Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

EXOC2 (exocyst complex component 2)

Identity

Alias (NCBI)NEDFACH
SEC5
SEC5L1
Sec5p
HGNC (Hugo) EXOC2
HGNC Alias symbFLJ11026
Sec5p
HGNC Previous nameSEC5L1
HGNC Previous nameSEC5-like 1 (S. cerevisiae)
LocusID (NCBI) 55770
Atlas_Id 42239
Location 6p25.3  [Link to chromosome band 6p25]
Location_base_pair Starts at 485154 and ends at 693139 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDYL (6p25.1) / EXOC2 (6p25.3)EXOC2 (6p25.3) / SH3RF3 (2q12.3)RAB9A (Xp22.2) / EXOC2 (6p25.3)
EXOC2 6p25.3 / SH3RF3 2q12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;6)(p12;p25) IRF4/IGK::t(6;14)(p25;q32) IRF4/IGH::t(6;22)(p25;q11) IRF4/IGL


External links

 

Nomenclature
HGNC (Hugo)EXOC2   24968
Cards
Entrez_Gene (NCBI)EXOC2    exocyst complex component 2
AliasesNEDFACH; SEC5; SEC5L1; Sec5p
GeneCards (Weizmann)EXOC2
Ensembl hg19 (Hinxton)ENSG00000112685 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112685 [Gene_View]  ENSG00000112685 [Sequence]  chr6:485154-693139 [Contig_View]  EXOC2 [Vega]
ICGC DataPortalENSG00000112685
TCGA cBioPortalEXOC2
AceView (NCBI)EXOC2
Genatlas (Paris)EXOC2
SOURCE (Princeton)EXOC2
Genetics Home Reference (NIH)EXOC2
Genomic and cartography
GoldenPath hg38 (UCSC)EXOC2  -     chr6:485154-693139 -  6p25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EXOC2  -     6p25.3   [Description]    (hg19-Feb_2009)
GoldenPathEXOC2 - 6p25.3 [CytoView hg19]  EXOC2 - 6p25.3 [CytoView hg38]
ImmunoBaseENSG00000112685
Genome Data Viewer NCBIEXOC2 [Mapview hg19]  
OMIM615329   619306   
Gene and transcription
Genbank (Entrez)AJ414403 AJ420556 AK001888 AK056564 AK302941
RefSeq transcript (Entrez)NM_018303
Consensus coding sequences : CCDS (NCBI)EXOC2
Gene ExpressionEXOC2 [ NCBI-GEO ]   EXOC2 [ EBI - ARRAY_EXPRESS ]   EXOC2 [ SEEK ]   EXOC2 [ MEM ]
Gene Expression Viewer (FireBrowse)EXOC2 [ Firebrowse - Broad ]
GenevisibleExpression of EXOC2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55770
GTEX Portal (Tissue expression)EXOC2
Human Protein AtlasENSG00000112685-EXOC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96KP1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96KP1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96KP1
PhosPhoSitePlusQ96KP1
Domains : Interpro (EBI)EXOC2/Sec5    EXOC2/Sec5_N_dom    Ig-like_fold    Ig_E-set    IPT_dom   
Domain families : Pfam (Sanger)Sec5 (PF15469)    TIG (PF01833)   
Domain families : Pfam (NCBI)pfam15469    pfam01833   
Conserved Domain (NCBI)EXOC2
SuperfamilyQ96KP1
AlphaFold pdb e-kbQ96KP1   
Human Protein Atlas [tissue]ENSG00000112685-EXOC2 [tissue]
HPRD11544
Protein Interaction databases
DIP (DOE-UCLA)Q96KP1
IntAct (EBI)Q96KP1
BioGRIDEXOC2
STRING (EMBL)EXOC2
ZODIACEXOC2
Ontologies - Pathways
QuickGOQ96KP1
Ontology : AmiGOexocyst  exocyst  protein binding  cytosol  plasma membrane  exocytosis  Golgi to plasma membrane transport  protein transport  membrane  protein kinase binding  small GTPase binding  protein N-terminus binding  cilium assembly  Flemming body  regulation of entry of bacterium into host cell  
Ontology : EGO-EBIexocyst  exocyst  protein binding  cytosol  plasma membrane  exocytosis  Golgi to plasma membrane transport  protein transport  membrane  protein kinase binding  small GTPase binding  protein N-terminus binding  cilium assembly  Flemming body  regulation of entry of bacterium into host cell  
Pathways : KEGGRas signaling pathway   
NDEx NetworkEXOC2
Atlas of Cancer Signalling NetworkEXOC2
Wikipedia pathwaysEXOC2
Orthology - Evolution
OrthoDB55770
GeneTree (enSembl)ENSG00000112685
Phylogenetic Trees/Animal Genes : TreeFamEXOC2
Homologs : HomoloGeneEXOC2
Homology/Alignments : Family Browser (UCSC)EXOC2
Gene fusions - Rearrangements
Fusion : MitelmanEXOC2/SH3RF3 [6p25.3/2q12.3]  
Fusion : MitelmanRAB9A/EXOC2 [Xp22.2/6p25.3]  
Fusion : QuiverEXOC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEXOC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EXOC2
dbVarEXOC2
ClinVarEXOC2
MonarchEXOC2
1000_GenomesEXOC2 
Exome Variant ServerEXOC2
GNOMAD BrowserENSG00000112685
Varsome BrowserEXOC2
ACMGEXOC2 variants
VarityQ96KP1
Genomic Variants (DGV)EXOC2 [DGVbeta]
DECIPHEREXOC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEXOC2 
Mutations
ICGC Data PortalEXOC2 
TCGA Data PortalEXOC2 
Broad Tumor PortalEXOC2
OASIS PortalEXOC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEXOC2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEXOC2
Mutations and Diseases : HGMDEXOC2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaEXOC2
DgiDB (Drug Gene Interaction Database)EXOC2
DoCM (Curated mutations)EXOC2
CIViC (Clinical Interpretations of Variants in Cancer)EXOC2
Cancer3DEXOC2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615329    619306   
Orphanet
DisGeNETEXOC2
MedgenEXOC2
Genetic Testing Registry EXOC2
NextProtQ96KP1 [Medical]
GENETestsEXOC2
Target ValidationEXOC2
Huge Navigator EXOC2 [HugePedia]
ClinGenEXOC2
Clinical trials, drugs, therapy
MyCancerGenomeEXOC2
Protein Interactions : CTDEXOC2
Pharm GKB GenePA134862170
PharosQ96KP1
Clinical trialEXOC2
Miscellaneous
canSAR (ICR)EXOC2
HarmonizomeEXOC2
DataMed IndexEXOC2
Probes
Litterature
PubMed78 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXEXOC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:08:37 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.