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F9 (coagulation factor IX)

Identity

Alias (NCBI)F9 p22
FIX
HEMB
P19
PTC
THPH8
HGNC (Hugo) F9
HGNC Alias symbFIX
HGNC Alias nameFactor IX
 plasma thromboplastic component
 Christmas disease
 hemophilia B
LocusID (NCBI) 2158
Atlas_Id 56350
Location Xq27.1  [Link to chromosome band Xq27]
Location_base_pair Starts at 139530736 and ends at 139563458 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)F9   3551
LRG (Locus Reference Genomic)LRG_556
Cards
Entrez_Gene (NCBI)F9    coagulation factor IX
AliasesF9; FIX; HEMB; P19; 
PTC; THPH8
GeneCards (Weizmann)F9
Ensembl hg19 (Hinxton)ENSG00000101981 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101981 [Gene_View]  ENSG00000101981 [Sequence]  chrX:139530736-139563458 [Contig_View]  F9 [Vega]
ICGC DataPortalENSG00000101981
TCGA cBioPortalF9
AceView (NCBI)F9
Genatlas (Paris)F9
SOURCE (Princeton)F9
Genetics Home Reference (NIH)F9
Genomic and cartography
GoldenPath hg38 (UCSC)F9  -     chrX:139530736-139563458 +  Xq27.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)F9  -     Xq27.1   [Description]    (hg19-Feb_2009)
GoldenPathF9 - Xq27.1 [CytoView hg19]  F9 - Xq27.1 [CytoView hg38]
ImmunoBaseENSG00000101981
Genome Data Viewer NCBIF9 [Mapview hg19]  
OMIM300746   300807   301052   306900   
Gene and transcription
Genbank (Entrez)A13997 AB186358 AK292749 BC109214 BC109215
RefSeq transcript (Entrez)NM_000133 NM_001313913
Consensus coding sequences : CCDS (NCBI)F9
Gene ExpressionF9 [ NCBI-GEO ]   F9 [ EBI - ARRAY_EXPRESS ]   F9 [ SEEK ]   F9 [ MEM ]
Gene Expression Viewer (FireBrowse)F9 [ Firebrowse - Broad ]
GenevisibleExpression of F9 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2158
GTEX Portal (Tissue expression)F9
Human Protein AtlasENSG00000101981-F9 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP00740   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP00740  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP00740
PhosPhoSitePlusP00740
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    GLA_1 (PS00011)    GLA_2 (PS50998)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Coagulation_fac-like_Gla_dom    Coagulation_factor_IX    EGF-like_Ca-bd_dom    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    GLA-like_dom_SF    GLA_domain    Pept_S1A_FX    Peptidase_S1_PA    Peptidase_S1_PA_chymotrypsin    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)EGF (PF00008)    Gla (PF00594)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00008    pfam00594    pfam00089   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  GLA (SM00069)  Tryp_SPc (SM00020)  
Conserved Domain (NCBI)F9
PDB (RSDB)1CFH    1CFI    1EDM    1IXA    1MGX    1NL0    1RFN    2WPH    2WPI    2WPJ    2WPK    2WPL    2WPM    3KCG    3LC3    3LC5    4WM0    4WMA    4WMB    4WMI    4WMK    4WN2    4WNH    4YZU    4Z0K    4ZAE    5EGM    5F84    5F85    5F86    5JB8    5JB9    5JBA    5JBB    5JBC    5TNO    5TNT    5VYG    6MV4    6RFK    6X5J    6X5L    6X5P   
PDB Europe1CFH    1CFI    1EDM    1IXA    1MGX    1NL0    1RFN    2WPH    2WPI    2WPJ    2WPK    2WPL    2WPM    3KCG    3LC3    3LC5    4WM0    4WMA    4WMB    4WMI    4WMK    4WN2    4WNH    4YZU    4Z0K    4ZAE    5EGM    5F84    5F85    5F86    5JB8    5JB9    5JBA    5JBB    5JBC    5TNO    5TNT    5VYG    6MV4    6RFK    6X5J    6X5L    6X5P   
PDB (PDBSum)1CFH    1CFI    1EDM    1IXA    1MGX    1NL0    1RFN    2WPH    2WPI    2WPJ    2WPK    2WPL    2WPM    3KCG    3LC3    3LC5    4WM0    4WMA    4WMB    4WMI    4WMK    4WN2    4WNH    4YZU    4Z0K    4ZAE    5EGM    5F84    5F85    5F86    5JB8    5JB9    5JBA    5JBB    5JBC    5TNO    5TNT    5VYG    6MV4    6RFK    6X5J    6X5L    6X5P   
PDB (IMB)1CFH    1CFI    1EDM    1IXA    1MGX    1NL0    1RFN    2WPH    2WPI    2WPJ    2WPK    2WPL    2WPM    3KCG    3LC3    3LC5    4WM0    4WMA    4WMB    4WMI    4WMK    4WN2    4WNH    4YZU    4Z0K    4ZAE    5EGM    5F84    5F85    5F86    5JB8    5JB9    5JBA    5JBB    5JBC    5TNO    5TNT    5VYG    6MV4    6RFK    6X5J    6X5L    6X5P   
