EZR (ezrin)

2007-02-01 Affiliation

Identity

HGNC

EZR

LOCATION

6q25.3

LOCUSID

7430

ALIAS

CVIL,CVL,HEL-S-105,VIL2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7430
MIM: 123900
HGNC: 12691
Ensembl: ENSG00000092820

Variants:

dbSNP: 7430
ClinVar: 7430
TCGA: ENSG00000092820
COSMIC: EZR

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000092820	ENST00000337147	P15311
ENSG00000092820	ENST00000367075	P15311
ENSG00000092820	ENST00000392177	E7EQR4

Expression (GTEx)

100

150

200

250

300

350

400

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Tight junction	KEGG	ko04530
Leukocyte transendothelial migration	KEGG	ko04670
Regulation of actin cytoskeleton	KEGG	ko04810
Pathogenic Escherichia coli infection	KEGG	ko05130
Tight junction	KEGG	hsa04530
Leukocyte transendothelial migration	KEGG	hsa04670
Regulation of actin cytoskeleton	KEGG	hsa04810
Pathogenic Escherichia coli infection	KEGG	hsa05130
Gastric acid secretion	KEGG	ko04971
Gastric acid secretion	KEGG	hsa04971
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
MicroRNAs in cancer	KEGG	hsa05206
MicroRNAs in cancer	KEGG	ko05206
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
Netrin-1 signaling	REACTOME	R-HSA-373752
L1CAM interactions	REACTOME	R-HSA-373760
Recycling pathway of L1	REACTOME	R-HSA-437239

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
14704791	2004	The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis.	219
19890007	2009	Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.	148
14704789	2004	Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators.	133
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19386264	2009	Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.	74
16648854	2006	Quantitative proteomic analysis of B cell lipid rafts reveals that ezrin regulates antigen receptor-mediated lipid raft dynamics.	72
17237445	2007	Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus.	70
18840437	2008	MicroRNA-183 regulates Ezrin expression in lung cancer cells.	65
15843435	2005	G protein-coupled receptor kinase 2-mediated phosphorylation of ezrin is required for G protein-coupled receptor-dependent reorganization of the actin cytoskeleton.	63
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62

Citation

Dessen P

EZR (ezrin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/44029/ezr