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EXOSC10 (exosome component 10)

Identity

Alias_namesPMSCL2
polymyositis/scleroderma autoantigen 2, 100kDa
Alias_symbol (synonym)PM-Scl
PM/Scl-100
Rrp6p
RRP6
p2
p3
p4
Other aliasPMSCL
HGNC (Hugo) EXOSC10
LocusID (NCBI) 5394
Atlas_Id 62949
Location 1p36.22  [Link to chromosome band 1p36]
Location_base_pair Starts at 11066613 and ends at 11099910 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CASC3 (17q21.1) / EXOSC10 (1p36.22)EXOSC10 (1p36.22) / IDO1 (8p11.21)EXOSC10 (1p36.22) / KPNA6 (1p35.1)
KRT19 (17q21.2) / EXOSC10 (1p36.22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EXOSC10   9138
Cards
Entrez_Gene (NCBI)EXOSC10  5394  exosome component 10
AliasesPM-Scl; PM/Scl-100; PMSCL; PMSCL2; 
RRP6; Rrp6p; p2; p3; p4
GeneCards (Weizmann)EXOSC10
Ensembl hg19 (Hinxton)ENSG00000171824 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171824 [Gene_View]  chr1:11066613-11099910 [Contig_View]  EXOSC10 [Vega]
ICGC DataPortalENSG00000171824
TCGA cBioPortalEXOSC10
AceView (NCBI)EXOSC10
Genatlas (Paris)EXOSC10
WikiGenes5394
SOURCE (Princeton)EXOSC10
Genetics Home Reference (NIH)EXOSC10
Genomic and cartography
GoldenPath hg38 (UCSC)EXOSC10  -     chr1:11066613-11099910 -  1p36.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EXOSC10  -     1p36.22   [Description]    (hg19-Feb_2009)
EnsemblEXOSC10 - 1p36.22 [CytoView hg19]  EXOSC10 - 1p36.22 [CytoView hg38]
Mapping of homologs : NCBIEXOSC10 [Mapview hg19]  EXOSC10 [Mapview hg38]
OMIM605960   
Gene and transcription
Genbank (Entrez)AB209236 AK093955 AK123365 AK294058 AK296559
RefSeq transcript (Entrez)NM_001001998 NM_002685
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EXOSC10
Cluster EST : UnigeneHs.632368 [ NCBI ]
CGAP (NCI)Hs.632368
Alternative Splicing GalleryENSG00000171824
Gene ExpressionEXOSC10 [ NCBI-GEO ]   EXOSC10 [ EBI - ARRAY_EXPRESS ]   EXOSC10 [ SEEK ]   EXOSC10 [ MEM ]
Gene Expression Viewer (FireBrowse)EXOSC10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5394
GTEX Portal (Tissue expression)EXOSC10
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ01780   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ01780  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ01780
Splice isoforms : SwissVarQ01780
Catalytic activity : Enzyme3.1.13.- [ Enzyme-Expasy ]   3.1.13.-3.1.13.- [ IntEnz-EBI ]   3.1.13.- [ BRENDA ]   3.1.13.- [ KEGG ]   
PhosPhoSitePlusQ01780
Domaine pattern : Prosite (Expaxy)HRDC (PS50967)   
Domains : Interpro (EBI)3'-5'_exonuclease_dom    Exosome-assoc_fac_Rrp6_N    HRDC-like    HRDC_dom    RNaseH-like_dom   
Domain families : Pfam (Sanger)DNA_pol_A_exo1 (PF01612)    HRDC (PF00570)    PMC2NT (PF08066)   
Domain families : Pfam (NCBI)pfam01612    pfam00570    pfam08066   
Domain families : Smart (EMBL)35EXOc (SM00474)  HRDC (SM00341)  
Conserved Domain (NCBI)EXOSC10
DMDM Disease mutations5394
Blocks (Seattle)EXOSC10
PDB (SRS)2CPR    3SAF    3SAG    3SAH   
PDB (PDBSum)2CPR    3SAF    3SAG    3SAH   
PDB (IMB)2CPR    3SAF    3SAG    3SAH   
PDB (RSDB)2CPR    3SAF    3SAG    3SAH   
Structural Biology KnowledgeBase2CPR    3SAF    3SAG    3SAH   
SCOP (Structural Classification of Proteins)2CPR    3SAF    3SAG    3SAH   
CATH (Classification of proteins structures)2CPR    3SAF    3SAG    3SAH   
SuperfamilyQ01780
Human Protein AtlasENSG00000171824
Peptide AtlasQ01780
HPRD16180
IPIIPI00009464   IPI00220336   IPI01010048   IPI00815844   
Protein Interaction databases
DIP (DOE-UCLA)Q01780
IntAct (EBI)Q01780
FunCoupENSG00000171824
BioGRIDEXOSC10
STRING (EMBL)EXOSC10
ZODIACEXOSC10
Ontologies - Pathways
QuickGOQ01780