Structural Biology KnowledgeBase1CFH    1CFI    1EDM    1IXA    1MGX    1NL0    1RFN    2WPH    2WPI    2WPJ    2WPK    2WPL    2WPM    3KCG    3LC3    3LC5    4WM0    4WMA    4WMB    4WMI    4WMK    4WN2    4WNH    4YZU    4Z0K    4ZAE    5EGM    5F84    5F85    5F86    5JB8    5JB9    5JBA    5JBB    5JBC    5TNO    5TNT    5VYG    6MV4    6RFK    6X5J    6X5L    6X5P   
SCOP (Structural Classification of Proteins)1CFH    1CFI    1EDM    1IXA    1MGX    1NL0    1RFN    2WPH    2WPI    2WPJ    2WPK    2WPL    2WPM    3KCG    3LC3    3LC5    4WM0    4WMA    4WMB    4WMI    4WMK    4WN2    4WNH    4YZU    4Z0K    4ZAE    5EGM    5F84    5F85    5F86    5JB8    5JB9    5JBA    5JBB    5JBC    5TNO    5TNT    5VYG    6MV4    6RFK    6X5J    6X5L    6X5P   
CATH (Classification of proteins structures)1CFH    1CFI    1EDM    1IXA    1MGX    1NL0    1RFN    2WPH    2WPI    2WPJ    2WPK    2WPL    2WPM    3KCG    3LC3    3LC5    4WM0    4WMA    4WMB    4WMI    4WMK    4WN2    4WNH    4YZU    4Z0K    4ZAE    5EGM    5F84    5F85    5F86    5JB8    5JB9    5JBA    5JBB    5JBC    5TNO    5TNT    5VYG    6MV4    6RFK    6X5J    6X5L    6X5P   
SuperfamilyP00740
AlphaFold pdb e-kbP00740   
Human Protein Atlas [tissue]ENSG00000101981-F9 [tissue]
HPRD02385
Protein Interaction databases
DIP (DOE-UCLA)P00740
IntAct (EBI)P00740
BioGRIDF9
STRING (EMBL)F9
ZODIACF9
Ontologies - Pathways
QuickGOP00740
Ontology : AmiGOendopeptidase activity  serine-type endopeptidase activity  calcium ion binding  protein binding  extracellular region  extracellular region  extracellular space  extracellular space  endoplasmic reticulum lumen  Golgi lumen  plasma membrane  proteolysis  endoplasmic reticulum to Golgi vesicle-mediated transport  blood coagulation  blood coagulation  blood coagulation  blood coagulation, intrinsic pathway  zymogen activation  zymogen activation  collagen-containing extracellular matrix  extracellular exosome  
Ontology : EGO-EBIendopeptidase activity  serine-type endopeptidase activity  calcium ion binding  protein binding  extracellular region  extracellular region  extracellular space  extracellular space  endoplasmic reticulum lumen  Golgi lumen  plasma membrane  proteolysis  endoplasmic reticulum to Golgi vesicle-mediated transport  blood coagulation  blood coagulation  blood coagulation  blood coagulation, intrinsic pathway  zymogen activation  zymogen activation  collagen-containing extracellular matrix  extracellular exosome  
Pathways : BIOCARTAIntrinsic Prothrombin Activation Pathway [Genes]    Platelet Amyloid Precursor Protein Pathway [Genes]   
Pathways : KEGGComplement and coagulation cascades   
NDEx NetworkF9
Atlas of Cancer Signalling NetworkF9
Wikipedia pathwaysF9
Orthology - Evolution
OrthoDB2158
GeneTree (enSembl)ENSG00000101981
Phylogenetic Trees/Animal Genes : TreeFamF9
Homologs : HomoloGeneF9
Homology/Alignments : Family Browser (UCSC)F9
Gene fusions - Rearrangements
Fusion : QuiverF9
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerF9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)F9
dbVarF9
ClinVarF9
MonarchF9
1000_GenomesF9 
Exome Variant ServerF9
GNOMAD BrowserENSG00000101981
Varsome BrowserF9
ACMGF9 variants
VarityP00740
Genomic Variants (DGV)F9 [DGVbeta]
DECIPHERF9 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisF9 
Mutations
ICGC Data PortalF9 
TCGA Data PortalF9 
Broad Tumor PortalF9
OASIS PortalF9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICF9  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DF9
Mutations and Diseases : HGMDF9
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaF9
DgiDB (Drug Gene Interaction Database)F9
DoCM (Curated mutations)F9
CIViC (Clinical Interpretations of Variants in Cancer)F9
Cancer3DF9
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300746    300807    301052    306900   
Orphanet17871    17870    17869    17997   
DisGeNETF9
MedgenF9
Genetic Testing Registry F9
NextProtP00740 [Medical]
GENETestsF9
Target ValidationF9
Huge Navigator F9 [HugePedia]
ClinGenF9
Clinical trials, drugs, therapy
MyCancerGenomeF9
Protein Interactions : CTDF9
Pharm GKB GenePA27954
Pharm GKB PathwaysPA145011114   
PharosP00740
Clinical trialF9
Miscellaneous
canSAR (ICR)F9
HarmonizomeF9
DataMed IndexF9
Probes
Litterature
PubMed271 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXF9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:08:45 CEST 2021

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