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ETV5 (ETS variant transcription factor 5)

Identity

Alias (NCBI)ERM
HGNC (Hugo) ETV5
HGNC Alias symbERM
HGNC Alias nameets-related molecule
HGNC Previous nameets variant gene 5 (ets-related molecule)
 ETS variant 5
LocusID (NCBI) 2119
Atlas_Id 40505
Location 3q27.2  [Link to chromosome band 3q27]
Location_base_pair Starts at 186046314 and ends at 186109089 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACTN4 (19q13.2)::ETV5 (3q27.2)EPG5 (18q12.3)::ETV5 (3q27.2)ETV5 (3q27.2)::LOC284889 ()
ETV5 (3q27.2)::SCL45A3 ()ETV5 (3q27.2)::TMPRSS2 (21q22.3)RNF213 (17q25.3)::ETV5 (3q27.2)
SLC45A3 (1q32.1)::ETV5 (3q27.2)TMPRSS2 (21q22.3)::ETV5 (3q27.2)SLC45A3 1q32.1::ETV5 3q27.2
TMPRSS2 21q22.3::ETV5 3q27.2RNF213 17q25.3::ETV5 3q27.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Breakpoints

 


External links

 

Nomenclature
HGNC (Hugo)ETV5   3494
Cards
Entrez_Gene (NCBI)ETV5    ETS variant transcription factor 5
AliasesERM
GeneCards (Weizmann)ETV5
Ensembl hg19 (Hinxton)ENSG00000244405 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000244405 [Gene_View]  ENSG00000244405 [Sequence]  chr3:186046314-186109089 [Contig_View]  ETV5 [Vega]
ICGC DataPortalENSG00000244405
TCGA cBioPortalETV5
AceView (NCBI)ETV5
Genatlas (Paris)ETV5
SOURCE (Princeton)ETV5
Genetics Home Reference (NIH)ETV5
Genomic and cartography
GoldenPath hg38 (UCSC)ETV5  -     chr3:186046314-186109089 -  3q27.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ETV5  -     3q27.2   [Description]    (hg19-Feb_2009)
GoldenPathETV5 - 3q27.2 [CytoView hg19]  ETV5 - 3q27.2 [CytoView hg38]
ImmunoBaseENSG00000244405
Genome Data Viewer NCBIETV5 [Mapview hg19]  
OMIM601600   
Gene and transcription
Genbank (Entrez)AK301878 BC007333 BT006713 CR456767 X76184
RefSeq transcript (Entrez)NM_004454
Consensus coding sequences : CCDS (NCBI)ETV5
Gene ExpressionETV5 [ NCBI-GEO ]   ETV5 [ EBI - ARRAY_EXPRESS ]   ETV5 [ SEEK ]   ETV5 [ MEM ]
Gene Expression Viewer (FireBrowse)ETV5 [ Firebrowse - Broad ]
GenevisibleExpression of ETV5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2119
GTEX Portal (Tissue expression)ETV5
Human Protein AtlasENSG00000244405-ETV5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41161   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP41161  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP41161
PhosPhoSitePlusP41161
Domaine pattern : Prosite (Expaxy)ETS_DOMAIN_1 (PS00345)    ETS_DOMAIN_2 (PS00346)    ETS_DOMAIN_3 (PS50061)   
Domains : Interpro (EBI)Ets_dom    ETS_PEA3_N    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)Ets (PF00178)    ETS_PEA3_N (PF04621)   
Domain families : Pfam (NCBI)pfam00178    pfam04621   
Domain families : Smart (EMBL)ETS (SM00413)  
Conserved Domain (NCBI)ETV5
PDB (RSDB)4UNO    5ILV   
PDB Europe4UNO    5ILV   
PDB (PDBSum)4UNO    5ILV   
PDB (IMB)4UNO    5ILV   
Structural Biology KnowledgeBase4UNO    5ILV   
SCOP (Structural Classification of Proteins)4UNO    5ILV   
CATH (Classification of proteins structures)4UNO    5ILV   
SuperfamilyP41161
AlphaFold pdb e-kbP41161   
Human Protein Atlas [tissue]ENSG00000244405-ETV5 [tissue]
HPRD09035
Protein Interaction databases
DIP (DOE-UCLA)P41161
IntAct (EBI)P41161
BioGRIDETV5
STRING (EMBL)ETV5
ZODIACETV5
Ontologies - Pathways
QuickGOP41161
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  chromatin  transcription cis-regulatory region binding  RNA polymerase II transcription regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA binding  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleoplasm  regulation of transcription by RNA polymerase II  cell differentiation  cellular response to oxidative stress  positive regulation of transcription by RNA polymerase II  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  chromatin  transcription cis-regulatory region binding  RNA polymerase II transcription regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA binding  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleoplasm  regulation of transcription by RNA polymerase II  cell differentiation  cellular response to oxidative stress  positive regulation of transcription by RNA polymerase II  sequence-specific double-stranded DNA binding  
Pathways : BIOCARTABIOCARTA_IL12PATHWAY   
NDEx NetworkETV5
Atlas of Cancer Signalling NetworkETV5
Wikipedia pathwaysETV5
Orthology - Evolution
OrthoDB2119
GeneTree (enSembl)ENSG00000244405
Phylogenetic Trees/Animal Genes : TreeFamETV5
Homologs : HomoloGeneETV5
Homology/Alignments : Family Browser (UCSC)ETV5
Gene fusions - Rearrangements
Fusion : MitelmanRNF213::ETV5 [17q25.3/3q27.2]  
Fusion : MitelmanSLC45A3::ETV5 [1q32.1/3q27.2]  
Fusion : MitelmanTMPRSS2::ETV5 [21q22.3/3q27.2]  
Fusion : QuiverETV5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerETV5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ETV5
dbVarETV5
ClinVarETV5
MonarchETV5
1000_GenomesETV5 
Exome Variant ServerETV5
GNOMAD BrowserENSG00000244405
Varsome BrowserETV5
ACMGETV5 variants
VarityP41161
Genomic Variants (DGV)ETV5 [DGVbeta]
DECIPHERETV5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisETV5 
Mutations
ICGC Data PortalETV5 
TCGA Data PortalETV5 
Broad Tumor PortalETV5
OASIS PortalETV5 [ Somatic mutations - Copy number]
Cancer Gene: CensusETV5 
Somatic Mutations in Cancer : COSMICETV5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DETV5
Mutations and Diseases : HGMDETV5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaETV5
DgiDB (Drug Gene Interaction Database)ETV5
DoCM (Curated mutations)ETV5
CIViC (Clinical Interpretations of Variants in Cancer)ETV5
Cancer3DETV5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601600   
Orphanet
DisGeNETETV5
MedgenETV5
Genetic Testing Registry ETV5
NextProtP41161 [Medical]
GENETestsETV5
Target ValidationETV5
Huge Navigator ETV5 [HugePedia]
ClinGenETV5
Clinical trials, drugs, therapy
MyCancerGenomeETV5
Protein Interactions : CTDETV5
Pharm GKB GenePA27908
PharosP41161
Clinical trialETV5
Miscellaneous
canSAR (ICR)ETV5
HarmonizomeETV5
ARCHS4ETV5
DataMed IndexETV5
Probes
Litterature
PubMed87 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXETV5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:32:36 CET 2022

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