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F11 (coagulation factor XI)

Identity

Alias_symbol (synonym)FXI
Other alias
HGNC (Hugo) F11
LocusID (NCBI) 2160
Atlas_Id 40519
Location 4q35.2  [Link to chromosome band 4q35]
Location_base_pair Starts at 186265964 and ends at 186289681 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
F11 (4q35.2) / ANKH (5p15.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)F11   3529
LRG (Locus Reference Genomic)LRG_583
Cards
Entrez_Gene (NCBI)F11  2160  coagulation factor XI
AliasesFXI
GeneCards (Weizmann)F11
Ensembl hg19 (Hinxton)ENSG00000088926 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000088926 [Gene_View]  chr4:186265964-186289681 [Contig_View]  F11 [Vega]
ICGC DataPortalENSG00000088926
TCGA cBioPortalF11
AceView (NCBI)F11
Genatlas (Paris)F11
WikiGenes2160
SOURCE (Princeton)F11
Genetics Home Reference (NIH)F11
Genomic and cartography
GoldenPath hg38 (UCSC)F11  -     chr4:186265964-186289681 +  4q35.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)F11  -     4q35.2   [Description]    (hg19-Feb_2009)
EnsemblF11 - 4q35.2 [CytoView hg19]  F11 - 4q35.2 [CytoView hg38]
Mapping of homologs : NCBIF11 [Mapview hg19]  F11 [Mapview hg38]
OMIM264900   612416   
Gene and transcription
Genbank (Entrez)AF045649 AK313195 BC020617 BC029374 BC119014
RefSeq transcript (Entrez)NM_000128 NM_019559
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)F11
Cluster EST : UnigeneHs.1430 [ NCBI ]
CGAP (NCI)Hs.1430
Alternative Splicing GalleryENSG00000088926
Gene ExpressionF11 [ NCBI-GEO ]   F11 [ EBI - ARRAY_EXPRESS ]   F11 [ SEEK ]   F11 [ MEM ]
Gene Expression Viewer (FireBrowse)F11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2160
GTEX Portal (Tissue expression)F11
Protein : pattern, domain, 3D structure
UniProt/SwissProtP03951   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP03951  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP03951
Splice isoforms : SwissVarP03951
Catalytic activity : Enzyme3.4.21.27 [ Enzyme-Expasy ]   3.4.21.273.4.21.27 [ IntEnz-EBI ]   3.4.21.27 [ BRENDA ]   3.4.21.27 [ KEGG ]   
PhosPhoSitePlusP03951
Domaine pattern : Prosite (Expaxy)APPLE (PS00495)    PAN (PS50948)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Apple    Pan_app    Peptidase_S1_PA    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)PAN_1 (PF00024)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00024    pfam00089   
Domain families : Smart (EMBL)APPLE (SM00223)  Tryp_SPc (SM00020)  
Conserved Domain (NCBI)F11
DMDM Disease mutations2160
Blocks (Seattle)F11
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyP03951
Human Protein AtlasENSG00000088926
Peptide AtlasP03951
HPRD07524
IPIIPI00008556   IPI00216588   IPI00966219   IPI00967092   
Protein Interaction databases
DIP (DOE-UCLA)P03951
IntAct (EBI)P03951
FunCoupENSG00000088926
BioGRIDF11
STRING (EMBL)F11
ZODIACF11
Ontologies - Pathways
QuickGOP03951
Ontology : AmiGOserine-type endopeptidase activity  protein binding  extracellular region  extracellular region  extracellular space  plasma membrane  blood coagulation  blood coagulation  blood coagulation, intrinsic pathway  heparin binding  membrane  plasminogen activation  positive regulation of fibrinolysis  serine-type aminopeptidase activity  extracellular exosome  
Ontology : EGO-EBIserine-type endopeptidase activity  protein binding  extracellular region  extracellular region  extracellular space  plasma membrane  blood coagulation  blood coagulation  blood coagulation, intrinsic pathway  heparin binding  membrane  plasminogen activation  positive regulation of fibrinolysis  serine-type aminopeptidase activity  extracellular exosome  
Pathways : BIOCARTAIntrinsic Prothrombin Activation Pathway [Genes]    Platelet Amyloid Precursor Protein Pathway [Genes]   
Pathways : KEGGComplement and coagulation cascades   
NDEx NetworkF11
Atlas of Cancer Signalling NetworkF11
Wikipedia pathwaysF11
Orthology - Evolution
OrthoDB2160
GeneTree (enSembl)ENSG00000088926
Phylogenetic Trees/Animal Genes : TreeFamF11
HOVERGENP03951
HOGENOMP03951
Homologs : HomoloGeneF11
Homology/Alignments : Family Browser (UCSC)F11
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerF11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)F11
dbVarF11
ClinVarF11
1000_GenomesF11 
Exome Variant ServerF11
ExAC (Exome Aggregation Consortium)F11 (select the gene name)
Genetic variants : HAPMAP2160
Genomic Variants (DGV)F11 [DGVbeta]
DECIPHERF11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisF11 
Mutations
ICGC Data PortalF11 
TCGA Data PortalF11 
Broad Tumor PortalF11
OASIS PortalF11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICF11  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDF11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch F11
DgiDB (Drug Gene Interaction Database)F11
DoCM (Curated mutations)F11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)F11 (select a term)
intoGenF11
Cancer3DF11(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM264900    612416   
Orphanet4511   
MedgenF11
Genetic Testing Registry F11
NextProtP03951 [Medical]
TSGene2160
GENETestsF11
Target ValidationF11
Huge Navigator F11 [HugePedia]
snp3D : Map Gene to Disease2160
BioCentury BCIQF11
ClinGenF11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2160
Chemical/Pharm GKB GenePA27941
Clinical trialF11
Miscellaneous
canSAR (ICR)F11 (select the gene name)
Probes
Litterature
PubMed181 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineF11
EVEXF11
GoPubMedF11
iHOPF11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:33:06 CEST 2017

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