Atlas of Genetics and Cytogenetics in Oncology and Haematology


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EXOC2 (exocyst complex component 2)

Identity

Alias_namesSEC5L1
SEC5-like 1 (S. cerevisiae)
Alias_symbol (synonym)FLJ11026
Sec5p
Other aliasSEC5
HGNC (Hugo) EXOC2
LocusID (NCBI) 55770
Atlas_Id 42239
Location 6p25.3  [Link to chromosome band 6p25]
Location_base_pair Starts at 485138 and ends at 693141 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDYL (6p25.1) / EXOC2 (6p25.3)EXOC2 (6p25.3) / SH3RF3 (2q12.3)RAB9A (Xp22.2) / EXOC2 (6p25.3)
EXOC2 6p25.3 / SH3RF3 2q12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(2;6)(q12;p25) EXOC2/SH3RF3
t(X;6)(p22;p25) RAB9A/EXOC2


External links

Nomenclature
HGNC (Hugo)EXOC2   24968
Cards
Entrez_Gene (NCBI)EXOC2  55770  exocyst complex component 2
AliasesSEC5; SEC5L1; Sec5p
GeneCards (Weizmann)EXOC2
Ensembl hg19 (Hinxton)ENSG00000112685 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112685 [Gene_View]  ENSG00000112685 [Sequence]  chr6:485138-693141 [Contig_View]  EXOC2 [Vega]
ICGC DataPortalENSG00000112685
TCGA cBioPortalEXOC2
AceView (NCBI)EXOC2
Genatlas (Paris)EXOC2
WikiGenes55770
SOURCE (Princeton)EXOC2
Genetics Home Reference (NIH)EXOC2
Genomic and cartography
GoldenPath hg38 (UCSC)EXOC2  -     chr6:485138-693141 -  6p25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EXOC2  -     6p25.3   [Description]    (hg19-Feb_2009)
EnsemblEXOC2 - 6p25.3 [CytoView hg19]  EXOC2 - 6p25.3 [CytoView hg38]
Mapping of homologs : NCBIEXOC2 [Mapview hg19]  EXOC2 [Mapview hg38]
OMIM615329   
Gene and transcription
Genbank (Entrez)AJ414403 AJ420556 AK001888 AK056564 AK302941
RefSeq transcript (Entrez)NM_018303
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EXOC2
Cluster EST : UnigeneHs.484412 [ NCBI ]
CGAP (NCI)Hs.484412
Alternative Splicing GalleryENSG00000112685
Gene ExpressionEXOC2 [ NCBI-GEO ]   EXOC2 [ EBI - ARRAY_EXPRESS ]   EXOC2 [ SEEK ]   EXOC2 [ MEM ]
Gene Expression Viewer (FireBrowse)EXOC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55770
GTEX Portal (Tissue expression)EXOC2
Human Protein AtlasENSG00000112685-EXOC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96KP1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96KP1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96KP1
Splice isoforms : SwissVarQ96KP1
PhosPhoSitePlusQ96KP1
Domains : Interpro (EBI)EXOC2/Sec5    Ig-like_fold    Ig_E-set    IPT_dom   
Domain families : Pfam (Sanger)TIG (PF01833)   
Domain families : Pfam (NCBI)pfam01833   
Conserved Domain (NCBI)EXOC2
DMDM Disease mutations55770
Blocks (Seattle)EXOC2
SuperfamilyQ96KP1
Human Protein Atlas [tissue]ENSG00000112685-EXOC2 [tissue]
Peptide AtlasQ96KP1
HPRD11544
IPIIPI00783559   IPI01010762   IPI00789279   
Protein Interaction databases
DIP (DOE-UCLA)Q96KP1
IntAct (EBI)Q96KP1
FunCoupENSG00000112685
BioGRIDEXOC2
STRING (EMBL)EXOC2
ZODIACEXOC2
Ontologies - Pathways
QuickGOQ96KP1
Ontology : AmiGOexocyst  exocyst  exocyst assembly  protein binding  cytosol  plasma membrane  Golgi to plasma membrane transport  protein transport  membrane  Ral GTPase binding  protein kinase binding  protein N-terminus binding  Flemming body  regulation of entry of bacterium into host cell  
Ontology : EGO-EBIexocyst  exocyst  exocyst assembly  protein binding  cytosol  plasma membrane  Golgi to plasma membrane transport  protein transport  membrane  Ral GTPase binding  protein kinase binding  protein N-terminus binding  Flemming body  regulation of entry of bacterium into host cell  
Pathways : KEGGRas signaling pathway   
NDEx NetworkEXOC2
Atlas of Cancer Signalling NetworkEXOC2
Wikipedia pathwaysEXOC2
Orthology - Evolution
OrthoDB55770
GeneTree (enSembl)ENSG00000112685
Phylogenetic Trees/Animal Genes : TreeFamEXOC2
HOVERGENQ96KP1
HOGENOMQ96KP1
Homologs : HomoloGeneEXOC2
Homology/Alignments : Family Browser (UCSC)EXOC2
Gene fusions - Rearrangements
Fusion : MitelmanEXOC2/SH3RF3 [6p25.3/2q12.3]  
Fusion : MitelmanRAB9A/EXOC2 [Xp22.2/6p25.3]  [t(X;6)(p22;p25)]  
Fusion PortalEXOC2 6p25.3 SH3RF3 2q12.3 BRCA
Fusion : QuiverEXOC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEXOC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EXOC2
dbVarEXOC2
ClinVarEXOC2
1000_GenomesEXOC2 
Exome Variant ServerEXOC2
ExAC (Exome Aggregation Consortium)ENSG00000112685
GNOMAD BrowserENSG00000112685
Varsome BrowserEXOC2
Genetic variants : HAPMAP55770
Genomic Variants (DGV)EXOC2 [DGVbeta]
DECIPHEREXOC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEXOC2 
Mutations
ICGC Data PortalEXOC2 
TCGA Data PortalEXOC2 
Broad Tumor PortalEXOC2
OASIS PortalEXOC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEXOC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEXOC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EXOC2
DgiDB (Drug Gene Interaction Database)EXOC2
DoCM (Curated mutations)EXOC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EXOC2 (select a term)
intoGenEXOC2
Cancer3DEXOC2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615329   
Orphanet
DisGeNETEXOC2
MedgenEXOC2
Genetic Testing Registry EXOC2
NextProtQ96KP1 [Medical]
TSGene55770
GENETestsEXOC2
Target ValidationEXOC2
Huge Navigator EXOC2 [HugePedia]
snp3D : Map Gene to Disease55770
BioCentury BCIQEXOC2
ClinGenEXOC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55770
Chemical/Pharm GKB GenePA134862170
Clinical trialEXOC2
Miscellaneous
canSAR (ICR)EXOC2 (select the gene name)
Probes
Litterature
PubMed64 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEXOC2
EVEXEXOC2
GoPubMedEXOC2
iHOPEXOC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:05:17 CET 2018

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