FAAH (fatty acid amide hydrolase)

2008-09-01  

Identity

HGNC
LOCATION
1p33
LOCUSID
ALIAS
FAAH-1,PSAB
FUSION GENES

Other Information

Locus ID:

NCBI: 2166
MIM: 602935
HGNC: 3553
Ensembl: ENSG00000117480

Variants:

dbSNP: 2166
ClinVar: 2166
TCGA: ENSG00000117480
COSMIC: FAAH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117480ENST00000243167O00519
ENSG00000117480ENST00000484697A0A087WYA0

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Retrograde endocannabinoid signalingKEGGhsa04723
Retrograde endocannabinoid signalingKEGGko04723
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10026aripiprazoleChemicalClinicalAnnotationassociatedPD20631561
PA131890620cannabinoidsChemicalClinicalAnnotationassociatedPD17290447
PA444702KyphosisDiseaseVariantAnnotationassociatedPD
PA445522Respiratory InsufficiencyDiseaseVariantAnnotationambiguousPD
PA445619ScoliosisDiseaseVariantAnnotationassociatedPD
PA446876Substance-Related DisordersDiseaseClinicalAnnotationassociatedPD17290447, 23556448, 31789429
PA446970Postoperative Nausea and VomitingDiseaseVariantAnnotationnot associatedPD
PA447215Psychotic DisordersDiseaseClinicalAnnotationassociatedPD20631561
PA449061clozapineChemicalClinicalAnnotationassociatedPD20631561
PA449841haloperidolChemicalClinicalAnnotationassociatedPD20631561
PA449957ibuprofenChemicalPathwayassociated25502615
PA450403methamphetamineChemicalClinicalAnnotationassociatedPD23556448, 31789429
PA450550morphineChemicalClinicalAnnotation, VariantAnnotationambiguousPD
PA450688olanzapineChemicalClinicalAnnotationassociatedPD20631561
PA451201quetiapineChemicalClinicalAnnotationassociatedPD20631561
PA451257risperidoneChemicalClinicalAnnotationassociatedPD20631561
PA452618opioidsChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
146571722003Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains.130
170653422006Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity.129
120607822002A missense mutation in human fatty acid amide hydrolase associated with problem drug use.101
191034372009Divergent effects of genetic variation in endocannabinoid signaling on human threat- and reward-related brain function.95
191034372009Divergent effects of genetic variation in endocannabinoid signaling on human threat- and reward-related brain function.95
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
152540192004Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use.90
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
257317442015FAAH genetic variation enhances fronto-amygdala function in mouse and human.78
184937292008Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors.54

Citation

Dessen P

FAAH (fatty acid amide hydrolase)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50330/faah