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FADD (Fas associated via death domain)

Identity

Alias_namesFas (TNFRSF6)-associated via death domain
Alias_symbol (synonym)MORT1
GIG3
Other alias
HGNC (Hugo) FADD
LocusID (NCBI) 8772
Atlas_Id 40525
Location 11q13.3  [Link to chromosome band 11q13]
Location_base_pair Starts at 70049269 and ends at 70053508 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ARAP1 (11q13.4) / FADD (11q13.3)IKBKB (8p11.21) / FADD (11q13.3)PPP6R3 (11q13.2) / FADD (11q13.3)
ARAP1 11q13.4 / FADD 11q13.3IKBKB 8p11.21 / FADD 11q13.3PPP6R3 11q13.2 / FADD 11q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FADD   3573
LRG (Locus Reference Genomic)LRG_228
Cards
Entrez_Gene (NCBI)FADD  8772  Fas associated via death domain
AliasesGIG3; MORT1
GeneCards (Weizmann)FADD
Ensembl hg19 (Hinxton)ENSG00000168040 [Gene_View]  chr11:70049269-70053508 [Contig_View]  FADD [Vega]
Ensembl hg38 (Hinxton)ENSG00000168040 [Gene_View]  chr11:70049269-70053508 [Contig_View]  FADD [Vega]
ICGC DataPortalENSG00000168040
TCGA cBioPortalFADD
AceView (NCBI)FADD
Genatlas (Paris)FADD
WikiGenes8772
SOURCE (Princeton)FADD
Genetics Home Reference (NIH)FADD
Genomic and cartography
GoldenPath hg19 (UCSC)FADD  -     chr11:70049269-70053508 +  11q13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FADD  -     11q13.3   [Description]    (hg38-Dec_2013)
EnsemblFADD - 11q13.3 [CytoView hg19]  FADD - 11q13.3 [CytoView hg38]
Mapping of homologs : NCBIFADD [Mapview hg19]  FADD [Mapview hg38]
OMIM602457   613759   
Gene and transcription
Genbank (Entrez)AI886015 AK291005 AK293320 AL575732 AY423721
RefSeq transcript (Entrez)NM_003824
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_027966 NT_167190 NW_004929380
Consensus coding sequences : CCDS (NCBI)FADD
Cluster EST : UnigeneHs.86131 [ NCBI ]
CGAP (NCI)Hs.86131
Alternative Splicing GalleryENSG00000168040
Gene ExpressionFADD [ NCBI-GEO ]   FADD [ EBI - ARRAY_EXPRESS ]   FADD [ SEEK ]   FADD [ MEM ]
Gene Expression Viewer (FireBrowse)FADD [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8772
GTEX Portal (Tissue expression)FADD
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13158   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13158  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13158
Splice isoforms : SwissVarQ13158
PhosPhoSitePlusQ13158
Domaine pattern : Prosite (Expaxy)DEATH_DOMAIN (PS50017)    DED (PS50168)   
Domains : Interpro (EBI)DEATH-like_dom    Death_domain    DED_dom    FADD   
Domain families : Pfam (Sanger)Death (PF00531)    DED (PF01335)   
Domain families : Pfam (NCBI)pfam00531    pfam01335   
Domain families : Smart (EMBL)DEATH (SM00005)  DED (SM00031)  
Conserved Domain (NCBI)FADD
DMDM Disease mutations8772
Blocks (Seattle)FADD
PDB (SRS)1A1W    1A1Z    1E3Y    1E41    2GF5    3EZQ    3OQ9   
PDB (PDBSum)1A1W    1A1Z    1E3Y    1E41    2GF5    3EZQ    3OQ9   
PDB (IMB)1A1W    1A1Z    1E3Y    1E41    2GF5    3EZQ    3OQ9   
PDB (RSDB)1A1W    1A1Z    1E3Y    1E41    2GF5    3EZQ    3OQ9   
Structural Biology KnowledgeBase1A1W    1A1Z    1E3Y    1E41    2GF5    3EZQ    3OQ9   
SCOP (Structural Classification of Proteins)1A1W    1A1Z    1E3Y    1E41    2GF5    3EZQ    3OQ9   
CATH (Classification of proteins structures)1A1W    1A1Z    1E3Y    1E41    2GF5    3EZQ    3OQ9   
SuperfamilyQ13158
Human Protein AtlasENSG00000168040
Peptide AtlasQ13158
HPRD03909
IPIIPI00011919   
Protein Interaction databases
DIP (DOE-UCLA)Q13158
IntAct (EBI)Q13158
FunCoupENSG00000168040
BioGRIDFADD
STRING (EMBL)FADD
ZODIACFADD
Ontologies - Pathways
QuickGOQ13158
Ontology : AmiGOpositive regulation of T cell mediated cytotoxicity  protease binding  positive regulation of adaptive immune response  death receptor binding  tumor necrosis factor receptor binding  protein binding  cytoplasm  cytosol  cytosol  plasma membrane  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  cell surface receptor signaling pathway  extrinsic apoptotic signaling pathway via death domain receptors  viral process  death-inducing signaling complex  death-inducing signaling complex  CD95 death-inducing signaling complex  protein complex binding  positive regulation of interferon-gamma production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  tumor necrosis factor receptor superfamily binding  T cell differentiation in thymus  TRIF-dependent toll-like receptor signaling pathway  death effector domain binding  TRAIL-activated apoptotic signaling pathway  positive regulation of activated T cell proliferation  identical protein binding  neuron projection  T cell homeostasis  positive regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  cell body  innate immune response  membrane raft  positive regulation of macrophage differentiation  positive regulation of proteolysis  positive regulation of transcription from RNA polymerase II promoter  lymph node development  spleen development  thymus development  protein heterooligomerization  defense response to virus  positive regulation of type I interferon-mediated signaling pathway  negative regulation of necroptotic process  negative regulation of activation-induced cell death of T cells  cellular response to mechanical stimulus  death-inducing signaling complex assembly  caspase binding  motor neuron apoptotic process  apoptotic signaling pathway  apoptotic signaling pathway  extrinsic apoptotic signaling pathway  extrinsic apoptotic signaling pathway  extrinsic apoptotic signaling pathway  extrinsic apoptotic signaling pathway in absence of