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ERBIN (erbb2 interacting protein)

Identity

Alias_namesERBB2IP
erbb2-interacting protein
Alias_symbol (synonym)LAP2
Other aliasHEL-S-78
HGNC (Hugo) ERBIN
LocusID (NCBI) 55914
Atlas_Id 55621
Location 5q12.3  [Link to chromosome band 5q12]
Location_base_pair Starts at 65222382 and ends at 65376851 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ERBIN (5q12.3) / ASXL1 (20q11.21)ERBIN (5q12.3) / ERBIN (5q12.3)ERBIN (5q12.3) / NLN (5q12.3)
ERBIN (5q12.3) / PPWD1 (5q12.3)ERBIN (5q12.3) / SYNPO2L (10q22.2)ERBIN (5q12.3) / TJP2 (9q21.11)
ERBIN (5q12.3) / TRAPPC13 (5q12.3)ERBIN (5q12.3) / ZBTB10 (8q21.13)SF3B3 (16q22.1) / ERBIN (5q12.3)
SPTBN1 (2p16.2) / ERBIN (5q12.3)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)ERBIN   15842
Cards
Entrez_Gene (NCBI)ERBIN  55914  erbb2 interacting protein
AliasesERBB2IP; HEL-S-78; LAP2
GeneCards (Weizmann)ERBIN
Ensembl hg19 (Hinxton)ENSG00000112851 [Gene_View]  chr5:65222382-65376851 [Contig_View]  ERBIN [Vega]
Ensembl hg38 (Hinxton)ENSG00000112851 [Gene_View]  chr5:65222382-65376851 [Contig_View]  ERBIN [Vega]
ICGC DataPortalENSG00000112851
TCGA cBioPortalERBIN
AceView (NCBI)ERBIN
Genatlas (Paris)ERBIN
WikiGenes55914
SOURCE (Princeton)ERBIN
Genetics Home Reference (NIH)ERBIN
Genomic and cartography
GoldenPath hg19 (UCSC)ERBIN  -     chr5:65222382-65376851 +  5q12.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ERBIN  -     5q12.3   [Description]    (hg38-Dec_2013)
EnsemblERBIN - 5q12.3 [CytoView hg19]  ERBIN - 5q12.3 [CytoView hg38]
Mapping of homologs : NCBIERBIN [Mapview hg19]  ERBIN [Mapview hg38]
OMIM606944   
Gene and transcription
Genbank (Entrez)AB033051 AF263744 AF276423 AI082776 AK001180
RefSeq transcript (Entrez)NM_001006600 NM_001253697 NM_001253698 NM_001253699 NM_001253701 NM_018695
RefSeq genomic (Entrez)NC_000005 NC_018916 NG_031822 NT_034772 NW_004929322
Consensus coding sequences : CCDS (NCBI)ERBIN
Cluster EST : UnigeneHs.597241 [ NCBI ]
CGAP (NCI)Hs.597241
Alternative Splicing GalleryENSG00000112851
Gene ExpressionERBIN [ NCBI-GEO ]   ERBIN [ EBI - ARRAY_EXPRESS ]   ERBIN [ SEEK ]   ERBIN [ MEM ]
Gene Expression Viewer (FireBrowse)ERBIN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55914
GTEX Portal (Tissue expression)ERBIN
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96RT1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96RT1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96RT1
Splice isoforms : SwissVarQ96RT1
PhosPhoSitePlusQ96RT1
Domaine pattern : Prosite (Expaxy)LRR (PS51450)    PDZ (PS50106)   
Domains : Interpro (EBI)L_dom-like    Leu-rich_rpt    PDZ   
Domain families : Pfam (Sanger)LRR_8 (PF13855)    PDZ (PF00595)   
Domain families : Pfam (NCBI)pfam13855    pfam00595   
Domain families : Smart (EMBL)PDZ (SM00228)  
Conserved Domain (NCBI)ERBIN
DMDM Disease mutations55914
Blocks (Seattle)ERBIN
PDB (SRS)1MFG    1MFL    1N7T    2H3L    2QBW    3CH8   
PDB (PDBSum)1MFG    1MFL    1N7T    2H3L    2QBW    3CH8   
PDB (IMB)1MFG    1MFL    1N7T    2H3L    2QBW    3CH8   
PDB (RSDB)1MFG    1MFL    1N7T    2H3L    2QBW    3CH8   
Structural Biology KnowledgeBase1MFG    1MFL    1N7T    2H3L    2QBW    3CH8   
SCOP (Structural Classification of Proteins)1MFG    1MFL    1N7T    2H3L    2QBW    3CH8   
CATH (Classification of proteins structures)1MFG    1MFL    1N7T    2H3L    2QBW    3CH8   
SuperfamilyQ96RT1
Human Protein AtlasENSG00000112851
Peptide AtlasQ96RT1
HPRD06090
IPIIPI00438286   IPI00438287   IPI00438288   IPI00438289   IPI00438290   IPI00438291   IPI00438292   IPI00966896   IPI00910753   IPI00966557   IPI00967119   IPI00966353   
Protein Interaction databases
DIP (DOE-UCLA)Q96RT1
IntAct (EBI)Q96RT1
FunCoupENSG00000112851
