EXOC7 (exocyst complex component 7)

2014-08-01  

Identity

HGNC
EXOC7
LOCATION
17q25.1
LOCUSID
23265
ALIAS
2-5-3p,BLOM4,EX070,EXO70,EXOC1,Exo70p,NEDSEBA,YJL085W
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23265
MIM: 608163
HGNC: 23214
Ensembl: ENSG00000182473

Variants:

dbSNP: 23265
ClinVar: 23265
TCGA: ENSG00000182473
COSMIC: EXOC7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182473ENST00000332065Q9UPT5
ENSG00000182473ENST00000335146Q9UPT5
ENSG00000182473ENST00000357231A0A0A0MRE1
ENSG00000182473ENST00000405575A0A0A0MSB8
ENSG00000182473ENST00000406660B5MCY9
ENSG00000182473ENST00000411744Q9UPT5
ENSG00000182473ENST00000420116C9JKC2
ENSG00000182473ENST00000442951C9JME6
ENSG00000182473ENST00000467929B4DJ07
ENSG00000182473ENST00000589210Q9UPT5
ENSG00000182473ENST00000589507K7ERQ5
ENSG00000182473ENST00000592559K7ENP8
ENSG00000182473ENST00000607838B4DJ07
ENSG00000182473ENST00000634349Q9UPT5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Insulin signaling pathwayKEGGko04910
Insulin signaling pathwayKEGGhsa04910
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Insulin processingREACTOMER-HSA-264876
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
VxPx cargo-targeting to ciliumREACTOMER-HSA-5620916
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
239482532013Exo70 generates membrane curvature for morphogenesis and cell migration.45
225956712012ERK1/2 regulate exocytosis through direct phosphorylation of the exocyst component Exo70.34
243319282013Exo70 isoform switching upon epithelial-mesenchymal transition mediates cancer cell invasion.33
220490252012An association between type Iγ PI4P 5-kinase and Exo70 directs E-cadherin clustering and epithelial polarization.22
157057152005Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70.19
233007272012Exo70 subunit of the exocyst complex is involved in adhesion-dependent trafficking of caveolin-1.6
286985702017Exo70 is an independent prognostic factor in colon cancer.6
265147252015GIV/girdin binds exocyst subunit-Exo70 and regulates exocytosis of GLUT4 storage vesicles.5
270256102016Cortactin and Exo70 mediated invasion of hepatoma carcinoma cells by MMP-9 secretion.4
268488642016Exo70 is transcriptionally up-regulated by hepatic nuclear factor 4α and contributes to cell cycle control in hepatoma cells.3

Citation

Dessen P

EXOC7 (exocyst complex component 7)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54294/exoc7