Ontology : AmiGOnucleotide binding  3'-5'-exoribonuclease activity  3'-5'-exoribonuclease activity  nuclear exosome (RNase complex)  exosome (RNase complex)  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  maturation of 5.8S rRNA  nuclear-transcribed mRNA catabolic process  RNA binding  exoribonuclease activity  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  rRNA processing  dosage compensation by inactivation of X chromosome  membrane  negative regulation of telomere maintenance via telomerase  transcriptionally active chromatin  telomerase RNA binding  nuclear mRNA surveillance  CUT catabolic process  nuclear polyadenylation-dependent rRNA catabolic process  histone mRNA catabolic process  nuclear retention of unspliced pre-mRNA at the site of transcription  RNA phosphodiester bond hydrolysis, exonucleolytic  regulation of telomerase RNA localization to Cajal body  
Ontology : EGO-EBInucleotide binding  3'-5'-exoribonuclease activity  3'-5'-exoribonuclease activity  nuclear exosome (RNase complex)  exosome (RNase complex)  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  maturation of 5.8S rRNA  nuclear-transcribed mRNA catabolic process  RNA binding  exoribonuclease activity  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  rRNA processing  dosage compensation by inactivation of X chromosome  membrane  negative regulation of telomere maintenance via telomerase  transcriptionally active chromatin  telomerase RNA binding  nuclear mRNA surveillance  CUT catabolic process  nuclear polyadenylation-dependent rRNA catabolic process  histone mRNA catabolic process  nuclear retention of unspliced pre-mRNA at the site of transcription  RNA phosphodiester bond hydrolysis, exonucleolytic  regulation of telomerase RNA localization to Cajal body  
Pathways : KEGGRNA degradation   
NDEx NetworkEXOSC10
Atlas of Cancer Signalling NetworkEXOSC10
Wikipedia pathwaysEXOSC10
Orthology - Evolution
OrthoDB5394
GeneTree (enSembl)ENSG00000171824
Phylogenetic Trees/Animal Genes : TreeFamEXOSC10
HOVERGENQ01780
HOGENOMQ01780
Homologs : HomoloGeneEXOSC10
Homology/Alignments : Family Browser (UCSC)EXOSC10
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEXOSC10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EXOSC10
dbVarEXOSC10
ClinVarEXOSC10
1000_GenomesEXOSC10 
Exome Variant ServerEXOSC10
ExAC (Exome Aggregation Consortium)EXOSC10 (select the gene name)
Genetic variants : HAPMAP5394
Genomic Variants (DGV)EXOSC10 [DGVbeta]
DECIPHEREXOSC10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEXOSC10 
Mutations
ICGC Data PortalEXOSC10 
TCGA Data PortalEXOSC10 
Broad Tumor PortalEXOSC10
OASIS PortalEXOSC10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEXOSC10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEXOSC10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EXOSC10
DgiDB (Drug Gene Interaction Database)EXOSC10
DoCM (Curated mutations)EXOSC10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EXOSC10 (select a term)
intoGenEXOSC10
Cancer3DEXOSC10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605960   
Orphanet
MedgenEXOSC10
Genetic Testing Registry EXOSC10
NextProtQ01780 [Medical]
TSGene5394
GENETestsEXOSC10
Huge Navigator EXOSC10 [HugePedia]
snp3D : Map Gene to Disease5394
BioCentury BCIQEXOSC10
ClinGenEXOSC10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5394
Chemical/Pharm GKB GenePA33464
Clinical trialEXOSC10
Miscellaneous
canSAR (ICR)EXOSC10 (select the gene name)
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEXOSC10
EVEXEXOSC10
GoPubMedEXOSC10
iHOPEXOSC10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 11:10:17 CEST 2017

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