EPX (eosinophil peroxidase)

2016-10-01  

Identity

HGNC
LOCATION
17q22
LOCUSID
ALIAS
EPO,EPP,EPX-PEN,EPXD

Other Information

Locus ID:

NCBI: 8288
MIM: 131399
HGNC: 3423
Ensembl: ENSG00000121053

Variants:

dbSNP: 8288
ClinVar: 8288
TCGA: ENSG00000121053
COSMIC: EPX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121053ENST00000225371P11678

Expression (GTEx)

0
1
2
3

Pathways

PathwaySourceExternal ID
AsthmaKEGGko05310
AsthmaKEGGhsa05310
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
204530002010A Large-scale genetic association study of esophageal adenocarcinoma risk.23
158948002005Thiocyanate modulates the catalytic activity of mammalian peroxidases.21
239316432013Eosinophil peroxidase in sputum represents a unique biomarker of airway eosinophilia.21
125405362003Human eosinophil peroxidase induces surface alteration, killing, and lysis of Mycobacterium tuberculosis.19
205016632010Protein Radical Formation Resulting from Eosinophil Peroxidase-catalyzed Oxidation of Sulfite.17
227505392012A sensitive high throughput ELISA for human eosinophil peroxidase: a specific assay to quantify eosinophil degranulation from patient-derived sources.12
186949362008Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase.10
282600492017Inflammatory peroxidases promote breast cancer progression in mice via regulation of the tumour microenvironment.9
146578712003High contribution contrast between the genes of eosinophil peroxidase and IL-4 receptor alpha-chain in Japanese cedar pollinosis.8

Citation

Dessen P

EPX (eosinophil peroxidase)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56108/epx