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EXOSC6 (exosome component 6)

Identity

Alias_symbol (synonym)MTR3
hMtr3p
Mtr3p
EAP4
p11
Other alias
HGNC (Hugo) EXOSC6
LocusID (NCBI) 118460
Atlas_Id 62953
Location 16q22.1  [Link to chromosome band 16q22]
Location_base_pair Starts at 70250231 and ends at 70251930 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EXOSC6 (16q22.1) / ENO1 (1p36.23)EXOSC6 (16q22.1) / LDLR (19p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EXOSC6   19055
Cards
Entrez_Gene (NCBI)EXOSC6  118460  exosome component 6
AliasesEAP4; MTR3; Mtr3p; hMtr3p; 
p11
GeneCards (Weizmann)EXOSC6
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr16:70250231-70251930 [Contig_View]  EXOSC6 [Vega]
TCGA cBioPortalEXOSC6
AceView (NCBI)EXOSC6
Genatlas (Paris)EXOSC6
WikiGenes118460
SOURCE (Princeton)EXOSC6
Genetics Home Reference (NIH)EXOSC6
Genomic and cartography
GoldenPath hg38 (UCSC)EXOSC6  -     chr16:70250231-70251930 -  16q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EXOSC6  -     16q22.1   [Description]    (hg19-Feb_2009)
EnsemblEXOSC6 - 16q22.1 [CytoView hg19]  EXOSC6 - 16q22.1 [CytoView hg38]
Mapping of homologs : NCBIEXOSC6 [Mapview hg19]  EXOSC6 [Mapview hg38]
OMIM606490   
Gene and transcription
Genbank (Entrez)AK024276 AK095542 BC052252
RefSeq transcript (Entrez)NM_058219
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EXOSC6
Cluster EST : UnigeneHs.744085 [ NCBI ]
CGAP (NCI)Hs.744085
Gene ExpressionEXOSC6 [ NCBI-GEO ]   EXOSC6 [ EBI - ARRAY_EXPRESS ]   EXOSC6 [ SEEK ]   EXOSC6 [ MEM ]
Gene Expression Viewer (FireBrowse)EXOSC6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)118460
GTEX Portal (Tissue expression)EXOSC6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5RKV6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5RKV6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5RKV6
Splice isoforms : SwissVarQ5RKV6
PhosPhoSitePlusQ5RKV6
Domains : Interpro (EBI)ExoRNase_PH_dom1    ExoRNase_PH_dom2    PNPase/RNase_PH_dom    Ribosomal_S5_D2-typ_fold   
Domain families : Pfam (Sanger)RNase_PH (PF01138)   
Domain families : Pfam (NCBI)pfam01138   
Conserved Domain (NCBI)EXOSC6
DMDM Disease mutations118460
Blocks (Seattle)EXOSC6
PDB (SRS)2NN6   
PDB (PDBSum)2NN6   
PDB (IMB)2NN6   
PDB (RSDB)2NN6   
Structural Biology KnowledgeBase2NN6   
SCOP (Structural Classification of Proteins)2NN6   
CATH (Classification of proteins structures)2NN6   
SuperfamilyQ5RKV6
Peptide AtlasQ5RKV6
HPRD12107
IPIIPI00073602   
Protein Interaction databases
DIP (DOE-UCLA)Q5RKV6
IntAct (EBI)Q5RKV6
BioGRIDEXOSC6
STRING (EMBL)EXOSC6
ZODIACEXOSC6
Ontologies - Pathways
QuickGOQ5RKV6
Ontology : AmiGOnuclear exosome (RNase complex)  cytoplasmic exosome (RNase complex)  exosome (RNase complex)  RNA binding  exoribonuclease activity  nucleoplasm  nucleolus  cytosol  rRNA processing  rRNA catabolic process  rRNA 3'-end processing  nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'  U4 snRNA 3'-end processing  regulation of mRNA stability  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay  DNA deamination  isotype switching  positive regulation of isotype switching  nuclear mRNA surveillance  polyadenylation-dependent snoRNA 3'-end processing  
Ontology : EGO-EBInuclear exosome (RNase complex)  cytoplasmic exosome (RNase complex)  exosome (RNase complex)  RNA binding  exoribonuclease activity  nucleoplasm  nucleolus  cytosol  rRNA processing  rRNA catabolic process  rRNA 3'-end processing  nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'  U4 snRNA 3'-end processing  regulation of mRNA stability  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay  DNA deamination  isotype switching  positive regulation of isotype switching  nuclear mRNA surveillance  polyadenylation-dependent snoRNA 3'-end processing  
Pathways : KEGGRNA degradation   
NDEx NetworkEXOSC6
Atlas of Cancer Signalling NetworkEXOSC6
Wikipedia pathwaysEXOSC6
Orthology - Evolution
OrthoDB118460
Phylogenetic Trees/Animal Genes : TreeFamEXOSC6
HOVERGENQ5RKV6
HOGENOMQ5RKV6
Homologs : HomoloGeneEXOSC6
Homology/Alignments : Family Browser (UCSC)EXOSC6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEXOSC6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EXOSC6
dbVarEXOSC6
ClinVarEXOSC6
1000_GenomesEXOSC6 
Exome Variant ServerEXOSC6
ExAC (Exome Aggregation Consortium)EXOSC6 (select the gene name)
Genetic variants : HAPMAP118460
Genomic Variants (DGV)EXOSC6 [DGVbeta]
DECIPHEREXOSC6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEXOSC6 
Mutations
ICGC Data PortalEXOSC6 
TCGA Data PortalEXOSC6 
Broad Tumor PortalEXOSC6
OASIS PortalEXOSC6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEXOSC6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEXOSC6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EXOSC6
DgiDB (Drug Gene Interaction Database)EXOSC6
DoCM (Curated mutations)EXOSC6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EXOSC6 (select a term)
intoGenEXOSC6
Cancer3DEXOSC6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606490   
Orphanet
MedgenEXOSC6
Genetic Testing Registry EXOSC6
NextProtQ5RKV6 [Medical]
TSGene118460
GENETestsEXOSC6
Target ValidationEXOSC6
Huge Navigator EXOSC6 [HugePedia]
snp3D : Map Gene to Disease118460
BioCentury BCIQEXOSC6
ClinGenEXOSC6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD118460
Chemical/Pharm GKB GenePA134932096
Clinical trialEXOSC6
Miscellaneous
canSAR (ICR)EXOSC6 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEXOSC6
EVEXEXOSC6
GoPubMedEXOSC6
iHOPEXOSC6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 15:47:34 CEST 2017

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