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F5 (coagulation factor V (proaccelerin, labile factor))

Identity

Other namesFVL
PCCF
RPRGL1
THPH2
HGNC (Hugo) F5
LocusID (NCBI) 2153
Atlas_Id 45563
Location 1q24.2
Location_base_pair Starts at 169481192 and ends at 169555769 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2015)
ARNT 1q21.3 / F5 1q24.2NOS1AP 1q23.3 / F5 1q24.2SRF 6p21.1 / F5 1q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)F5   3542
Cards
Entrez_Gene (NCBI)F5  2153  coagulation factor V (proaccelerin, labile factor)
GeneCards (Weizmann)F5
Ensembl hg19 (Hinxton) [Gene_View]  chr1:169481192-169555769 [Contig_View]  F5 [Vega]
Ensembl hg38 (Hinxton) [Gene_View]  chr1:169481192-169555769 [Contig_View]  F5 [Vega]
TCGA cBioPortalF5
AceView (NCBI)F5
Genatlas (Paris)F5
WikiGenes2153
SOURCE (Princeton)F5
Genomic and cartography
GoldenPath hg19 (UCSC)F5  -     chr1:169481192-169555769 -  1q24.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)F5  -     1q24.2   [Description]    (hg38-Dec_2013)
EnsemblF5 - 1q24.2 [CytoView hg19]  F5 - 1q24.2 [CytoView hg38]
Mapping of homologs : NCBIF5 [Mapview hg19]  F5 [Mapview hg38]
OMIM188055   227400   600880   601367   612309   614389   
Gene and transcription
Genbank (Entrez)AJ297254 AJ297255 AK226079 AK291613 AK300469
RefSeq transcript (Entrez)NM_000130
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_011806 NT_004487 NW_004929293
Consensus coding sequences : CCDS (NCBI)F5
Cluster EST : UnigeneHs.30054 [ NCBI ]
CGAP (NCI)Hs.30054
Alternative Splicing : Fast-db (Paris)GSHG0002724
Gene ExpressionF5 [ NCBI-GEO ]     F5 [ SEEK ]   F5 [ MEM ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)2153
Protein : pattern, domain, 3D structure
UniProt/SwissProtP12259 (Uniprot)
NextProtP12259  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP12259
Splice isoforms : SwissVarP12259 (Swissvar)
PhosPhoSitePlusP12259
Domaine pattern : Prosite (Expaxy)FA58C_1 (PS01285)    FA58C_2 (PS01286)    FA58C_3 (PS50022)    MULTICOPPER_OXIDASE1 (PS00079)   
Domains : Interpro (EBI)Coagulation_fac_5/8-C_type_dom    Cu-oxidase_3    Cu_oxidase_Cu_BS    Cupredoxin    Factor_5/8    Factor_V    Galactose-bd-like   
Domain families : Pfam (Sanger)Cu-oxidase_3 (PF07732)    F5_F8_type_C (PF00754)   
Domain families : Pfam (NCBI)pfam07732    pfam00754   
Domain families : Smart (EMBL)FA58C (SM00231)  
DMDM Disease mutations2153
Blocks (Seattle)F5
PDB (SRS)1CZS    1CZT    1CZV    1FV4    1Y61    3P6Z    3P70    3S9C   
PDB (PDBSum)1CZS    1CZT    1CZV    1FV4    1Y61    3P6Z    3P70    3S9C   
PDB (IMB)1CZS    1CZT    1CZV    1FV4    1Y61    3P6Z    3P70    3S9C   
PDB (RSDB)1CZS    1CZT    1CZV    1FV4    1Y61    3P6Z    3P70    3S9C   
Structural Biology KnowledgeBase1CZS    1CZT    1CZV    1FV4    1Y61    3P6Z    3P70    3S9C   
SCOP (Structural Classification of Proteins)1CZS    1CZT    1CZV    1FV4    1Y61    3P6Z    3P70    3S9C   
CATH (Classification of proteins structures)1CZS    1CZT    1CZV    1FV4    1Y61    3P6Z    3P70    3S9C   
Peptide AtlasP12259
HPRD01964
IPIIPI00478809   IPI01015326   IPI00953390   IPI00815941   IPI00022937   
Protein Interaction databases
DIP (DOE-UCLA)P12259
IntAct (EBI)P12259
BioGRIDF5
IntegromeDBF5
STRING (EMBL)F5
ZODIACF5
Ontologies - Pathways
QuickGOP12259
Ontology : AmiGOGolgi membrane  platelet degranulation  copper ion binding  protein binding  extracellular region  extracellular region  extracellular space  endoplasmic reticulum lumen  plasma membrane  ER to Golgi vesicle-mediated transport  blood coagulation  blood circulation  membrane  protein N-linked glycosylation via asparagine  ER to Golgi transport vesicle  platelet activation  platelet alpha granule lumen  endoplasmic reticulum-Golgi intermediate compartment membrane  post-translational protein modification  cellular protein metabolic process  COPII vesicle coating  membrane organization  extracellular vesicle  
Ontology : EGO-EBIGolgi membrane  platelet degranulation  copper ion binding  protein binding  extracellular region  extracellular region  extracellular space  endoplasmic reticulum lumen  plasma membrane  ER to Golgi vesicle-mediated transport  blood coagulation  blood circulation  membrane  protein N-linked glycosylation via asparagine  ER to Golgi transport vesicle  platelet activation  platelet alpha granule lumen  endoplasmic reticulum-Golgi intermediate compartment membrane  post-translational protein modification  cellular protein metabolic process  COPII vesicle coating  membrane organization  extracellular vesicle  
Pathways : BIOCARTAIntrinsic Prothrombin Activation Pathway [Genes]    Extrinsic Prothrombin Activation Pathway [Genes]   
Pathways : KEGGComplement and coagulation cascades   
Protein Interaction DatabaseF5
Atlas of Cancer Signalling NetworkF5
Wikipedia pathwaysF5
Orthology - Evolution
OrthoDB2153
Phylogenetic Trees/Animal Genes : TreeFamF5
Homologs : HomoloGeneF5
Homology/Alignments : Family Browser (UCSC)F5
Gene fusions - Rearrangements
Fusion: TCGAARNT 1q21.3 F5 1q24.2 LUAD
Fusion: TCGANOS1AP 1q23.3 F5 1q24.2 LUAD
Fusion: TCGASRF 6p21.1 F5 1q24.2 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerF5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)F5
dbVarF5
ClinVarF5
1000_GenomesF5 
Exome Variant ServerF5
SNP (GeneSNP Utah)F5
SNP : HGBaseF5
Genetic variants : HAPMAPF5
Genomic Variants (DGV)F5 [DGVbeta]
Mutations
ICGC Data PortalF5 
TCGA Data PortalF5 
Tumor PortalF5
TCGA Copy Number PortalF5
Somatic Mutations in Cancer : COSMICF5 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch F5
DgiDB (Drug Gene Interaction Database)F5
DoCM (Curated mutations)F5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)F5 (select a term)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:169481192-169555769
CONAN: Copy Number AnalysisF5 
Mutations and Diseases : HGMDF5
OMIM188055    227400    600880    601367    612309    614389   
MedgenF5
NextProtP12259 [Medical]
TSGene2153
GENETestsF5
Huge Navigator F5 [HugePedia]  F5 [HugeCancerGEM]
snp3D : Map Gene to Disease2153
BioCentury BCIQF5
General knowledge
Chemical/Protein Interactions : CTD2153
Chemical/Pharm GKB GenePA159
Clinical trialF5
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineF5
GoPubMedF5
iHOPF5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jan 16 18:35:50 CET 2016

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