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F2 (coagulation factor II, thrombin)

Identity

Alias_namescoagulation factor II (thrombin)
Other aliasPT
RPRGL2
THPH1
HGNC (Hugo) F2
LocusID (NCBI) 2147
Atlas_Id 40520
Location 11p11.2  [Link to chromosome band 11p11]
Location_base_pair Starts at 46719166 and ends at 46739508 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
C11orf49 (11p11.2) / F2 (11p11.2)LPP (3q28) / F2 (11p11.2)C11orf49 11p11.2 / F2 11p11.2
LPP 3q28 / F2 11p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Liver: Undifferentiated carcinoma


External links

Nomenclature
HGNC (Hugo)F2   3535
LRG (Locus Reference Genomic)LRG_551
Cards
Entrez_Gene (NCBI)F2  2147  coagulation factor II, thrombin
AliasesPT; RPRGL2; THPH1
GeneCards (Weizmann)F2
Ensembl hg19 (Hinxton)ENSG00000180210 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000180210 [Gene_View]  chr11:46719166-46739508 [Contig_View]  F2 [Vega]
ICGC DataPortalENSG00000180210
TCGA cBioPortalF2
AceView (NCBI)F2
Genatlas (Paris)F2
WikiGenes2147
SOURCE (Princeton)F2
Genetics Home Reference (NIH)F2
Genomic and cartography
GoldenPath hg38 (UCSC)F2  -     chr11:46719166-46739508 +  11p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)F2  -     11p11.2   [Description]    (hg19-Feb_2009)
EnsemblF2 - 11p11.2 [CytoView hg19]  F2 - 11p11.2 [CytoView hg38]
Mapping of homologs : NCBIF2 [Mapview hg19]  F2 [Mapview hg38]
OMIM176930   188050   601367   613679   614390   
Gene and transcription
Genbank (Entrez)AJ972449 AK222775 AK222777 AK293326 AK303747
RefSeq transcript (Entrez)NM_000506 NM_001311257
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)F2
Cluster EST : UnigeneHs.655207 [ NCBI ]
CGAP (NCI)Hs.655207
Alternative Splicing GalleryENSG00000180210
Gene ExpressionF2 [ NCBI-GEO ]   F2 [ EBI - ARRAY_EXPRESS ]   F2 [ SEEK ]   F2 [ MEM ]
Gene Expression Viewer (FireBrowse)F2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2147
GTEX Portal (Tissue expression)F2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP00734   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP00734  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP00734
Splice isoforms : SwissVarP00734
Catalytic activity : Enzyme3.4.21.5 [ Enzyme-Expasy ]   3.4.21.53.4.21.5 [ IntEnz-EBI ]   3.4.21.5 [ BRENDA ]   3.4.21.5 [ KEGG ]   
PhosPhoSitePlusP00734
Domaine pattern : Prosite (Expaxy)GLA_1 (PS00011)    GLA_2 (PS50998)    KRINGLE_1 (PS00021)    KRINGLE_2 (PS50070)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Coagulation_fac_subgr_Gla_dom    GLA_domain    Kringle    Kringle-like    Kringle_CS    Peptidase_S1_PA    Peptidase_S1A    Prothrombin/thrombin    Thrombin_light_chain    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)Gla (PF00594)    Kringle (PF00051)    Thrombin_light (PF09396)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00594    pfam00051    pfam09396    pfam00089   
Domain families : Smart (EMBL)GLA (SM00069)  KR (SM00130)  Tryp_SPc (SM00020)  
Conserved Domain (NCBI)F2
DMDM Disease mutations2147
Blocks (Seattle)F2
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyP00734
Human Protein AtlasENSG00000180210
Peptide AtlasP00734
HPRD01488
IPIIPI00019568   IPI00816612   IPI00877967   IPI00975497   
Protein Interaction databases
DIP (DOE-UCLA)P00734
IntAct (EBI)P00734
FunCoupENSG00000180210
BioGRIDF2
STRING (EMBL)F2
ZODIACF2
Ontologies - Pathways
QuickGOP00734
Ontology : AmiGOpositive regulation of protein phosphorylation  serine-type endopeptidase activity  serine-type endopeptidase activity  receptor binding  calcium ion binding  protein binding  extracellular region  extracellular space  endoplasmic reticulum lumen  Golgi lumen  plasma membrane  signal peptide processing  proteolysis  ER to Golgi vesicle-mediated transport  acute-phase response  cell surface receptor signaling pathway  multicellular organism development  blood coagulation  blood coagulation, intrinsic pathway  growth factor activity  positive regulation of cell proliferation  regulation of cell shape  response to wounding  regulation of gene expression  negative regulation of platelet activation  positive regulation of phosphatidylinositol 3-kinase signaling  peptidyl-glutamic acid carboxylation  platelet activation  platelet activation  regulation of blood coagulation  positive regulation of blood coagulation  