| Nomenclature | | HGNC (Hugo) | EZH2 3527 |
| Entrez_Gene (NCBI) | EZH2 2146 enhancer of zeste homolog 2 (Drosophila) |
| Cards | | GeneCards (Weizmann) | EZH2 |
| Ensembl (Hinxton) | ENSG00000106462 [Gene_View] chr7:148504464-148581441 [Contig_View] EZH2 [Vega] |
| AceView (NCBI) | EZH2 |
| Genatlas (Paris) | EZH2 |
| SOURCE (Stanford) | NM_001203247 NM_001203248 NM_001203249 NM_004456 NM_152998 |
| Genomic and cartography | | GoldenPath (UCSC) | EZH2 - 7q36.1 chr7:148504464-148581441 - 7q36.1 [Description] (hg19-Feb_2009) |
| Ensembl | EZH2 - 7q36.1 [CytoView] |
| Mapping of homologs : NCBI | EZH2 [Mapview] |
| OMIM | 277590 601573 614421 |
| Gene and transcription |
| Genbank (Entrez) | AB208895 AK092676 AK293239 AK302216 AK303585 |
| RefSeq transcript (SRS) | NM_001203247 NM_001203248 NM_001203249 NM_004456 NM_152998 |
| RefSeq transcript (Entrez) | NM_001203247 NM_001203248 NM_001203249 NM_004456 NM_152998 |
| RefSeq genomic (SRS) | AC_000068 AC_000139 NC_000007 NC_018918 NG_032043 NT_007914 NT_079596 NW_001839078 NW_004078033 |
| RefSeq genomic (Entrez) | AC_000068 AC_000139 NC_000007 NC_018918 NG_032043 NT_007914 NT_079596 NW_001839078 NW_004078033 |
| Consensus coding sequences : CCDS (NCBI) | EZH2 |
| Cluster EST : Unigene | Hs.732308 [ SRS ] Hs.732308 [ NCBI ] |
| CGAP (NCI) | Hs.732308 |
| Alternative Splicing : Fast-db (Paris) | GSHG0028690 |
| Alternative Splicing Gallery | ENSG00000106462 |
| Gene Expression | EZH2 [ NCBI-GEO ] EZH2 [ EBI - ARRAY_EXPRESS ] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q15910 (SRS) Q15910 (Uniprot) |
| NextProt | Q15910 |
| With graphics : InterPro | Q15910 |
| Splice isoforms : SwissVar | Q15910(Swissvar) |
| Domaine pattern : Prosite (SRS) | CXC (PS51633) SET (PS50280) |
| Domaine pattern : Prosite (Expaxy) | CXC (PS51633) SET (PS50280) |
| Domains : Interpro (SRS) | CXC_dom EZH2_WD-Binding SANT/Myb SET_dom |
| Domains : Interpro (EBI) | CXC_dom EZH2_WD-Binding SANT/Myb SET_dom |
| Related proteins : CluSTr | Q15910 |
| Domain families : Pfam (SRS) | EZH2_WD-Binding (PF11616) SET (PF00856) |
| Domain families : Pfam (Sanger) | EZH2_WD-Binding (PF11616) SET (PF00856) |
| Domain families : Pfam (NCBI) | pfam11616 pfam00856 |
| Domain families : Smart (EMBL) | SANT (SM00717) SET (SM00317) |
| DMDM | 2146 |
| Blocks (Seattle) | Q15910 |
| PDB (SRS) | 2C6V |
| PDB (PDBSum) | 2C6V |
| PDB (IMB) | 2C6V |
| PDB (RSDB) | 2C6V |
| Human Protein Atlas | ENSG00000106462 |
| HPRD | 03342 |
| IPI | IPI00947357 IPI00376787 IPI00171252 IPI00947348 IPI00945286 IPI00941520 IPI00935586 IPI00946998 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q15910 |
| IntAct (EBI) | Q15910 |
| FunCoup | ENSG00000106462 |
| REACTOME | EZH2 |
| Protein Interaction Database | 2146 |
| BioGRID | EZH2 |
| InParanoid | Q15910 |
| Interologous Interaction database | Q15910 |
| IntegromeDB | EZH2 |
| Polymorphism : SNP, mutations, diseases | | SNP Single Nucleotide Polymorphism (NCBI) | EZH2 |
| SNP (GeneSNP Utah) | EZH2 |
| SNP : HGBase | EZH2 |
| Genetic variants : HAPMAP | EZH2 |
| Cancer Gene: Census | EZH2 |
| Somatic Mutations in Cancer : COSMIC | EZH2 |
| CONAN: Copy Number Analysis | EZH2 |
| Mutations and Diseases : HGMD | EZH2 |
