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FADD (Fas associated via death domain)

Identity

Alias (NCBI)GIG3
IMD90
MORT1
HGNC (Hugo) FADD
HGNC Alias symbMORT1
GIG3
HGNC Alias nameFas-associating protein with death domain
 Fas-associating death domain-containing protein
 mediator of receptor-induced toxicity
 growth-inhibiting gene 3 protein
HGNC Previous nameFas (TNFRSF6)-associated via death domain
LocusID (NCBI) 8772
Atlas_Id 40525
Location 11q13.3  [Link to chromosome band 11q13]
Location_base_pair Starts at 70203296 and ends at 70207386 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARAP1 (11q13.4)::FADD (11q13.3)IKBKB (8p11.21)::FADD (11q13.3)PPP6R3 (11q13.2)::FADD (11q13.3)
ARAP1 11q13.4::FADD 11q13.3IKBKB 8p11.21::FADD 11q13.3PPP6R3 11q13.2::FADD 11q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  dup(1q) in ALL


External links

 

Nomenclature
HGNC (Hugo)FADD   3573
LRG (Locus Reference Genomic)LRG_228
Cards
Entrez_Gene (NCBI)FADD    Fas associated via death domain
AliasesGIG3; IMD90; MORT1
GeneCards (Weizmann)FADD
Ensembl hg19 (Hinxton)ENSG00000168040 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168040 [Gene_View]  ENSG00000168040 [Sequence]  chr11:70203296-70207386 [Contig_View]  FADD [Vega]
ICGC DataPortalENSG00000168040
TCGA cBioPortalFADD
AceView (NCBI)FADD
Genatlas (Paris)FADD
SOURCE (Princeton)FADD
Genetics Home Reference (NIH)FADD
Genomic and cartography
GoldenPath hg38 (UCSC)FADD  -     chr11:70203296-70207386 +  11q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FADD  -     11q13.3   [Description]    (hg19-Feb_2009)
GoldenPathFADD - 11q13.3 [CytoView hg19]  FADD - 11q13.3 [CytoView hg38]
ImmunoBaseENSG00000168040
Genome Data Viewer NCBIFADD [Mapview hg19]  
OMIM602457   613759   
Gene and transcription
Genbank (Entrez)AI886015 AK291005 AK293320 AL575732 AY423721
RefSeq transcript (Entrez)NM_003824
Consensus coding sequences : CCDS (NCBI)FADD
Gene ExpressionFADD [ NCBI-GEO ]   FADD [ EBI - ARRAY_EXPRESS ]   FADD [ SEEK ]   FADD [ MEM ]
Gene Expression Viewer (FireBrowse)FADD [ Firebrowse - Broad ]
GenevisibleExpression of FADD in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8772
GTEX Portal (Tissue expression)FADD
Human Protein AtlasENSG00000168040-FADD [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13158   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13158  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13158
PhosPhoSitePlusQ13158
Domaine pattern : Prosite (Expaxy)DEATH_DOMAIN (PS50017)    DED (PS50168)   
Domains : Interpro (EBI)DEATH-like_dom_sf    Death_domain    DED_dom    FADD   
Domain families : Pfam (Sanger)Death (PF00531)    DED (PF01335)   
Domain families : Pfam (NCBI)pfam00531    pfam01335   
Domain families : Smart (EMBL)DEATH (SM00005)  DED (SM00031)  
Conserved Domain (NCBI)FADD
PDB (RSDB)1A1W    1A1Z    1E3Y    1E41    2GF5    3EZQ    3OQ9    6ACI   
PDB Europe1A1W    1A1Z    1E3Y    1E41    2GF5    3EZQ    3OQ9    6ACI   
PDB (PDBSum)1A1W    1A1Z    1E3Y    1E41    2GF5    3EZQ    3OQ9    6ACI   
PDB (IMB)1A1W    1A1Z    1E3Y    1E41    2GF5    3EZQ    3OQ9    6ACI   
Structural Biology KnowledgeBase1A1W    1A1Z    1E3Y    1E41    2GF5    3EZQ    3OQ9    6ACI   
SCOP (Structural Classification of Proteins)1A1W    1A1Z    1E3Y    1E41    2GF5    3EZQ    3OQ9    6ACI   
CATH (Classification of proteins structures)1A1W    1A1Z    1E3Y    1E41    2GF5    3EZQ    3OQ9    6ACI   
SuperfamilyQ13158
AlphaFold pdb e-kbQ13158   
Human Protein Atlas [tissue]ENSG00000168040-FADD [tissue]
HPRD03909
Protein Interaction databases
DIP (DOE-UCLA)Q13158
IntAct (EBI)Q13158
BioGRIDFADD
STRING (EMBL)FADD
ZODIACFADD
Ontologies - Pathways
QuickGOQ13158