ligand  activation of cysteine-type endopeptidase activity  activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  ripoptosome  necroptotic signaling pathway  regulation of extrinsic apoptotic signaling pathway via death domain receptors  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation  positive regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIpositive regulation of T cell mediated cytotoxicity  protease binding  positive regulation of adaptive immune response  death receptor binding  tumor necrosis factor receptor binding  protein binding  cytoplasm  cytosol  cytosol  plasma membrane  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  cell surface receptor signaling pathway  extrinsic apoptotic signaling pathway via death domain receptors  viral process  death-inducing signaling complex  death-inducing signaling complex  CD95 death-inducing signaling complex  protein complex binding  positive regulation of interferon-gamma production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  tumor necrosis factor receptor superfamily binding  T cell differentiation in thymus  TRIF-dependent toll-like receptor signaling pathway  death effector domain binding  TRAIL-activated apoptotic signaling pathway  positive regulation of activated T cell proliferation  identical protein binding  neuron projection  T cell homeostasis  positive regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  cell body  innate immune response  membrane raft  positive regulation of macrophage differentiation  positive regulation of proteolysis  positive regulation of transcription from RNA polymerase II promoter  lymph node development  spleen development  thymus development  protein heterooligomerization  defense response to virus  positive regulation of type I interferon-mediated signaling pathway  negative regulation of necroptotic process  negative regulation of activation-induced cell death of T cells  cellular response to mechanical stimulus  death-inducing signaling complex assembly  caspase binding  motor neuron apoptotic process  apoptotic signaling pathway  apoptotic signaling pathway  extrinsic apoptotic signaling pathway  extrinsic apoptotic signaling pathway  extrinsic apoptotic signaling pathway  extrinsic apoptotic signaling pathway in absence of ligand  activation of cysteine-type endopeptidase activity  activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  ripoptosome  necroptotic signaling pathway  regulation of extrinsic apoptotic signaling pathway via death domain receptors  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation  positive regulation of extrinsic apoptotic signaling pathway  
Pathways : BIOCARTAAcetylation and Deacetylation of RelA in The Nucleus [Genes]    TNFR1 Signaling Pathway [Genes]    Induction of apoptosis through DR3 and DR4/5 Death Receptors [Genes]    FAS signaling pathway ( CD95 ) [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]    Ceramide Signaling Pathway [Genes]    NF-kB Signaling Pathway [Genes]    SODD/TNFR1 Signaling Pathway [Genes]   
Pathways : KEGGApoptosis    Toll-like receptor signaling pathway    RIG-I-like receptor signaling pathway    TNF signaling pathway    Alzheimer's disease    Chagas disease (American trypanosomiasis)    Tuberculosis    Hepatitis B    Herpes simplex infection    Pathways in cancer   
NDEx NetworkFADD
Atlas of Cancer Signalling NetworkFADD
Wikipedia pathwaysFADD
Orthology - Evolution
OrthoDB8772
GeneTree (enSembl)ENSG00000168040
Phylogenetic Trees/Animal Genes : TreeFamFADD
HOVERGENQ13158
HOGENOMQ13158
Homologs : HomoloGeneFADD
Homology/Alignments : Family Browser (UCSC)FADD
Gene fusions - Rearrangements
Fusion : MitelmanARAP1/FADD [11q13.4/11q13.3]  [t(11;11)(q13;q13)]  
Fusion : MitelmanIKBKB/FADD [8p11.21/11q13.3]  [t(8;11)(p11;q13)]  
Fusion : MitelmanPPP6R3/FADD [11q13.2/11q13.3]  [t(11;11)(q13;q13)]  
Fusion: TCGAARAP1 11q13.4 FADD 11q13.3 LUAD
Fusion: TCGAIKBKB 8p11.21 FADD 11q13.3 BRCA
Fusion: TCGAPPP6R3 11q13.2 FADD 11q13.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFADD [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FADD
dbVarFADD
ClinVarFADD
1000_GenomesFADD 
Exome Variant ServerFADD
ExAC (Exome Aggregation Consortium)FADD (select the gene name)
Genetic variants : HAPMAP8772
Genomic Variants (DGV)FADD [DGVbeta]
DECIPHER (Syndromes)11:70049269-70053508  ENSG00000168040
CONAN: Copy Number AnalysisFADD 
Mutations
ICGC Data PortalFADD 
TCGA Data PortalFADD 
Broad Tumor PortalFADD
OASIS PortalFADD [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFADD  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFADD
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch FADD
DgiDB (Drug Gene Interaction Database)FADD
DoCM (Curated mutations)FADD (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FADD (select a term)
intoGenFADD
Cancer3DFADD(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602457    613759   
Orphanet21230    14379   
MedgenFADD
Genetic Testing Registry FADD
NextProtQ13158 [Medical]
TSGene8772
GENETestsFADD
Huge Navigator FADD [HugePedia]
snp3D : Map Gene to Disease8772
BioCentury BCIQFADD
ClinGenFADD
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8772
Chemical/Pharm GKB GenePA27972
Clinical trialFADD
Miscellaneous
canSAR (ICR)FADD (select the gene name)
Probes
Litterature
PubMed256 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFADD
EVEXFADD
GoPubMedFADD
iHOPFADD
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:05:18 CET 2017

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