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F10 (coagulation factor X)

Identity

Other aliasFX
FXA
HGNC (Hugo) F10
LocusID (NCBI) 2159
Atlas_Id 46152
Location 13q34  [Link to chromosome band 13q34]
Location_base_pair Starts at 113122799 and ends at 113149529 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EEF2 (19p13.3) / F10 (13q34)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)F10   3528
LRG (Locus Reference Genomic)LRG_548
Cards
Entrez_Gene (NCBI)F10  2159  coagulation factor X
AliasesFX; FXA
GeneCards (Weizmann)F10
Ensembl hg19 (Hinxton)ENSG00000126218 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126218 [Gene_View]  chr13:113122799-113149529 [Contig_View]  F10 [Vega]
ICGC DataPortalENSG00000126218
TCGA cBioPortalF10
AceView (NCBI)F10
Genatlas (Paris)F10
WikiGenes2159
SOURCE (Princeton)F10
Genetics Home Reference (NIH)F10
Genomic and cartography
GoldenPath hg38 (UCSC)F10  -     chr13:113122799-113149529 +  13q34   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)F10  -     13q34   [Description]    (hg19-Feb_2009)
EnsemblF10 - 13q34 [CytoView hg19]  F10 - 13q34 [CytoView hg38]
Mapping of homologs : NCBIF10 [Mapview hg19]  F10 [Mapview hg38]
OMIM227600   613872   
Gene and transcription
Genbank (Entrez)AK310772 AK310775 AK313798 BC040125 BC046125
RefSeq transcript (Entrez)NM_000504 NM_001312674 NM_001312675
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)F10
Cluster EST : UnigeneHs.361463 [ NCBI ]
CGAP (NCI)Hs.361463
Alternative Splicing GalleryENSG00000126218
Gene ExpressionF10 [ NCBI-GEO ]   F10 [ EBI - ARRAY_EXPRESS ]   F10 [ SEEK ]   F10 [ MEM ]
Gene Expression Viewer (FireBrowse)F10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2159
GTEX Portal (Tissue expression)F10
Protein : pattern, domain, 3D structure
UniProt/SwissProtP00742   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP00742  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP00742
Splice isoforms : SwissVarP00742
Catalytic activity : Enzyme3.4.21.6 [ Enzyme-Expasy ]   3.4.21.63.4.21.6 [ IntEnz-EBI ]   3.4.21.6 [ BRENDA ]   3.4.21.6 [ KEGG ]   
PhosPhoSitePlusP00742
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    GLA_1 (PS00011)    GLA_2 (PS50998)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Coagulation_fac_subgr_Gla_dom    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    GLA_domain    Pept_S1A_FX    Peptidase_S1_PA    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)EGF (PF00008)    Gla (PF00594)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00008    pfam00594    pfam00089   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  GLA (SM00069)  Tryp_SPc (SM00020)  
Conserved Domain (NCBI)F10
DMDM Disease mutations2159
Blocks (Seattle)F10
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyP00742
Human Protein AtlasENSG00000126218
Peptide AtlasP00742
HPRD01966
IPIIPI00019576   IPI00815679   IPI00552633   IPI00916794   IPI00916124   
Protein Interaction databases
DIP (DOE-UCLA)P00742
IntAct (EBI)P00742
FunCoupENSG00000126218
BioGRIDF10
STRING (EMBL)F10
ZODIACF10
Ontologies - Pathways
QuickGOP00742
Ontology : AmiGOserine-type endopeptidase activity  serine-type endopeptidase activity  serine-type endopeptidase activity  calcium ion binding  protein binding  phospholipid binding  extracellular region  extracellular region  endoplasmic reticulum lumen  Golgi lumen  plasma membrane  signal peptide processing  ER to Golgi vesicle-mediated transport  blood coagulation  blood coagulation  blood coagulation, intrinsic pathway  blood coagulation, extrinsic pathway  peptidyl-glutamic acid carboxylation  positive regulation of cell migration  intrinsic component of external side of plasma membrane  positive regulation of protein kinase B signaling  
Ontology : EGO-EBIserine-type endopeptidase activity  serine-type endopeptidase activity  serine-type endopeptidase activity  calcium ion binding  protein binding  phospholipid binding  extracellular region  extracellular region  endoplasmic reticulum lumen  Golgi lumen  plasma membrane  signal peptide processing  ER to Golgi vesicle-mediated transport  blood coagulation  blood coagulation  blood coagulation, intrinsic pathway  blood coagulation, extrinsic pathway  peptidyl-glutamic acid carboxylation  positive regulation of cell migration  intrinsic component of external side of plasma membrane  positive regulation of protein kinase B signaling  
Pathways : BIOCARTAExtrinsic Prothrombin Activation Pathway [Genes]    Intrinsic Prothrombin Activation Pathway [Genes]    Acute Myocardial Infarction [Genes]   
Pathways : KEGGComplement and coagulation cascades   
NDEx NetworkF10
Atlas of Cancer Signalling NetworkF10
Wikipedia pathwaysF10
Orthology - Evolution
OrthoDB2159
GeneTree (enSembl)ENSG00000126218
Phylogenetic Trees/Animal Genes : TreeFamF10
HOVERGENP00742
HOGENOMP00742
Homologs : HomoloGeneF10
Homology/Alignments : Family Browser (UCSC)F10
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerF10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)F10
dbVarF10
ClinVarF10
1000_GenomesF10 
Exome Variant ServerF10
ExAC (Exome Aggregation Consortium)F10 (select the gene name)
Genetic variants : HAPMAP2159
Genomic Variants (DGV)F10 [DGVbeta]
DECIPHERF10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisF10 
Mutations
ICGC Data PortalF10 
TCGA Data PortalF10 
Broad Tumor PortalF10
OASIS PortalF10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICF10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDF10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch F10
DgiDB (Drug Gene Interaction Database)F10
DoCM (Curated mutations)F10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)F10 (select a term)
intoGenF10
Cancer3DF10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM227600    613872   
Orphanet3652   
MedgenF10
Genetic Testing Registry F10
NextProtP00742 [Medical]
TSGene2159
GENETestsF10
Target ValidationF10
Huge Navigator F10 [HugePedia]
snp3D : Map Gene to Disease2159
BioCentury BCIQF10
ClinGenF10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2159
Chemical/Pharm GKB GenePA27940
Clinical trialF10
Miscellaneous
canSAR (ICR)F10 (select the gene name)
Probes
Litterature
PubMed277 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineF10
EVEXF10
GoPubMedF10
iHOPF10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:00:45 CEST 2017

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