EXOC2 (exocyst complex component 2)

2004-02-01  

Identity

HGNC
LOCATION
6p25.3
LOCUSID
ALIAS
NEDFACH,SEC5,SEC5L1,Sec5p
FUSION GENES

Other Information

Locus ID:

NCBI: 55770
MIM: 615329
HGNC: 24968
Ensembl: ENSG00000112685

Variants:

dbSNP: 55770
ClinVar: 55770
TCGA: ENSG00000112685
COSMIC: EXOC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112685ENST00000230449Q96KP1
ENSG00000112685ENST00000230449A0A024QZT2
ENSG00000112685ENST00000443083Q2MDF5

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Ras signaling pathwayKEGGhsa04014
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Insulin processingREACTOMER-HSA-264876
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
VxPx cargo-targeting to ciliumREACTOMER-HSA-5620916
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148

References

Pubmed IDYearTitleCitations
170182832006RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival.173
205709662010Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.130
145259762003Ral GTPases regulate exocyst assembly through dual subunit interactions.103
125759512003Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
186978302008Ral-regulated interaction between Sec5 and paxillin targets Exocyst to focal complexes during cell migration.48
211976182011Model-based prediction of human hair color using DNA variants.27
201450372010Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis.19
206165602010Genetic differences between five European populations.13
238440302013Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion.8

Citation

Dessen P

EXOC2 (exocyst complex component 2)

Atlas Genet Cytogenet Oncol Haematol. 2004-02-01

Online version: http://atlasgeneticsoncology.org/gene/42239/exoc2