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ESYT2 (extended synaptotagmin 2)

Identity

Alias_namesFAM62B
family with sequence similarity 62 (C2 domain containing), member B
extended synaptotagmin-like protein 2
Alias_symbol (synonym)KIAA1228
CHR2SYT
Other aliasE-Syt2
HGNC (Hugo) ESYT2
LocusID (NCBI) 57488
Atlas_Id 62925
Location 7q36.3  [Link to chromosome band 7q36]
Location_base_pair Starts at 158730998 and ends at 158829628 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ESYT2 (7q36.3) / ATRN (20p13)ESYT2 (7q36.3) / CPED1 (7q31.31)ESYT2 (7q36.3) / EIF3CL (16p11.2)
ESYT2 (7q36.3) / ENO1 (1p36.23)ESYT2 (7q36.3) / ESYT2 (7q36.3)ESYT2 (7q36.3) / PPIA (7p13)
ESYT2 (7q36.3) / PTPRN2 (7q36.3)GORASP2 (2q31.1) / ESYT2 (7q36.3)HTT (4p16.3) / ESYT2 (7q36.3)
NCAPG2 (7q36.3) / ESYT2 (7q36.3)OLFML2A (9q33.3) / ESYT2 (7q36.3)RPH3AL (17p13.3) / ESYT2 (7q36.3)
TERF1 (8q21.11) / ESYT2 (7q36.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ESYT2   22211
Cards
Entrez_Gene (NCBI)ESYT2  57488  extended synaptotagmin 2
AliasesCHR2SYT; E-Syt2; FAM62B
GeneCards (Weizmann)ESYT2
Ensembl hg19 (Hinxton)ENSG00000117868 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000117868 [Gene_View]  chr7:158730998-158829628 [Contig_View]  ESYT2 [Vega]
ICGC DataPortalENSG00000117868
TCGA cBioPortalESYT2
AceView (NCBI)ESYT2
Genatlas (Paris)ESYT2
WikiGenes57488
SOURCE (Princeton)ESYT2
Genetics Home Reference (NIH)ESYT2
Genomic and cartography
GoldenPath hg38 (UCSC)ESYT2  -     chr7:158730998-158829628 -  7q36.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ESYT2  -     7q36.3   [Description]    (hg19-Feb_2009)
EnsemblESYT2 - 7q36.3 [CytoView hg19]  ESYT2 - 7q36.3 [CytoView hg38]
Mapping of homologs : NCBIESYT2 [Mapview hg19]  ESYT2 [Mapview hg38]
OMIM616691   
Gene and transcription
Genbank (Entrez)AB033054 AJ303365 AK001181 AK026710 AK056953
RefSeq transcript (Entrez)NM_020728
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ESYT2
Cluster EST : UnigeneHs.490795 [ NCBI ]
CGAP (NCI)Hs.490795
Alternative Splicing GalleryENSG00000117868
Gene ExpressionESYT2 [ NCBI-GEO ]   ESYT2 [ EBI - ARRAY_EXPRESS ]   ESYT2 [ SEEK ]   ESYT2 [ MEM ]
Gene Expression Viewer (FireBrowse)ESYT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57488
GTEX Portal (Tissue expression)ESYT2
Protein : pattern, domain, 3D structure
UniProt/SwissProtA0FGR8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA0FGR8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA0FGR8
Splice isoforms : SwissVarA0FGR8
PhosPhoSitePlusA0FGR8
Domaine pattern : Prosite (Expaxy)C2 (PS50004)   
Domains : Interpro (EBI)C2_dom    SMP_LBD   
Domain families : Pfam (Sanger)C2 (PF00168)    SMP_LBD (PF17047)   
Domain families : Pfam (NCBI)pfam00168    pfam17047   
Domain families : Smart (EMBL)C2 (SM00239)  
Conserved Domain (NCBI)ESYT2
DMDM Disease mutations57488
Blocks (Seattle)ESYT2
PDB (SRS)2DMG    4NPJ    4NPK    4P42   
PDB (PDBSum)2DMG    4NPJ    4NPK    4P42   
PDB (IMB)2DMG    4NPJ    4NPK    4P42   
PDB (RSDB)2DMG    4NPJ    4NPK    4P42   
Structural Biology KnowledgeBase2DMG    4NPJ    4NPK    4P42   
SCOP (Structural Classification of Proteins)2DMG    4NPJ    4NPK    4P42   
CATH (Classification of proteins structures)2DMG    4NPJ    4NPK    4P42   
