPTOR_TYR_KIN_V_2 (PS00791)    SAM_DOMAIN (PS50105)   
Domains : Interpro (EBI)Eph_TM    Ephrin_rcpt_lig-bd_dom    Fibronectin_type3    Galactose-bd-like    Growth_fac_rcpt_N_dom    Ig-like_fold    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    SAM    SAM/pointed    SAM_type1    Ser-Thr/Tyr_kinase_cat_dom    Tyr-kin_ephrin_A/B_rcpt-like    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_ephrin_rcpt    Tyr_kinase_rcpt_V_CS   
Related proteins : CluSTrP54760
Domain families : Pfam (Sanger)EphA2_TM (PF14575)    Ephrin_lbd (PF01404)    fn3 (PF00041)    GCC2_GCC3 (PF07699)    Pkinase_Tyr (PF07714)    SAM_1 (PF00536)   
Domain families : Pfam (NCBI)pfam14575    pfam01404    pfam00041    pfam07699    pfam07714    pfam00536   
Domain families : Smart (EMBL)EPH_lbd (SM00615)  FN3 (SM00060)  SAM (SM00454)  TyrKc (SM00219)  
DMDM Disease mutations2050
Blocks (Seattle)P54760
PDB (SRS)2BBA    2E7H    2HLE    2QKQ    2VWU    2VWV    2VWW    2VWX    2VWY    2VWZ    2VX0    2VX1    2X9F    2XVD    4AW5    4BB4   
PDB (PDBSum)2BBA    2E7H    2HLE    2QKQ    2VWU    2VWV    2VWW    2VWX    2VWY    2VWZ    2VX0    2VX1    2X9F    2XVD    4AW5    4BB4   
PDB (IMB)2BBA    2E7H    2HLE    2QKQ    2VWU    2VWV    2VWW    2VWX    2VWY    2VWZ    2VX0    2VX1    2X9F    2XVD    4AW5    4BB4   
PDB (RSDB)2BBA    2E7H    2HLE    2QKQ    2VWU    2VWV    2VWW    2VWX    2VWY    2VWZ    2VX0    2VX1    2X9F    2XVD    4AW5    4BB4   
Human Protein AtlasENSG00000196411
Peptide AtlasP54760
HPRD02481
IPIIPI00289342   IPI00909048   IPI00186826   
Protein Interaction databases
DIP (DOE-UCLA)P54760
IntAct (EBI)P54760
FunCoupENSG00000196411
BioGRIDEPHB4
InParanoidP54760
Interologous Interaction database P54760
IntegromeDBEPHB4
STRING (EMBL)EPHB4
Ontologies - Pathways
Ontology : AmiGOangiogenesis  cell migration involved in sprouting angiogenesis  heart morphogenesis  transmembrane receptor protein tyrosine kinase activity  ephrin receptor activity  protein binding  ATP binding  integral to plasma membrane  cell adhesion  cell surface  protein autophosphorylation  ephrin receptor signaling pathway  
Ontology : EGO-EBIangiogenesis  cell migration involved in sprouting angiogenesis  heart morphogenesis  transmembrane receptor protein tyrosine kinase activity  ephrin receptor activity  protein binding  ATP binding  integral to plasma membrane  cell adhesion  cell surface  protein autophosphorylation  ephrin receptor signaling pathway  
Pathways : KEGGAxon guidance   
REACTOMEEPHB4
Protein Interaction DatabaseEPHB4
Wikipedia pathwaysEPHB4
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)EPHB4
SNP (GeneSNP Utah)EPHB4
SNP : HGBaseEPHB4
Genetic variants : HAPMAPEPHB4
1000_GenomesEPHB4 
ICGC programENSG00000196411 
Somatic Mutations in Cancer : COSMICEPHB4 
CONAN: Copy Number AnalysisEPHB4 
Mutations and Diseases : HGMDEPHB4
OMIM600011   
GENETestsEPHB4
Disease Genetic AssociationEPHB4
Huge Navigator EPHB4 [HugePedia]  EPHB4 [HugeCancerGEM]
Genomic VariantsEPHB4  EPHB4 [DGVbeta]
Exome VariantEPHB4
dbVarEPHB4
ClinVarEPHB4
snp3D : Map Gene to Disease2050
General knowledge
Homologs : HomoloGeneEPHB4
Homology/Alignments : Family Browser (UCSC)EPHB4
Phylogenetic Trees/Animal Genes : TreeFamEPHB4
Chemical/Protein Interactions : CTD2050
Chemical/Pharm GKB GenePA27827
Clinical trialEPHB4
Cancer Resource (Charite)ENSG00000196411
Other databases
Probes
Litterature
PubMed85 Pubmed reference(s) in Entrez
CoreMineEPHB4
iHOPEPHB4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 16:44:11 CEST 2014

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