Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

EXO1 (exonuclease 1)

Identity

Alias (NCBI)HEX1
hExoI
HGNC (Hugo) EXO1
HGNC Alias symbHEX1
hExoI
HGNC Alias namerad2 nuclease family member, homolog of S. cerevisiae exonuclease 1
LocusID (NCBI) 9156
Atlas_Id 40512
Location 1q43  [Link to chromosome band 1q43]
Location_base_pair Starts at 241848204 and ends at 241889939 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)EXO1   3511
Cards
Entrez_Gene (NCBI)EXO1    exonuclease 1
AliasesHEX1; hExoI
GeneCards (Weizmann)EXO1
Ensembl hg19 (Hinxton)ENSG00000174371 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000174371 [Gene_View]  ENSG00000174371 [Sequence]  chr1:241848204-241889939 [Contig_View]  EXO1 [Vega]
ICGC DataPortalENSG00000174371
TCGA cBioPortalEXO1
AceView (NCBI)EXO1
Genatlas (Paris)EXO1
SOURCE (Princeton)EXO1
Genetics Home Reference (NIH)EXO1
Genomic and cartography
GoldenPath hg38 (UCSC)EXO1  -     chr1:241848204-241889939 +  1q43   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EXO1  -     1q43   [Description]    (hg19-Feb_2009)
GoldenPathEXO1 - 1q43 [CytoView hg19]  EXO1 - 1q43 [CytoView hg38]
ImmunoBaseENSG00000174371
Genome Data Viewer NCBIEXO1 [Mapview hg19]  
OMIM606063   
Gene and transcription
Genbank (Entrez)AF042282 AF060479 AF084974 AF091740 AK291291
RefSeq transcript (Entrez)NM_001319224 NM_003686 NM_006027 NM_130398
Consensus coding sequences : CCDS (NCBI)EXO1
Gene ExpressionEXO1 [ NCBI-GEO ]   EXO1 [ EBI - ARRAY_EXPRESS ]   EXO1 [ SEEK ]   EXO1 [ MEM ]
Gene Expression Viewer (FireBrowse)EXO1 [ Firebrowse - Broad ]
GenevisibleExpression of EXO1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9156
GTEX Portal (Tissue expression)EXO1
Human Protein AtlasENSG00000174371-EXO1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UQ84   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UQ84  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UQ84
Catalytic activity : Enzyme3.1.-.- [ Enzyme-Expasy ]   3.1.-.-3.1.-.- [ IntEnz-EBI ]   3.1.-.- [ BRENDA ]   3.1.-.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9UQ84
Domaine pattern : Prosite (Expaxy)XPG_1 (PS00841)    XPG_2 (PS00842)   
Domains : Interpro (EBI)5-3_exonuclease_C_sf    Exo1    EXO1_H3TH    HhH2    PIN-like_dom_sf    XPG-I_dom    XPG/Rad2    XPG_CS    XPG_DNA_repair_N   
Domain families : Pfam (Sanger)XPG_I (PF00867)    XPG_N (PF00752)   
Domain families : Pfam (NCBI)pfam00867    pfam00752   
Domain families : Smart (EMBL)HhH2 (SM00279)  XPGI (SM00484)  XPGN (SM00485)  
Conserved Domain (NCBI)EXO1
PDB (RSDB)3QE9    3QEA    3QEB    5UZV    5V04    5V05    5V06    5V07    5V08    5V09    5V0A    5V0B    5V0C    5V0D    5V0E   
PDB Europe3QE9    3QEA    3QEB    5UZV    5V04    5V05    5V06    5V07    5V08    5V09    5V0A    5V0B    5V0C    5V0D    5V0E   
PDB (PDBSum)3QE9    3QEA    3QEB    5UZV    5V04    5V05    5V06    5V07    5V08    5V09    5V0A    5V0B    5V0C    5V0D    5V0E   
PDB (IMB)3QE9    3QEA    3QEB    5UZV    5V04    5V05    5V06    5V07    5V08    5V09    5V0A    5V0B    5V0C    5V0D    5V0E   
Structural Biology KnowledgeBase3QE9    3QEA    3QEB    5UZV    5V04    5V05    5V06    5V07    5V08    5V09    5V0A    5V0B    5V0C    5V0D    5V0E   
SCOP (Structural Classification of Proteins)3QE9    3QEA    3QEB    5UZV    5V04    5V05    5V06    5V07    5V08    5V09    5V0A    5V0B    5V0C    5V0D    5V0E   
CATH (Classification of proteins structures)3QE9    3QEA    3QEB    5UZV    5V04    5V05    5V06    5V07    5V08    5V09    5V0A    5V0B    5V0C    5V0D    5V0E   
SuperfamilyQ9UQ84
AlphaFold pdb e-kbQ9UQ84   
Human Protein Atlas [tissue]ENSG00000174371-EXO1 [tissue]
HPRD06932
Protein Interaction databases
DIP (DOE-UCLA)Q9UQ84
IntAct (EBI)Q9UQ84
