EZH1 (enhancer of zeste 1 polycomb repressive complex 2 subunit)

2007-04-01  

Identity

HGNC
LOCATION
17q21.2
LOCUSID
ALIAS
KMT6B
FUSION GENES

Other Information

Locus ID:

NCBI: 2145
MIM: 601674
HGNC: 3526
Ensembl: ENSG00000108799

Variants:

dbSNP: 2145
ClinVar: 2145
TCGA: ENSG00000108799
COSMIC: EZH1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108799ENST00000415827A0A0A0MSY9
ENSG00000108799ENST00000428826Q92800
ENSG00000108799ENST00000585893Q92800
ENSG00000108799ENST00000586089K7EM79
ENSG00000108799ENST00000586382K7EIH5
ENSG00000108799ENST00000586867K7EJU6
ENSG00000108799ENST00000586935K7EK26
ENSG00000108799ENST00000588239K7ESB9
ENSG00000108799ENST00000588897K7ENP2
ENSG00000108799ENST00000590078Q92800
ENSG00000108799ENST00000592492K7EK66
ENSG00000108799ENST00000592743Q92800
ENSG00000108799ENST00000593214K7EPC0

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Lysine degradationKEGGko00310
Lysine degradationKEGGhsa00310

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
190267812008Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.280
255788782015Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions.42
208197782010MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.21
276301262016Chronic Myelogenous Leukemia- Initiating Cells Require Polycomb Group Protein EZH2.18
293421432018Regulation of embryonic haematopoietic multipotency by EZH1.17
289398842017PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs.14
283464332017A cytosolic Ezh1 isoform modulates a PRC2-Ezh1 epigenetic adaptive response in postmitotic cells.12
287014752017HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1 histone methyltransferase.10
271272292016The EZH1-SUZ12 complex positively regulates the transcription of NF-κB target genes through interaction with UXT.9
275004882016Recurrent EZH1 mutations are a second hit in autonomous thyroid adenomas.9

Citation

Dessen P

EZH1 (enhancer of zeste 1 polycomb repressive complex 2 subunit)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47297/ezh1