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EXOC4 (exocyst complex component 4)

Identity

Alias (NCBI)SEC8
SEC8L1
Sec8p
HGNC (Hugo) EXOC4
HGNC Alias symbKIAA1699
MGC27170
SEC8
Sec8p
HGNC Previous nameSEC8L1
HGNC Previous nameSEC8-like 1 (S. cerevisiae)
LocusID (NCBI) 60412
Atlas_Id 42244
Location 7q33  [Link to chromosome band 7q33]
Location_base_pair Starts at 133253078 and ends at 134065760 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ABCD3 (1p21.3) / EXOC4 (7q33)CHCHD3 (7q32.3) / EXOC4 (7q33)EFHB (3p24.3) / EXOC4 (7q33)
EXOC4 (7q33) / CSRNP2 (12q13.12)EXOC4 (7q33) / EXOC4 (7q33)EXOC4 (7q33) / FARS2 (6p25.1)
EXOC4 (7q33) / LRGUK (7q33)EXOC4 (7q33) / NDUFS5 (1p34.3)EXOC4 (7q33) / PTAFR (1p35.3)
EXOC4 (7q33) / PTEN (10q23.31)EXOC4 (7q33) / PVT1 (8q24.21)EXOC4 (7q33) / SLC25A13 (7q21.3)
EXOC4 (7q33) / SUPT3H (6p21.1)EXOC4 (7q33) / TGFB1 (19q13.2)EXOC4 (7q33) / UBR2 (6p21.1)
SMAD3 (15q22.33) / EXOC4 (7q33)SNX30 (9q32) / EXOC4 (7q33)EXOC4 7q33 / PTAFR 1p35.3
EXOC4 7q33 / SLC25A13 7q21.3EXOC4 7q33 / SUPT3H 6p21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)EXOC4   30389
Cards
Entrez_Gene (NCBI)EXOC4    exocyst complex component 4
AliasesSEC8; SEC8L1; Sec8p
GeneCards (Weizmann)EXOC4
Ensembl hg19 (Hinxton)ENSG00000131558 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000131558 [Gene_View]  ENSG00000131558 [Sequence]  chr7:133253078-134065760 [Contig_View]  EXOC4 [Vega]
ICGC DataPortalENSG00000131558
TCGA cBioPortalEXOC4
AceView (NCBI)EXOC4
Genatlas (Paris)EXOC4
SOURCE (Princeton)EXOC4
Genetics Home Reference (NIH)EXOC4
Genomic and cartography
GoldenPath hg38 (UCSC)EXOC4  -     chr7:133253078-134065760 +  7q33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EXOC4  -     7q33   [Description]    (hg19-Feb_2009)
GoldenPathEXOC4 - 7q33 [CytoView hg19]  EXOC4 - 7q33 [CytoView hg38]
ImmunoBaseENSG00000131558
Genome Data Viewer NCBIEXOC4 [Mapview hg19]  
OMIM608185   
Gene and transcription
Genbank (Entrez)AB051486 AF132734 AF380839 AK022751 AK027688
RefSeq transcript (Entrez)NM_001037126 NM_021807
Consensus coding sequences : CCDS (NCBI)EXOC4
Gene ExpressionEXOC4 [ NCBI-GEO ]   EXOC4 [ EBI - ARRAY_EXPRESS ]   EXOC4 [ SEEK ]   EXOC4 [ MEM ]
Gene Expression Viewer (FireBrowse)EXOC4 [ Firebrowse - Broad ]
GenevisibleExpression of EXOC4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)60412
GTEX Portal (Tissue expression)EXOC4
Human Protein AtlasENSG00000131558-EXOC4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96A65   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96A65  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96A65
PhosPhoSitePlusQ96A65
Domains : Interpro (EBI)Sec8/EXOC4    Sec8_exocyst   
Domain families : Pfam (Sanger)Sec8_exocyst (PF04048)   
Domain families : Pfam (NCBI)pfam04048   
Conserved Domain (NCBI)EXOC4
SuperfamilyQ96A65
AlphaFold pdb e-kbQ96A65   
Human Protein Atlas [tissue]ENSG00000131558-EXOC4 [tissue]
HPRD12185
Protein Interaction databases
DIP (DOE-UCLA)Q96A65
IntAct (EBI)Q96A65
BioGRIDEXOC4
STRING (EMBL)EXOC4
ZODIACEXOC4
Ontologies - Pathways
QuickGOQ96A65
