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F7 (coagulation factor VII)

Identity

Alias_namescoagulation factor VII (serum prothrombin conversion accelerator)
Other aliasSPCA
HGNC (Hugo) F7
LocusID (NCBI) 2155
Atlas_Id 46526
Location 13q34  [Link to chromosome band 13q34]
Location_base_pair Starts at 113105788 and ends at 113120681 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)F7   3544
LRG (Locus Reference Genomic)LRG_554
Cards
Entrez_Gene (NCBI)F7  2155  coagulation factor VII
AliasesSPCA
GeneCards (Weizmann)F7
Ensembl hg19 (Hinxton)ENSG00000057593 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000057593 [Gene_View]  ENSG00000057593 [Sequence]  chr13:113105788-113120681 [Contig_View]  F7 [Vega]
ICGC DataPortalENSG00000057593
TCGA cBioPortalF7
AceView (NCBI)F7
Genatlas (Paris)F7
WikiGenes2155
SOURCE (Princeton)F7
Genetics Home Reference (NIH)F7
Genomic and cartography
GoldenPath hg38 (UCSC)F7  -     chr13:113105788-113120681 +  13q34   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)F7  -     13q34   [Description]    (hg19-Feb_2009)
EnsemblF7 - 13q34 [CytoView hg19]  F7 - 13q34 [CytoView hg38]
Mapping of homologs : NCBIF7 [Mapview hg19]  F7 [Mapview hg38]
OMIM227500   608446   613878   
Gene and transcription
Genbank (Entrez)AI076552 AK298404 AK310779 AK311565 AK311682
RefSeq transcript (Entrez)NM_000131 NM_001267554 NM_019616
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)F7
Cluster EST : UnigeneHs.36989 [ NCBI ]
CGAP (NCI)Hs.36989
Alternative Splicing GalleryENSG00000057593
Gene ExpressionF7 [ NCBI-GEO ]   F7 [ EBI - ARRAY_EXPRESS ]   F7 [ SEEK ]   F7 [ MEM ]
Gene Expression Viewer (FireBrowse)F7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2155
GTEX Portal (Tissue expression)F7
Human Protein AtlasENSG00000057593-F7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08709   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08709  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08709
Splice isoforms : SwissVarP08709
Catalytic activity : Enzyme3.4.21.21 [ Enzyme-Expasy ]   3.4.21.213.4.21.21 [ IntEnz-EBI ]   3.4.21.21 [ BRENDA ]   3.4.21.21 [ KEGG ]   
PhosPhoSitePlusP08709
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    GLA_1 (PS00011)    GLA_2 (PS50998)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Coagulation_fac-like_Gla_dom    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    F7    GLA-like_dom_SF    GLA_domain    Pept_S1A_FX    Peptidase_S1_PA    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)EGF (PF00008)    Gla (PF00594)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00008    pfam00594    pfam00089   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  GLA (SM00069)  Tryp_SPc (SM00020)  
Conserved Domain (NCBI)F7
DMDM Disease mutations2155
Blocks (Seattle)F7
PDB (SRS)1BF9    1CVW    1DAN    1DVA    1F7E    1F7M    1FAK    1FF7    1FFM    1J9C    1JBU    1KLI    1KLJ    1NL8    1O5D    1QFK    1W0Y    1W2K    1W7X    1W8B    1WQV    1WSS    1WTG    1WUN    1WV7    1YGC    1Z6J    2A2Q    2AEI    2AER    2B7D    2B8O    2BZ6    2C4F    2EC9    2F9B    2FIR    2FLB    2FLR    2PUQ    2ZP0    2ZWL    2ZZU    3ELA    3TH2    3TH3    3TH4    4IBL    4ISH    4ISI    4JYU    4JYV    4JZD    4JZE    4JZF    4NA9    4NG9    4NGA    4X8S    4X8T    4X8U    4X8V    4YLQ    4YT6    4YT7    4Z6A    4ZMA    4ZXX    4ZXY    5I46    5L0S    5L2Y    5L2Z    5L30    5PA8    5PA9    5PAA    5PAB    5PAC    5PAE    5PAF    5PAG    5PAI    5PAJ    5PAK    5PAM    5PAN    5PAO    5PAQ    5PAR    5PAS    5PAT    5PAU    5PAV    5PAW    5PAX    5PAY    5PB0    5PB1    5PB2    5PB3    5PB4    5PB5    5PB6    5TQE    5TQF    5TQG    5U6J   
