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EREG (epiregulin)

Identity

Alias_symbol (synonym)ER
Other aliasEPR
Ep
HGNC (Hugo) EREG
LocusID (NCBI) 2069
Atlas_Id 40484
Location 4q13.3  [Link to chromosome band 4q13]
Location_base_pair Starts at 75230860 and ends at 75254477 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EREG   3443
Cards
Entrez_Gene (NCBI)EREG  2069  epiregulin
AliasesEPR; ER; Ep
GeneCards (Weizmann)EREG
Ensembl hg19 (Hinxton)ENSG00000124882 [Gene_View]  chr4:75230860-75254477 [Contig_View]  EREG [Vega]
Ensembl hg38 (Hinxton)ENSG00000124882 [Gene_View]  chr4:75230860-75254477 [Contig_View]  EREG [Vega]
ICGC DataPortalENSG00000124882
TCGA cBioPortalEREG
AceView (NCBI)EREG
Genatlas (Paris)EREG
WikiGenes2069
SOURCE (Princeton)EREG
Genetics Home Reference (NIH)EREG
Genomic and cartography
GoldenPath hg19 (UCSC)EREG  -     chr4:75230860-75254477 +  4q13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)EREG  -     4q13.3   [Description]    (hg38-Dec_2013)
EnsemblEREG - 4q13.3 [CytoView hg19]  EREG - 4q13.3 [CytoView hg38]
Mapping of homologs : NCBIEREG [Mapview hg19]  EREG [Mapview hg38]
OMIM602061   
Gene and transcription
Genbank (Entrez)AK314959 BC035806 BC136404 BC136405 CR541887
RefSeq transcript (Entrez)NM_001432
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)EREG
Cluster EST : UnigeneHs.115263 [ NCBI ]
CGAP (NCI)Hs.115263
Alternative Splicing GalleryENSG00000124882
Gene ExpressionEREG [ NCBI-GEO ]   EREG [ EBI - ARRAY_EXPRESS ]   EREG [ SEEK ]   EREG [ MEM ]
Gene Expression Viewer (FireBrowse)EREG [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2069
GTEX Portal (Tissue expression)EREG
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14944   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14944  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14944
Splice isoforms : SwissVarO14944
PhosPhoSitePlusO14944
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)   
Domains : Interpro (EBI)EGF-like_CS    EGF-like_dom    EGF_rcpt_ligand   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)EGF (SM00181)  
Conserved Domain (NCBI)EREG
DMDM Disease mutations2069
Blocks (Seattle)EREG
PDB (SRS)1K36    1K37    5E8D   
PDB (PDBSum)1K36    1K37    5E8D   
PDB (IMB)1K36    1K37    5E8D   
PDB (RSDB)1K36    1K37    5E8D   
Structural Biology KnowledgeBase1K36    1K37    5E8D   
SCOP (Structural Classification of Proteins)1K36    1K37    5E8D   
CATH (Classification of proteins structures)1K36    1K37    5E8D   
SuperfamilyO14944
Human Protein AtlasENSG00000124882
Peptide AtlasO14944
HPRD03638
IPIIPI00024741   
Protein Interaction databases
DIP (DOE-UCLA)O14944
IntAct (EBI)O14944
FunCoupENSG00000124882
BioGRIDEREG
STRING (EMBL)EREG
ZODIACEREG
Ontologies - Pathways
QuickGOO14944
Ontology : AmiGOMAPK cascade  angiogenesis  ovarian cumulus expansion  oocyte maturation  positive regulation of cytokine production  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  epidermal growth factor receptor binding  epidermal growth factor receptor binding  protein binding  extracellular region  extracellular space  intracellular  integral component of plasma membrane  female meiotic division  epidermal growth factor receptor signaling pathway  epidermal growth factor receptor signaling pathway  cell-cell signaling  growth factor activity  positive regulation of cell proliferation  positive regulation of cell proliferation  negative regulation of cell proliferation  mRNA transcription  anatomical structure morphogenesis  organ morphogenesis  regulation of phosphatidylinositol 3-kinase signaling  peptidyl-tyrosine phosphorylation  cytokine-mediated signaling pathway  keratinocyte differentiation  ovulation  ERBB2 signaling pathway  wound healing  positive regulation of cytokine biosynthetic process  positive regulation of phosphorylation  positive regulation of phosphorylation  luteinizing hormone signaling pathway  response to peptide hormone  positive regulation of GTPase activity  keratinocyte proliferation  positive regulation of innate immune response  positive regulation of interleukin-6 biosynthetic process  positive regulation of DNA replication  positive regulation of DNA replication  positive regulation of epidermal growth factor-activated receptor activity  positive regulation of mitotic nuclear division  positive regulation of protein kinase activity  negative regulation of transcription, DNA-templated  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  positive regulation of fibroblast proliferation  primary follicle stage  positive regulation of smooth muscle cell proliferation  negative regulation of epithelial cell proliferation  negative regulation of smooth muscle cell differentiation  regulation of cell motility  
