ETF1 (eukaryotic translation termination factor 1)

2003-02-01  

Identity

HGNC
LOCATION
5q31.2
LOCUSID
ALIAS
D5S1995,ERF,ERF1,RF1,SUP45L1,TB3-1
FUSION GENES

Other Information

Locus ID:

NCBI: 2107
MIM: 600285
HGNC: 3477
Ensembl: ENSG00000120705

Variants:

dbSNP: 2107
ClinVar: 2107
TCGA: ENSG00000120705
COSMIC: ETF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120705ENST00000360541P62495
ENSG00000120705ENST00000499810P62495
ENSG00000120705ENST00000503014B7Z7P8
ENSG00000120705ENST00000507939D6RJE8
ENSG00000120705ENST00000512198D6RCB3
ENSG00000120705ENST00000572514I3L492

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation TerminationREACTOMER-HSA-72764
Gene ExpressionREACTOMER-HSA-74160
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)REACTOMER-HSA-975956

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
164525072006Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay.245
262453812015Structural basis for stop codon recognition in eukaryotes.83
117795112001Bacterial polypeptide release factor RF2 is structurally distinct from eukaryotic eRF1.54
123567462002The invariant uridine of stop codons contacts the conserved NIKSR loop of human eRF1 in the ribosome.46
244860192014Optimal translational termination requires C4 lysyl hydroxylation of eRF1.39
162825902005Invariant amino acids essential for decoding function of polypeptide release factor eRF1.33
230910042012Cryo-EM structure of the mammalian eukaryotic release factor eRF1-eRF3-associated termination complex.31
167971132006Class-1 release factor eRF1 promotes GTP binding by class-2 release factor eRF3.20
204183722010Identification of a cellular factor that modulates HIV-1 programmed ribosomal frameshifting.17
206888682010Three distinct peptides from the N domain of translation termination factor eRF1 surround stop codon in the ribosome.17

Citation

Dessen P

ETF1 (eukaryotic translation termination factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40501/etf1