PDB (PDBSum)1BF9    1CVW    1DAN    1DVA    1F7E    1F7M    1FAK    1FF7    1FFM    1J9C    1JBU    1KLI    1KLJ    1NL8    1O5D    1QFK    1W0Y    1W2K    1W7X    1W8B    1WQV    1WSS    1WTG    1WUN    1WV7    1YGC    1Z6J    2A2Q    2AEI    2AER    2B7D    2B8O    2BZ6    2C4F    2EC9    2F9B    2FIR    2FLB    2FLR    2PUQ    2ZP0    2ZWL    2ZZU    3ELA    3TH2    3TH3    3TH4    4IBL    4ISH    4ISI    4JYU    4JYV    4JZD    4JZE    4JZF    4NA9    4NG9    4NGA    4X8S    4X8T    4X8U    4X8V    4YLQ    4YT6    4YT7    4Z6A    4ZMA    4ZXX    4ZXY    5I46    5L0S    5L2Y    5L2Z    5L30    5PA8    5PA9    5PAA    5PAB    5PAC    5PAE    5PAF    5PAG    5PAI    5PAJ    5PAK    5PAM    5PAN    5PAO    5PAQ    5PAR    5PAS    5PAT    5PAU    5PAV    5PAW    5PAX    5PAY    5PB0    5PB1    5PB2    5PB3    5PB4    5PB5    5PB6    5TQE    5TQF    5TQG    5U6J   
PDB (IMB)1BF9    1CVW    1DAN    1DVA    1F7E    1F7M    1FAK    1FF7    1FFM    1J9C    1JBU    1KLI    1KLJ    1NL8    1O5D    1QFK    1W0Y    1W2K    1W7X    1W8B    1WQV    1WSS    1WTG    1WUN    1WV7    1YGC    1Z6J    2A2Q    2AEI    2AER    2B7D    2B8O    2BZ6    2C4F    2EC9    2F9B    2FIR    2FLB    2FLR    2PUQ    2ZP0    2ZWL    2ZZU    3ELA    3TH2    3TH3    3TH4    4IBL    4ISH    4ISI    4JYU    4JYV    4JZD    4JZE    4JZF    4NA9    4NG9    4NGA    4X8S    4X8T    4X8U    4X8V    4YLQ    4YT6    4YT7    4Z6A    4ZMA    4ZXX    4ZXY    5I46    5L0S    5L2Y    5L2Z    5L30    5PA8    5PA9    5PAA    5PAB    5PAC    5PAE    5PAF    5PAG    5PAI    5PAJ    5PAK    5PAM    5PAN    5PAO    5PAQ    5PAR    5PAS    5PAT    5PAU    5PAV    5PAW    5PAX    5PAY    5PB0    5PB1    5PB2    5PB3    5PB4    5PB5    5PB6    5TQE    5TQF    5TQG    5U6J   
PDB (RSDB)1BF9    1CVW    1DAN    1DVA    1F7E    1F7M    1FAK    1FF7    1FFM    1J9C    1JBU    1KLI    1KLJ    1NL8    1O5D    1QFK    1W0Y    1W2K    1W7X    1W8B    1WQV    1WSS    1WTG    1WUN    1WV7    1YGC    1Z6J    2A2Q    2AEI    2AER    2B7D    2B8O    2BZ6    2C4F    2EC9    2F9B    2FIR    2FLB    2FLR    2PUQ    2ZP0    2ZWL    2ZZU    3ELA    3TH2    3TH3    3TH4    4IBL    4ISH    4ISI    4JYU    4JYV    4JZD    4JZE    4JZF    4NA9    4NG9    4NGA    4X8S    4X8T    4X8U    4X8V    4YLQ    4YT6    4YT7    4Z6A    4ZMA    4ZXX    4ZXY    5I46    5L0S    5L2Y    5L2Z    5L30    5PA8    5PA9    5PAA    5PAB    5PAC    5PAE    5PAF    5PAG    5PAI    5PAJ    5PAK    5PAM    5PAN    5PAO    5PAQ    5PAR    5PAS    5PAT    5PAU    5PAV    5PAW    5PAX    5PAY    5PB0    5PB1    5PB2    5PB3    5PB4    5PB5    5PB6    5TQE    5TQF    5TQG    5U6J   
Structural Biology KnowledgeBase1BF9    1CVW    1DAN    1DVA    1F7E    1F7M    1FAK    1FF7    1FFM    1J9C    1JBU    1KLI    1KLJ    1NL8    1O5D    1QFK    1W0Y    1W2K    1W7X    1W8B    1WQV    1WSS    1WTG    1WUN    1WV7    1YGC    1Z6J    2A2Q    2AEI    2AER    2B7D    2B8O    2BZ6    2C4F    2EC9    2F9B    2FIR    2FLB    2FLR    2PUQ    2ZP0    2ZWL    2ZZU    3ELA    3TH2    3TH3    3TH4    4IBL    4ISH    4ISI    4JYU    4JYV    4JZD    4JZE    4JZF    4NA9    4NG9    4NGA    4X8S    4X8T    4X8U    4X8V    4YLQ    4YT6    4YT7    4Z6A    4ZMA    4ZXX    4ZXY    5I46    5L0S    5L2Y    5L2Z    5L30    5PA8    5PA9    5PAA    5PAB    5PAC    5PAE    5PAF    5PAG    5PAI    5PAJ    5PAK    5PAM    5PAN    5PAO    5PAQ    5PAR    5PAS    5PAT    5PAU    5PAV    5PAW    5PAX    5PAY    5PB0    5PB1    5PB2    5PB3    5PB4    5PB5    5PB6    5TQE    5TQF    5TQG    5U6J   
