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EZH1 (enhancer of zeste homolog 1 (Drosophila))

Identity

Other namesKMT6B
HGNC (Hugo) EZH1
LocusID (NCBI) 2145
Location 17q21.2
Location_base_pair Starts at 40852293 and ends at 40897071 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)EZH1   3526
Entrez_Gene (NCBI)EZH1  2145  enhancer of zeste homolog 1 (Drosophila)
Cards
GeneCards (Weizmann)EZH1
Ensembl (Hinxton)ENSG00000108799 [Gene_View]  chr17:40852293-40897071 [Contig_View]  EZH1 [Vega]
AceView (NCBI)EZH1
Genatlas (Paris)EZH1
SOURCE (Stanford)NM_001991
Genomic and cartography
GoldenPath (UCSC)EZH1  -  17q21.2   chr17:40852293-40897071 -  17q21.2   [Description]    (hg19-Feb_2009)
EnsemblEZH1 - 17q21.2 [CytoView]
Mapping of homologs : NCBIEZH1 [Mapview]
OMIM601674   
Gene and transcription
Genbank (Entrez)AB002386 AB004818 AK295626 AK295853 AK299887
RefSeq transcript (SRS)NM_001991
RefSeq transcript (Entrez)NM_001991
RefSeq genomic (SRS)AC_000149 NC_000017 NC_018928 NT_010783 NW_001838436 NW_004078092
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NT_010783 NW_001838436 NW_004078092
Consensus coding sequences : CCDS (NCBI)EZH1
Cluster EST : UnigeneHs.194669 [ SRS ] Hs.194669 [ NCBI ]
CGAP (NCI)Hs.194669
Alternative Splicing : Fast-db (Paris)GSHG0013428
Alternative Splicing GalleryENSG00000108799
Gene ExpressionEZH1 [ NCBI-GEO ]   EZH1 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92800 (SRS) Q92800 (Uniprot)
NextProtQ92800
With graphics : InterProQ92800
Splice isoforms : SwissVarQ92800(Swissvar)
Domaine pattern : Prosite (SRS)CXC (PS51633)    SET (PS50280)   
Domaine pattern : Prosite (Expaxy)CXC (PS51633)    SET (PS50280)   
Domains : Interpro (SRS)CXC_dom    EZH2_WD-Binding    SANT/Myb    SET_dom   
Domains : Interpro (EBI)CXC_dom    EZH2_WD-Binding    SANT/Myb    SET_dom   
Related proteins : CluSTrQ92800
Domain families : Pfam (SRS)EZH2_WD-Binding (PF11616)    SET (PF00856)   
Domain families : Pfam (Sanger)EZH2_WD-Binding (PF11616)    SET (PF00856)   
Domain families : Pfam (NCBI)pfam11616    pfam00856   
Domain families : Smart (EMBL)SANT (SM00717)  SET (SM00317)  
DMDM2145
Blocks (Seattle)Q92800
Human Protein AtlasENSG00000108799
HPRD03397
IPIIPI00023672   IPI00921311   IPI00921284   IPI00921136   IPI00921257   
Protein Interaction databases
DIP (DOE-UCLA)Q92800
IntAct (EBI)Q92800
FunCoupENSG00000108799
REACTOMEEZH1
Protein Interaction Database2145
BioGRIDEZH1
InParanoidQ92800
Interologous Interaction database Q92800
IntegromeDBEZH1
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)EZH1
SNP (GeneSNP Utah)EZH1
SNP : HGBaseEZH1
Genetic variants : HAPMAPEZH1
Somatic Mutations in Cancer : COSMICEZH1 
CONAN: Copy Number AnalysisEZH1 
Mutations and Diseases : HGMDEZH1
OMIM601674   
GENETests601674   
Disease Genetic AssociationEZH1
Huge Navigator EZH1 [HugePedia]  EZH1 [HugeCancerGEM]
Genomic VariantsEZH1  EZH1 [DGVbeta]
ClinVarEZH1
snp3D : Map Gene to Disease2145
General knowledge
Homologs : HomoloGeneEZH1
Homology/Alignments : Family Browser (UCSC)EZH1
Phylogenetic Trees/Animal Genes : TreeFamEZH1
Catalytic activity : Enzyme2.1.1.43 [ Enzyme-Expasy ]   2.1.1.43 [ Enzyme-SRS ]   2.1.1.43 [ IntEnz-EBI ]   2.1.1.43 [ BRENDA ]   2.1.1.43 [ KEGG ]   
Chemical/Protein Interactions : CTD2145
Chemical/Pharm GKB GenePA27938
Clinical trialEZH1
Cancer Resource (Charite)ENSG00000108799
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  chromatin binding  nucleus  nucleolus  transcription, DNA-dependent  anatomical structure morphogenesis  ESC/E(Z) complex  histone methyltransferase activity (H3-K27 specific)  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  chromatin binding  nucleus  nucleolus  transcription, DNA-dependent  anatomical structure morphogenesis  ESC/E(Z) complex  histone methyltransferase activity (H3-K27 specific)  
Pathways : BIOCARTAThe PRC2 Complex Sets Long-term Gene Silencing Through Modification of Histone Tails [Genes]   
Other databases
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
PubGeneEZH1
iHOPEZH1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 14 18:00:33 CEST 2013
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