EPPIN (epididymal peptidase inhibitor)

2012-09-01  

Identity

HGNC
LOCATION
20q13.12
LOCUSID
ALIAS
CT71,CT72,SPINLW1,WAP7,WFDC7,dJ461P17.2

Other Information

Locus ID:

NCBI: 57119
MIM: 609031
HGNC: 15932
Ensembl: ENSG00000101448

Variants:

dbSNP: 57119
ClinVar: 57119
TCGA: ENSG00000101448
COSMIC: EPPIN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101448ENST00000336443O95925
ENSG00000101448ENST00000354280O95925
ENSG00000101448ENST00000354280A0A384NYB9
ENSG00000101448ENST00000409554B7ZBA9

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Antimicrobial peptidesREACTOMER-HSA-6803157

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
152291362004Antimicrobial activity of human EPPIN, an androgen-regulated, sperm-bound protein with a whey acidic protein motif.29
155909012005Association of eppin with semenogelin on human spermatozoa.21
198899472010Analysis of recombinant human semenogelin as an inhibitor of human sperm motility.18
243126232013Interacting proteins on human spermatozoa: adaptive evolution of the binding of semenogelin I to EPPIN.7
198015692010The effect of anti-eppin antibodies on ionophore A23187-induced calcium influx and acrosome reaction of human spermatozoa.6
183313572008Functional domains of the human epididymal protease inhibitor, eppin.5
204888032010Variants of the EPPIN gene affect the risk of idiopathic male infertility in the Han-Chinese population.5
204888032010Variants of the EPPIN gene affect the risk of idiopathic male infertility in the Han-Chinese population.5
226994872012Characterization of EPPIN's semenogelin I binding site: a contraceptive drug target.5
186456812008Molecular mechanism of epididymal protease inhibitor modulating the liquefaction of human semen.3

Citation

Dessen P

EPPIN (epididymal peptidase inhibitor)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52857/eppin