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EXOSC5 (exosome component 5)

Identity

Alias_symbol (synonym)hRrp46p
Rrp46p
RRP46
RRP41B
MGC12901
p12B
Other alias
HGNC (Hugo) EXOSC5
LocusID (NCBI) 56915
Atlas_Id 50386
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 41386371 and ends at 41397351 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EXOSC5 (19q13.2) / LEUTX (19q13.2)EXOSC5 19q13.2 / LEUTX 19q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EXOSC5   24662
Cards
Entrez_Gene (NCBI)EXOSC5  56915  exosome component 5
AliasesRRP41B; RRP46; Rrp46p; hRrp46p; 
p12B
GeneCards (Weizmann)EXOSC5
Ensembl hg19 (Hinxton)ENSG00000077348 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000077348 [Gene_View]  chr19:41386371-41397351 [Contig_View]  EXOSC5 [Vega]
ICGC DataPortalENSG00000077348
TCGA cBioPortalEXOSC5
AceView (NCBI)EXOSC5
Genatlas (Paris)EXOSC5
WikiGenes56915
SOURCE (Princeton)EXOSC5
Genetics Home Reference (NIH)EXOSC5
Genomic and cartography
GoldenPath hg38 (UCSC)EXOSC5  -     chr19:41386371-41397351 -  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EXOSC5  -     19q13.2   [Description]    (hg19-Feb_2009)
EnsemblEXOSC5 - 19q13.2 [CytoView hg19]  EXOSC5 - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBIEXOSC5 [Mapview hg19]  EXOSC5 [Mapview hg38]
OMIM606492   
Gene and transcription
Genbank (Entrez)AF281134 AF285785 AK314941 BC007742 BC107696
RefSeq transcript (Entrez)NM_020158
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EXOSC5
Cluster EST : UnigeneHs.283741 [ NCBI ]
CGAP (NCI)Hs.283741
Alternative Splicing GalleryENSG00000077348
Gene ExpressionEXOSC5 [ NCBI-GEO ]   EXOSC5 [ EBI - ARRAY_EXPRESS ]   EXOSC5 [ SEEK ]   EXOSC5 [ MEM ]
Gene Expression Viewer (FireBrowse)EXOSC5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56915
GTEX Portal (Tissue expression)EXOSC5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NQT4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NQT4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NQT4
Splice isoforms : SwissVarQ9NQT4
PhosPhoSitePlusQ9NQT4
Domains : Interpro (EBI)ExoRNase_PH_dom1    ExoRNase_PH_dom2    PNPase/RNase_PH_dom    Ribosomal_S5_D2-typ_fold   
Domain families : Pfam (Sanger)RNase_PH (PF01138)    RNase_PH_C (PF03725)   
Domain families : Pfam (NCBI)pfam01138    pfam03725   
Conserved Domain (NCBI)EXOSC5
DMDM Disease mutations56915
Blocks (Seattle)EXOSC5
PDB (SRS)2NN6   
PDB (PDBSum)2NN6   
PDB (IMB)2NN6   
PDB (RSDB)2NN6   
Structural Biology KnowledgeBase2NN6   
SCOP (Structural Classification of Proteins)2NN6   
CATH (Classification of proteins structures)2NN6   
SuperfamilyQ9NQT4
Human Protein AtlasENSG00000077348
Peptide AtlasQ9NQT4
HPRD16222
IPIIPI00644775   
Protein Interaction databases
DIP (DOE-UCLA)Q9NQT4
IntAct (EBI)Q9NQT4
FunCoupENSG00000077348
BioGRIDEXOSC5
STRING (EMBL)EXOSC5
ZODIACEXOSC5
Ontologies - Pathways
QuickGOQ9NQT4
Ontology : AmiGO3'-5'-exoribonuclease activity  nuclear exosome (RNase complex)  cytoplasmic exosome (RNase complex)  exosome (RNase complex)  RNA binding  exoribonuclease activity  protein binding  nucleus  nucleoplasm  nucleolus  nucleolus  nucleolus  cytoplasm  cytosol  rRNA processing  rRNA processing  rRNA catabolic process  rRNA 3'-end processing  nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'  U4 snRNA 3'-end processing  transcriptionally active chromatin  regulation of mRNA stability  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay  DNA deamination  defense response to virus  nuclear mRNA surveillance  polyadenylation-dependent snoRNA 3'-end processing  RNA phosphodiester bond hydrolysis, exonucleolytic  
Ontology : EGO-EBI3'-5'-exoribonuclease activity  nuclear exosome (RNase complex)  cytoplasmic exosome (RNase complex)  exosome (RNase complex)  RNA binding  exoribonuclease activity  protein binding  nucleus  nucleoplasm  nucleolus  nucleolus  nucleolus  cytoplasm  cytosol  rRNA processing  rRNA processing  rRNA catabolic process  rRNA 3'-end processing  nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'  U4 snRNA 3'-end processing  transcriptionally active chromatin  regulation of mRNA stability  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay  DNA deamination  defense response to virus  nuclear mRNA surveillance  polyadenylation-dependent snoRNA 3'-end processing  RNA phosphodiester bond hydrolysis, exonucleolytic  
Pathways : KEGGRNA degradation   
NDEx NetworkEXOSC5
Atlas of Cancer Signalling NetworkEXOSC5
Wikipedia pathwaysEXOSC5
Orthology - Evolution
OrthoDB56915
GeneTree (enSembl)ENSG00000077348
Phylogenetic Trees/Animal Genes : TreeFamEXOSC5
HOVERGENQ9NQT4
HOGENOMQ9NQT4
Homologs : HomoloGeneEXOSC5
Homology/Alignments : Family Browser (UCSC)EXOSC5
Gene fusions - Rearrangements
Fusion : MitelmanEXOSC5/LEUTX [19q13.2/19q13.2]  
Fusion: TCGAEXOSC5 19q13.2 LEUTX 19q13.2 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEXOSC5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EXOSC5
dbVarEXOSC5
ClinVarEXOSC5
1000_GenomesEXOSC5 
Exome Variant ServerEXOSC5
ExAC (Exome Aggregation Consortium)EXOSC5 (select the gene name)
Genetic variants : HAPMAP56915
Genomic Variants (DGV)EXOSC5 [DGVbeta]
DECIPHEREXOSC5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEXOSC5 
Mutations
ICGC Data PortalEXOSC5 
TCGA Data PortalEXOSC5 
Broad Tumor PortalEXOSC5
OASIS PortalEXOSC5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEXOSC5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEXOSC5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EXOSC5
DgiDB (Drug Gene Interaction Database)EXOSC5
DoCM (Curated mutations)EXOSC5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EXOSC5 (select a term)
intoGenEXOSC5
Cancer3DEXOSC5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606492   
Orphanet
MedgenEXOSC5
Genetic Testing Registry EXOSC5
NextProtQ9NQT4 [Medical]
TSGene56915
GENETestsEXOSC5
Huge Navigator EXOSC5 [HugePedia]
snp3D : Map Gene to Disease56915
BioCentury BCIQEXOSC5
ClinGenEXOSC5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD56915
Chemical/Pharm GKB GenePA134890468
Clinical trialEXOSC5
Miscellaneous
canSAR (ICR)EXOSC5 (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEXOSC5
EVEXEXOSC5
GoPubMedEXOSC5
iHOPEXOSC5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:15:08 CEST 2017

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