Atlas of Genetics and Cytogenetics in Oncology and Haematology

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EXOC6 (exocyst complex component 6)

Identity

Alias (NCBI)EXOC6A
SEC15
SEC15L
SEC15L1
SEC15L3
Sec15p
HGNC (Hugo) EXOC6
HGNC Alias symbSEC15L
FLJ1125
DKFZp761I2124
MGC33397
Sec15p
EXOC6A
HGNC Previous nameSEC15L1
HGNC Previous nameSEC15-like 1 (S. cerevisiae)
LocusID (NCBI) 54536
Atlas_Id 62946
Location 10q23.33  [Link to chromosome band 10q23]
Location_base_pair Starts at 92848455 and ends at 93059494 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CHEK1 (11q24.2) / EXOC6 (10q23.33)EXOC6 (10q23.33) / DTNB (2p23.3)TBC1D12 (10q23.33) / EXOC6 (10q23.33)
TBC1D12 EXOC6CHEK1 EXOC6

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(2;10)(p23;q23) EXOC6/DTNB
TBC1D12/EXOC6 (10q23)
t(10;11)(q23;q24) CHEK1/EXOC6

External links

Nomenclature
HGNC (Hugo)EXOC6   23196
Cards
Entrez_Gene (NCBI)EXOC6  54536  exocyst complex component 6
AliasesEXOC6A; SEC15; SEC15L; SEC15L1; 
SEC15L3; Sec15p
GeneCards (Weizmann)EXOC6
Ensembl hg19 (Hinxton)ENSG00000138190 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138190 [Gene_View]  ENSG00000138190 [Sequence]  chr10:92848455-93059494 [Contig_View]  EXOC6 [Vega]
ICGC DataPortalENSG00000138190
TCGA cBioPortalEXOC6
AceView (NCBI)EXOC6
Genatlas (Paris)EXOC6
WikiGenes54536
SOURCE (Princeton)EXOC6
Genetics Home Reference (NIH)EXOC6
Genomic and cartography
GoldenPath hg38 (UCSC)EXOC6  -     chr10:92848455-93059494 +  10q23.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EXOC6  -     10q23.33   [Description]    (hg19-Feb_2009)
GoldenPathEXOC6 - 10q23.33 [CytoView hg19]  EXOC6 - 10q23.33 [CytoView hg38]
ImmunoBaseENSG00000138190
genome Data Viewer NCBIEXOC6 [Mapview hg19]  
OMIM609672   
Gene and transcription
Genbank (Entrez)AF220217 AI039616 AI680957 AK002113 AK123268
RefSeq transcript (Entrez)NM_001013848 NM_001319194 NM_001319195 NM_001319200 NM_019053
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EXOC6
Alternative Splicing GalleryENSG00000138190
Gene ExpressionEXOC6 [ NCBI-GEO ]   EXOC6 [ EBI - ARRAY_EXPRESS ]   EXOC6 [ SEEK ]   EXOC6 [ MEM ]
Gene Expression Viewer (FireBrowse)EXOC6 [ Firebrowse - Broad ]
GenevisibleExpression of EXOC6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54536
GTEX Portal (Tissue expression)EXOC6
Human Protein AtlasENSG00000138190-EXOC6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TAG9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TAG9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TAG9
Splice isoforms : SwissVarQ8TAG9
PhosPhoSitePlusQ8TAG9
Domains : Interpro (EBI)EXOC6/Sec15    EXOC6/Sec15_C_dom1    EXOC6/Sec15_C_dom2   
Domain families : Pfam (Sanger)Sec15 (PF04091)   
Domain families : Pfam (NCBI)pfam04091   
Conserved Domain (NCBI)EXOC6
DMDM Disease mutations54536
Blocks (Seattle)EXOC6
SuperfamilyQ8TAG9
Human Protein Atlas [tissue]ENSG00000138190-EXOC6 [tissue]
Peptide AtlasQ8TAG9
HPRD10216
IPIIPI01013822   IPI00828051   IPI00555694   IPI01008948   IPI00010953   
Protein Interaction databases
DIP (DOE-UCLA)Q8TAG9
IntAct (EBI)Q8TAG9
FunCoupENSG00000138190
BioGRIDEXOC6
STRING (EMBL)EXOC6
ZODIACEXOC6
Ontologies - Pathways
QuickGOQ8TAG9
Ontology : AmiGOexocyst  protein binding  cytosol  plasma membrane  exocytosis  Golgi to plasma membrane transport  vesicle docking involved in exocytosis  protein transport  growth cone  perinuclear region of cytoplasm  Flemming body  
Ontology : EGO-EBIexocyst  protein binding  cytosol  plasma membrane  exocytosis  Golgi to plasma membrane transport  vesicle docking involved in exocytosis  protein transport  growth cone  perinuclear region of cytoplasm  Flemming body  
NDEx NetworkEXOC6
Atlas of Cancer Signalling NetworkEXOC6
Wikipedia pathwaysEXOC6
Orthology - Evolution
OrthoDB54536
GeneTree (enSembl)ENSG00000138190
Phylogenetic Trees/Animal Genes : TreeFamEXOC6
HOGENOMQ8TAG9
Homologs : HomoloGeneEXOC6
Homology/Alignments : Family Browser (UCSC)EXOC6
Gene fusions - Rearrangements
Fusion PortalTBC1D12 EXOC6
Fusion PortalCHEK1 EXOC6
Fusion : QuiverEXOC6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEXOC6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EXOC6
dbVarEXOC6
ClinVarEXOC6
1000_GenomesEXOC6 
Exome Variant ServerEXOC6
GNOMAD BrowserENSG00000138190
Varsome BrowserEXOC6
Genetic variants : HAPMAP54536
Genomic Variants (DGV)EXOC6 [DGVbeta]
DECIPHEREXOC6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEXOC6 
Mutations
ICGC Data PortalEXOC6 
TCGA Data PortalEXOC6 
Broad Tumor PortalEXOC6
OASIS PortalEXOC6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEXOC6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DEXOC6
Mutations and Diseases : HGMDEXOC6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EXOC6
DgiDB (Drug Gene Interaction Database)EXOC6
DoCM (Curated mutations)EXOC6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EXOC6 (select a term)
intoGenEXOC6
Cancer3DEXOC6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609672   
Orphanet
DisGeNETEXOC6
MedgenEXOC6
Genetic Testing Registry EXOC6
NextProtQ8TAG9 [Medical]
TSGene54536
GENETestsEXOC6
Target ValidationEXOC6
Huge Navigator EXOC6 [HugePedia]
snp3D : Map Gene to Disease54536
BioCentury BCIQEXOC6
ClinGenEXOC6
Clinical trials, drugs, therapy
Protein Interactions : CTD54536
Pharm GKB GenePA134908462
Clinical trialEXOC6
Miscellaneous
canSAR (ICR)EXOC6 (select the gene name)
HarmonizomeEXOC6
DataMed IndexEXOC6
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEXOC6
EVEXEXOC6
GoPubMedEXOC6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 15:54:47 CEST 2020
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