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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
Note: we send fiscal receipts for donations equal or above 50 Euros or Dollars

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ERAP1 (endoplasmic reticulum aminopeptidase 1)

Identity

Other namesA-LAP
ALAP
APPILS
ARTS-1
ARTS1
ERAAP
ERAAP1
PILS-AP
PILSAP
HGNC (Hugo) ERAP1
LocusID (NCBI) 51752
Location 5q15
Location_base_pair Starts at 96110188 and ends at 96143892 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ERAP1   18173
Cards
Entrez_Gene (NCBI)ERAP1  51752  endoplasmic reticulum aminopeptidase 1
GeneCards (Weizmann)ERAP1
Ensembl hg19 (Hinxton)ENSG00000164307 [Gene_View]  chr5:96110188-96143892 [Contig_View]  ERAP1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000164307 [Gene_View]  chr5:96110188-96143892 [Contig_View]  ERAP1 [Vega]
ICGC DataPortalENSG00000164307
cBioPortalERAP1
AceView (NCBI)ERAP1
Genatlas (Paris)ERAP1
WikiGenes51752
SOURCE (Princeton)ERAP1
Genomic and cartography
GoldenPath hg19 (UCSC)ERAP1  -     chr5:96110188-96143892 -  5q15   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ERAP1  -     5q15   [Description]    (hg38-Dec_2013)
EnsemblERAP1 - 5q15 [CytoView hg19]  ERAP1 - 5q15 [CytoView hg38]
Mapping of homologs : NCBIERAP1 [Mapview hg19]  ERAP1 [Mapview hg38]
OMIM606832   
Gene and transcription
Genbank (Entrez)AB011097 AF106037 AF183569 AF222340 AK222873
RefSeq transcript (Entrez)NM_001040458 NM_001198541 NM_016442
RefSeq genomic (Entrez)NC_000005 NC_018916 NG_027839 NT_034772 NW_004929323
Consensus coding sequences : CCDS (NCBI)ERAP1
Cluster EST : UnigeneHs.666524 [ NCBI ]
CGAP (NCI)Hs.666524
Alternative Splicing : Fast-db (Paris)GSHG0033460
Alternative Splicing GalleryENSG00000164307
Gene ExpressionERAP1 [ NCBI-GEO ]     ERAP1 [ SEEK ]   ERAP1 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NZ08 (Uniprot)
NextProtQ9NZ08  [Medical]
With graphics : InterProQ9NZ08
Splice isoforms : SwissVarQ9NZ08 (Swissvar)
Catalytic activity : Enzyme3.4.11.- [ Enzyme-Expasy ]   3.4.11.-3.4.11.- [ IntEnz-EBI ]   3.4.11.- [ BRENDA ]   3.4.11.- [ KEGG ]   
Domaine pattern : Prosite (Expaxy)ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ERAP1-like_C_dom    Peptidase_M1    Peptidase_M1_N   
Related proteins : CluSTrQ9NZ08
Domain families : Pfam (Sanger)ERAP1_C (PF11838)    Peptidase_M1 (PF01433)   
Domain families : Pfam (NCBI)pfam11838    pfam01433   
DMDM Disease mutations51752
Blocks (Seattle)Q9NZ08
PDB (SRS)2YD0    3MDJ    3QNF    3RJO   
PDB (PDBSum)2YD0    3MDJ    3QNF    3RJO   
PDB (IMB)2YD0    3MDJ    3QNF    3RJO   
PDB (RSDB)2YD0    3MDJ    3QNF    3RJO   
Human Protein AtlasENSG00000164307
Peptide AtlasQ9NZ08
HPRD06015
IPIIPI00477831   IPI00165949   IPI00964441   IPI00964173   IPI00966575   
Protein Interaction databases
DIP (DOE-UCLA)Q9NZ08
IntAct (EBI)Q9NZ08
FunCoupENSG00000164307
BioGRIDERAP1
IntegromeDBERAP1
STRING (EMBL)ERAP1
Ontologies - Pathways
QuickGOQ9NZ08
Ontology : AmiGOangiogenesis  antigen processing and presentation of peptide antigen via MHC class I  aminopeptidase activity  interleukin-6 receptor binding  interleukin-1, Type II receptor binding  protein binding  extracellular region  extracellular space  endoplasmic reticulum  endoplasmic reticulum lumen  endoplasmic reticulum membrane  cytosol  membrane protein ectodomain proteolysis  regulation of blood pressure  regulation of blood pressure  metalloexopeptidase activity  zinc ion binding  response to bacterium  membrane  integral component of membrane  antigen processing and presentation of endogenous peptide antigen via MHC class I  antigen processing and presentation of endogenous peptide antigen via MHC class I  regulation of innate immune response  fat cell differentiation  positive regulation of angiogenesis  extracellular exosome  
Ontology : EGO-EBIangiogenesis  antigen processing and presentation of peptide antigen via MHC class I  aminopeptidase activity  interleukin-6 receptor binding  interleukin-1, Type II receptor binding  protein binding  extracellular region  extracellular space  endoplasmic reticulum  endoplasmic reticulum lumen  endoplasmic reticulum membrane  cytosol  membrane protein ectodomain proteolysis  regulation of blood pressure  regulation of blood pressure  metalloexopeptidase activity  zinc ion binding  response to bacterium  membrane  integral component of membrane  antigen processing and presentation of endogenous peptide antigen via MHC class I  antigen processing and presentation of endogenous peptide antigen via MHC class I  regulation of innate immune response  fat cell differentiation  positive regulation of angiogenesis  extracellular exosome  
Protein Interaction DatabaseERAP1
DoCM (Curated mutations)ERAP1
Wikipedia pathwaysERAP1
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerERAP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ERAP1
dbVarERAP1
ClinVarERAP1
1000_GenomesERAP1 
Exome Variant ServerERAP1
SNP (GeneSNP Utah)ERAP1
SNP : HGBaseERAP1
Genetic variants : HAPMAPERAP1
Genomic Variants (DGV)ERAP1 [DGVbeta]
Mutations
ICGC Data PortalENSG00000164307 
Somatic Mutations in Cancer : COSMICERAP1 
CONAN: Copy Number AnalysisERAP1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)5:96110188-96143892
Mutations and Diseases : HGMDERAP1
OMIM606832   
MedgenERAP1
NextProtQ9NZ08 [Medical]
GENETestsERAP1
Disease Genetic AssociationERAP1
Huge Navigator ERAP1 [HugePedia]  ERAP1 [HugeCancerGEM]
snp3D : Map Gene to Disease51752
DGIdb (Drug Gene Interaction db)ERAP1
General knowledge
Homologs : HomoloGeneERAP1
Homology/Alignments : Family Browser (UCSC)ERAP1
Phylogenetic Trees/Animal Genes : TreeFamERAP1
Chemical/Protein Interactions : CTD51752
Chemical/Pharm GKB GenePA162385163
Clinical trialERAP1
Cancer Resource (Charite)ENSG00000164307
Other databases
Probes
Litterature
PubMed112 Pubmed reference(s) in Entrez
CoreMineERAP1
GoPubMedERAP1
iHOPERAP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Mar 28 15:18:31 CET 2015

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.