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ERAP2 (endoplasmic reticulum aminopeptidase 2)

Identity

Alias_symbol (synonym)L-RAP
LRAP
Other alias
HGNC (Hugo) ERAP2
LocusID (NCBI) 64167
Atlas_Id 46264
Location 5q15  [Link to chromosome band 5q15]
Location_base_pair Starts at 96875939 and ends at 96919716 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FAM172A (5q15) / ERAP2 (5q15)FAM172A 5q15 / ERAP2 5q15

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ERAP2   29499
Cards
Entrez_Gene (NCBI)ERAP2  64167  endoplasmic reticulum aminopeptidase 2
AliasesL-RAP; LRAP
GeneCards (Weizmann)ERAP2
Ensembl hg19 (Hinxton)ENSG00000164308 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164308 [Gene_View]  chr5:96875939-96919716 [Contig_View]  ERAP2 [Vega]
ICGC DataPortalENSG00000164308
TCGA cBioPortalERAP2
AceView (NCBI)ERAP2
Genatlas (Paris)ERAP2
WikiGenes64167
SOURCE (Princeton)ERAP2
Genetics Home Reference (NIH)ERAP2
Genomic and cartography
GoldenPath hg38 (UCSC)ERAP2  -     chr5:96875939-96919716 +  5q15   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ERAP2  -     5q15   [Description]    (hg19-Feb_2009)
EnsemblERAP2 - 5q15 [CytoView hg19]  ERAP2 - 5q15 [CytoView hg38]
Mapping of homologs : NCBIERAP2 [Mapview hg19]  ERAP2 [Mapview hg38]
OMIM609497   
Gene and transcription
Genbank (Entrez)AB109031 AB163917 AF191545 AK074213 AK074281
RefSeq transcript (Entrez)NM_001130140 NM_001329229 NM_001329233 NM_022350
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ERAP2
Cluster EST : UnigeneHs.482910 [ NCBI ]
CGAP (NCI)Hs.482910
Alternative Splicing GalleryENSG00000164308
Gene ExpressionERAP2 [ NCBI-GEO ]   ERAP2 [ EBI - ARRAY_EXPRESS ]   ERAP2 [ SEEK ]   ERAP2 [ MEM ]
Gene Expression Viewer (FireBrowse)ERAP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64167
GTEX Portal (Tissue expression)ERAP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6P179   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6P179  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6P179
Splice isoforms : SwissVarQ6P179
Catalytic activity : Enzyme3.4.11.- [ Enzyme-Expasy ]   3.4.11.-3.4.11.- [ IntEnz-EBI ]   3.4.11.- [ BRENDA ]   3.4.11.- [ KEGG ]   
PhosPhoSitePlusQ6P179
Domaine pattern : Prosite (Expaxy)ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ERAP1-like_C_dom    ERAP2    M1_APN-typ    Peptidase_M1    Peptidase_M1_N   
Domain families : Pfam (Sanger)ERAP1_C (PF11838)    Peptidase_M1 (PF01433)   
Domain families : Pfam (NCBI)pfam11838    pfam01433   
Conserved Domain (NCBI)ERAP2
DMDM Disease mutations64167
Blocks (Seattle)ERAP2
PDB (SRS)3SE6    4E36    4JBS    5AB0    5AB2    5CU5   
PDB (PDBSum)3SE6    4E36    4JBS    5AB0    5AB2    5CU5   
PDB (IMB)3SE6    4E36    4JBS    5AB0    5AB2    5CU5   
PDB (RSDB)3SE6    4E36    4JBS    5AB0    5AB2    5CU5   
Structural Biology KnowledgeBase3SE6    4E36    4JBS    5AB0    5AB2    5CU5   
SCOP (Structural Classification of Proteins)3SE6    4E36    4JBS    5AB0    5AB2    5CU5   
CATH (Classification of proteins structures)3SE6    4E36    4JBS    5AB0    5AB2    5CU5   
SuperfamilyQ6P179
Human Protein AtlasENSG00000164308
Peptide AtlasQ6P179
HPRD14306
IPIIPI00465261   IPI00877711   IPI00747807   IPI00878267   IPI00965123   IPI00965891   IPI00965644   IPI00964185   
Protein Interaction databases
DIP (DOE-UCLA)Q6P179
IntAct (EBI)Q6P179
FunCoupENSG00000164308
BioGRIDERAP2
STRING (EMBL)ERAP2
ZODIACERAP2
Ontologies - Pathways
QuickGOQ6P179
Ontology : AmiGOadaptive immune response  antigen processing and presentation of peptide antigen via MHC class I  endopeptidase activity  aminopeptidase activity  endoplasmic reticulum lumen  endoplasmic reticulum membrane  proteolysis  signal transduction  cell-cell signaling  regulation of blood pressure  metallopeptidase activity  zinc ion binding  integral component of membrane  antigen processing and presentation of endogenous peptide antigen via MHC class I  peptide binding  peptide catabolic process  metalloaminopeptidase activity  
Ontology : EGO-EBIadaptive immune response  antigen processing and presentation of peptide antigen via MHC class I  endopeptidase activity  aminopeptidase activity  endoplasmic reticulum lumen  endoplasmic reticulum membrane  proteolysis  signal transduction  cell-cell signaling  regulation of blood pressure  metallopeptidase activity  zinc ion binding  integral component of membrane  antigen processing and presentation of endogenous peptide antigen via MHC class I  peptide binding  peptide catabolic process  metalloaminopeptidase activity  
NDEx NetworkERAP2
Atlas of Cancer Signalling NetworkERAP2
Wikipedia pathwaysERAP2
Orthology - Evolution
OrthoDB64167
GeneTree (enSembl)ENSG00000164308
Phylogenetic Trees/Animal Genes : TreeFamERAP2
HOVERGENQ6P179
HOGENOMQ6P179
Homologs : HomoloGeneERAP2
Homology/Alignments : Family Browser (UCSC)ERAP2
Gene fusions - Rearrangements
Fusion: TCGAFAM172A 5q15 ERAP2 5q15 KIRC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerERAP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ERAP2
dbVarERAP2
ClinVarERAP2
1000_GenomesERAP2 
Exome Variant ServerERAP2
ExAC (Exome Aggregation Consortium)ERAP2 (select the gene name)
Genetic variants : HAPMAP64167
Genomic Variants (DGV)ERAP2 [DGVbeta]
DECIPHERERAP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisERAP2 
Mutations
ICGC Data PortalERAP2 
TCGA Data PortalERAP2 
Broad Tumor PortalERAP2
OASIS PortalERAP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICERAP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDERAP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ERAP2
DgiDB (Drug Gene Interaction Database)ERAP2
DoCM (Curated mutations)ERAP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ERAP2 (select a term)
intoGenERAP2
Cancer3DERAP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609497   
Orphanet
MedgenERAP2
Genetic Testing Registry ERAP2
NextProtQ6P179 [Medical]
TSGene64167
GENETestsERAP2
Target ValidationERAP2
Huge Navigator ERAP2 [HugePedia]
snp3D : Map Gene to Disease64167
BioCentury BCIQERAP2
ClinGenERAP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64167
Chemical/Pharm GKB GenePA162385208
Clinical trialERAP2
Miscellaneous
canSAR (ICR)ERAP2 (select the gene name)
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineERAP2
EVEXERAP2
GoPubMedERAP2
iHOPERAP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:32:47 CEST 2017

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