BioGRIDERBIN
STRING (EMBL)ERBIN
ZODIACERBIN
Ontologies - Pathways
QuickGOQ96RT1
Ontology : AmiGOreceptor binding  ErbB-2 class receptor binding  integrin binding  structural constituent of cytoskeleton  protein binding  basement membrane  nucleus  nucleoplasm  cytoplasm  plasma membrane  plasma membrane  protein targeting  cell cycle  cell adhesion  signal transduction  epidermal growth factor receptor signaling pathway  integrin-mediated signaling pathway  basal plasma membrane  cell growth  basolateral plasma membrane  cell junction  hemidesmosome  nuclear membrane  negative regulation of NF-kappaB transcription factor activity  response to muramyl dipeptide  response to lipopolysaccharide  ERBB2 signaling pathway  intermediate filament cytoskeleton organization  basal protein localization  establishment or maintenance of epithelial cell apical/basal polarity  negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  cellular response to tumor necrosis factor  negative regulation of monocyte chemotactic protein-1 production  
Ontology : EGO-EBIreceptor binding  ErbB-2 class receptor binding  integrin binding  structural constituent of cytoskeleton  protein binding  basement membrane  nucleus  nucleoplasm  cytoplasm  plasma membrane  plasma membrane  protein targeting  cell cycle  cell adhesion  signal transduction  epidermal growth factor receptor signaling pathway  integrin-mediated signaling pathway  basal plasma membrane  cell growth  basolateral plasma membrane  cell junction  hemidesmosome  nuclear membrane  negative regulation of NF-kappaB transcription factor activity  response to muramyl dipeptide  response to lipopolysaccharide  ERBB2 signaling pathway  intermediate filament cytoskeleton organization  basal protein localization  establishment or maintenance of epithelial cell apical/basal polarity  negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  cellular response to tumor necrosis factor  negative regulation of monocyte chemotactic protein-1 production  
NDEx NetworkERBIN
Atlas of Cancer Signalling NetworkERBIN
Wikipedia pathwaysERBIN
Orthology - Evolution
OrthoDB55914
GeneTree (enSembl)ENSG00000112851
Phylogenetic Trees/Animal Genes : TreeFamERBIN
HOVERGENQ96RT1
HOGENOMQ96RT1
Homologs : HomoloGeneERBIN
Homology/Alignments : Family Browser (UCSC)ERBIN
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerERBIN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ERBIN
dbVarERBIN
ClinVarERBIN
1000_GenomesERBIN 
Exome Variant ServerERBIN
ExAC (Exome Aggregation Consortium)ERBIN (select the gene name)
Genetic variants : HAPMAP55914
Genomic Variants (DGV)ERBIN [DGVbeta]
DECIPHER (Syndromes)5:65222382-65376851  ENSG00000112851
CONAN: Copy Number AnalysisERBIN 
Mutations
ICGC Data PortalERBIN 
TCGA Data PortalERBIN 
Broad Tumor PortalERBIN
OASIS PortalERBIN [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDERBIN
BioMutasearch ERBIN
DgiDB (Drug Gene Interaction Database)ERBIN
DoCM (Curated mutations)ERBIN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ERBIN (select a term)
intoGenERBIN
Cancer3DERBIN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606944   
Orphanet
MedgenERBIN
Genetic Testing Registry ERBIN
NextProtQ96RT1 [Medical]
TSGene55914
GENETestsERBIN
Huge Navigator ERBIN [HugePedia]
snp3D : Map Gene to Disease55914
BioCentury BCIQERBIN
ClinGenERBIN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55914
Chemical/Pharm GKB GenePA27845
Clinical trialERBIN
Miscellaneous
canSAR (ICR)ERBIN (select the gene name)
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineERBIN
EVEXERBIN
GoPubMedERBIN
iHOPERBIN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:00:16 CEST 2017

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