Atlas of Genetics and Cytogenetics in Oncology and Haematology

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F2RL1 (F2R like trypsin receptor 1)

Identity

Alias_namesGPR11
coagulation factor II (thrombin) receptor-like 1
Alias_symbol (synonym)PAR2
Other alias
HGNC (Hugo) F2RL1
LocusID (NCBI) 2150
Atlas_Id 43801
Location 5q13.3  [Link to chromosome band 5q13]
Location_base_pair Starts at 76818977 and ends at 76835315 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)F2RL1   3538
Cards
Entrez_Gene (NCBI)F2RL1  2150  F2R like trypsin receptor 1
AliasesGPR11; PAR2
GeneCards (Weizmann)F2RL1
Ensembl hg19 (Hinxton)ENSG00000164251 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164251 [Gene_View]  ENSG00000164251 [Sequence]  chr5:76818977-76835315 [Contig_View]  F2RL1 [Vega]
ICGC DataPortalENSG00000164251
TCGA cBioPortalF2RL1
AceView (NCBI)F2RL1
Genatlas (Paris)F2RL1
WikiGenes2150
SOURCE (Princeton)F2RL1
Genetics Home Reference (NIH)F2RL1
Genomic and cartography
GoldenPath hg38 (UCSC)F2RL1  -     chr5:76818977-76835315 +  5q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)F2RL1  -     5q13.3   [Description]    (hg19-Feb_2009)
GoldenPathF2RL1 - 5q13.3 [CytoView hg19]  F2RL1 - 5q13.3 [CytoView hg38]
ImmunoBaseENSG00000164251
Mapping of homologs : NCBIF2RL1 [Mapview hg19]  F2RL1 [Mapview hg38]
OMIM600933   
Gene and transcription
Genbank (Entrez)AY336105 BC012453 BC018130 BT009856 DB463838
RefSeq transcript (Entrez)NM_005242
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)F2RL1
Cluster EST : UnigeneHs.744181 [ NCBI ]
CGAP (NCI)Hs.744181
Alternative Splicing GalleryENSG00000164251
Gene ExpressionF2RL1 [ NCBI-GEO ]   F2RL1 [ EBI - ARRAY_EXPRESS ]   F2RL1 [ SEEK ]   F2RL1 [ MEM ]
Gene Expression Viewer (FireBrowse)F2RL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2150
GTEX Portal (Tissue expression)F2RL1
Human Protein AtlasENSG00000164251-F2RL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55085   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP55085  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55085
Splice isoforms : SwissVarP55085
PhosPhoSitePlusP55085
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    Pro_rcpt_2    Protea_act_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)F2RL1
DMDM Disease mutations2150
Blocks (Seattle)F2RL1
PDB (RSDB)5NDD    5NDZ    5NJ6   
PDB Europe5NDD    5NDZ    5NJ6   
PDB (PDBSum)5NDD    5NDZ    5NJ6   
PDB (IMB)5NDD    5NDZ    5NJ6   
Structural Biology KnowledgeBase5NDD    5NDZ    5NJ6   
SCOP (Structural Classification of Proteins)5NDD    5NDZ    5NJ6   
CATH (Classification of proteins structures)5NDD    5NDZ    5NJ6   
SuperfamilyP55085
Human Protein Atlas [tissue]ENSG00000164251-F2RL1 [tissue]
Peptide AtlasP55085
HPRD02960
IPIIPI00296446   IPI00967959   
Protein Interaction databases
DIP (DOE-UCLA)P55085
IntAct (EBI)P55085
FunCoupENSG00000164251
BioGRIDF2RL1
STRING (EMBL)F2RL1
ZODIACF2RL1
Ontologies - Pathways
QuickGOP55085
Ontology : AmiGOG-protein alpha-subunit binding  T cell activation involved in immune response  positive regulation of leukocyte chemotaxis  positive regulation of cytokine secretion involved in immune response  positive regulation of glomerular filtration  G protein-coupled receptor activity  G protein-coupled receptor activity  G protein-coupled receptor activity  signaling receptor binding  protein binding  early endosome  Golgi apparatus  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  inflammatory response  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  positive regulation of cytosolic calcium ion concentration  blood coagulation  negative regulation of tumor necrosis factor-mediated signaling pathway  positive regulation of phosphatidylinositol 3-kinase signaling  thrombin-activated receptor activity  regulation of blood coagulation  positive regulation of cell migration  positive regulation of actin filament depolymerization  pseudopodium  positive regulation of pseudopodium assembly  G-protein beta-subunit binding  positive regulation of superoxide anion generation  positive regulation of toll-like receptor 2 signaling pathway  negative regulation of toll-like receptor 3 signaling pathway  positive regulation of toll-like receptor 3 signaling pathway  positive regulation of toll-like receptor 4 signaling pathway  positive regulation of Rho protein signal transduction  positive regulation of Rho protein signal transduction  positive regulation of Rho protein signal transduction  chemokine (C-C motif) ligand 2 secretion  signaling receptor activity  neutrophil activation  regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of eosinophil degranulation  positive regulation of GTPase activity  innate immune response  cell-cell junction maintenance  positive regulation of transcription by RNA polymerase II  regulation of JNK cascade  negative regulation of JNK cascade  positive regulation of JNK cascade  interleukin-1 beta secretion  leukocyte migration  positive regulation of chemotaxis  positive regulation of positive chemotaxis  positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  defense response to virus  positive regulation of phagocytosis, engulfment  establishment of endothelial barrier  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  thrombin-activated receptor signaling pathway  leukocyte proliferation  positive regulation of neutrophil mediated killing of gram-negative bacterium  interleukin-10 secretion  interferon-gamma secretion  chemokine secretion  negative regulation of chemokine secretion  mature conventional dendritic cell differentiation  mature conventional dendritic cell differentiation  positive regulation of blood vessel diameter  positive regulation of renin secretion into blood stream  positive regulation of interleukin-8 secretion  positive regulation of interleukin-6 secretion  
