| Nomenclature |
|---|
| HGNC (Hugo) | EXOSC5 24662 |
| Cards |
|---|
| Entrez_Gene (NCBI) | EXOSC5 56915 exosome component 5 |
| Aliases | RRP41B; RRP46; Rrp46p; hRrp46p; |
| p12B |
| GeneCards (Weizmann) | EXOSC5 |
| Ensembl hg19 (Hinxton) | ENSG00000077348 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000077348 [Gene_View] ENSG00000077348 [Sequence] chr19:41386371-41397351 [Contig_View] EXOSC5 [Vega] |
| ICGC DataPortal | ENSG00000077348 |
| TCGA cBioPortal | EXOSC5 |
| AceView (NCBI) | EXOSC5 |
| Genatlas (Paris) | EXOSC5 |
| WikiGenes | 56915 |
| SOURCE (Princeton) | EXOSC5 |
| Genetics Home Reference (NIH) | EXOSC5 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | EXOSC5 - chr19:41386371-41397351 - 19q13.2 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | EXOSC5 - 19q13.2 [Description] (hg19-Feb_2009) |
| Ensembl | EXOSC5 - 19q13.2 [CytoView hg19] EXOSC5 - 19q13.2 [CytoView hg38] |
| Mapping of homologs : NCBI | EXOSC5 [Mapview hg19] EXOSC5 [Mapview hg38] |
| OMIM | 606492 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF281134 AF285785 AK314941 BC007742 BC107696 |
| RefSeq transcript (Entrez) | NM_020158 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | EXOSC5 |
| Cluster EST : Unigene | Hs.283741 [ NCBI ] |
| CGAP (NCI) | Hs.283741 |
| Alternative Splicing Gallery | ENSG00000077348 |
| Gene Expression | EXOSC5 [ NCBI-GEO ] EXOSC5 [ EBI - ARRAY_EXPRESS ]
EXOSC5 [ SEEK ] EXOSC5 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | EXOSC5 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 56915 |
| GTEX Portal (Tissue expression) | EXOSC5 |
| Human Protein Atlas | ENSG00000077348-EXOSC5 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q9NQT4 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q9NQT4 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q9NQT4 |
| Splice isoforms : SwissVar | Q9NQT4 |
| PhosPhoSitePlus | Q9NQT4 |
| Domains : Interpro (EBI) | ExoRNase_PH_dom1 ExoRNase_PH_dom2 ExoRNase_PH_dom2_sf PNPase/RNase_PH_dom_sf Ribosomal_S5_D2-typ_fold |
| Domain families : Pfam (Sanger) | RNase_PH (PF01138) RNase_PH_C (PF03725) |
| Domain families : Pfam (NCBI) | pfam01138 pfam03725 |
| Conserved Domain (NCBI) | EXOSC5 |
| DMDM Disease mutations | 56915 |
| Blocks (Seattle) | EXOSC5 |
| PDB (SRS) | 2NN6 |
| PDB (PDBSum) | 2NN6 |
| PDB (IMB) | 2NN6 |
| PDB (RSDB) | 2NN6 |
| Structural Biology KnowledgeBase | 2NN6 |
| SCOP (Structural Classification of Proteins) | 2NN6 |
| CATH (Classification of proteins structures) | 2NN6 |
| Superfamily | Q9NQT4 |
| Human Protein Atlas [tissue] | ENSG00000077348-EXOSC5 [tissue] |
| Peptide Atlas | Q9NQT4 |
| HPRD | 16222 |
| IPI | IPI00644775 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q9NQT4 |
| IntAct (EBI) | Q9NQT4 |
| FunCoup | ENSG00000077348 |
| BioGRID | EXOSC5 |
| STRING (EMBL) | EXOSC5 |
| ZODIAC | EXOSC5 |
| Ontologies - Pathways |
|---|
| QuickGO | Q9NQT4 |
| Ontology : AmiGO | 3'-5'-exoribonuclease activity nuclear exosome (RNase complex) cytoplasmic exosome (RNase complex) exosome (RNase complex) RNA binding exoribonuclease activity protein binding nucleus nucleoplasm nucleolus nucleolus nucleolus cytoplasm cytosol rRNA processing rRNA processing rRNA catabolic process nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' U4 snRNA 3'-end processing transcriptionally active chromatin regulation of mRNA stability exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay DNA deamination defense response to virus nuclear mRNA surveillance polyadenylation-dependent snoRNA 3'-end processing RNA phosphodiester bond hydrolysis, exonucleolytic |
