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F7 (coagulation factor VII (serum prothrombin conversion accelerator))

Identity

Other namesSPCA
HGNC (Hugo) F7
LocusID (NCBI) 2155
Location 13q34
Location_base_pair Starts at 113760102 and ends at 113774995 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)F7   3544
Cards
Entrez_Gene (NCBI)F7  2155  coagulation factor VII (serum prothrombin conversion accelerator)
GeneCards (Weizmann)F7
Ensembl (Hinxton)ENSG00000057593 [Gene_View]  chr13:113760102-113774995 [Contig_View]  F7 [Vega]
ICGC DataPortalENSG00000057593
cBioPortalF7
AceView (NCBI)F7
Genatlas (Paris)F7
WikiGenes2155
SOURCE (Princeton)NM_000131 NM_001267554 NM_019616
Genomic and cartography
GoldenPath (UCSC)F7  -  13q34   chr13:113760102-113774995 +  13q34   [Description]    (hg19-Feb_2009)
EnsemblF7 - 13q34 [CytoView]
Mapping of homologs : NCBIF7 [Mapview]
OMIM227500   608446   613878   
Gene and transcription
Genbank (Entrez)AI076552 AK298404 AK310779 AK311565 AK311682
RefSeq transcript (Entrez)NM_000131 NM_001267554 NM_019616
RefSeq genomic (Entrez)AC_000145 NC_000013 NC_018924 NG_009262 NT_027140 NW_001838085 NW_004929390
Consensus coding sequences : CCDS (NCBI)F7
Cluster EST : UnigeneHs.36989 [ NCBI ]
CGAP (NCI)Hs.36989
Alternative Splicing : Fast-db (Paris)GSHG0008310
Alternative Splicing GalleryENSG00000057593
Gene ExpressionF7 [ NCBI-GEO ]     F7 [ SEEK ]   F7 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08709 (Uniprot)
NextProtP08709  [Medical]
With graphics : InterProP08709
Splice isoforms : SwissVarP08709 (Swissvar)
Catalytic activity : Enzyme3.4.21.21 [ Enzyme-Expasy ]   3.4.21.213.4.21.21 [ IntEnz-EBI ]   3.4.21.21 [ BRENDA ]   3.4.21.21 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    GLA_1 (PS00011)    GLA_2 (PS50998)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Coagulation_fac_subgr_Gla_dom [organisation]   EG-like_dom [organisation]   EGF-like_Ca-bd_dom [organisation]   EGF-like_CS [organisation]   EGF-type_Asp/Asn_hydroxyl_site [organisation]   EGF_Ca-bd_CS [organisation]   GLA_domain [organisation]   Pept_S1A_FX [organisation]   Peptidase_S1 [organisation]   Peptidase_S1_AS [organisation]   Peptidase_S1A [organisation]   Trypsin-like_Pept_dom [organisation]  
Related proteins : CluSTrP08709
Domain families : Pfam (Sanger)EGF (PF00008)    Gla (PF00594)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00008    pfam00594    pfam00089   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  GLA (SM00069)  Tryp_SPc (SM00020)  
DMDM Disease mutations2155
Blocks (Seattle)P08709
PDB (SRS)1BF9    1CVW    1DAN    1DVA    1F7E    1F7M    1FAK    1FF7    1FFM    1J9C    1JBU    1KLI    1KLJ    1NL8    1O5D    1QFK    1W0Y    1W2K    1W7X    1W8B    1WQV    1WSS    1WTG    1WUN    1WV7    1YGC    1Z6J    2A2Q    2AEI    2AER    2B7D    2B8O    2BZ6    2C4F    2EC9    2F9B    2FIR    2FLB    2FLR    2PUQ    2ZP0    2ZWL    2ZZU    3ELA    3TH2    3TH3    3TH4    4ISH    4ISI   
PDB (PDBSum)1BF9    1CVW    1DAN    1DVA    1F7E    1F7M    1FAK    1FF7    1FFM    1J9C    1JBU    1KLI    1KLJ    1NL8    1O5D    1QFK    1W0Y    1W2K    1W7X    1W8B    1WQV    1WSS    1WTG    1WUN    1WV7    1YGC    1Z6J    2A2Q    2AEI    2AER    2B7D    2B8O    2BZ6    2C4F    2EC9    2F9B    2FIR    2FLB    2FLR    2PUQ    2ZP0    2ZWL    2ZZU    3ELA    3TH2    3TH3    3TH4    4ISH    4ISI   
PDB (IMB)1BF9    1CVW    1DAN    1DVA    1F7E    1F7M    1FAK    1FF7    1FFM    1J9C    1JBU    1KLI    1KLJ    1NL8    1O5D    1QFK    1W0Y    1W2K    1W7X    1W8B    1WQV    1WSS    1WTG    1WUN    1WV7    1YGC    1Z6J    2A2Q    2AEI    2AER    2B7D    2B8O    2BZ6    2C4F    2EC9    2F9B    2FIR    2FLB    2FLR    2PUQ    2ZP0    2ZWL    2ZZU    3ELA    3TH2    3TH3    3TH4    4ISH    4ISI   
