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EXOC6B (exocyst complex component 6B)

Identity

Alias_namesSEC15L2
SEC15B
SEC15-like 2 (S. cerevisiae)
SEC15 homolog B (S. cerevisiae)
Alias_symbol (synonym)KIAA0919
Other alias
HGNC (Hugo) EXOC6B
LocusID (NCBI) 23233
Atlas_Id 50565
Location 2p13.2  [Link to chromosome band 2p13]
Location_base_pair Starts at 72175984 and ends at 72826042 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CCK (3p22.1) / EXOC6B (2p13.2)COL16A1 (1p35.2) / EXOC6B (2p13.2)DLEC1 (3p22.2) / EXOC6B (2p13.2)
EXOC6B (2p13.2) / EXOC6B (2p13.2)EXOC6B (2p13.2) / HNRNPLL (2p22.1)EXOC6B (2p13.2) / MYH11 (16p13.11)
EXOC6B (2p13.2) / SFXN5 (2p13.2)EXOC6B (2p13.2) / TNS3 (7p12.3)HAT1 (2q31.1) / EXOC6B (2p13.2)
MIR548H3 (6q16.1) / EXOC6B (2p13.2)MLLT4 (6q27) / EXOC6B (2p13.2)MTAP (9p21.3) / EXOC6B (2p13.2)
RALGPS1 (9q33.3) / EXOC6B (2p13.2)ZNF638 (2p13.2) / EXOC6B (2p13.2)EXOC6B 2p13.2 HNRPLL
EXOC6B 2p13.2 / SFXN5 2p13.2HAT1 2q31.1 / EXOC6B 2p13.2MLLT4 6q27 / EXOC6B 2p13.2
MTAP 9p21.3 / EXOC6B 2p13.2ZNF638 2p13.2 / EXOC6B 2p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EXOC6B   17085
Cards
Entrez_Gene (NCBI)EXOC6B  23233  exocyst complex component 6B
AliasesSEC15B; SEC15L2
GeneCards (Weizmann)EXOC6B
Ensembl hg19 (Hinxton)ENSG00000144036 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000144036 [Gene_View]  chr2:72175984-72826042 [Contig_View]  EXOC6B [Vega]
ICGC DataPortalENSG00000144036
TCGA cBioPortalEXOC6B
AceView (NCBI)EXOC6B
Genatlas (Paris)EXOC6B
WikiGenes23233
SOURCE (Princeton)EXOC6B
Genetics Home Reference (NIH)EXOC6B
Genomic and cartography
GoldenPath hg38 (UCSC)EXOC6B  -     chr2:72175984-72826042 -  2p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EXOC6B  -     2p13.2   [Description]    (hg19-Feb_2009)
EnsemblEXOC6B - 2p13.2 [CytoView hg19]  EXOC6B - 2p13.2 [CytoView hg38]
Mapping of homologs : NCBIEXOC6B [Mapview hg19]  EXOC6B [Mapview hg38]
OMIM607880   
Gene and transcription
Genbank (Entrez)AB023136 AK023791 AK026474 BC029921 BC160001
RefSeq transcript (Entrez)NM_001321729 NM_001321730 NM_001321731 NM_001321733 NM_001321734 NM_015189
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EXOC6B
Cluster EST : UnigeneHs.303454 [ NCBI ]
CGAP (NCI)Hs.303454
Alternative Splicing GalleryENSG00000144036
Gene ExpressionEXOC6B [ NCBI-GEO ]   EXOC6B [ EBI - ARRAY_EXPRESS ]   EXOC6B [ SEEK ]   EXOC6B [ MEM ]
Gene Expression Viewer (FireBrowse)EXOC6B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23233
GTEX Portal (Tissue expression)EXOC6B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2D4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2D4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2D4
Splice isoforms : SwissVarQ9Y2D4
PhosPhoSitePlusQ9Y2D4
Domains : Interpro (EBI)EXOC6/Sec15   
Domain families : Pfam (Sanger)Sec15 (PF04091)   
Domain families : Pfam (NCBI)pfam04091   
Conserved Domain (NCBI)EXOC6B
DMDM Disease mutations23233
Blocks (Seattle)EXOC6B
SuperfamilyQ9Y2D4
Human Protein AtlasENSG00000144036
