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F5 (coagulation factor V (proaccelerin, labile factor))

Identity

Other namesFVL
PCCF
RPRGL1
THPH2
HGNC (Hugo) F5
LocusID (NCBI) 2153
Location 1q24.2
Location_base_pair Starts at 169481192 and ends at 169555769 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)F5   3542
Cards
Entrez_Gene (NCBI)F5  2153  coagulation factor V (proaccelerin, labile factor)
GeneCards (Weizmann)F5
Ensembl (Hinxton) [Gene_View]  chr1:169481192-169555769 [Contig_View]  F5 [Vega]
cBioPortalF5
AceView (NCBI)F5
Genatlas (Paris)F5
WikiGenes2153
SOURCE (Princeton)NM_000130
Genomic and cartography
GoldenPath (UCSC)F5  -  1q24.2   chr1:169481192-169555769 -  1q24.2   [Description]    (hg19-Feb_2009)
EnsemblF5 - 1q24.2 [CytoView]
Mapping of homologs : NCBIF5 [Mapview]
OMIM188055   227400   600880   601367   612309   614389   
Gene and transcription
Genbank (Entrez)AJ297254 AJ297255 AK226079 AK291613 AK300469
RefSeq transcript (Entrez)NM_000130
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_011806 NT_004487 NW_001838533 NW_004929293
Consensus coding sequences : CCDS (NCBI)F5
Cluster EST : UnigeneHs.30054 [ NCBI ]
CGAP (NCI)Hs.30054
Alternative Splicing : Fast-db (Paris)GSHG0002724
Gene ExpressionF5 [ NCBI-GEO ]     F5 [ SEEK ]   F5 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP12259 (Uniprot)
NextProtP12259  [Medical]
With graphics : InterProP12259
Splice isoforms : SwissVarP12259 (Swissvar)
Domaine pattern : Prosite (Expaxy)FA58C_1 (PS01285)    FA58C_2 (PS01286)    FA58C_3 (PS50022)    MULTICOPPER_OXIDASE1 (PS00079)   
Domains : Interpro (EBI)Coagulation_fac_5/8-C_type_dom [organisation]   Cu-oxidase_3 [organisation]   Cu_oxidase_Cu_BS [organisation]   Cupredoxin [organisation]   Factor_5/8 [organisation]   Galactose-bd-like [organisation]  
Related proteins : CluSTrP12259
Domain families : Pfam (Sanger)Cu-oxidase_3 (PF07732)    F5_F8_type_C (PF00754)   
Domain families : Pfam (NCBI)pfam07732    pfam00754   
Domain families : Smart (EMBL)FA58C (SM00231)  
DMDM Disease mutations2153
Blocks (Seattle)P12259
PDB (SRS)1CZS    1CZT    1CZV    1FV4    1Y61    3P6Z    3P70    3S9C   
PDB (PDBSum)1CZS    1CZT    1CZV    1FV4    1Y61    3P6Z    3P70    3S9C   
PDB (IMB)1CZS    1CZT    1CZV    1FV4    1Y61    3P6Z    3P70    3S9C   
PDB (RSDB)1CZS    1CZT    1CZV    1FV4    1Y61    3P6Z    3P70    3S9C   
Peptide AtlasP12259
HPRD01964
IPIIPI00478809   IPI01015326   IPI00953390   IPI00815941   IPI00022937   
Protein Interaction databases
DIP (DOE-UCLA)P12259
IntAct (EBI)P12259
BioGRIDF5
InParanoidP12259
Interologous Interaction database P12259
IntegromeDBF5
STRING (EMBL)F5
Ontologies - Pathways
Ontology : AmiGOplatelet degranulation  serine-type endopeptidase activity  copper ion binding  protein binding  extracellular region  extracellular region  extracellular space  plasma membrane  proteolysis  cell adhesion  blood coagulation  blood circulation  membrane  platelet activation  platelet alpha granule lumen  
Ontology : EGO-EBIplatelet degranulation  serine-type endopeptidase activity  copper ion binding  protein binding  extracellular region  extracellular region  extracellular space  plasma membrane  proteolysis  cell adhesion  blood coagulation  blood circulation  membrane  platelet activation  platelet alpha granule lumen  
Pathways : BIOCARTAIntrinsic Prothrombin Activation Pathway [Genes]    Extrinsic Prothrombin Activation Pathway [Genes]   
Pathways : KEGGComplement and coagulation cascades   
Protein Interaction DatabaseF5
Wikipedia pathwaysF5
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)F5
snp3D : Map Gene to Disease2153
SNP (GeneSNP Utah)F5
SNP : HGBaseF5
Genetic variants : HAPMAPF5
Exome VariantF5
1000_GenomesF5 
Somatic Mutations in Cancer : COSMICF5 
CONAN: Copy Number AnalysisF5 
Mutations and Diseases : HGMDF5
Mutations and Diseases : intOGenF5
Genomic VariantsF5  F5 [DGVbeta]
dbVarF5
ClinVarF5
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM188055    227400    600880    601367    612309    614389   
MedgenF5
GENETestsF5
Disease Genetic AssociationF5
Huge Navigator F5 [HugePedia]  F5 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneF5
Homology/Alignments : Family Browser (UCSC)F5
Phylogenetic Trees/Animal Genes : TreeFamF5
Chemical/Protein Interactions : CTD2153
Chemical/Pharm GKB GenePA159
Clinical trialF5
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineF5
iHOPF5
OncoSearchF5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:46:17 CEST 2014

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