SuperfamilyA0FGR8
Human Protein AtlasENSG00000117868
Peptide AtlasA0FGR8
HPRD13053
IPIIPI00827920   IPI00409635   IPI00827794   IPI00827663   IPI00953221   IPI00446435   IPI00953444   
Protein Interaction databases
DIP (DOE-UCLA)A0FGR8
IntAct (EBI)A0FGR8
FunCoupENSG00000117868
BioGRIDESYT2
STRING (EMBL)ESYT2
ZODIACESYT2
Ontologies - Pathways
QuickGOA0FGR8
Ontology : AmiGOcalcium ion binding  protein binding  calcium-dependent phospholipid binding  endoplasmic reticulum membrane  integral component of plasma membrane  glycosphingolipid metabolic process  lipid transport  endocytosis  phosphatidylethanolamine binding  membrane  phosphatidylcholine binding  intrinsic component of endoplasmic reticulum membrane  extrinsic component of cytoplasmic side of plasma membrane  phosphatidylinositol binding  identical protein binding  organelle membrane contact site  cadherin binding  
Ontology : EGO-EBIcalcium ion binding  protein binding  calcium-dependent phospholipid binding  endoplasmic reticulum membrane  integral component of plasma membrane  glycosphingolipid metabolic process  lipid transport  endocytosis  phosphatidylethanolamine binding  membrane  phosphatidylcholine binding  intrinsic component of endoplasmic reticulum membrane  extrinsic component of cytoplasmic side of plasma membrane  phosphatidylinositol binding  identical protein binding  organelle membrane contact site  cadherin binding  
NDEx NetworkESYT2
Atlas of Cancer Signalling NetworkESYT2
Wikipedia pathwaysESYT2
Orthology - Evolution
OrthoDB57488
GeneTree (enSembl)ENSG00000117868
Phylogenetic Trees/Animal Genes : TreeFamESYT2
HOVERGENA0FGR8
HOGENOMA0FGR8
Homologs : HomoloGeneESYT2
Homology/Alignments : Family Browser (UCSC)ESYT2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerESYT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ESYT2
dbVarESYT2
ClinVarESYT2
1000_GenomesESYT2 
Exome Variant ServerESYT2
ExAC (Exome Aggregation Consortium)ESYT2 (select the gene name)
Genetic variants : HAPMAP57488
Genomic Variants (DGV)ESYT2 [DGVbeta]
DECIPHERESYT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisESYT2 
Mutations
ICGC Data PortalESYT2 
TCGA Data PortalESYT2 
Broad Tumor PortalESYT2
OASIS PortalESYT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICESYT2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDESYT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ESYT2
DgiDB (Drug Gene Interaction Database)ESYT2
DoCM (Curated mutations)ESYT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ESYT2 (select a term)
intoGenESYT2
Cancer3DESYT2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616691   
Orphanet
MedgenESYT2
Genetic Testing Registry ESYT2
NextProtA0FGR8 [Medical]
TSGene57488
GENETestsESYT2
Target ValidationESYT2
Huge Navigator ESYT2 [HugePedia]
snp3D : Map Gene to Disease57488
BioCentury BCIQESYT2
ClinGenESYT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57488
Chemical/Pharm GKB GenePA165617947
Clinical trialESYT2
Miscellaneous
canSAR (ICR)ESYT2 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineESYT2
EVEXESYT2
GoPubMedESYT2
iHOPESYT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:07:22 CEST 2017

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