Ontology : AmiGOexocyst  protein binding  cytoplasm  cytosol  plasma membrane  microvillus  exocytosis  Golgi to plasma membrane transport  vesicle docking involved in exocytosis  chemical synaptic transmission  protein transport  membrane  regulation of macroautophagy  PDZ domain binding  small GTPase binding  growth cone membrane  myelin sheath abaxonal region  synapse  protein N-terminus binding  paraxial mesoderm formation  cilium assembly  vesicle tethering involved in exocytosis  Flemming body  
Ontology : EGO-EBIexocyst  protein binding  cytoplasm  cytosol  plasma membrane  microvillus  exocytosis  Golgi to plasma membrane transport  vesicle docking involved in exocytosis  chemical synaptic transmission  protein transport  membrane  regulation of macroautophagy  PDZ domain binding  small GTPase binding  growth cone membrane  myelin sheath abaxonal region  synapse  protein N-terminus binding  paraxial mesoderm formation  cilium assembly  vesicle tethering involved in exocytosis  Flemming body  
Pathways : KEGGTight junction   
NDEx NetworkEXOC4
Atlas of Cancer Signalling NetworkEXOC4
Wikipedia pathwaysEXOC4
Orthology - Evolution
OrthoDB60412
GeneTree (enSembl)ENSG00000131558
Phylogenetic Trees/Animal Genes : TreeFamEXOC4
Homologs : HomoloGeneEXOC4
Homology/Alignments : Family Browser (UCSC)EXOC4
Gene fusions - Rearrangements
Fusion : MitelmanEXOC4/PTAFR [7q33/1p35.3]  
Fusion : MitelmanEXOC4/SLC25A13 [7q33/7q21.3]  
Fusion : MitelmanEXOC4/SUPT3H [7q33/6p21.1]  
Fusion Cancer (Beijing)EXOC4 [7q33]  -  PVT1 [8q24.21]  [FUSC004024]  [FUSC004024]  [FUSC004024]
Fusion : QuiverEXOC4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEXOC4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EXOC4
dbVarEXOC4
ClinVarEXOC4
MonarchEXOC4
1000_GenomesEXOC4 
Exome Variant ServerEXOC4
GNOMAD BrowserENSG00000131558
Varsome BrowserEXOC4
ACMGEXOC4 variants
VarityQ96A65
Genomic Variants (DGV)EXOC4 [DGVbeta]
DECIPHEREXOC4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEXOC4 
Mutations
ICGC Data PortalEXOC4 
TCGA Data PortalEXOC4 
Broad Tumor PortalEXOC4
OASIS PortalEXOC4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEXOC4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEXOC4
Mutations and Diseases : HGMDEXOC4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaEXOC4
DgiDB (Drug Gene Interaction Database)EXOC4
DoCM (Curated mutations)EXOC4
CIViC (Clinical Interpretations of Variants in Cancer)EXOC4
Cancer3DEXOC4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608185   
Orphanet
DisGeNETEXOC4
MedgenEXOC4
Genetic Testing Registry EXOC4
NextProtQ96A65 [Medical]
GENETestsEXOC4
Target ValidationEXOC4
Huge Navigator EXOC4 [HugePedia]
ClinGenEXOC4
Clinical trials, drugs, therapy
MyCancerGenomeEXOC4
Protein Interactions : CTDEXOC4
Pharm GKB GenePA134944654
PharosQ96A65
Clinical trialEXOC4
Miscellaneous
canSAR (ICR)EXOC4
HarmonizomeEXOC4
DataMed IndexEXOC4
Probes
Litterature
PubMed94 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXEXOC4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:08:38 CEST 2021

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