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ETV3 (ETS variant 3)

Identity

Other namesMETS
PE-1
PE1
bA110J1.4
HGNC (Hugo) ETV3
LocusID (NCBI) 2117
Atlas_Id 40504
Location 1q23.1
Location_base_pair Starts at 157094459 and ends at 157108383 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ARHGEF11 (1q23.1) / ETV3 (1q23.1)ETV3 (1q23.1) / MNDA (1q23.1)IKZF3 (17q12) / ETV3 (1q23.1)
IQGAP3 (1q22) / ETV3 (1q23.1)ARHGEF11 1q23.1 / ETV3 1q23.1ETV3 1q23.1 / MNDA 1q23.1
IQGAP3 1q22 / ETV3 1q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ETV3   3492
Cards
Entrez_Gene (NCBI)ETV3  2117  ETS variant 3
GeneCards (Weizmann)ETV3
Ensembl hg19 (Hinxton)ENSG00000117036 [Gene_View]  chr1:157094459-157108383 [Contig_View]  ETV3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000117036 [Gene_View]  chr1:157094459-157108383 [Contig_View]  ETV3 [Vega]
ICGC DataPortalENSG00000117036
TCGA cBioPortalETV3
AceView (NCBI)ETV3
Genatlas (Paris)ETV3
WikiGenes2117
SOURCE (Princeton)ETV3
Genomic and cartography
GoldenPath hg19 (UCSC)ETV3  -     chr1:157094459-157108383 -  1q23.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ETV3  -     1q23.1   [Description]    (hg38-Dec_2013)
EnsemblETV3 - 1q23.1 [CytoView hg19]  ETV3 - 1q23.1 [CytoView hg38]
Mapping of homologs : NCBIETV3 [Mapview hg19]  ETV3 [Mapview hg38]
OMIM164873   
Gene and transcription
Genbank (Entrez)AF218540 AK304789 AK316274 BC022868 DQ893155
RefSeq transcript (Entrez)NM_001145312 NM_005240
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_004487 NW_004929293
Consensus coding sequences : CCDS (NCBI)ETV3
Cluster EST : UnigeneHs.105636 [ NCBI ]
CGAP (NCI)Hs.105636
Alternative Splicing : Fast-db (Paris)GSHG0002624
Alternative Splicing GalleryENSG00000117036
Gene ExpressionETV3 [ NCBI-GEO ]   ETV3 [ EBI - ARRAY_EXPRESS ]   ETV3 [ SEEK ]   ETV3 [ MEM ]
Gene Expression Viewer (FireBrowse)ETV3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)2117
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41162 (Uniprot)
NextProtP41162  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP41162
Splice isoforms : SwissVarP41162 (Swissvar)
PhosPhoSitePlusP41162
Domaine pattern : Prosite (Expaxy)ETS_DOMAIN_1 (PS00345)    ETS_DOMAIN_2 (PS00346)    ETS_DOMAIN_3 (PS50061)   
Domains : Interpro (EBI)Ets_dom    ETV3    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)Ets (PF00178)   
Domain families : Pfam (NCBI)pfam00178   
Domain families : Smart (EMBL)ETS (SM00413)  
DMDM Disease mutations2117
Blocks (Seattle)ETV3
SuperfamilyP41162
Human Protein AtlasENSG00000117036
Peptide AtlasP41162
HPRD01282
IPIIPI00032598   IPI00514913   
Protein Interaction databases
DIP (DOE-UCLA)P41162
IntAct (EBI)P41162
FunCoupENSG00000117036
BioGRIDETV3
STRING (EMBL)ETV3
ZODIACETV3
Ontologies - Pathways
QuickGOP41162
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding  molecular_function  nucleus  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  biological_process  negative regulation of cell proliferation  DEAD/H-box RNA helicase binding  cell differentiation  RNA polymerase II transcription repressor complex  cellular response to granulocyte macrophage colony-stimulating factor stimulus  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding  molecular_function  nucleus  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  biological_process  negative regulation of cell proliferation  DEAD/H-box RNA helicase binding  cell differentiation  RNA polymerase II transcription repressor complex  cellular response to granulocyte macrophage colony-stimulating factor stimulus  
Pathways : BIOCARTAMETS affect on Macrophage Differentiation [Genes]   
NDEx Network
Atlas of Cancer Signalling NetworkETV3
Wikipedia pathwaysETV3
Orthology - Evolution
OrthoDB2117
GeneTree (enSembl)ENSG00000117036
Phylogenetic Trees/Animal Genes : TreeFamETV3
Homologs : HomoloGeneETV3
Homology/Alignments : Family Browser (UCSC)ETV3
Gene fusions - Rearrangements
Fusion: TCGAARHGEF11 1q23.1 ETV3 1q23.1 BRCA
Fusion: TCGAETV3 1q23.1 MNDA 1q23.1 PRAD
Fusion: TCGAIQGAP3 1q22 ETV3 1q23.1 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerETV3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ETV3
dbVarETV3
ClinVarETV3
1000_GenomesETV3 
Exome Variant ServerETV3
ExAC (Exome Aggregation Consortium)ETV3 (select the gene name)
SNP (GeneSNP Utah)ETV3
SNP : HGBaseETV3
Genetic variants : HAPMAPETV3
Genomic Variants (DGV)ETV3 [DGVbeta]
Mutations
ICGC Data PortalETV3 
TCGA Data PortalETV3 
Broad Tumor PortalETV3
OASIS PortalETV3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICETV3 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ETV3
DgiDB (Drug Gene Interaction Database)ETV3
DoCM (Curated mutations)ETV3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ETV3 (select a term)
intoGenETV3
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:157094459-157108383
CONAN: Copy Number AnalysisETV3 
Mutations and Diseases : HGMDETV3
OMIM164873   
MedgenETV3
Genetic Testing Registry ETV3
NextProtP41162 [Medical]
TSGene2117
GENETestsETV3
Huge Navigator ETV3 [HugePedia]  ETV3 [HugeCancerGEM]
snp3D : Map Gene to Disease2117
BioCentury BCIQETV3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2117
Chemical/Pharm GKB GenePA27906
Clinical trialETV3
Miscellaneous
canSAR (ICR)ETV3 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineETV3
GoPubMedETV3
iHOPETV3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Apr 16 17:44:05 CEST 2016

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