EXOG (exo/endonuclease G)

2018-12-01  

Identity

HGNC
LOCATION
3p22.2
LOCUSID
ALIAS
ENDOGL1,ENDOGL2,ENGL,ENGL-a,ENGL-b,ENGLA,ENGLB

Other Information

Locus ID:

NCBI: 9941
MIM: 604051
HGNC: 3347
Ensembl: ENSG00000157036

Variants:

dbSNP: 9941
ClinVar: 9941
TCGA: ENSG00000157036
COSMIC: EXOG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157036ENST00000287675Q9Y2C4
ENSG00000157036ENST00000412107F2Z2D3
ENSG00000157036ENST00000422077Q9Y2C4
ENSG00000157036ENST00000431472F8WE28
ENSG00000157036ENST00000436414F8WEP0
ENSG00000157036ENST00000438992F2Z2D3
ENSG00000157036ENST00000443942F2Z2D3
ENSG00000157036ENST00000447573F2Z2D3
ENSG00000157036ENST00000450732H7C451
ENSG00000157036ENST00000453767H7C0W6
ENSG00000157036ENST00000454803F8WC11
ENSG00000157036ENST00000457367F8WE38
ENSG00000157036ENST00000470291H0Y8P1
ENSG00000157036ENST00000630638F2Z2D3

Expression (GTEx)

0
5
10
15

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
217686462011Apoptosis induced by persistent single-strand breaks in mitochondrial genome: critical role of EXOG (5'-EXO/endonuclease) in their repair.62
181875032008EXOG, a novel paralog of Endonuclease G in higher eukaryotes.32
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
239865852013Mitochondrial nucleases ENDOG and EXOG participate in mitochondrial DNA depletion initiated by herpes simplex virus 1 UL12.5.10
284668552017A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease.6
174155502007Genetic association of single nucleotide polymorphisms in endonuclease G-like 1 gene with type 2 diabetes in a Japanese population.5
174155502007Genetic association of single nucleotide polymorphisms in endonuclease G-like 1 gene with type 2 diabetes in a Japanese population.5
309497022019A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication.2

Citation

Dessen P

EXOG (exo/endonuclease G)

Atlas Genet Cytogenet Oncol Haematol. 2018-12-01

Online version: http://atlasgeneticsoncology.org/gene/57775/exog