| OMIM | 277590 601573 614421 |
| GENETests | 277590 601573 614421 |
| Disease Genetic Association | EZH2 |
| Huge Navigator |
EZH2 [HugePedia] EZH2 [HugeCancerGEM] |
| Genomic Variants | EZH2 EZH2 [DGVbeta] |
| ClinVar | EZH2 |
| snp3D : Map Gene to Disease | 2146 |
| General knowledge |
|---|
| Homologs : HomoloGene | EZH2 |
| Homology/Alignments : Family Browser (UCSC) | EZH2 |
| Phylogenetic Trees/Animal Genes : TreeFam | EZH2 |
| Catalytic activity : Enzyme | 2.1.1.43 [ Enzyme-Expasy ] 2.1.1.43 [ Enzyme-SRS ] 2.1.1.43 [ IntEnz-EBI ] 2.1.1.43 [ BRENDA ] 2.1.1.43 [ KEGG ] |
| Chemical/Protein Interactions : CTD | 2146 |
| Chemical/Pharm GKB Gene | PA27939 |
| Drug Sensitivity | EZH2 |
| Clinical trial | EZH2 |
| Cancer Resource (Charite) | ENSG00000106462 |
| Ontology : AmiGO | S phase of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter core promoter binding DNA binding chromatin binding protein binding chromatin organization transcription, DNA-dependent regulation of transcription, DNA-dependent positive regulation of epithelial to mesenchymal transition regulation of gliogenesis histone-lysine N-methyltransferase activity cerebellar cortex development positive regulation of Ras GTPase activity negative regulation of transcription elongation from RNA polymerase II promoter ESC/E(Z) complex histone methyltransferase activity regulation of cell proliferation positive regulation of MAP kinase activity sequence-specific DNA binding pronucleus negative regulation of epidermal cell differentiation negative regulation of gene expression, epigenetic negative regulation of transcription, DNA-dependent negative regulation of retinoic acid receptor signaling pathway negative regulation of striated muscle cell differentiation G1 to G0 transition histone H3-K27 methylation positive regulation of protein serine/threonine kinase activity |
| Ontology : EGO-EBI | S phase of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter core promoter binding DNA binding chromatin binding protein binding chromatin organization transcription, DNA-dependent regulation of transcription, DNA-dependent positive regulation of epithelial to mesenchymal transition regulation of gliogenesis histone-lysine N-methyltransferase activity cerebellar cortex development positive regulation of Ras GTPase activity negative regulation of transcription elongation from RNA polymerase II promoter ESC/E(Z) complex histone methyltransferase activity regulation of cell proliferation positive regulation of MAP kinase activity sequence-specific DNA binding pronucleus negative regulation of epidermal cell differentiation negative regulation of gene expression, epigenetic negative regulation of transcription, DNA-dependent negative regulation of retinoic acid receptor signaling pathway negative regulation of striated muscle cell differentiation G1 to G0 transition histone H3-K27 methylation positive regulation of protein serine/threonine kinase activity |
| Pathways : BIOCARTA | The PRC2 Complex Sets Long-term Gene Silencing Through Modification of Histone Tails [Genes] |
| Other databases |
| Probes |
|---|
| Litterature | | PubMed | 304 Pubmed reference(s) in Entrez |
| PubGene | EZH2 |
| iHOP | EZH2 |
