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ERN2 (endoplasmic reticulum to nucleus signaling 2)

Identity

Alias_namesER to nucleus signalling 2
Alias_symbol (synonym)IRE1b
Other aliasIRE1-BETA
IRE2p
hIRE2p
HGNC (Hugo) ERN2
LocusID (NCBI) 10595
Atlas_Id 43248
Location 16p12.2  [Link to chromosome band 16p12]
Location_base_pair Starts at 23690305 and ends at 23713500 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ERN2 (16p12.2) / ERN2 (16p12.2)ERN2 (16p12.2) / PLK1 (16p12.2)PLK1 (16p12.2) / ERN2 (16p12.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ERN2   16942
Cards
Entrez_Gene (NCBI)ERN2  10595  endoplasmic reticulum to nucleus signaling 2
AliasesIRE1-BETA; IRE1b; IRE2p; hIRE2p
GeneCards (Weizmann)ERN2
Ensembl hg19 (Hinxton)ENSG00000134398 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134398 [Gene_View]  chr16:23690305-23713500 [Contig_View]  ERN2 [Vega]
ICGC DataPortalENSG00000134398
TCGA cBioPortalERN2
AceView (NCBI)ERN2
Genatlas (Paris)ERN2
WikiGenes10595
SOURCE (Princeton)ERN2
Genetics Home Reference (NIH)ERN2
Genomic and cartography
GoldenPath hg38 (UCSC)ERN2  -     chr16:23690305-23713500 -  16p12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ERN2  -     16p12.2   [Description]    (hg19-Feb_2009)
EnsemblERN2 - 16p12.2 [CytoView hg19]  ERN2 - 16p12.2 [CytoView hg38]
Mapping of homologs : NCBIERN2 [Mapview hg19]  ERN2 [Mapview hg38]
OMIM604034   
Gene and transcription
Genbank (Entrez)AB047079 AK131280 AK309313 AK310834 BC156238
RefSeq transcript (Entrez)NM_001308220 NM_033266
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ERN2
Cluster EST : UnigeneHs.592041 [ NCBI ]
CGAP (NCI)Hs.592041
Alternative Splicing GalleryENSG00000134398
Gene ExpressionERN2 [ NCBI-GEO ]   ERN2 [ EBI - ARRAY_EXPRESS ]   ERN2 [ SEEK ]   ERN2 [ MEM ]
Gene Expression Viewer (FireBrowse)ERN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10595
GTEX Portal (Tissue expression)ERN2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ76MJ5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ76MJ5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ76MJ5
Splice isoforms : SwissVarQ76MJ5
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ76MJ5
Domaine pattern : Prosite (Expaxy)KEN (PS51392)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)IRE2    KEN_dom    Kinase-like_dom    PQQ_beta_propeller_repeat    Prot_kinase_dom    PUB_domain    Quinoprotein_ADH-like_fam    Quinoprotein_ADH-like_supfam    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)    Ribonuc_2-5A (PF06479)   
Domain families : Pfam (NCBI)pfam00069    pfam06479   
Domain families : Smart (EMBL)PQQ (SM00564)  PUG (SM00580)  S_TKc (SM00220)  
Conserved Domain (NCBI)ERN2
DMDM Disease mutations10595
Blocks (Seattle)ERN2
SuperfamilyQ76MJ5
Human Protein AtlasENSG00000134398
Peptide AtlasQ76MJ5
HPRD04944
IPIIPI00940726   IPI00456641   
Protein Interaction databases
DIP (DOE-UCLA)Q76MJ5
IntAct (EBI)Q76MJ5
FunCoupENSG00000134398
BioGRIDERN2
STRING (EMBL)ERN2
ZODIACERN2
Ontologies - Pathways
QuickGOQ76MJ5
Ontology : AmiGOmagnesium ion binding  endonuclease activity  ribonuclease activity  protein serine/threonine kinase activity  ATP binding  transcription, DNA-templated  mRNA processing  protein phosphorylation  cell cycle arrest  activation of JUN kinase activity  integral component of membrane  rRNA catabolic process  apoptotic chromosome condensation  response to endoplasmic reticulum stress  negative regulation of transcription, DNA-templated  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  RNA phosphodiester bond hydrolysis  IRE1-TRAF2-ASK1 complex  
Ontology : EGO-EBImagnesium ion binding  endonuclease activity  ribonuclease activity  protein serine/threonine kinase activity  ATP binding  transcription, DNA-templated  mRNA processing  protein phosphorylation  cell cycle arrest  activation of JUN kinase activity  integral component of membrane  rRNA catabolic process  apoptotic chromosome condensation  response to endoplasmic reticulum stress  negative regulation of transcription, DNA-templated  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  RNA phosphodiester bond hydrolysis  IRE1-TRAF2-ASK1 complex  
NDEx NetworkERN2
Atlas of Cancer Signalling NetworkERN2
Wikipedia pathwaysERN2
Orthology - Evolution
OrthoDB10595
GeneTree (enSembl)ENSG00000134398
Phylogenetic Trees/Animal Genes : TreeFamERN2
HOVERGENQ76MJ5
HOGENOMQ76MJ5
Homologs : HomoloGeneERN2
Homology/Alignments : Family Browser (UCSC)ERN2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerERN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ERN2
dbVarERN2
ClinVarERN2
1000_GenomesERN2 
Exome Variant ServerERN2
ExAC (Exome Aggregation Consortium)ERN2 (select the gene name)
Genetic variants : HAPMAP10595
Genomic Variants (DGV)ERN2 [DGVbeta]
DECIPHERERN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisERN2 
Mutations
ICGC Data PortalERN2 
TCGA Data PortalERN2 
Broad Tumor PortalERN2
OASIS PortalERN2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDERN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ERN2
DgiDB (Drug Gene Interaction Database)ERN2
DoCM (Curated mutations)ERN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ERN2 (select a term)
intoGenERN2
Cancer3DERN2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604034   
Orphanet
MedgenERN2
Genetic Testing Registry ERN2
NextProtQ76MJ5 [Medical]
TSGene10595
GENETestsERN2
Target ValidationERN2
Huge Navigator ERN2 [HugePedia]
snp3D : Map Gene to Disease10595
BioCentury BCIQERN2
ClinGenERN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10595
Chemical/Pharm GKB GenePA134889542
Clinical trialERN2
Miscellaneous
canSAR (ICR)ERN2 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineERN2
EVEXERN2
GoPubMedERN2
iHOPERN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:00:36 CEST 2017

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