EXOSC6 (exosome component 6)

2014-11-01  

Identity

HGNC
LOCATION
16q22.1
LOCUSID
ALIAS
EAP4,MTR3,Mtr3p,hMtr3p,p11
FUSION GENES

Other Information

Locus ID:

NCBI: 118460
MIM: 606490
HGNC: 19055
Ensembl: ENSG00000223496

Variants:

dbSNP: 118460
ClinVar: 118460
TCGA: ENSG00000223496
COSMIC: EXOSC6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000223496ENST00000435634Q5RKV6

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Exosome, eukaryotesKEGGhsa_M00391
Exosome, eukaryotesKEGGM00391
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
PERK regulates gene expressionREACTOMER-HSA-381042
ATF4 activates genesREACTOMER-HSA-380994
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
mRNA decay by 3' to 5' exoribonucleaseREACTOMER-HSA-429958
Regulation of mRNA stability by proteins that bind AU-rich elementsREACTOMER-HSA-450531
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNAREACTOMER-HSA-450385
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNAREACTOMER-HSA-450513
KSRP (KHSRP) binds and destabilizes mRNAREACTOMER-HSA-450604
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

References

Pubmed IDYearTitleCitations
124192562002Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.25
182897152008Direct effects of alcohol on hepatic fibrinolytic balance: implications for alcoholic liver disease.16

Citation

Dessen P

EXOSC6 (exosome component 6)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62953/exosc6