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ERI1 (exoribonuclease 1)

Identity

Alias (NCBI)3'HEXO
HEXO
THEX1
HGNC (Hugo) ERI1
HGNC Alias symb3'HEXO
HGNC Alias nameexoribonuclease 1
 enhanced RNAi three prime mRNA exonuclease homolog 1 (C.elegans)
HGNC Previous nameTHEX1
HGNC Previous namethree prime histone mRNA exonuclease 1
LocusID (NCBI) 90459
Atlas_Id 62880
Location 8p23.1  [Link to chromosome band 8p23]
Location_base_pair Starts at 9002897 and ends at 9033338 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ERI1 (8p23.1) / SCNN1B (16p12.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ERI1   23994
Cards
Entrez_Gene (NCBI)ERI1    exoribonuclease 1
Aliases3'HEXO; HEXO; THEX1
GeneCards (Weizmann)ERI1
Ensembl hg19 (Hinxton)ENSG00000104626 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104626 [Gene_View]  ENSG00000104626 [Sequence]  chr8:9002897-9033338 [Contig_View]  ERI1 [Vega]
ICGC DataPortalENSG00000104626
TCGA cBioPortalERI1
AceView (NCBI)ERI1
Genatlas (Paris)ERI1
SOURCE (Princeton)ERI1
Genetics Home Reference (NIH)ERI1
Genomic and cartography
GoldenPath hg38 (UCSC)ERI1  -     chr8:9002897-9033338 +  8p23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ERI1  -     8p23.1   [Description]    (hg19-Feb_2009)
GoldenPathERI1 - 8p23.1 [CytoView hg19]  ERI1 - 8p23.1 [CytoView hg38]
ImmunoBaseENSG00000104626
Genome Data Viewer NCBIERI1 [Mapview hg19]  
OMIM608739   
Gene and transcription
Genbank (Entrez)AK024646 AK226180 AK291062 AK301506 AL137679
RefSeq transcript (Entrez)NM_001354635 NM_001354636 NM_001354638 NM_153332
Consensus coding sequences : CCDS (NCBI)ERI1
Gene ExpressionERI1 [ NCBI-GEO ]   ERI1 [ EBI - ARRAY_EXPRESS ]   ERI1 [ SEEK ]   ERI1 [ MEM ]
Gene Expression Viewer (FireBrowse)ERI1 [ Firebrowse - Broad ]
GenevisibleExpression of ERI1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)90459
GTEX Portal (Tissue expression)ERI1
Human Protein AtlasENSG00000104626-ERI1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IV48   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IV48  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IV48
Catalytic activity : Enzyme3.1.-.- [ Enzyme-Expasy ]   3.1.-.-3.1.-.- [ IntEnz-EBI ]   3.1.-.- [ BRENDA ]   3.1.-.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ8IV48
Domaine pattern : Prosite (Expaxy)SAP (PS50800)   
Domains : Interpro (EBI)Exonuclease_RNaseT/DNA_pol3    RNaseH-like_sf    RNaseH_sf    SAP_dom    SAP_dom_sf   
Domain families : Pfam (Sanger)RNase_T (PF00929)    SAP (PF02037)   
Domain families : Pfam (NCBI)pfam00929    pfam02037   
Domain families : Smart (EMBL)EXOIII (SM00479)  SAP (SM00513)  
Conserved Domain (NCBI)ERI1
PDB (RSDB)1W0H    1ZBH    1ZBU    4L8R    4QOZ   
PDB Europe1W0H    1ZBH    1ZBU    4L8R    4QOZ   
PDB (PDBSum)1W0H    1ZBH    1ZBU    4L8R    4QOZ   
PDB (IMB)1W0H    1ZBH    1ZBU    4L8R    4QOZ   
Structural Biology KnowledgeBase1W0H    1ZBH    1ZBU    4L8R    4QOZ   
SCOP (Structural Classification of Proteins)1W0H    1ZBH    1ZBU    4L8R    4QOZ   
CATH (Classification of proteins structures)1W0H    1ZBH    1ZBU    4L8R    4QOZ   
SuperfamilyQ8IV48
AlphaFold pdb e-kbQ8IV48   
Human Protein Atlas [tissue]ENSG00000104626-ERI1 [tissue]
HPRD11784
Protein Interaction databases
DIP (DOE-UCLA)Q8IV48
IntAct (EBI)Q8IV48
BioGRIDERI1
STRING (EMBL)ERI1
ZODIACERI1
Ontologies - Pathways
QuickGOQ8IV48
Ontology : AmiGO3'-5'-exoribonuclease activity  exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)  protein binding  nucleus  nucleolus  nucleolus  nucleolus  cytoplasm  cytoplasm  cytoplasm  3'-5' exonuclease activity  rRNA binding  gene silencing by RNA  rRNA 3'-end processing  ribosome binding  metal ion binding  histone mRNA catabolic process  histone pre-mRNA 3'end processing complex  histone pre-mRNA stem-loop binding  
Ontology : EGO-EBI3'-5'-exoribonuclease activity  exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)  protein binding  nucleus  nucleolus  nucleolus  nucleolus  cytoplasm  cytoplasm  cytoplasm  3'-5' exonuclease activity  rRNA binding  gene silencing by RNA  rRNA 3'-end processing  ribosome binding  metal ion binding  histone mRNA catabolic process  histone pre-mRNA 3'end processing complex  histone pre-mRNA stem-loop binding  
NDEx NetworkERI1
Atlas of Cancer Signalling NetworkERI1
Wikipedia pathwaysERI1
Orthology - Evolution
OrthoDB90459
GeneTree (enSembl)ENSG00000104626
Phylogenetic Trees/Animal Genes : TreeFamERI1
Homologs : HomoloGeneERI1
Homology/Alignments : Family Browser (UCSC)ERI1
Gene fusions - Rearrangements
Fusion : QuiverERI1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerERI1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ERI1
dbVarERI1
ClinVarERI1
MonarchERI1
1000_GenomesERI1 
Exome Variant ServerERI1
GNOMAD BrowserENSG00000104626
Varsome BrowserERI1
ACMGERI1 variants
VarityQ8IV48
Genomic Variants (DGV)ERI1 [DGVbeta]
DECIPHERERI1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisERI1 
Mutations
ICGC Data PortalERI1 
TCGA Data PortalERI1 
Broad Tumor PortalERI1
OASIS PortalERI1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICERI1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DERI1
Mutations and Diseases : HGMDERI1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaERI1
DgiDB (Drug Gene Interaction Database)ERI1
DoCM (Curated mutations)ERI1
CIViC (Clinical Interpretations of Variants in Cancer)ERI1
Cancer3DERI1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608739   
Orphanet
DisGeNETERI1
MedgenERI1
Genetic Testing Registry ERI1
NextProtQ8IV48 [Medical]
GENETestsERI1
Target ValidationERI1
Huge Navigator ERI1 [HugePedia]
ClinGenERI1
Clinical trials, drugs, therapy
MyCancerGenomeERI1
Protein Interactions : CTDERI1
Pharm GKB GenePA164719226
PharosQ8IV48
Clinical trialERI1
Miscellaneous
canSAR (ICR)ERI1
HarmonizomeERI1
DataMed IndexERI1
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXERI1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:49:02 CEST 2021

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