EXOC1 (exocyst complex component 1)

2003-12-01  

Identity

HGNC
LOCATION
4q12
LOCUSID
ALIAS
BM-102,SEC3,SEC3L1,SEC3P
FUSION GENES

Other Information

Locus ID:

NCBI: 55763
MIM: 607879
HGNC: 30380
Ensembl: ENSG00000090989

Variants:

dbSNP: 55763
ClinVar: 55763
TCGA: ENSG00000090989
COSMIC: EXOC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090989ENST00000346134Q9NV70
ENSG00000090989ENST00000346134A0A024RDA9
ENSG00000090989ENST00000349598Q9NV70
ENSG00000090989ENST00000349598A0A024RDA1
ENSG00000090989ENST00000381295Q9NV70
ENSG00000090989ENST00000381295A0A024RDA9

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Insulin processingREACTOMER-HSA-264876
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
VxPx cargo-targeting to ciliumREACTOMER-HSA-5620916
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
185417052008The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA.133
198898372010Sec3-containing exocyst complex is required for desmosome assembly in mammalian epithelial cells.20
235220082013West Nile virus and dengue virus capsid protein negates the antiviral activity of human Sec3 protein through the proteasome pathway.10
198890842010Human Sec3 protein is a novel transcriptional and translational repressor of flavivirus.7
255917742015Ezrin/Exocyst complex regulates mucin 5AC secretion induced by neutrophil elastase in human airway epithelial cells.6
286942122017Role of rs13117307 single nuclear polymorphism in the risk of uterine cervical cancer from Polish population and its impact on exocyst complex component 1 expression.2
314954942019Sec3 knockdown inhibits TGF-β induced epithelial-mesenchymal transition through the down-regulation of Akt phosphorylation in A549 cells.0

Citation

Dessen P

EXOC1 (exocyst complex component 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/42238/exoc1