Atlas of Genetics and Cytogenetics in Oncology and Haematology


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EXO1 (exonuclease 1)

Identity

Alias_nameshomolog of S. cerevisiae exonuclease 1
Alias_symbol (synonym)HEX1
hExoI
Other alias
HGNC (Hugo) EXO1
LocusID (NCBI) 9156
Atlas_Id 40512
Location 1q43  [Link to chromosome band 1q43]
Location_base_pair Starts at 241848191 and ends at 241889939 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EXO1   3511
Cards
Entrez_Gene (NCBI)EXO1  9156  exonuclease 1
AliasesHEX1; hExoI
GeneCards (Weizmann)EXO1
Ensembl hg19 (Hinxton)ENSG00000174371 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000174371 [Gene_View]  chr1:241848191-241889939 [Contig_View]  EXO1 [Vega]
ICGC DataPortalENSG00000174371
TCGA cBioPortalEXO1
AceView (NCBI)EXO1
Genatlas (Paris)EXO1
WikiGenes9156
SOURCE (Princeton)EXO1
Genetics Home Reference (NIH)EXO1
Genomic and cartography
GoldenPath hg38 (UCSC)EXO1  -     chr1:241848191-241889939 +  1q43   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EXO1  -     1q43   [Description]    (hg19-Feb_2009)
EnsemblEXO1 - 1q43 [CytoView hg19]  EXO1 - 1q43 [CytoView hg38]
Mapping of homologs : NCBIEXO1 [Mapview hg19]  EXO1 [Mapview hg38]
OMIM606063   
Gene and transcription
Genbank (Entrez)AF042282 AF060479 AF084974 AF091740 AK291291
RefSeq transcript (Entrez)NM_001319224 NM_003686 NM_006027 NM_130398
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EXO1
Cluster EST : UnigeneHs.498248 [ NCBI ]
CGAP (NCI)Hs.498248
Alternative Splicing GalleryENSG00000174371
Gene ExpressionEXO1 [ NCBI-GEO ]   EXO1 [ EBI - ARRAY_EXPRESS ]   EXO1 [ SEEK ]   EXO1 [ MEM ]
Gene Expression Viewer (FireBrowse)EXO1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9156
GTEX Portal (Tissue expression)EXO1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UQ84   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UQ84  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UQ84
Splice isoforms : SwissVarQ9UQ84
Catalytic activity : Enzyme3.1.-.- [ Enzyme-Expasy ]   3.1.-.-3.1.-.- [ IntEnz-EBI ]   3.1.-.- [ BRENDA ]   3.1.-.- [ KEGG ]   
PhosPhoSitePlusQ9UQ84
Domaine pattern : Prosite (Expaxy)XPG_1 (PS00841)    XPG_2 (PS00842)   
Domains : Interpro (EBI)5-3_exonuclease_C    Exo1    HhH2    PIN_domain-like    XPG-I_dom    XPG/Rad2    XPG_CS    XPG_DNA_repair_N   
Domain families : Pfam (Sanger)XPG_I (PF00867)    XPG_N (PF00752)   
Domain families : Pfam (NCBI)pfam00867    pfam00752   
Domain families : Smart (EMBL)HhH2 (SM00279)  XPGI (SM00484)  XPGN (SM00485)  
Conserved Domain (NCBI)EXO1
DMDM Disease mutations9156
Blocks (Seattle)EXO1
PDB (SRS)3QE9    3QEA    3QEB   
PDB (PDBSum)3QE9    3QEA    3QEB   
PDB (IMB)3QE9    3QEA    3QEB   
PDB (RSDB)3QE9    3QEA    3QEB   
Structural Biology KnowledgeBase3QE9    3QEA    3QEB   
SCOP (Structural Classification of Proteins)3QE9    3QEA    3QEB   
CATH (Classification of proteins structures)3QE9    3QEA    3QEB   
SuperfamilyQ9UQ84
Human Protein AtlasENSG00000174371
Peptide AtlasQ9UQ84
HPRD06932
IPIIPI00219173   IPI00556476   IPI01012173   IPI00844071   IPI00644243   IPI00976950   IPI00978371   IPI00976376   
Protein Interaction databases
DIP (DOE-UCLA)Q9UQ84
IntAct (EBI)Q9UQ84
FunCoupENSG00000174371
BioGRIDEXO1
STRING (EMBL)EXO1
ZODIACEXO1
Ontologies - Pathways
QuickGOQ9UQ84
