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EXOSC7 (exosome component 7)

Identity

Alias_symbol (synonym)hRrp42p
Rrp42p
RRP42
EAP1
KIAA0116
p8
Other alias
HGNC (Hugo) EXOSC7
LocusID (NCBI) 23016
Atlas_Id 52157
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 44976249 and ends at 45011470 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EXOSC7 (3p21.31) / EXOSC7 (3p21.31)EXOSC7 (3p21.31) / PRR4 (12p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EXOSC7   28112
Cards
Entrez_Gene (NCBI)EXOSC7  23016  exosome component 7
AliasesEAP1; RRP42; Rrp42p; hRrp42p; 
p8
GeneCards (Weizmann)EXOSC7
Ensembl hg19 (Hinxton)ENSG00000075914 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000075914 [Gene_View]  chr3:44976249-45011470 [Contig_View]  EXOSC7 [Vega]
ICGC DataPortalENSG00000075914
TCGA cBioPortalEXOSC7
AceView (NCBI)EXOSC7
Genatlas (Paris)EXOSC7
WikiGenes23016
SOURCE (Princeton)EXOSC7
Genetics Home Reference (NIH)EXOSC7
Genomic and cartography
GoldenPath hg38 (UCSC)EXOSC7  -     chr3:44976249-45011470 +  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EXOSC7  -     3p21.31   [Description]    (hg19-Feb_2009)
EnsemblEXOSC7 - 3p21.31 [CytoView hg19]  EXOSC7 - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBIEXOSC7 [Mapview hg19]  EXOSC7 [Mapview hg38]
OMIM606488   
Gene and transcription
Genbank (Entrez)AK090511 AK130053 AK295779 AK315741 BC012831
RefSeq transcript (Entrez)NM_015004
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EXOSC7
Cluster EST : UnigeneHs.719958 [ NCBI ]
CGAP (NCI)Hs.719958
Alternative Splicing GalleryENSG00000075914
Gene ExpressionEXOSC7 [ NCBI-GEO ]   EXOSC7 [ EBI - ARRAY_EXPRESS ]   EXOSC7 [ SEEK ]   EXOSC7 [ MEM ]
Gene Expression Viewer (FireBrowse)EXOSC7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23016
GTEX Portal (Tissue expression)EXOSC7
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15024   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15024  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15024
Splice isoforms : SwissVarQ15024
PhosPhoSitePlusQ15024
Domains : Interpro (EBI)ExoRNase_PH_dom1    ExoRNase_PH_dom2    PNPase/RNase_PH_dom    Ribosomal_S5_D2-typ_fold   
Domain families : Pfam (Sanger)RNase_PH (PF01138)    RNase_PH_C (PF03725)   
Domain families : Pfam (NCBI)pfam01138    pfam03725   
Conserved Domain (NCBI)EXOSC7
DMDM Disease mutations23016
Blocks (Seattle)EXOSC7
PDB (SRS)2NN6   
PDB (PDBSum)2NN6   
PDB (IMB)2NN6   
PDB (RSDB)2NN6   
Structural Biology KnowledgeBase2NN6   
SCOP (Structural Classification of Proteins)2NN6   
CATH (Classification of proteins structures)2NN6   
SuperfamilyQ15024
Human Protein AtlasENSG00000075914
Peptide AtlasQ15024
HPRD09401
IPIIPI00014198   
Protein Interaction databases
DIP (DOE-UCLA)Q15024
IntAct (EBI)Q15024
FunCoupENSG00000075914
BioGRIDEXOSC7
STRING (EMBL)EXOSC7
ZODIACEXOSC7
Ontologies - Pathways
QuickGOQ15024
Ontology : AmiGO3'-5'-exoribonuclease activity  exosome (RNase complex)  exosome (RNase complex)  RNA binding  exoribonuclease activity  protein binding  nucleoplasm  nucleolus  cytosol  rRNA processing  RNA catabolic process  regulation of mRNA stability  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay  RNA phosphodiester bond hydrolysis, exonucleolytic  
Ontology : EGO-EBI3'-5'-exoribonuclease activity  exosome (RNase complex)  exosome (RNase complex)  RNA binding  exoribonuclease activity  protein binding  nucleoplasm  nucleolus  cytosol  rRNA processing  RNA catabolic process  regulation of mRNA stability  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay  RNA phosphodiester bond hydrolysis, exonucleolytic  
Pathways : KEGGRNA degradation   
NDEx NetworkEXOSC7
Atlas of Cancer Signalling NetworkEXOSC7
Wikipedia pathwaysEXOSC7
Orthology - Evolution
OrthoDB23016
GeneTree (enSembl)ENSG00000075914
Phylogenetic Trees/Animal Genes : TreeFamEXOSC7
HOVERGENQ15024
HOGENOMQ15024
Homologs : HomoloGeneEXOSC7
Homology/Alignments : Family Browser (UCSC)EXOSC7
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEXOSC7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EXOSC7
dbVarEXOSC7
ClinVarEXOSC7
1000_GenomesEXOSC7 
Exome Variant ServerEXOSC7
ExAC (Exome Aggregation Consortium)EXOSC7 (select the gene name)
Genetic variants : HAPMAP23016
Genomic Variants (DGV)EXOSC7 [DGVbeta]
DECIPHEREXOSC7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEXOSC7 
Mutations
ICGC Data PortalEXOSC7 
TCGA Data PortalEXOSC7 
Broad Tumor PortalEXOSC7
OASIS PortalEXOSC7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEXOSC7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEXOSC7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EXOSC7
DgiDB (Drug Gene Interaction Database)EXOSC7
DoCM (Curated mutations)EXOSC7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EXOSC7 (select a term)
intoGenEXOSC7
Cancer3DEXOSC7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606488   
Orphanet
MedgenEXOSC7
Genetic Testing Registry EXOSC7
NextProtQ15024 [Medical]
TSGene23016
GENETestsEXOSC7
Target ValidationEXOSC7
Huge Navigator EXOSC7 [HugePedia]
snp3D : Map Gene to Disease23016
BioCentury BCIQEXOSC7
ClinGenEXOSC7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23016
Chemical/Pharm GKB GenePA134880567
Clinical trialEXOSC7
Miscellaneous
canSAR (ICR)EXOSC7 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEXOSC7
EVEXEXOSC7
GoPubMedEXOSC7
iHOPEXOSC7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:33:04 CEST 2017

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