Ontology : EGO-EBIG-protein alpha-subunit binding  T cell activation involved in immune response  positive regulation of leukocyte chemotaxis  positive regulation of cytokine secretion involved in immune response  positive regulation of glomerular filtration  G protein-coupled receptor activity  G protein-coupled receptor activity  G protein-coupled receptor activity  signaling receptor binding  protein binding  early endosome  Golgi apparatus  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  inflammatory response  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  positive regulation of cytosolic calcium ion concentration  blood coagulation  negative regulation of tumor necrosis factor-mediated signaling pathway  positive regulation of phosphatidylinositol 3-kinase signaling  thrombin-activated receptor activity  regulation of blood coagulation  positive regulation of cell migration  positive regulation of actin filament depolymerization  pseudopodium  positive regulation of pseudopodium assembly  G-protein beta-subunit binding  positive regulation of superoxide anion generation  positive regulation of toll-like receptor 2 signaling pathway  negative regulation of toll-like receptor 3 signaling pathway  positive regulation of toll-like receptor 3 signaling pathway  positive regulation of toll-like receptor 4 signaling pathway  positive regulation of Rho protein signal transduction  positive regulation of Rho protein signal transduction  positive regulation of Rho protein signal transduction  chemokine (C-C motif) ligand 2 secretion  signaling receptor activity  neutrophil activation  regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of eosinophil degranulation  positive regulation of GTPase activity  innate immune response  cell-cell junction maintenance  positive regulation of transcription by RNA polymerase II  regulation of JNK cascade  negative regulation of JNK cascade  positive regulation of JNK cascade  interleukin-1 beta secretion  leukocyte migration  positive regulation of chemotaxis  positive regulation of positive chemotaxis  positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  defense response to virus  positive regulation of phagocytosis, engulfment  establishment of endothelial barrier  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  thrombin-activated receptor signaling pathway  leukocyte proliferation  positive regulation of neutrophil mediated killing of gram-negative bacterium  interleukin-10 secretion  interferon-gamma secretion  chemokine secretion  negative regulation of chemokine secretion  mature conventional dendritic cell differentiation  mature conventional dendritic cell differentiation  positive regulation of blood vessel diameter  positive regulation of renin secretion into blood stream  positive regulation of interleukin-8 secretion  positive regulation of interleukin-6 secretion  
Pathways : KEGGNeuroactive ligand-receptor interaction    African trypanosomiasis   
NDEx NetworkF2RL1
Atlas of Cancer Signalling NetworkF2RL1
Wikipedia pathwaysF2RL1
Orthology - Evolution
OrthoDB2150
GeneTree (enSembl)ENSG00000164251
Phylogenetic Trees/Animal Genes : TreeFamF2RL1
HOGENOMP55085
Homologs : HomoloGeneF2RL1
Homology/Alignments : Family Browser (UCSC)F2RL1
Gene fusions - Rearrangements
Fusion : QuiverF2RL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerF2RL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)F2RL1
dbVarF2RL1
ClinVarF2RL1
1000_GenomesF2RL1 
Exome Variant ServerF2RL1
ExAC (Exome Aggregation Consortium)ENSG00000164251
GNOMAD BrowserENSG00000164251
Varsome BrowserF2RL1
Genetic variants : HAPMAP2150
Genomic Variants (DGV)F2RL1 [DGVbeta]
DECIPHERF2RL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisF2RL1 
Mutations
ICGC Data PortalF2RL1 
TCGA Data PortalF2RL1 
Broad Tumor PortalF2RL1
OASIS PortalF2RL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICF2RL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDF2RL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch F2RL1
DgiDB (Drug Gene Interaction Database)F2RL1
DoCM (Curated mutations)F2RL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)F2RL1 (select a term)
intoGenF2RL1
Cancer3DF2RL1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600933   
Orphanet
DisGeNETF2RL1
MedgenF2RL1
Genetic Testing Registry F2RL1
NextProtP55085 [Medical]
TSGene2150
GENETestsF2RL1
Target ValidationF2RL1
Huge Navigator F2RL1 [HugePedia]
snp3D : Map Gene to Disease2150
BioCentury BCIQF2RL1
ClinGenF2RL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2150
Chemical/Pharm GKB GenePA27947
Clinical trialF2RL1
Miscellaneous
canSAR (ICR)F2RL1 (select the gene name)
DataMed IndexF2RL1
Probes
Litterature
PubMed338 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineF2RL1
EVEXF2RL1
GoPubMedF2RL1
iHOPF2RL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Jul 8 11:19:33 CEST 2019
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