Ontology : EGO-EBIMAPK cascade  angiogenesis  ovarian cumulus expansion  oocyte maturation  positive regulation of cytokine production  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  epidermal growth factor receptor binding  epidermal growth factor receptor binding  protein binding  extracellular region  extracellular space  intracellular  integral component of plasma membrane  female meiotic division  epidermal growth factor receptor signaling pathway  epidermal growth factor receptor signaling pathway  cell-cell signaling  growth factor activity  positive regulation of cell proliferation  positive regulation of cell proliferation  negative regulation of cell proliferation  mRNA transcription  anatomical structure morphogenesis  organ morphogenesis  regulation of phosphatidylinositol 3-kinase signaling  peptidyl-tyrosine phosphorylation  cytokine-mediated signaling pathway  keratinocyte differentiation  ovulation  ERBB2 signaling pathway  wound healing  positive regulation of cytokine biosynthetic process  positive regulation of phosphorylation  positive regulation of phosphorylation  luteinizing hormone signaling pathway  response to peptide hormone  positive regulation of GTPase activity  keratinocyte proliferation  positive regulation of innate immune response  positive regulation of interleukin-6 biosynthetic process  positive regulation of DNA replication  positive regulation of DNA replication  positive regulation of epidermal growth factor-activated receptor activity  positive regulation of mitotic nuclear division  positive regulation of protein kinase activity  negative regulation of transcription, DNA-templated  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  positive regulation of fibroblast proliferation  primary follicle stage  positive regulation of smooth muscle cell proliferation  negative regulation of epithelial cell proliferation  negative regulation of smooth muscle cell differentiation  regulation of cell motility  
Pathways : KEGGErbB signaling pathway   
NDEx NetworkEREG
Atlas of Cancer Signalling NetworkEREG
Wikipedia pathwaysEREG
Orthology - Evolution
OrthoDB2069
GeneTree (enSembl)ENSG00000124882
Phylogenetic Trees/Animal Genes : TreeFamEREG
HOVERGENO14944
HOGENOMO14944
Homologs : HomoloGeneEREG
Homology/Alignments : Family Browser (UCSC)EREG
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEREG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EREG
dbVarEREG
ClinVarEREG
1000_GenomesEREG 
Exome Variant ServerEREG
ExAC (Exome Aggregation Consortium)EREG (select the gene name)
Genetic variants : HAPMAP2069
Genomic Variants (DGV)EREG [DGVbeta]
DECIPHER (Syndromes)4:75230860-75254477  ENSG00000124882
CONAN: Copy Number AnalysisEREG 
Mutations
ICGC Data PortalEREG 
TCGA Data PortalEREG 
Broad Tumor PortalEREG
OASIS PortalEREG [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEREG  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEREG
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch EREG
DgiDB (Drug Gene Interaction Database)EREG
DoCM (Curated mutations)EREG (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EREG (select a term)
intoGenEREG
Cancer3DEREG(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602061   
Orphanet
MedgenEREG
Genetic Testing Registry EREG
NextProtO14944 [Medical]
TSGene2069
GENETestsEREG
Huge Navigator EREG [HugePedia]
snp3D : Map Gene to Disease2069
BioCentury BCIQEREG
ClinGenEREG
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2069
Chemical/Pharm GKB GenePA27856
Clinical trialEREG
Miscellaneous
canSAR (ICR)EREG (select the gene name)
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEREG
EVEXEREG
GoPubMedEREG
iHOPEREG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:04:56 CET 2017

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