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EPRS (glutamyl-prolyl-tRNA synthetase)

Identity

Alias_namesQPRS
QARS
Alias_symbol (synonym)EARS
PARS
GLUPRORS
HGNC (Hugo) EPRS
LocusID (NCBI) 2058
Atlas_Id 62870
Location 1q41  [Link to chromosome band 1q41]
Location_base_pair Starts at 220141942 and ends at 220220000 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CDC42BPA (1q42.13) / EPRS (1q41)EPRS (1q41) / DNAH14 (1q42.12)EPRS (1q41) / USH2A (1q41)
EPRS DNAH14EPRS USH2A

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EPRS   3418
Cards
Entrez_Gene (NCBI)EPRS  2058  glutamyl-prolyl-tRNA synthetase
AliasesEARS; GLUPRORS; PARS; PIG32; 
QARS; QPRS
GeneCards (Weizmann)EPRS
Ensembl hg19 (Hinxton)ENSG00000136628 [Gene_View]  chr1:220141942-220220000 [Contig_View]  EPRS [Vega]
Ensembl hg38 (Hinxton)ENSG00000136628 [Gene_View]  chr1:220141942-220220000 [Contig_View]  EPRS [Vega]
ICGC DataPortalENSG00000136628
TCGA cBioPortalEPRS
AceView (NCBI)EPRS
Genatlas (Paris)EPRS
WikiGenes2058
SOURCE (Princeton)EPRS
Genetics Home Reference (NIH)EPRS
Genomic and cartography
GoldenPath hg19 (UCSC)EPRS  -     chr1:220141942-220220000 -  1q41   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)EPRS  -     1q41   [Description]    (hg38-Dec_2013)
EnsemblEPRS - 1q41 [CytoView hg19]  EPRS - 1q41 [CytoView hg38]
Mapping of homologs : NCBIEPRS [Mapview hg19]  EPRS [Mapview hg38]
OMIM138295   
Gene and transcription
Genbank (Entrez)AA196283 AK296755 AK298192 AK307534 AY493416
RefSeq transcript (Entrez)NM_004446
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_004487 NW_004929294
Consensus coding sequences : CCDS (NCBI)EPRS
Cluster EST : UnigeneHs.497788 [ NCBI ]
CGAP (NCI)Hs.497788
Alternative Splicing GalleryENSG00000136628
Gene ExpressionEPRS [ NCBI-GEO ]   EPRS [ EBI - ARRAY_EXPRESS ]   EPRS [ SEEK ]   EPRS [ MEM ]
Gene Expression Viewer (FireBrowse)EPRS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2058
GTEX Portal (Tissue expression)EPRS
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07814   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07814  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07814
Splice isoforms : SwissVarP07814
Catalytic activity : Enzyme6.1.1.17 [ Enzyme-Expasy ]   6.1.1.176.1.1.17 [ IntEnz-EBI ]   6.1.1.17 [ BRENDA ]   6.1.1.17 [ KEGG ]   
PhosPhoSitePlusP07814
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_I (PS00178)    AA_TRNA_LIGASE_II (PS50862)    WHEP_TRS_1 (PS00762)    WHEP_TRS_2 (PS51185)   
Domains : Interpro (EBI)aa-tRNA-synt_IIb_cons-dom    aa-tRNA-synth_I_CS    aa-tRNA-synth_II    Anticodon-bd    Glu-tRNA-synth_arc/euk    Glu/Gln-tRNA-synth    Glu/Gln-tRNA-synth_Ib_a-bdl    Glu/Gln-tRNA-synth_Ib_cat-dom    Glu/Gln-tRNA-synth_Ib_codon-bd    Glutathione-S-Trfase_C-like    GST_C    Pro-tRNA-ligase_IIa_arc-type    Pro-tRNA_ligase_II_C    Pro-tRNA_synth_II    Rbsml_L25/Gln-tRNA_synth_b-brl    Ribosomal_L25/Gln-tRNA_synth    Rossmann-like_a/b/a_fold    S15_NS1_RNA-bd    WHEP-TRS   
Domain families : Pfam (Sanger)GST_C_3 (PF14497)    HGTP_anticodon (PF03129)    ProRS-C_1 (PF09180)    tRNA-synt_1c (PF00749)    tRNA-synt_1c_C (PF03950)    tRNA-synt_2b (PF00587)    WHEP-TRS (PF00458)   
Domain families : Pfam (NCBI)pfam14497    pfam03129    pfam09180    pfam00749    pfam03950    pfam00587    pfam00458   
Domain families : Smart (EMBL)ProRS-C_1 (SM00946)  WHEP-TRS (SM00991)  
Conserved Domain (NCBI)EPRS
DMDM Disease mutations2058
Blocks (Seattle)EPRS
PDB (SRS)1FYJ    4HVC    4K86    4K87    4K88   
PDB (PDBSum)1FYJ    4HVC    4K86    4K87    4K88   
PDB (IMB)1FYJ    4HVC    4K86    4K87    4K88   