| Ontology : EGO-EBI | 3'-5'-exoribonuclease activity nuclear exosome (RNase complex) cytoplasmic exosome (RNase complex) exosome (RNase complex) RNA binding exoribonuclease activity protein binding nucleus nucleoplasm nucleolus nucleolus nucleolus cytoplasm cytosol rRNA processing rRNA processing rRNA catabolic process nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' U4 snRNA 3'-end processing transcriptionally active chromatin regulation of mRNA stability exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay DNA deamination defense response to virus nuclear mRNA surveillance polyadenylation-dependent snoRNA 3'-end processing RNA phosphodiester bond hydrolysis, exonucleolytic |
| Pathways : KEGG | RNA degradation |
| NDEx Network | EXOSC5 |
| Atlas of Cancer Signalling Network | EXOSC5 |
| Wikipedia pathways | EXOSC5 |
| Orthology - Evolution |
|---|
| OrthoDB | 56915 |
| GeneTree (enSembl) | ENSG00000077348 |
| Phylogenetic Trees/Animal Genes : TreeFam | EXOSC5 |
| HOGENOM | Q9NQT4 |
| Homologs : HomoloGene | EXOSC5 |
| Homology/Alignments : Family Browser (UCSC) | EXOSC5 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | EXOSC5/LEUTX [19q13.2/19q13.2] |
| Fusion Portal | EXOSC5 19q13.2 LEUTX 19q13.2 LGG |
| Fusion : Quiver | EXOSC5 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | EXOSC5 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | EXOSC5 |
| dbVar | EXOSC5 |
| ClinVar | EXOSC5 |
| 1000_Genomes | EXOSC5 |
| Exome Variant Server | EXOSC5 |
| ExAC (Exome Aggregation Consortium) | ENSG00000077348 |
| GNOMAD Browser | ENSG00000077348 |
| Varsome Browser | EXOSC5 |
| Genetic variants : HAPMAP | 56915 |
| Genomic Variants (DGV) | EXOSC5 [DGVbeta] |
| DECIPHER | EXOSC5 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | EXOSC5 |
| Mutations |
|---|
| ICGC Data Portal | EXOSC5 |
| TCGA Data Portal | EXOSC5 |
| Broad Tumor Portal | EXOSC5 |
| OASIS Portal | EXOSC5 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | EXOSC5 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | EXOSC5 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search EXOSC5 |
| DgiDB (Drug Gene Interaction Database) | EXOSC5 |
| DoCM (Curated mutations) | EXOSC5 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | EXOSC5 (select a term) |
| intoGen | EXOSC5 |
| Cancer3D | EXOSC5(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 606492 |
| Orphanet | |
| DisGeNET | EXOSC5 |
| Medgen | EXOSC5 |
| Genetic Testing Registry | EXOSC5
|
| NextProt | Q9NQT4 [Medical] |
| TSGene | 56915 |
| GENETests | EXOSC5 |
| Target Validation | EXOSC5 |
| Huge Navigator |
EXOSC5 [HugePedia] |
| snp3D : Map Gene to Disease | 56915 |
| BioCentury BCIQ | EXOSC5 |
| ClinGen | EXOSC5 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 56915 |
| Chemical/Pharm GKB Gene | PA134890468 |
| Clinical trial | EXOSC5 |
| Miscellaneous |
|---|
| canSAR (ICR) | EXOSC5 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 52 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | EXOSC5 |
| EVEX | EXOSC5 |
| GoPubMed | EXOSC5 |
| iHOP | EXOSC5 |