BioGRIDEXO1
STRING (EMBL)EXO1
ZODIACEXO1
Ontologies - Pathways
QuickGOQ9UQ84
Ontology : AmiGOhumoral immune response mediated by circulating immunoglobulin  DNA binding  chromatin binding  RNA-DNA hybrid ribonuclease activity  exonuclease activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  plasma membrane  DNA replication  DNA repair  mismatch repair  mismatch repair  mismatch repair  mismatch repair  mismatch repair  mismatch repair  DNA recombination  DNA recombination  5'-3' exonuclease activity  somatic hypermutation of immunoglobulin genes  nuclear body  5'-flap endonuclease activity  5'-3' exodeoxyribonuclease activity  5'-3' exodeoxyribonuclease activity  single-stranded DNA 5'-3' exodeoxyribonuclease activity  isotype switching  metal ion binding  flap endonuclease activity  meiotic cell cycle  double-stranded DNA 5'-3' exodeoxyribonuclease activity  RNA phosphodiester bond hydrolysis, endonucleolytic  t-circle formation  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIhumoral immune response mediated by circulating immunoglobulin  DNA binding  chromatin binding  RNA-DNA hybrid ribonuclease activity  exonuclease activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  plasma membrane  DNA replication  DNA repair  mismatch repair  mismatch repair  mismatch repair  mismatch repair  mismatch repair  mismatch repair  DNA recombination  DNA recombination  5'-3' exonuclease activity  somatic hypermutation of immunoglobulin genes  nuclear body  5'-flap endonuclease activity  5'-3' exodeoxyribonuclease activity  5'-3' exodeoxyribonuclease activity  single-stranded DNA 5'-3' exodeoxyribonuclease activity  isotype switching  metal ion binding  flap endonuclease activity  meiotic cell cycle  double-stranded DNA 5'-3' exodeoxyribonuclease activity  RNA phosphodiester bond hydrolysis, endonucleolytic  t-circle formation  regulation of signal transduction by p53 class mediator  
Pathways : KEGGMismatch repair   
NDEx NetworkEXO1
Atlas of Cancer Signalling NetworkEXO1
Wikipedia pathwaysEXO1
Orthology - Evolution
OrthoDB9156
GeneTree (enSembl)ENSG00000174371
Phylogenetic Trees/Animal Genes : TreeFamEXO1
Homologs : HomoloGeneEXO1
Homology/Alignments : Family Browser (UCSC)EXO1
Gene fusions - Rearrangements
Fusion : QuiverEXO1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEXO1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EXO1
dbVarEXO1
ClinVarEXO1
MonarchEXO1
1000_GenomesEXO1 
Exome Variant ServerEXO1
GNOMAD BrowserENSG00000174371
Varsome BrowserEXO1
ACMGEXO1 variants
VarityQ9UQ84
Genomic Variants (DGV)EXO1 [DGVbeta]
DECIPHEREXO1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEXO1 
Mutations
ICGC Data PortalEXO1 
TCGA Data PortalEXO1 
Broad Tumor PortalEXO1
OASIS PortalEXO1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEXO1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEXO1
Mutations and Diseases : HGMDEXO1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaEXO1
DgiDB (Drug Gene Interaction Database)EXO1
DoCM (Curated mutations)EXO1
CIViC (Clinical Interpretations of Variants in Cancer)EXO1
Cancer3DEXO1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606063   
Orphanet
DisGeNETEXO1
MedgenEXO1
Genetic Testing Registry EXO1
NextProtQ9UQ84 [Medical]
GENETestsEXO1
Target ValidationEXO1
Huge Navigator EXO1 [HugePedia]
ClinGenEXO1
Clinical trials, drugs, therapy
MyCancerGenomeEXO1
Protein Interactions : CTDEXO1
Pharm GKB GenePA27923
PharosQ9UQ84
Clinical trialEXO1
Miscellaneous
canSAR (ICR)EXO1
HarmonizomeEXO1
DataMed IndexEXO1
Probes
Litterature
PubMed131 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXEXO1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:08:37 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.