ERN2 (endoplasmic reticulum to nucleus signaling 2)

2006-10-01  

Identity

HGNC
LOCATION
16p12.2
LOCUSID
ALIAS
IRE1-BETA,IRE1b,IRE2p,hIRE2p
FUSION GENES

Other Information

Locus ID:

NCBI: 10595
MIM: 604034
HGNC: 16942
Ensembl: ENSG00000134398

Variants:

dbSNP: 10595
ClinVar: 10595
TCGA: ENSG00000134398
COSMIC: ERN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134398ENST00000256797Q76MJ5
ENSG00000134398ENST00000457008E7ETG2
ENSG00000134398ENST00000562458H3BSU1
ENSG00000134398ENST00000562562H3BTW8
ENSG00000134398ENST00000569903H3BUU2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
169737402006The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response.122
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
182421822008RNase domains determine the functional difference between IRE1alpha and IRE1beta.26
232364642012Direct association of unfolded proteins with mammalian ER stress sensor, IRE1β.22
211465302011Mammalian ER stress sensor IRE1β specifically down-regulates the synthesis of secretory pathway proteins.19
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
309737542019XBP1S Regulates MUC5B in a Promoter Variant-Dependent Pathway in Idiopathic Pulmonary Fibrosis Airway Epithelia.10
277746542017Endoplasmic reticulum stress in the regulation of liver diseases: Involvement of Regulated IRE1α and β-dependent decay and miRNA.2
319857472020IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress.1

Citation

Dessen P

ERN2 (endoplasmic reticulum to nucleus signaling 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43248/ern2