Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ERI1 (exoribonuclease 1)

Identity

Alias_namesTHEX1
three prime histone mRNA exonuclease 1
Alias_symbol (synonym)3'HEXO
Other aliasHEXO
HGNC (Hugo) ERI1
LocusID (NCBI) 90459
Atlas_Id 62880
Location 8p23.1  [Link to chromosome band 8p23]
Location_base_pair Starts at 8860314 and ends at 8890849 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ERI1 (8p23.1) / SCNN1B (16p12.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ERI1   23994
Cards
Entrez_Gene (NCBI)ERI1  90459  exoribonuclease 1
Aliases3'HEXO; HEXO; THEX1
GeneCards (Weizmann)ERI1
Ensembl hg19 (Hinxton)ENSG00000104626 [Gene_View]  chr8:8860314-8890849 [Contig_View]  ERI1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000104626 [Gene_View]  chr8:8860314-8890849 [Contig_View]  ERI1 [Vega]
ICGC DataPortalENSG00000104626
TCGA cBioPortalERI1
AceView (NCBI)ERI1
Genatlas (Paris)ERI1
WikiGenes90459
SOURCE (Princeton)ERI1
Genetics Home Reference (NIH)ERI1
Genomic and cartography
GoldenPath hg19 (UCSC)ERI1  -     chr8:8860314-8890849 +  8p23.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ERI1  -     8p23.1   [Description]    (hg38-Dec_2013)
EnsemblERI1 - 8p23.1 [CytoView hg19]  ERI1 - 8p23.1 [CytoView hg38]
Mapping of homologs : NCBIERI1 [Mapview hg19]  ERI1 [Mapview hg38]
OMIM608739   
Gene and transcription
Genbank (Entrez)AK024646 AK226180 AK291062 AK301506 AL137679
RefSeq transcript (Entrez)NM_153332
RefSeq genomic (Entrez)NC_000008 NC_018919 NT_077531 NW_004929336
Consensus coding sequences : CCDS (NCBI)ERI1
Cluster EST : UnigeneHs.20000 [ NCBI ]
CGAP (NCI)Hs.20000
Alternative Splicing GalleryENSG00000104626
Gene ExpressionERI1 [ NCBI-GEO ]   ERI1 [ EBI - ARRAY_EXPRESS ]   ERI1 [ SEEK ]   ERI1 [ MEM ]
Gene Expression Viewer (FireBrowse)ERI1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)90459
GTEX Portal (Tissue expression)ERI1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IV48   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IV48  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IV48
Splice isoforms : SwissVarQ8IV48
Catalytic activity : Enzyme3.1.-.- [ Enzyme-Expasy ]   3.1.-.-3.1.-.- [ IntEnz-EBI ]   3.1.-.- [ BRENDA ]   3.1.-.- [ KEGG ]   
PhosPhoSitePlusQ8IV48
Domaine pattern : Prosite (Expaxy)SAP (PS50800)   
Domains : Interpro (EBI)Exonuclease    Exonuclease_RNaseT/DNA_pol3    RNaseH-like_dom    SAP_dom   
Domain families : Pfam (Sanger)RNase_T (PF00929)    SAP (PF02037)   
Domain families : Pfam (NCBI)pfam00929    pfam02037   
Domain families : Smart (EMBL)EXOIII (SM00479)  SAP (SM00513)  
Conserved Domain (NCBI)ERI1
DMDM Disease mutations90459
Blocks (Seattle)ERI1
PDB (SRS)1W0H    1ZBH    1ZBU    4L8R    4QOZ   
PDB (PDBSum)1W0H    1ZBH    1ZBU    4L8R    4QOZ   
PDB (IMB)1W0H    1ZBH    1ZBU    4L8R    4QOZ   
PDB (RSDB)1W0H    1ZBH    1ZBU    4L8R    4QOZ   
Structural Biology KnowledgeBase1W0H    1ZBH    1ZBU    4L8R    4QOZ   
SCOP (Structural Classification of Proteins)1W0H    1ZBH    1ZBU    4L8R    4QOZ   
CATH (Classification of proteins structures)1W0H    1ZBH    1ZBU    4L8R    4QOZ   
SuperfamilyQ8IV48
Human Protein AtlasENSG00000104626
Peptide AtlasQ8IV48
HPRD11784
IPIIPI00216873   IPI00974449   IPI00977311   
Protein Interaction databases
DIP (DOE-UCLA)Q8IV48
IntAct (EBI)Q8IV48
FunCoupENSG00000104626
BioGRIDERI1
STRING (EMBL)ERI1
ZODIACERI1
Ontologies - Pathways
QuickGOQ8IV48
Ontology : AmiGO3'-5'-exoribonuclease activity  exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)  DNA catabolic process, exonucleolytic  nucleus  nucleolus  nucleolus  cytoplasm  cytoplasm  3'-5' exonuclease activity  rRNA binding  gene silencing by RNA  rRNA 3'-end processing  ribosome binding  metal ion binding  histone mRNA catabolic process  histone pre-mRNA 3'end processing complex  histone pre-mRNA stem-loop binding  
Ontology : EGO-EBI3'-5'-exoribonuclease activity  exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)  DNA catabolic process, exonucleolytic  nucleus  nucleolus  nucleolus  cytoplasm  cytoplasm  3'-5' exonuclease activity  rRNA binding  gene silencing by RNA  rRNA 3'-end processing  ribosome binding  metal ion binding  histone mRNA catabolic process  histone pre-mRNA 3'end processing complex  histone pre-mRNA stem-loop binding  
NDEx NetworkERI1
Atlas of Cancer Signalling NetworkERI1
Wikipedia pathwaysERI1
Orthology - Evolution
OrthoDB90459
GeneTree (enSembl)ENSG00000104626
Phylogenetic Trees/Animal Genes : TreeFamERI1
HOVERGENQ8IV48
HOGENOMQ8IV48
Homologs : HomoloGeneERI1
Homology/Alignments : Family Browser (UCSC)ERI1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerERI1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ERI1
dbVarERI1
ClinVarERI1
1000_GenomesERI1 
Exome Variant ServerERI1
ExAC (Exome Aggregation Consortium)ERI1 (select the gene name)
Genetic variants : HAPMAP90459
Genomic Variants (DGV)ERI1 [DGVbeta]
DECIPHER (Syndromes)8:8860314-8890849  ENSG00000104626
CONAN: Copy Number AnalysisERI1 
Mutations
ICGC Data PortalERI1 
TCGA Data PortalERI1 
Broad Tumor PortalERI1
OASIS PortalERI1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICERI1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDERI1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ERI1
DgiDB (Drug Gene Interaction Database)ERI1
DoCM (Curated mutations)ERI1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ERI1 (select a term)
intoGenERI1
Cancer3DERI1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608739   
Orphanet
MedgenERI1
Genetic Testing Registry ERI1
NextProtQ8IV48 [Medical]
TSGene90459
GENETestsERI1
Huge Navigator ERI1 [HugePedia]
snp3D : Map Gene to Disease90459
BioCentury BCIQERI1
ClinGenERI1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD90459
Chemical/Pharm GKB GenePA164719226
Clinical trialERI1
Miscellaneous
canSAR (ICR)ERI1 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineERI1
EVEXERI1
GoPubMedERI1
iHOPERI1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:03:02 CET 2017

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