ESRRB (estrogen related receptor beta)

2008-07-01  

Identity

HGNC
LOCATION
14q24.3
LOCUSID
ALIAS
DFNB35,ERR
FUSION GENES

Other Information

Locus ID:

NCBI: 2103
MIM: 602167
HGNC: 3473
Ensembl: ENSG00000119715

Variants:

dbSNP: 2103
ClinVar: 2103
TCGA: ENSG00000119715
COSMIC: ESRRB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119715ENST00000380887O95718
ENSG00000119715ENST00000505752O95718
ENSG00000119715ENST00000509242O95718
ENSG00000119715ENST00000509323A0A2R8Y509
ENSG00000119715ENST00000512784E7EWD9
ENSG00000119715ENST00000644823A0A2R8Y491

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Nuclear Receptor transcription pathwayREACTOMER-HSA-383280

References

Pubmed IDYearTitleCitations
189574142008Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells.67
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
200806502010Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.46
181798912008Mutations of ESRRB encoding estrogen-related receptor beta cause autosomal-recessive nonsyndromic hearing impairment DFNB35.44
181798912008Mutations of ESRRB encoding estrogen-related receptor beta cause autosomal-recessive nonsyndromic hearing impairment DFNB35.44
185090532008Involvement of estrogen-related receptors in transcriptional response to hypoxia and growth of solid tumors.44
155986862005Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues.40
180713052008Orphan nuclear receptor estrogen-related receptor-beta suppresses in vitro and in vivo growth of prostate cancer cells via p21(WAF1/CIP1) induction and as a potential therapeutic target in prostate cancer.31
211772572011Parkin degrades estrogen-related receptors to limit the expression of monoamine oxidases.23
163329392006Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta.19

Citation

Dessen P

ESRRB (estrogen related receptor beta)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50173/esrrb