Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

EXO5 (exonuclease 5)

Identity

Alias_namesC1orf176
DEM1
chromosome 1 open reading frame 176
defects in morphology 1 homolog (S. cerevisiae)
Alias_symbol (synonym)FLJ21144
Other aliasExo V
hExo5
HGNC (Hugo) EXO5
LocusID (NCBI) 64789
Atlas_Id 53140
Location 1p34.2  [Link to chromosome band 1p34]
Location_base_pair Starts at 40508719 and ends at 40516050 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BCL2L1 (20q11.21) / EXO5 (1p34.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)EXO5   26115
Cards
Entrez_Gene (NCBI)EXO5  64789  exonuclease 5
AliasesC1orf176; DEM1; Exo; hExo5
GeneCards (Weizmann)EXO5
Ensembl hg19 (Hinxton)ENSG00000164002 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164002 [Gene_View]  chr1:40508719-40516050 [Contig_View]  EXO5 [Vega]
ICGC DataPortalENSG00000164002
TCGA cBioPortalEXO5
AceView (NCBI)EXO5
Genatlas (Paris)EXO5
WikiGenes64789
SOURCE (Princeton)EXO5
Genetics Home Reference (NIH)EXO5
Genomic and cartography
GoldenPath hg38 (UCSC)EXO5  -     chr1:40508719-40516050 +  1p34.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EXO5  -     1p34.2   [Description]    (hg19-Feb_2009)
EnsemblEXO5 - 1p34.2 [CytoView hg19]  EXO5 - 1p34.2 [CytoView hg38]
Mapping of homologs : NCBIEXO5 [Mapview hg19]  EXO5 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF086542 AK021507 AK023245 AK024797 AK094092
RefSeq transcript (Entrez)NM_001346946 NM_001346947 NM_001346948 NM_001346949 NM_001346950 NM_001346951 NM_001346952 NM_001346953 NM_001346954 NM_001346955 NM_001346956 NM_022774
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EXO5
Cluster EST : UnigeneHs.733167 [ NCBI ]
CGAP (NCI)Hs.733167
Alternative Splicing GalleryENSG00000164002
Gene ExpressionEXO5 [ NCBI-GEO ]   EXO5 [ EBI - ARRAY_EXPRESS ]   EXO5 [ SEEK ]   EXO5 [ MEM ]
Gene Expression Viewer (FireBrowse)EXO5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64789
GTEX Portal (Tissue expression)EXO5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H790   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H790  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H790
Splice isoforms : SwissVarQ9H790
Catalytic activity : Enzyme3.1.-.- [ Enzyme-Expasy ]   3.1.-.-3.1.-.- [ IntEnz-EBI ]   3.1.-.- [ BRENDA ]   3.1.-.- [ KEGG ]   
PhosPhoSitePlusQ9H790
Domains : Interpro (EBI)EXOV   
Domain families : Pfam (Sanger)Exo5 (PF09810)   
Domain families : Pfam (NCBI)pfam09810   
Conserved Domain (NCBI)EXO5
DMDM Disease mutations64789
Blocks (Seattle)EXO5
SuperfamilyQ9H790
Human Protein AtlasENSG00000164002
Peptide AtlasQ9H790
HPRD07955
IPIIPI00291022   IPI00640952   IPI00644741   IPI00644176   IPI00640478   IPI00642400   
Protein Interaction databases
DIP (DOE-UCLA)Q9H790
IntAct (EBI)Q9H790
FunCoupENSG00000164002
BioGRIDEXO5
STRING (EMBL)EXO5
ZODIACEXO5
Ontologies - Pathways
QuickGOQ9H790
Ontology : AmiGODNA binding  nucleus  nucleoplasm  cytosol  single-stranded DNA 3'-5' exodeoxyribonuclease activity  interstrand cross-link repair  protein homodimerization activity  single-stranded DNA 5'-3' exodeoxyribonuclease activity  metal ion binding  4 iron, 4 sulfur cluster binding  nucleic acid phosphodiester bond hydrolysis  
Ontology : EGO-EBIDNA binding  nucleus  nucleoplasm  cytosol  single-stranded DNA 3'-5' exodeoxyribonuclease activity  interstrand cross-link repair  protein homodimerization activity  single-stranded DNA 5'-3' exodeoxyribonuclease activity  metal ion binding  4 iron, 4 sulfur cluster binding  nucleic acid phosphodiester bond hydrolysis  
NDEx NetworkEXO5
Atlas of Cancer Signalling NetworkEXO5
Wikipedia pathwaysEXO5
Orthology - Evolution
OrthoDB64789
GeneTree (enSembl)ENSG00000164002
Phylogenetic Trees/Animal Genes : TreeFamEXO5
HOVERGENQ9H790
HOGENOMQ9H790
Homologs : HomoloGeneEXO5
Homology/Alignments : Family Browser (UCSC)EXO5
Gene fusions - Rearrangements
Fusion : MitelmanBCL2L1/EXO5 [20q11.21/1p34.2]  [t(1;20)(p34;q11)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEXO5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EXO5
dbVarEXO5
ClinVarEXO5
1000_GenomesEXO5 
Exome Variant ServerEXO5
ExAC (Exome Aggregation Consortium)EXO5 (select the gene name)
Genetic variants : HAPMAP64789
Genomic Variants (DGV)EXO5 [DGVbeta]
DECIPHEREXO5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEXO5 
Mutations
ICGC Data PortalEXO5 
TCGA Data PortalEXO5 
Broad Tumor PortalEXO5
OASIS PortalEXO5 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDEXO5
BioMutasearch EXO5
DgiDB (Drug Gene Interaction Database)EXO5
DoCM (Curated mutations)EXO5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EXO5 (select a term)
intoGenEXO5
Cancer3DEXO5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenEXO5
Genetic Testing Registry EXO5
NextProtQ9H790 [Medical]
TSGene64789
GENETestsEXO5
Huge Navigator EXO5 [HugePedia]
snp3D : Map Gene to Disease64789
BioCentury BCIQEXO5
ClinGenEXO5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64789
Chemical/Pharm GKB GenePA164718736
Clinical trialEXO5
Miscellaneous
canSAR (ICR)EXO5 (select the gene name)
Probes
Litterature
PubMed7 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEXO5
EVEXEXO5
GoPubMedEXO5
iHOPEXO5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:15:06 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.