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ERLIN1 (ER lipid raft associated 1)

Identity

Alias (NCBI)C10orf69
Erlin-1
KE04
KEO4
SPFH1
SPG62
HGNC (Hugo) ERLIN1
HGNC Alias symbKE04
Erlin-1
SPG62
HGNC Alias nameBand_7 23-211 Keo4 (Interim) similar to C.elegans protein C42C1.9
HGNC Previous nameC10orf69
 SPFH1
HGNC Previous namechromosome 10 open reading frame 69
 SPFH domain family, member 1
LocusID (NCBI) 10613
Atlas_Id 62895
Location 10q24.31  [Link to chromosome band 10q24]
Location_base_pair Starts at 100150094 and ends at 100186029 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ERLIN1 (10q24.31) / ERLIN1 (10q24.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ERLIN1   16947
Cards
Entrez_Gene (NCBI)ERLIN1    ER lipid raft associated 1
AliasesC10orf69; Erlin-1; KE04; KEO4; 
SPFH1; SPG62
GeneCards (Weizmann)ERLIN1
Ensembl hg19 (Hinxton)ENSG00000107566 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107566 [Gene_View]  ENSG00000107566 [Sequence]  chr10:100150094-100186029 [Contig_View]  ERLIN1 [Vega]
ICGC DataPortalENSG00000107566
TCGA cBioPortalERLIN1
AceView (NCBI)ERLIN1
Genatlas (Paris)ERLIN1
SOURCE (Princeton)ERLIN1
Genetics Home Reference (NIH)ERLIN1
Genomic and cartography
GoldenPath hg38 (UCSC)ERLIN1  -     chr10:100150094-100186029 -  10q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ERLIN1  -     10q24.31   [Description]    (hg19-Feb_2009)
GoldenPathERLIN1 - 10q24.31 [CytoView hg19]  ERLIN1 - 10q24.31 [CytoView hg38]
ImmunoBaseENSG00000107566
Genome Data Viewer NCBIERLIN1 [Mapview hg19]  
OMIM611604   615681   
Gene and transcription
Genbank (Entrez)AF064093 AK056574 AK127017 AK222480 AK298427
RefSeq transcript (Entrez)NM_001100626 NM_001347856 NM_001347857 NM_001347858 NM_001347859 NM_001347860 NM_001347861 NM_006459
Consensus coding sequences : CCDS (NCBI)ERLIN1
Gene ExpressionERLIN1 [ NCBI-GEO ]   ERLIN1 [ EBI - ARRAY_EXPRESS ]   ERLIN1 [ SEEK ]   ERLIN1 [ MEM ]
Gene Expression Viewer (FireBrowse)ERLIN1 [ Firebrowse - Broad ]
GenevisibleExpression of ERLIN1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10613
GTEX Portal (Tissue expression)ERLIN1
Human Protein AtlasENSG00000107566-ERLIN1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75477   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75477  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75477
PhosPhoSitePlusO75477
Domains : Interpro (EBI)Band_7    Band_7/SPFH_dom_sf    Erlin1/2   
Domain families : Pfam (Sanger)Band_7 (PF01145)   
Domain families : Pfam (NCBI)pfam01145   
Domain families : Smart (EMBL)PHB (SM00244)  
Conserved Domain (NCBI)ERLIN1
SuperfamilyO75477
AlphaFold pdb e-kbO75477   
Human Protein Atlas [tissue]ENSG00000107566-ERLIN1 [tissue]
HPRD08502
Protein Interaction databases
DIP (DOE-UCLA)O75477
IntAct (EBI)O75477
BioGRIDERLIN1
STRING (EMBL)ERLIN1
ZODIACERLIN1
Ontologies - Pathways
QuickGOO75477
Ontology : AmiGOprotein binding  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum membrane  endoplasmic reticulum membrane  cholesterol metabolic process  cholesterol binding  cholesterol binding  integral component of membrane  ubiquitin-dependent ERAD pathway  ubiquitin protein ligase binding  SREBP signaling pathway  SREBP signaling pathway  protein-containing complex  negative regulation of cholesterol biosynthetic process  negative regulation of fatty acid biosynthetic process  transmembrane transport  
Ontology : EGO-EBIprotein binding  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum membrane  endoplasmic reticulum membrane  cholesterol metabolic process  cholesterol binding  cholesterol binding  integral component of membrane  ubiquitin-dependent ERAD pathway  ubiquitin protein ligase binding  SREBP signaling pathway  SREBP signaling pathway  protein-containing complex  negative regulation of cholesterol biosynthetic process  negative regulation of fatty acid biosynthetic process  transmembrane transport  
NDEx NetworkERLIN1
Atlas of Cancer Signalling NetworkERLIN1
Wikipedia pathwaysERLIN1
Orthology - Evolution
OrthoDB10613
GeneTree (enSembl)ENSG00000107566
Phylogenetic Trees/Animal Genes : TreeFamERLIN1
Homologs : HomoloGeneERLIN1
Homology/Alignments : Family Browser (UCSC)ERLIN1
Gene fusions - Rearrangements
Fusion : QuiverERLIN1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerERLIN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ERLIN1
dbVarERLIN1
ClinVarERLIN1
MonarchERLIN1
1000_GenomesERLIN1 
Exome Variant ServerERLIN1
GNOMAD BrowserENSG00000107566
Varsome BrowserERLIN1
ACMGERLIN1 variants
VarityO75477
Genomic Variants (DGV)ERLIN1 [DGVbeta]
DECIPHERERLIN1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisERLIN1 
Mutations
ICGC Data PortalERLIN1 
TCGA Data PortalERLIN1 
Broad Tumor PortalERLIN1
OASIS PortalERLIN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICERLIN1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DERLIN1
Mutations and Diseases : HGMDERLIN1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaERLIN1
DgiDB (Drug Gene Interaction Database)ERLIN1
DoCM (Curated mutations)ERLIN1
CIViC (Clinical Interpretations of Variants in Cancer)ERLIN1
Cancer3DERLIN1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611604    615681   
Orphanet22829   
DisGeNETERLIN1
MedgenERLIN1
Genetic Testing Registry ERLIN1
NextProtO75477 [Medical]
GENETestsERLIN1
Target ValidationERLIN1
Huge Navigator ERLIN1 [HugePedia]
ClinGenERLIN1
Clinical trials, drugs, therapy
MyCancerGenomeERLIN1
Protein Interactions : CTDERLIN1
Pharm GKB GenePA162385299
PharosO75477
Clinical trialERLIN1
Miscellaneous
canSAR (ICR)ERLIN1
HarmonizomeERLIN1
DataMed IndexERLIN1
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXERLIN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:49:05 CEST 2021

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