PDB (RSDB)1BF9    1CVW    1DAN    1DVA    1F7E    1F7M    1FAK    1FF7    1FFM    1J9C    1JBU    1KLI    1KLJ    1NL8    1O5D    1QFK    1W0Y    1W2K    1W7X    1W8B    1WQV    1WSS    1WTG    1WUN    1WV7    1YGC    1Z6J    2A2Q    2AEI    2AER    2B7D    2B8O    2BZ6    2C4F    2EC9    2F9B    2FIR    2FLB    2FLR    2PUQ    2ZP0    2ZWL    2ZZU    3ELA    3TH2    3TH3    3TH4    4ISH    4ISI   
Human Protein AtlasENSG00000057593 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP08709
HPRD01965
IPIIPI00329555   IPI00798065   IPI00893182   
Protein Interaction databases
DIP (DOE-UCLA)P08709
IntAct (EBI)P08709
FunCoupENSG00000057593
BioGRIDF7
InParanoidP08709
Interologous Interaction database P08709
IntegromeDBF7
STRING (EMBL)F7
Ontologies - Pathways
Ontology : AmiGOglycoprotein binding  positive regulation of leukocyte chemotaxis  serine-type endopeptidase activity  receptor binding  calcium ion binding  extracellular region  extracellular space  endoplasmic reticulum lumen  Golgi lumen  plasma membrane  proteolysis  blood coagulation  blood coagulation, extrinsic pathway  circadian rhythm  serine-type peptidase activity  positive regulation of platelet-derived growth factor receptor signaling pathway  peptidyl-glutamic acid carboxylation  positive regulation of blood coagulation  positive regulation of cell migration  organ regeneration  vesicle  response to vitamin K  response to estrogen  post-translational protein modification  cellular protein metabolic process  positive regulation of positive chemotaxis  positive regulation of protein kinase B signaling cascade  response to growth hormone  
Ontology : EGO-EBIglycoprotein binding  positive regulation of leukocyte chemotaxis  serine-type endopeptidase activity  receptor binding  calcium ion binding  extracellular region  extracellular space  endoplasmic reticulum lumen  Golgi lumen  plasma membrane  proteolysis  blood coagulation  blood coagulation, extrinsic pathway  circadian rhythm  serine-type peptidase activity  positive regulation of platelet-derived growth factor receptor signaling pathway  peptidyl-glutamic acid carboxylation  positive regulation of blood coagulation  positive regulation of cell migration  organ regeneration  vesicle  response to vitamin K  response to estrogen  post-translational protein modification  cellular protein metabolic process  positive regulation of positive chemotaxis  positive regulation of protein kinase B signaling cascade  response to growth hormone  
Pathways : BIOCARTAExtrinsic Prothrombin Activation Pathway [Genes]    Acute Myocardial Infarction [Genes]   
Pathways : KEGGComplement and coagulation cascades   
Protein Interaction DatabaseF7
Wikipedia pathwaysF7
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)F7
snp3D : Map Gene to Disease2155
SNP (GeneSNP Utah)F7
SNP : HGBaseF7
Genetic variants : HAPMAPF7
Exome VariantF7
1000_GenomesF7 
ICGC programENSG00000057593 
Somatic Mutations in Cancer : COSMICF7 
CONAN: Copy Number AnalysisF7 
Mutations and Diseases : HGMDF7
Genomic VariantsF7  F7 [DGVbeta]
dbVarF7
ClinVarF7
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM227500    608446    613878   
MedgenF7
GENETestsF7
Disease Genetic AssociationF7
Huge Navigator F7 [HugePedia]  F7 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneF7
Homology/Alignments : Family Browser (UCSC)F7
Phylogenetic Trees/Animal Genes : TreeFamF7
Chemical/Protein Interactions : CTD2155
Chemical/Pharm GKB GenePA160
Clinical trialF7
Cancer Resource (Charite)ENSG00000057593
Other databases
Probes
Litterature
PubMed385 Pubmed reference(s) in Entrez
CoreMineF7
iHOPF7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jul 11 16:54:54 CEST 2014

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