PDB (RSDB)1FYJ    4HVC    4K86    4K87    4K88   
Structural Biology KnowledgeBase1FYJ    4HVC    4K86    4K87    4K88   
SCOP (Structural Classification of Proteins)1FYJ    4HVC    4K86    4K87    4K88   
CATH (Classification of proteins structures)1FYJ    4HVC    4K86    4K87    4K88   
SuperfamilyP07814
Human Protein AtlasENSG00000136628
Peptide AtlasP07814
HPRD00703
IPIIPI00013452   IPI00909383   IPI01009785   
Protein Interaction databases
DIP (DOE-UCLA)P07814
IntAct (EBI)P07814
FunCoupENSG00000136628
BioGRIDEPRS
STRING (EMBL)EPRS
ZODIACEPRS
Ontologies - Pathways
QuickGOP07814
Ontology : AmiGOglutamate-tRNA ligase activity  proline-tRNA ligase activity  protein binding  ATP binding  cytoplasm  cytosol  tRNA aminoacylation for protein translation  glutamyl-tRNA aminoacylation  prolyl-tRNA aminoacylation  protein complex assembly  gene expression  membrane  aminoacyl-tRNA synthetase multienzyme complex  negative regulation of translation  negative regulation of translation  ribonucleoprotein complex  RNA stem-loop binding  GTPase binding  cellular response to interferon-gamma  GAIT complex  
Ontology : EGO-EBIglutamate-tRNA ligase activity  proline-tRNA ligase activity  protein binding  ATP binding  cytoplasm  cytosol  tRNA aminoacylation for protein translation  glutamyl-tRNA aminoacylation  prolyl-tRNA aminoacylation  protein complex assembly  gene expression  membrane  aminoacyl-tRNA synthetase multienzyme complex  negative regulation of translation  negative regulation of translation  ribonucleoprotein complex  RNA stem-loop binding  GTPase binding  cellular response to interferon-gamma  GAIT complex  
Pathways : KEGGPorphyrin and chlorophyll metabolism    Aminoacyl-tRNA biosynthesis   
NDEx NetworkEPRS
Atlas of Cancer Signalling NetworkEPRS
Wikipedia pathwaysEPRS
Orthology - Evolution
OrthoDB2058
GeneTree (enSembl)ENSG00000136628
Phylogenetic Trees/Animal Genes : TreeFamEPRS
HOVERGENP07814
HOGENOMP07814
Homologs : HomoloGeneEPRS
Homology/Alignments : Family Browser (UCSC)EPRS
Gene fusions - Rearrangements
Fusion: TCGAEPRS DNAH14
Fusion: TCGAEPRS USH2A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEPRS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EPRS
dbVarEPRS
ClinVarEPRS
1000_GenomesEPRS 
Exome Variant ServerEPRS
ExAC (Exome Aggregation Consortium)EPRS (select the gene name)
Genetic variants : HAPMAP2058
Genomic Variants (DGV)EPRS [DGVbeta]
DECIPHER (Syndromes)1:220141942-220220000  ENSG00000136628
CONAN: Copy Number AnalysisEPRS 
Mutations
ICGC Data PortalEPRS 
TCGA Data PortalEPRS 
Broad Tumor PortalEPRS
OASIS PortalEPRS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEPRS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEPRS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EPRS
DgiDB (Drug Gene Interaction Database)EPRS
DoCM (Curated mutations)EPRS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EPRS (select a term)
intoGenEPRS
Cancer3DEPRS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138295   
Orphanet
MedgenEPRS
Genetic Testing Registry EPRS
NextProtP07814 [Medical]
TSGene2058
GENETestsEPRS
Huge Navigator EPRS [HugePedia]
snp3D : Map Gene to Disease2058
BioCentury BCIQEPRS
ClinGenEPRS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2058
Chemical/Pharm GKB GenePA27837
Clinical trialEPRS
Miscellaneous
canSAR (ICR)EPRS (select the gene name)
Probes
Litterature
PubMed79 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEPRS
EVEXEPRS
GoPubMedEPRS
iHOPEPRS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Dec 29 13:24:20 CET 2016

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