SCOP (Structural Classification of Proteins)1BF9    1CVW    1DAN    1DVA    1F7E    1F7M    1FAK    1FF7    1FFM    1J9C    1JBU    1KLI    1KLJ    1NL8    1O5D    1QFK    1W0Y    1W2K    1W7X    1W8B    1WQV    1WSS    1WTG    1WUN    1WV7    1YGC    1Z6J    2A2Q    2AEI    2AER    2B7D    2B8O    2BZ6    2C4F    2EC9    2F9B    2FIR    2FLB    2FLR    2PUQ    2ZP0    2ZWL    2ZZU    3ELA    3TH2    3TH3    3TH4    4IBL    4ISH    4ISI    4JYU    4JYV    4JZD    4JZE    4JZF    4NA9    4NG9    4NGA    4X8S    4X8T    4X8U    4X8V    4YLQ    4YT6    4YT7    4Z6A    4ZMA    4ZXX    4ZXY    5I46    5L0S    5L2Y    5L2Z    5L30    5PA8    5PA9    5PAA    5PAB    5PAC    5PAE    5PAF    5PAG    5PAI    5PAJ    5PAK    5PAM    5PAN    5PAO    5PAQ    5PAR    5PAS    5PAT    5PAU    5PAV    5PAW    5PAX    5PAY    5PB0    5PB1    5PB2    5PB3    5PB4    5PB5    5PB6    5TQE    5TQF    5TQG    5U6J   
CATH (Classification of proteins structures)1BF9    1CVW    1DAN    1DVA    1F7E    1F7M    1FAK    1FF7    1FFM    1J9C    1JBU    1KLI    1KLJ    1NL8    1O5D    1QFK    1W0Y    1W2K    1W7X    1W8B    1WQV    1WSS    1WTG    1WUN    1WV7    1YGC    1Z6J    2A2Q    2AEI    2AER    2B7D    2B8O    2BZ6    2C4F    2EC9    2F9B    2FIR    2FLB    2FLR    2PUQ    2ZP0    2ZWL    2ZZU    3ELA    3TH2    3TH3    3TH4    4IBL    4ISH    4ISI    4JYU    4JYV    4JZD    4JZE    4JZF    4NA9    4NG9    4NGA    4X8S    4X8T    4X8U    4X8V    4YLQ    4YT6    4YT7    4Z6A    4ZMA    4ZXX    4ZXY    5I46    5L0S    5L2Y    5L2Z    5L30    5PA8    5PA9    5PAA    5PAB    5PAC    5PAE    5PAF    5PAG    5PAI    5PAJ    5PAK    5PAM    5PAN    5PAO    5PAQ    5PAR    5PAS    5PAT    5PAU    5PAV    5PAW    5PAX    5PAY    5PB0    5PB1    5PB2    5PB3    5PB4    5PB5    5PB6    5TQE    5TQF    5TQG    5U6J   
SuperfamilyP08709
Human Protein Atlas [tissue]ENSG00000057593-F7 [tissue]
Peptide AtlasP08709
HPRD01965
IPIIPI00329555   IPI00798065   IPI00893182   
Protein Interaction databases
DIP (DOE-UCLA)P08709
IntAct (EBI)P08709
FunCoupENSG00000057593
BioGRIDF7
STRING (EMBL)F7
ZODIACF7
Ontologies - Pathways
QuickGOP08709
Ontology : AmiGOresponse to hypoxia  positive regulation of leukocyte chemotaxis  positive regulation of leukocyte chemotaxis  serine-type endopeptidase activity  signaling receptor binding  calcium ion binding  protein binding  extracellular region  extracellular space  extracellular space  endoplasmic reticulum lumen  Golgi lumen  plasma membrane  ER to Golgi vesicle-mediated transport  blood coagulation  blood coagulation  blood coagulation, extrinsic pathway  circadian rhythm  serine-type peptidase activity  response to carbon dioxide  positive regulation of platelet-derived growth factor receptor signaling pathway  protein processing  positive regulation of blood coagulation  positive regulation of cell migration  animal organ regeneration  vesicle  response to estradiol  response to vitamin K  response to genistein  response to estrogen  positive regulation of positive chemotaxis  positive regulation of protein kinase B signaling  response to growth hormone  response to cholesterol  response to thyroxine  response to Thyroid stimulating hormone  response to 2,3,7,8-tetrachlorodibenzodioxine  response to astaxanthin  response to thyrotropin-releasing hormone  serine-type peptidase complex  
