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EXOC1 (exocyst complex component 1)

Identity

Alias_namesSEC3L1
SEC3-like 1 (S. cerevisiae)
Alias_symbol (synonym)SEC3
FLJ10893
BM-102
Sec3p
Other aliasSEC3P
HGNC (Hugo) EXOC1
LocusID (NCBI) 55763
Atlas_Id 42238
Location 4q12  [Link to chromosome band 4q12]
Location_base_pair Starts at 55853650 and ends at 55905078 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EXOC1 (4q12) / IDO1 (8p11.21)EXOC1 (4q12) / XKR3 (22q11.1)RBM47 (4p14) / EXOC1 (4q12)
SPATA18 (4q12) / EXOC1 (4q12)EXOC1 4q12 / IDO1 8p11.21EXOC1 4q12 / XKR3 22q11.1
RBM47 4p14 / EXOC1 4q12SPATA18 4q12 / EXOC1 4q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EXOC1   30380
Cards
Entrez_Gene (NCBI)EXOC1  55763  exocyst complex component 1
AliasesBM-102; SEC3; SEC3L1; SEC3P
GeneCards (Weizmann)EXOC1
Ensembl hg19 (Hinxton)ENSG00000090989 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000090989 [Gene_View]  chr4:55853650-55905078 [Contig_View]  EXOC1 [Vega]
ICGC DataPortalENSG00000090989
TCGA cBioPortalEXOC1
AceView (NCBI)EXOC1
Genatlas (Paris)EXOC1
WikiGenes55763
SOURCE (Princeton)EXOC1
Genetics Home Reference (NIH)EXOC1
Genomic and cartography
GoldenPath hg38 (UCSC)EXOC1  -     chr4:55853650-55905078 +  4q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EXOC1  -     4q12   [Description]    (hg19-Feb_2009)
EnsemblEXOC1 - 4q12 [CytoView hg19]  EXOC1 - 4q12 [CytoView hg38]
Mapping of homologs : NCBIEXOC1 [Mapview hg19]  EXOC1 [Mapview hg38]
OMIM607879   
Gene and transcription
Genbank (Entrez)AF208854 AK001755 AK023461 AK027047 AK027413
RefSeq transcript (Entrez)NM_001024924 NM_018261 NM_178237
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EXOC1
Cluster EST : UnigeneHs.269665 [ NCBI ]
CGAP (NCI)Hs.269665
Alternative Splicing GalleryENSG00000090989
Gene ExpressionEXOC1 [ NCBI-GEO ]   EXOC1 [ EBI - ARRAY_EXPRESS ]   EXOC1 [ SEEK ]   EXOC1 [ MEM ]
Gene Expression Viewer (FireBrowse)EXOC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55763
GTEX Portal (Tissue expression)EXOC1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NV70   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NV70  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NV70
Splice isoforms : SwissVarQ9NV70
PhosPhoSitePlusQ9NV70
Domains : Interpro (EBI)Sec3-PIP2_bind    Sec3_C   
Domain families : Pfam (Sanger)Sec3-PIP2_bind (PF15277)    Sec3_C (PF09763)   
Domain families : Pfam (NCBI)pfam15277    pfam09763   
Domain families : Smart (EMBL)Sec3-PIP2_bind (SM01313)  
Conserved Domain (NCBI)EXOC1
DMDM Disease mutations55763
Blocks (Seattle)EXOC1
SuperfamilyQ9NV70
Human Protein AtlasENSG00000090989
Peptide AtlasQ9NV70
HPRD07615
IPIIPI00019427   IPI00215762   
Protein Interaction databases
DIP (DOE-UCLA)Q9NV70
IntAct (EBI)Q9NV70
FunCoupENSG00000090989
BioGRIDEXOC1
STRING (EMBL)EXOC1
ZODIACEXOC1
Ontologies - Pathways
QuickGOQ9NV70
Ontology : AmiGOexocyst  exocyst  protein binding  phosphatidylinositol-4,5-bisphosphate binding  cytoplasm  cytosol  plasma membrane  exocytosis  exocytosis  Golgi to plasma membrane transport  protein transport  membrane  regulation of macroautophagy  GTP-Rho binding  phosphatidylinositol-mediated signaling  positive regulation of protein secretion  exocyst localization  cytoplasmic side of apical plasma membrane  
Ontology : EGO-EBIexocyst  exocyst  protein binding  phosphatidylinositol-4,5-bisphosphate binding  cytoplasm  cytosol  plasma membrane  exocytosis  exocytosis  Golgi to plasma membrane transport  protein transport  membrane  regulation of macroautophagy  GTP-Rho binding  phosphatidylinositol-mediated signaling  positive regulation of protein secretion  exocyst localization  cytoplasmic side of apical plasma membrane  
NDEx NetworkEXOC1
Atlas of Cancer Signalling NetworkEXOC1
Wikipedia pathwaysEXOC1
Orthology - Evolution
OrthoDB55763
GeneTree (enSembl)ENSG00000090989
Phylogenetic Trees/Animal Genes : TreeFamEXOC1
HOVERGENQ9NV70
HOGENOMQ9NV70
Homologs : HomoloGeneEXOC1
Homology/Alignments : Family Browser (UCSC)EXOC1
Gene fusions - Rearrangements
Fusion : MitelmanEXOC1/IDO1 [4q12/8p11.21]  
Fusion : MitelmanEXOC1/XKR3 [4q12/22q11.1]  [t(4;22)(q12;q11)]  
Fusion: TCGAEXOC1 4q12 IDO1 8p11.21 LUAD
Fusion: TCGAEXOC1 4q12 XKR3 22q11.1 OV
Fusion: TCGARBM47 4p14 EXOC1 4q12 OV
Fusion: TCGASPATA18 4q12 EXOC1 4q12 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEXOC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EXOC1
dbVarEXOC1
ClinVarEXOC1
1000_GenomesEXOC1 
Exome Variant ServerEXOC1
ExAC (Exome Aggregation Consortium)EXOC1 (select the gene name)
Genetic variants : HAPMAP55763
Genomic Variants (DGV)EXOC1 [DGVbeta]
DECIPHEREXOC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEXOC1 
Mutations
ICGC Data PortalEXOC1 
TCGA Data PortalEXOC1 
Broad Tumor PortalEXOC1
OASIS PortalEXOC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEXOC1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEXOC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EXOC1
DgiDB (Drug Gene Interaction Database)EXOC1
DoCM (Curated mutations)EXOC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EXOC1 (select a term)
intoGenEXOC1
Cancer3DEXOC1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607879   
Orphanet
MedgenEXOC1
Genetic Testing Registry EXOC1
NextProtQ9NV70 [Medical]
TSGene55763
GENETestsEXOC1
Target ValidationEXOC1
Huge Navigator EXOC1 [HugePedia]
snp3D : Map Gene to Disease55763
BioCentury BCIQEXOC1
ClinGenEXOC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55763
Chemical/Pharm GKB GenePA134891660
Clinical trialEXOC1
Miscellaneous
canSAR (ICR)EXOC1 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEXOC1
EVEXEXOC1
GoPubMedEXOC1
iHOPEXOC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:33:01 CEST 2017

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