Ontology : AmiGODNA synthesis involved in DNA repair  strand displacement  humoral immune response mediated by circulating immunoglobulin  DNA binding  chromatin binding  RNA-DNA hybrid ribonuclease activity  exonuclease activity  protein binding  nucleus  nucleoplasm  nucleoplasm  DNA replication  DNA repair  mismatch repair  mismatch repair  mismatch repair  mismatch repair  mismatch repair  DNA recombination  5'-3' exonuclease activity  5'-3' exonuclease activity  somatic hypermutation of immunoglobulin genes  nuclear body  5'-3' exodeoxyribonuclease activity  single-stranded DNA 5'-3' exodeoxyribonuclease activity  isotype switching  metal ion binding  flap endonuclease activity  meiotic cell cycle  double-stranded DNA 5'-3' exodeoxyribonuclease activity  RNA phosphodiester bond hydrolysis, endonucleolytic  t-circle formation  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIDNA synthesis involved in DNA repair  strand displacement  humoral immune response mediated by circulating immunoglobulin  DNA binding  chromatin binding  RNA-DNA hybrid ribonuclease activity  exonuclease activity  protein binding  nucleus  nucleoplasm  nucleoplasm  DNA replication  DNA repair  mismatch repair  mismatch repair  mismatch repair  mismatch repair  mismatch repair  DNA recombination  5'-3' exonuclease activity  5'-3' exonuclease activity  somatic hypermutation of immunoglobulin genes  nuclear body  5'-3' exodeoxyribonuclease activity  single-stranded DNA 5'-3' exodeoxyribonuclease activity  isotype switching  metal ion binding  flap endonuclease activity  meiotic cell cycle  double-stranded DNA 5'-3' exodeoxyribonuclease activity  RNA phosphodiester bond hydrolysis, endonucleolytic  t-circle formation  regulation of signal transduction by p53 class mediator  
Pathways : KEGGMismatch repair   
NDEx NetworkEXO1
Atlas of Cancer Signalling NetworkEXO1
Wikipedia pathwaysEXO1
Orthology - Evolution
OrthoDB9156
GeneTree (enSembl)ENSG00000174371
Phylogenetic Trees/Animal Genes : TreeFamEXO1
HOVERGENQ9UQ84
HOGENOMQ9UQ84
Homologs : HomoloGeneEXO1
Homology/Alignments : Family Browser (UCSC)EXO1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEXO1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EXO1
dbVarEXO1
ClinVarEXO1
1000_GenomesEXO1 
Exome Variant ServerEXO1
ExAC (Exome Aggregation Consortium)EXO1 (select the gene name)
Genetic variants : HAPMAP9156
Genomic Variants (DGV)EXO1 [DGVbeta]
DECIPHEREXO1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEXO1 
Mutations
ICGC Data PortalEXO1 
TCGA Data PortalEXO1 
Broad Tumor PortalEXO1
OASIS PortalEXO1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEXO1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEXO1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EXO1
DgiDB (Drug Gene Interaction Database)EXO1
DoCM (Curated mutations)EXO1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EXO1 (select a term)
intoGenEXO1
Cancer3DEXO1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606063   
Orphanet
MedgenEXO1
Genetic Testing Registry EXO1
NextProtQ9UQ84 [Medical]
TSGene9156
GENETestsEXO1
Target ValidationEXO1
Huge Navigator EXO1 [HugePedia]
snp3D : Map Gene to Disease9156
BioCentury BCIQEXO1
ClinGenEXO1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9156
Chemical/Pharm GKB GenePA27923
Clinical trialEXO1
Miscellaneous
canSAR (ICR)EXO1 (select the gene name)
Probes
Litterature
PubMed102 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEXO1
EVEXEXO1
GoPubMedEXO1
iHOPEXO1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:33:01 CEST 2017

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