EVL (Enah/Vasp-like)

2008-05-01  

Identity

HGNC
LOCATION
14q32.2
LOCUSID
ALIAS
RNB6
FUSION GENES

Other Information

Locus ID:

NCBI: 51466
MIM: 616912
HGNC: 20234
Ensembl: ENSG00000196405

Variants:

dbSNP: 51466
ClinVar: 51466
TCGA: ENSG00000196405
COSMIC: EVL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196405ENST00000392920Q9UI08
ENSG00000196405ENST00000402714Q9UI08
ENSG00000196405ENST00000402714A0A024R6K5
ENSG00000196405ENST00000544450Q9UI08
ENSG00000196405ENST00000553875G3V535
ENSG00000196405ENST00000554031H0YJL6
ENSG00000196405ENST00000554045G3V3G2
ENSG00000196405ENST00000554695H0YJN0
ENSG00000196405ENST00000555048A0A087WYI2
ENSG00000196405ENST00000555706G3V2K5
ENSG00000196405ENST00000557153G3V5F7
ENSG00000196405ENST00000557384G3V314

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
TCR signalingREACTOMER-HSA-202403
Generation of second messenger moleculesREACTOMER-HSA-202433
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Signaling by Robo receptorREACTOMER-HSA-376176

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
159397382005Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins.134
182641392008Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer.100
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
179983982007Ena/VASP is required for endothelial barrier function in vivo.52
183573902008EVL (Ena/VASP-like) expression is up-regulated in human breast cancer and its relative expression level is correlated with clinical stages.21
163361932006Spectrin interacts with EVL (Enabled/vasodilator-stimulated phosphoprotein-like protein), a protein involved in actin polymerization.11
163765682006The state of the actin cytoskeleton determines its association with gephyrin: role of ena/VASP family members.10
193294392009Recombination activator function of the novel RAD51- and RAD51B-binding protein, human EVL.10
292421012018Epigenetic silencing of EVL/miR-342 in multiple myeloma.5
286301442017CRMP-1 enhances EVL-mediated actin elongation to build lamellipodia and the actin cortex.4

Citation

Dessen P

EVL (Enah/Vasp-like)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50152/evl