positive regulation of cell growth  positive regulation of collagen biosynthetic process  fibrinolysis  cellular protein metabolic process  negative regulation of proteolysis  negative regulation of astrocyte differentiation  leukocyte migration  positive regulation of release of sequestered calcium ion into cytosol  regulation of cytosolic calcium ion concentration  negative regulation of fibrinolysis  thrombospondin receptor activity  extracellular exosome  blood microparticle  positive regulation of lipid kinase activity  positive regulation of protein localization to nucleus  positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway  positive regulation of reactive oxygen species metabolic process  
Ontology : EGO-EBIpositive regulation of protein phosphorylation  serine-type endopeptidase activity  serine-type endopeptidase activity  receptor binding  calcium ion binding  protein binding  extracellular region  extracellular space  endoplasmic reticulum lumen  Golgi lumen  plasma membrane  signal peptide processing  proteolysis  ER to Golgi vesicle-mediated transport  acute-phase response  cell surface receptor signaling pathway  multicellular organism development  blood coagulation  blood coagulation, intrinsic pathway  growth factor activity  positive regulation of cell proliferation  regulation of cell shape  response to wounding  regulation of gene expression  negative regulation of platelet activation  positive regulation of phosphatidylinositol 3-kinase signaling  peptidyl-glutamic acid carboxylation  platelet activation  platelet activation  regulation of blood coagulation  positive regulation of blood coagulation  positive regulation of cell growth  positive regulation of collagen biosynthetic process  fibrinolysis  cellular protein metabolic process  negative regulation of proteolysis  negative regulation of astrocyte differentiation  leukocyte migration  positive regulation of release of sequestered calcium ion into cytosol  regulation of cytosolic calcium ion concentration  negative regulation of fibrinolysis  thrombospondin receptor activity  extracellular exosome  blood microparticle  positive regulation of lipid kinase activity  positive regulation of protein localization to nucleus  positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway  positive regulation of reactive oxygen species metabolic process  
Pathways : BIOCARTA [Genes]   
Pathways : KEGGNeuroactive ligand-receptor interaction    Complement and coagulation cascades    Regulation of actin cytoskeleton   
NDEx NetworkF2
Atlas of Cancer Signalling NetworkF2
Wikipedia pathwaysF2
Orthology - Evolution
OrthoDB2147
GeneTree (enSembl)ENSG00000180210
Phylogenetic Trees/Animal Genes : TreeFamF2
HOVERGENP00734
HOGENOMP00734
Homologs : HomoloGeneF2
Homology/Alignments : Family Browser (UCSC)F2
Gene fusions - Rearrangements
Fusion : MitelmanC11orf49/F2 [11p11.2/11p11.2]  [t(11;11)(p11;p11)]  
Fusion : MitelmanLPP/F2 [3q28/11p11.2]  [t(3;11)(q28;p11)]  
Fusion: TCGAC11orf49 11p11.2 F2 11p11.2 LUAD
Fusion: TCGALPP 3q28 F2 11p11.2 OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)F2
dbVarF2
ClinVarF2
1000_GenomesF2 
Exome Variant ServerF2
ExAC (Exome Aggregation Consortium)F2 (select the gene name)
Genetic variants : HAPMAP2147
Genomic Variants (DGV)F2 [DGVbeta]
DECIPHERF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisF2 
Mutations
ICGC Data PortalF2 
TCGA Data PortalF2 
Broad Tumor PortalF2
OASIS PortalF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch F2
DgiDB (Drug Gene Interaction Database)F2
DoCM (Curated mutations)F2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)F2 (select a term)
intoGenF2
Cancer3DF2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176930    188050    601367    613679    614390   
Orphanet3277    21909   
MedgenF2
Genetic Testing Registry F2
NextProtP00734 [Medical]
TSGene2147
GENETestsF2
Target ValidationF2
Huge Navigator F2 [HugePedia]
snp3D : Map Gene to Disease2147
BioCentury BCIQF2
ClinGenF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2147
Chemical/Pharm GKB GenePA157
Clinical trialF2
Miscellaneous
canSAR (ICR)F2 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineF2
EVEXF2
GoPubMedF2
iHOPF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:33:07 CEST 2017

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