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EPHX3 (epoxide hydrolase 3)

Identity

Alias (NCBI)ABHD9
EH3
HGNC (Hugo) EPHX3
HGNC Alias symbFLJ22408
HGNC Previous nameABHD9
HGNC Previous nameabhydrolase domain containing 9
LocusID (NCBI) 79852
Atlas_Id 50842
Location 19p13.12  [Link to chromosome band 19p13]
Location_base_pair Starts at 15226919 and ends at 15232448 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(14;19)(q32;p13) IGH::EPOR::t(14;19)(q32;p13) IGH::BRD4 ?


External links

 

Nomenclature
HGNC (Hugo)EPHX3   23760
Cards
Entrez_Gene (NCBI)EPHX3    epoxide hydrolase 3
AliasesABHD9; EH3
GeneCards (Weizmann)EPHX3
Ensembl hg19 (Hinxton)ENSG00000105131 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105131 [Gene_View]  ENSG00000105131 [Sequence]  chr19:15226919-15232448 [Contig_View]  EPHX3 [Vega]
ICGC DataPortalENSG00000105131
TCGA cBioPortalEPHX3
AceView (NCBI)EPHX3
Genatlas (Paris)EPHX3
SOURCE (Princeton)EPHX3
Genetics Home Reference (NIH)EPHX3
Genomic and cartography
GoldenPath hg38 (UCSC)EPHX3  -     chr19:15226919-15232448 -  19p13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EPHX3  -     19p13.12   [Description]    (hg19-Feb_2009)
GoldenPathEPHX3 - 19p13.12 [CytoView hg19]  EPHX3 - 19p13.12 [CytoView hg38]
ImmunoBaseENSG00000105131
Genome Data Viewer NCBIEPHX3 [Mapview hg19]  
OMIM617400   
Gene and transcription
Genbank (Entrez)AK026061 BC115002 BC132958 BC132960 CD632298
RefSeq transcript (Entrez)NM_001142886 NM_024794
Consensus coding sequences : CCDS (NCBI)EPHX3
Gene ExpressionEPHX3 [ NCBI-GEO ]   EPHX3 [ EBI - ARRAY_EXPRESS ]   EPHX3 [ SEEK ]   EPHX3 [ MEM ]
Gene Expression Viewer (FireBrowse)EPHX3 [ Firebrowse - Broad ]
GenevisibleExpression of EPHX3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79852
GTEX Portal (Tissue expression)EPHX3
Human Protein AtlasENSG00000105131-EPHX3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H6B9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H6B9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H6B9
PhosPhoSitePlusQ9H6B9
Domains : Interpro (EBI)AB_hydrolase    AB_hydrolase_1    Epox_hydrolase-like   
Domain families : Pfam (Sanger)Abhydrolase_6 (PF12697)   
Domain families : Pfam (NCBI)pfam12697   
Conserved Domain (NCBI)EPHX3
SuperfamilyQ9H6B9
AlphaFold pdb e-kbQ9H6B9   
Human Protein Atlas [tissue]ENSG00000105131-EPHX3 [tissue]
HPRD12410
Protein Interaction databases
DIP (DOE-UCLA)Q9H6B9
IntAct (EBI)Q9H6B9
BioGRIDEPHX3
STRING (EMBL)EPHX3
ZODIACEPHX3
Ontologies - Pathways
QuickGOQ9H6B9
Ontology : AmiGOepoxide hydrolase activity  endoplasmic reticulum  lipid metabolic process  membrane  integral component of membrane  hydrolase activity  intracellular membrane-bounded organelle  intracellular membrane-bounded organelle  epoxide metabolic process  
Ontology : EGO-EBIepoxide hydrolase activity  endoplasmic reticulum  lipid metabolic process  membrane  integral component of membrane  hydrolase activity  intracellular membrane-bounded organelle  intracellular membrane-bounded organelle  epoxide metabolic process  
NDEx NetworkEPHX3
Atlas of Cancer Signalling NetworkEPHX3
Wikipedia pathwaysEPHX3
Orthology - Evolution
OrthoDB79852
GeneTree (enSembl)ENSG00000105131
Phylogenetic Trees/Animal Genes : TreeFamEPHX3
Homologs : HomoloGeneEPHX3
Homology/Alignments : Family Browser (UCSC)EPHX3
Gene fusions - Rearrangements
Fusion : QuiverEPHX3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEPHX3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EPHX3
dbVarEPHX3
ClinVarEPHX3
MonarchEPHX3
1000_GenomesEPHX3 
Exome Variant ServerEPHX3
GNOMAD BrowserENSG00000105131
Varsome BrowserEPHX3
ACMGEPHX3 variants
VarityQ9H6B9
Genomic Variants (DGV)EPHX3 [DGVbeta]
DECIPHEREPHX3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEPHX3 
Mutations
ICGC Data PortalEPHX3 
TCGA Data PortalEPHX3 
Broad Tumor PortalEPHX3
OASIS PortalEPHX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEPHX3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEPHX3
Mutations and Diseases : HGMDEPHX3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaEPHX3
DgiDB (Drug Gene Interaction Database)EPHX3
DoCM (Curated mutations)EPHX3
CIViC (Clinical Interpretations of Variants in Cancer)EPHX3
Cancer3DEPHX3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617400   
Orphanet
DisGeNETEPHX3
MedgenEPHX3
Genetic Testing Registry EPHX3
NextProtQ9H6B9 [Medical]
GENETestsEPHX3
Target ValidationEPHX3
Huge Navigator EPHX3 [HugePedia]
ClinGenEPHX3
Clinical trials, drugs, therapy
MyCancerGenomeEPHX3
Protein Interactions : CTDEPHX3
Pharm GKB GenePA164719188
PharosQ9H6B9
Clinical trialEPHX3
Miscellaneous
canSAR (ICR)EPHX3
HarmonizomeEPHX3
ARCHS4EPHX3
DataMed IndexEPHX3
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXEPHX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:32:20 CET 2022

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