Ontology : EGO-EBIresponse to hypoxia  positive regulation of leukocyte chemotaxis  positive regulation of leukocyte chemotaxis  serine-type endopeptidase activity  signaling receptor binding  calcium ion binding  protein binding  extracellular region  extracellular space  extracellular space  endoplasmic reticulum lumen  Golgi lumen  plasma membrane  ER to Golgi vesicle-mediated transport  blood coagulation  blood coagulation  blood coagulation, extrinsic pathway  circadian rhythm  serine-type peptidase activity  response to carbon dioxide  positive regulation of platelet-derived growth factor receptor signaling pathway  protein processing  positive regulation of blood coagulation  positive regulation of cell migration  animal organ regeneration  vesicle  response to estradiol  response to vitamin K  response to genistein  response to estrogen  positive regulation of positive chemotaxis  positive regulation of protein kinase B signaling  response to growth hormone  response to cholesterol  response to thyroxine  response to Thyroid stimulating hormone  response to 2,3,7,8-tetrachlorodibenzodioxine  response to astaxanthin  response to thyrotropin-releasing hormone  serine-type peptidase complex  
Pathways : KEGGComplement and coagulation cascades   
NDEx NetworkF7
Atlas of Cancer Signalling NetworkF7
Wikipedia pathwaysF7
Orthology - Evolution
OrthoDB2155
GeneTree (enSembl)ENSG00000057593
Phylogenetic Trees/Animal Genes : TreeFamF7
HOVERGENP08709
HOGENOMP08709
Homologs : HomoloGeneF7
Homology/Alignments : Family Browser (UCSC)F7
Gene fusions - Rearrangements
Fusion : QuiverF7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerF7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)F7
dbVarF7
ClinVarF7
1000_GenomesF7 
Exome Variant ServerF7
ExAC (Exome Aggregation Consortium)ENSG00000057593
GNOMAD BrowserENSG00000057593
Varsome BrowserF7
Genetic variants : HAPMAP2155
Genomic Variants (DGV)F7 [DGVbeta]
DECIPHERF7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisF7 
Mutations
ICGC Data PortalF7 
TCGA Data PortalF7 
Broad Tumor PortalF7
OASIS PortalF7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICF7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDF7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch F7
DgiDB (Drug Gene Interaction Database)F7
DoCM (Curated mutations)F7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)F7 (select a term)
intoGenF7
Cancer3DF7(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM227500    608446    613878   
Orphanet916   
DisGeNETF7
MedgenF7
Genetic Testing Registry F7
NextProtP08709 [Medical]
TSGene2155
GENETestsF7
Target ValidationF7
Huge Navigator F7 [HugePedia]
snp3D : Map Gene to Disease2155
BioCentury BCIQF7
ClinGenF7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2155
Chemical/Pharm GKB GenePA160
Clinical trialF7
Miscellaneous
canSAR (ICR)F7 (select the gene name)
Probes
Litterature
PubMed442 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineF7
EVEXF7
GoPubMedF7
iHOPF7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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