EXD2 (exonuclease 3-5 domain containing 2)

2016-04-01  

Identity

HGNC
EXD2
LOCATION
14q24.1
LOCUSID
55218
ALIAS
C14orf114,EXDL2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55218
MIM: 616940
HGNC: 20217
Ensembl: ENSG00000081177

Variants:

dbSNP: 55218
ClinVar: 55218
TCGA: ENSG00000081177
COSMIC: EXD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000081177ENST00000312994Q9NVH0
ENSG00000081177ENST00000409014Q9NVH0
ENSG00000081177ENST00000409018Q9NVH0
ENSG00000081177ENST00000409242Q9NVH0
ENSG00000081177ENST00000409675Q9NVH0
ENSG00000081177ENST00000409949Q9NVH0
ENSG00000081177ENST00000413191C9JLF4

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
268076462016EXD2 promotes homologous recombination by facilitating DNA end resection.23
295995272018The mitochondrial outer-membrane location of the EXD2 exonuclease contradicts its direct role in nuclear DNA repair.4
311272912019The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.1
312554662019EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2.0

Citation

Dessen P

EXD2 (exonuclease 3-5 domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-04-01

Online version: http://atlasgeneticsoncology.org/gene/55696/exd2