Peptide AtlasQ9Y2D4
IPIIPI00852806   IPI00916499   IPI00917263   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2D4
IntAct (EBI)Q9Y2D4
FunCoupENSG00000144036
BioGRIDEXOC6B
STRING (EMBL)EXOC6B
ZODIACEXOC6B
Ontologies - Pathways
QuickGOQ9Y2D4
Ontology : AmiGOexocyst  protein binding  vesicle docking involved in exocytosis  protein transport  
Ontology : EGO-EBIexocyst  protein binding  vesicle docking involved in exocytosis  protein transport  
NDEx NetworkEXOC6B
Atlas of Cancer Signalling NetworkEXOC6B
Wikipedia pathwaysEXOC6B
Orthology - Evolution
OrthoDB23233
GeneTree (enSembl)ENSG00000144036
Phylogenetic Trees/Animal Genes : TreeFamEXOC6B
HOVERGENQ9Y2D4
HOGENOMQ9Y2D4
Homologs : HomoloGeneEXOC6B
Homology/Alignments : Family Browser (UCSC)EXOC6B
Gene fusions - Rearrangements
Fusion : MitelmanEXOC6B/HNRNPLL [2p13.2/2p22.1]  
Fusion : MitelmanEXOC6B/SFXN5 [2p13.2/2p13.2]  [t(2;2)(p13;p13)]  
Fusion : MitelmanHAT1/EXOC6B [2q31.1/2p13.2]  [t(2;2)(p13;q31)]  
Fusion : MitelmanMLLT4/EXOC6B [6q27/2p13.2]  [t(2;6)(p13;q27)]  
Fusion : MitelmanMTAP/EXOC6B [9p21.3/2p13.2]  [t(2;9)(p13;p21)]  
Fusion : MitelmanRALGPS1/EXOC6B [9q33.3/2p13.2]  [t(2;9)(p13;q33)]  
Fusion : MitelmanZNF638/EXOC6B [2p13.2/2p13.2]  [t(2;2)(p13;p13)]  
Fusion: TCGAEXOC6B 2p13.2 HNRPLL BLCA
Fusion: TCGAEXOC6B 2p13.2 SFXN5 2p13.2 BRCA LUAD
Fusion: TCGAHAT1 2q31.1 EXOC6B 2p13.2 LUAD
Fusion: TCGAMLLT4 6q27 EXOC6B 2p13.2 PRAD
Fusion: TCGAMTAP 9p21.3 EXOC6B 2p13.2 LUAD
Fusion: TCGAZNF638 2p13.2 EXOC6B 2p13.2 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEXOC6B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EXOC6B
dbVarEXOC6B
ClinVarEXOC6B
1000_GenomesEXOC6B 
Exome Variant ServerEXOC6B
ExAC (Exome Aggregation Consortium)EXOC6B (select the gene name)
Genetic variants : HAPMAP23233
Genomic Variants (DGV)EXOC6B [DGVbeta]
DECIPHEREXOC6B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEXOC6B 
Mutations
ICGC Data PortalEXOC6B 
TCGA Data PortalEXOC6B 
Broad Tumor PortalEXOC6B
OASIS PortalEXOC6B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEXOC6B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEXOC6B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EXOC6B
DgiDB (Drug Gene Interaction Database)EXOC6B
DoCM (Curated mutations)EXOC6B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EXOC6B (select a term)
intoGenEXOC6B
Cancer3DEXOC6B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607880   
Orphanet
MedgenEXOC6B
Genetic Testing Registry EXOC6B
NextProtQ9Y2D4 [Medical]
TSGene23233
GENETestsEXOC6B
Target ValidationEXOC6B
Huge Navigator EXOC6B [HugePedia]
snp3D : Map Gene to Disease23233
BioCentury BCIQEXOC6B
ClinGenEXOC6B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23233
Chemical/Pharm GKB GenePA162385463
Clinical trialEXOC6B
Miscellaneous
canSAR (ICR)EXOC6B (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEXOC6B
EVEXEXOC6B
GoPubMedEXOC6B
iHOPEXOC6B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:07:27 CEST 2017

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