Atlas of Genetics and Cytogenetics in Oncology and Haematology


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EXOSC8 (exosome component 8)

Identity

Alias_symbol (synonym)OIP2
RRP43
bA421P11.3
Rrp43p
EAP2
p9
CIP3
Other aliasPCH1C
HGNC (Hugo) EXOSC8
LocusID (NCBI) 11340
Atlas_Id 62954
Location 13q13.3  [Link to chromosome band 13q13]
Location_base_pair Starts at 37000541 and ends at 37009616 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)EXOSC8   17035
Cards
Entrez_Gene (NCBI)EXOSC8  11340  exosome component 8
AliasesCIP3; EAP2; OIP2; PCH1C; 
RRP43; Rrp43p; bA421P11.3; p9
GeneCards (Weizmann)EXOSC8
Ensembl hg19 (Hinxton)ENSG00000120699 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120699 [Gene_View]  chr13:37000541-37009616 [Contig_View]  EXOSC8 [Vega]
ICGC DataPortalENSG00000120699
TCGA cBioPortalEXOSC8
AceView (NCBI)EXOSC8
Genatlas (Paris)EXOSC8
WikiGenes11340
SOURCE (Princeton)EXOSC8
Genetics Home Reference (NIH)EXOSC8
Genomic and cartography
GoldenPath hg38 (UCSC)EXOSC8  -     chr13:37000541-37009616 +  13q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)EXOSC8  -     13q13.3   [Description]    (hg19-Feb_2009)
EnsemblEXOSC8 - 13q13.3 [CytoView hg19]  EXOSC8 - 13q13.3 [CytoView hg38]
Mapping of homologs : NCBIEXOSC8 [Mapview hg19]  EXOSC8 [Mapview hg38]
OMIM606019   616081   
Gene and transcription
Genbank (Entrez)AF025438 AF279901 AK096810 AK126602 AL050353
RefSeq transcript (Entrez)NM_181503
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)EXOSC8
Cluster EST : UnigeneHs.294041 [ NCBI ]
CGAP (NCI)Hs.294041
Alternative Splicing GalleryENSG00000120699
Gene ExpressionEXOSC8 [ NCBI-GEO ]   EXOSC8 [ EBI - ARRAY_EXPRESS ]   EXOSC8 [ SEEK ]   EXOSC8 [ MEM ]
Gene Expression Viewer (FireBrowse)EXOSC8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11340
GTEX Portal (Tissue expression)EXOSC8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96B26   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96B26  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96B26
Splice isoforms : SwissVarQ96B26
PhosPhoSitePlusQ96B26
Domains : Interpro (EBI)ExoRNase_PH_dom1    ExoRNase_PH_dom2    PNPase/RNase_PH_dom    Ribosomal_S5_D2-typ_fold    Rrp43   
Domain families : Pfam (Sanger)RNase_PH (PF01138)    RNase_PH_C (PF03725)   
Domain families : Pfam (NCBI)pfam01138    pfam03725   
Conserved Domain (NCBI)EXOSC8
DMDM Disease mutations11340
Blocks (Seattle)EXOSC8
PDB (SRS)2NN6   
PDB (PDBSum)2NN6   
PDB (IMB)2NN6   
PDB (RSDB)2NN6   
Structural Biology KnowledgeBase2NN6   
SCOP (Structural Classification of Proteins)2NN6   
CATH (Classification of proteins structures)2NN6   
SuperfamilyQ96B26
Human Protein AtlasENSG00000120699
Peptide AtlasQ96B26
HPRD09351
IPIIPI00552920   IPI00743554   IPI00947228   IPI00946523   
Protein Interaction databases
DIP (DOE-UCLA)Q96B26
IntAct (EBI)Q96B26
FunCoupENSG00000120699
BioGRIDEXOSC8
STRING (EMBL)EXOSC8
ZODIACEXOSC8
Ontologies - Pathways
QuickGOQ96B26
Ontology : AmiGOexosome (RNase complex)  exoribonuclease activity  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  rRNA processing  biological_process  AU-rich element binding  identical protein binding  regulation of mRNA stability  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay  
Ontology : EGO-EBIexosome (RNase complex)  exoribonuclease activity  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  rRNA processing  biological_process  AU-rich element binding  identical protein binding  regulation of mRNA stability  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay  
Pathways : KEGGRNA degradation   
NDEx NetworkEXOSC8
Atlas of Cancer Signalling NetworkEXOSC8
Wikipedia pathwaysEXOSC8
Orthology - Evolution
OrthoDB11340
GeneTree (enSembl)ENSG00000120699
Phylogenetic Trees/Animal Genes : TreeFamEXOSC8
HOVERGENQ96B26
HOGENOMQ96B26
Homologs : HomoloGeneEXOSC8
Homology/Alignments : Family Browser (UCSC)EXOSC8
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerEXOSC8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)EXOSC8
dbVarEXOSC8
ClinVarEXOSC8
1000_GenomesEXOSC8 
Exome Variant ServerEXOSC8
ExAC (Exome Aggregation Consortium)EXOSC8 (select the gene name)
Genetic variants : HAPMAP11340
Genomic Variants (DGV)EXOSC8 [DGVbeta]
DECIPHEREXOSC8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisEXOSC8 
Mutations
ICGC Data PortalEXOSC8 
TCGA Data PortalEXOSC8 
Broad Tumor PortalEXOSC8
OASIS PortalEXOSC8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICEXOSC8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDEXOSC8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch EXOSC8
DgiDB (Drug Gene Interaction Database)EXOSC8
DoCM (Curated mutations)EXOSC8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)EXOSC8 (select a term)
intoGenEXOSC8
Cancer3DEXOSC8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606019    616081   
Orphanet3132   
MedgenEXOSC8
Genetic Testing Registry EXOSC8
NextProtQ96B26 [Medical]
TSGene11340
GENETestsEXOSC8
Target ValidationEXOSC8
Huge Navigator EXOSC8 [HugePedia]
snp3D : Map Gene to Disease11340
BioCentury BCIQEXOSC8
ClinGenEXOSC8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11340
Chemical/Pharm GKB GenePA134922251
Clinical trialEXOSC8
Miscellaneous
canSAR (ICR)EXOSC8 (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineEXOSC8
EVEXEXOSC8
GoPubMedEXOSC8
iHOPEXOSC8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 13:07:27 CEST 2017

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