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EPHB4 (EPH receptor B4)

Identity

Other namesHTK
MYK1
TYRO11
HGNC (Hugo) EPHB4
LocusID (NCBI) 2050
Atlas_Id 40470
Location 7q22.1
Location_base_pair Starts at 100400187 and ends at 100425143 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)EPHB4   3395
Cards
Entrez_Gene (NCBI)EPHB4  2050  EPH receptor B4
GeneCards (Weizmann)EPHB4
Ensembl hg19 (Hinxton)ENSG00000196411 [Gene_View]  chr7:100400187-100425143 [Contig_View]  EPHB4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000196411 [Gene_View]  chr7:100400187-100425143 [Contig_View]  EPHB4 [Vega]
ICGC DataPortalENSG00000196411
TCGA cBioPortalEPHB4
AceView (NCBI)EPHB4
Genatlas (Paris)EPHB4
WikiGenes2050
SOURCE (Princeton)EPHB4
Genomic and cartography
GoldenPath hg19 (UCSC)EPHB4  -     chr7:100400187-100425143 -  7q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)EPHB4  -     7q22.1   [Description]    (hg38-Dec_2013)
EnsemblEPHB4 - 7q22.1 [CytoView hg19]  EPHB4 - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBIEPHB4 [Mapview hg19]  EPHB4 [Mapview hg38]
OMIM600011   
Gene and transcription
Genbank (Entrez)AB209644 AK301224 AY056048 BC004264 BC052804
RefSeq transcript (Entrez)NM_004444
RefSeq genomic (Entrez)NC_000007 NC_018918 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)EPHB4
Cluster EST : UnigeneHs.437008 [ NCBI ]
CGAP (NCI)Hs.437008
Alternative Splicing : Fast-db (Paris)GSHG0028421
Alternative Splicing GalleryENSG00000196411
Gene ExpressionEPHB4 [ NCBI-GEO ]     EPHB4 [ SEEK ]   EPHB4 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP54760 (Uniprot)
NextProtP54760  [Medical]
With graphics : InterProP54760
Splice isoforms : SwissVarP54760 (Swissvar)
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)EGF_2 (PS01186)    EPH_LBD (PS51550)    FN3 (PS50853)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_V_1 (PS00790)    RECEPTOR_TYR_KIN_V_2 (PS00791)    SAM_DOMAIN (PS50105)   
Domains : Interpro (EBI)Eph_TM    Ephrin_rcpt_lig-bd_dom    FN3_dom    Galactose-bd-like    Growth_fac_rcpt_N_dom    Ig-like_fold    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    SAM    SAM/pointed    SAM_type1    Ser-Thr/Tyr_kinase_cat_dom    Tyr-kin_ephrin_A/B_rcpt-like    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_ephrin_rcpt    Tyr_kinase_rcpt_V_CS   
Related proteins : CluSTrP54760
Domain families : Pfam (Sanger)EphA2_TM (PF14575)    Ephrin_lbd (PF01404)    fn3 (PF00041)    GCC2_GCC3 (PF07699)    Pkinase_Tyr (PF07714)    SAM_1 (PF00536)   
Domain families : Pfam (NCBI)pfam14575    pfam01404    pfam00041    pfam07699    pfam07714    pfam00536   
Domain families : Smart (EMBL)EPH_lbd (SM00615)  FN3 (SM00060)  SAM (SM00454)  TyrKc (SM00219)  
DMDM Disease mutations2050
Blocks (Seattle)P54760
PDB (SRS)2BBA    2E7H    2HLE    2QKQ    2VWU    2VWV    2VWW    2VWX    2VWY    2VWZ    2VX0    2VX1    2X9F    2XVD    2YN8    3ZEW    4AW5    4BB4   
PDB (PDBSum)2BBA    2E7H    2HLE    2QKQ    2VWU    2VWV    2VWW    2VWX    2VWY    2VWZ    2VX0    2VX1    2X9F    2XVD    2YN8    3ZEW    4AW5    4BB4   
PDB (IMB)2BBA    2E7H    2HLE    2QKQ    2VWU    2VWV    2VWW    2VWX    2VWY    2VWZ    2VX0    2VX1    2X9F    2XVD    2YN8    3ZEW    4AW5    4BB4   
PDB (RSDB)2BBA    2E7H    2HLE    2QKQ    2VWU    2VWV    2VWW    2VWX    2VWY    2VWZ    2VX0    2VX1    2X9F    2XVD    2YN8    3ZEW    4AW5    4BB4   
Human Protein AtlasENSG00000196411
Peptide AtlasP54760
HPRD02481
IPIIPI00289342   IPI00909048   IPI00186826   
Protein Interaction databases
DIP (DOE-UCLA)P54760
IntAct (EBI)P54760
FunCoupENSG00000196411
BioGRIDEPHB4
IntegromeDBEPHB4
STRING (EMBL)EPHB4
Ontologies - Pathways
QuickGOP54760
Ontology : AmiGOangiogenesis  cell migration involved in sprouting angiogenesis  heart morphogenesis  transmembrane receptor protein tyrosine kinase activity  ephrin receptor activity  protein binding  ATP binding  extracellular region  cytosol  plasma membrane  integral component of plasma membrane  cell adhesion  axon guidance  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  protein autophosphorylation  ephrin receptor signaling pathway  ephrin receptor signaling pathway  extracellular exosome  
Ontology : EGO-EBIangiogenesis  cell migration involved in sprouting angiogenesis  heart morphogenesis  transmembrane receptor protein tyrosine kinase activity  ephrin receptor activity  protein binding  ATP binding  extracellular region  cytosol  plasma membrane  integral component of plasma membrane  cell adhesion  axon guidance  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  protein autophosphorylation  ephrin receptor signaling pathway  ephrin receptor signaling pathway  extracellular exosome  
Pathways : KEGGAxon guidance   
Protein Interaction DatabaseEPHB4
DoCM (Curated mutations)EPHB4
Wikipedia pathwaysEPHB4
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerEPHB4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EPHB4
dbVarEPHB4
ClinVarEPHB4
1000_GenomesEPHB4 
Exome Variant ServerEPHB4
SNP (GeneSNP Utah)EPHB4
SNP : HGBaseEPHB4
Genetic variants : HAPMAPEPHB4
Genomic Variants (DGV)EPHB4 [DGVbeta]
Mutations
ICGC Data PortalEPHB4 
TCGA Data PortalEPHB4 
Tumor PortalEPHB4
Somatic Mutations in Cancer : COSMICEPHB4 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)7:100400187-100425143
CONAN: Copy Number AnalysisEPHB4 
Mutations and Diseases : HGMDEPHB4
OMIM600011   
MedgenEPHB4
NextProtP54760 [Medical]
GENETestsEPHB4
Disease Genetic AssociationEPHB4
Huge Navigator EPHB4 [HugePedia]  EPHB4 [HugeCancerGEM]
snp3D : Map Gene to Disease2050
DGIdb (Drug Gene Interaction db)EPHB4
General knowledge
Homologs : HomoloGeneEPHB4
Homology/Alignments : Family Browser (UCSC)EPHB4
Phylogenetic Trees/Animal Genes : TreeFamEPHB4
Chemical/Protein Interactions : CTD2050
Chemical/Pharm GKB GenePA27827
Clinical trialEPHB4
Cancer Resource (Charite)ENSG00000196411
Other databases
Probes
Litterature
PubMed97 Pubmed reference(s) in Entrez
CoreMineEPHB4
GoPubMedEPHB4
iHOPEPHB4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Apr 13 14:23:10 CEST 2015

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