Ontology : AmiGOkidney development  positive regulation of T cell mediated cytotoxicity  protease binding  positive regulation of adaptive immune response  death receptor binding  tumor necrosis factor receptor binding  protein binding  nucleus  cytoplasm  cytoplasm  cytosol  cytosol  plasma membrane  apoptotic process  extrinsic apoptotic signaling pathway via death domain receptors  death-inducing signaling complex  death-inducing signaling complex  CD95 death-inducing signaling complex  CD95 death-inducing signaling complex  positive regulation of interferon-gamma production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  tumor necrosis factor receptor superfamily binding  T cell differentiation in thymus  receptor serine/threonine kinase binding  death effector domain binding  TRAIL-activated apoptotic signaling pathway  TRAIL-activated apoptotic signaling pathway  positive regulation of activated T cell proliferation  identical protein binding  neuron projection  T cell homeostasis  positive regulation of apoptotic process  positive regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  response to morphine  cell body  protein-containing complex binding  innate immune response  membrane raft  positive regulation of macrophage differentiation  positive regulation of proteolysis  positive regulation of transcription by RNA polymerase II  behavioral response to cocaine  lymph node development  spleen development  thymus development  defense response to virus  positive regulation of type I interferon-mediated signaling pathway  negative regulation of necroptotic process  negative regulation of activation-induced cell death of T cells  cellular response to mechanical stimulus  death-inducing signaling complex assembly  caspase binding  caspase binding  caspase binding  motor neuron apoptotic process  apoptotic signaling pathway  extrinsic apoptotic signaling pathway  extrinsic apoptotic signaling pathway  extrinsic apoptotic signaling pathway  extrinsic apoptotic signaling pathway in absence of ligand  activation of cysteine-type endopeptidase activity  ripoptosome  necroptotic signaling pathway  positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation  positive regulation of extrinsic apoptotic signaling pathway  positive regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIkidney development  positive regulation of T cell mediated cytotoxicity  protease binding  positive regulation of adaptive immune response  death receptor binding  tumor necrosis factor receptor binding  protein binding  nucleus  cytoplasm  cytoplasm  cytosol  cytosol  plasma membrane  apoptotic process  extrinsic apoptotic signaling pathway via death domain receptors  death-inducing signaling complex  death-inducing signaling complex  CD95 death-inducing signaling complex  CD95 death-inducing signaling complex  positive regulation of interferon-gamma production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  tumor necrosis factor receptor superfamily binding  T cell differentiation in thymus  receptor serine/threonine kinase binding  death effector domain binding  TRAIL-activated apoptotic signaling pathway  TRAIL-activated apoptotic signaling pathway  positive regulation of activated T cell proliferation  identical protein binding  neuron projection  T cell homeostasis  positive regulation of apoptotic process  positive regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  response to morphine  cell body  protein-containing complex binding  innate immune response  membrane raft  positive regulation of macrophage differentiation  positive regulation of proteolysis  positive regulation of transcription by RNA polymerase II  behavioral response to cocaine  lymph node development  spleen development  thymus development  defense response to virus  positive regulation of type I interferon-mediated signaling pathway  negative regulation of necroptotic process  negative regulation of activation-induced cell death of T cells  cellular response to mechanical stimulus  death-inducing signaling complex assembly  caspase binding  caspase binding  caspase binding  motor neuron apoptotic process  apoptotic signaling pathway  extrinsic apoptotic signaling pathway  extrinsic apoptotic signaling pathway  extrinsic apoptotic signaling pathway  extrinsic apoptotic signaling pathway in absence of ligand  activation of cysteine-type endopeptidase activity  ripoptosome  necroptotic signaling pathway  positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation  positive regulation of extrinsic apoptotic signaling pathway  positive regulation of extrinsic apoptotic signaling pathway  
Pathways : BIOCARTABIOCARTA_RELAPATHWAY    BIOCARTA_CERAMIDEPATHWAY    BIOCARTA_FASPATHWAY    BIOCARTA_HIVNEFPATHWAY    BIOCARTA_DEATHPATHWAY    BIOCARTA_NFKBPATHWAY    BIOCARTA_SODDPATHWAY    BIOCARTA_TNFR1PATHWAY   
Pathways : KEGGKEGG_APOPTOSIS    KEGG_TOLL_LIKE_RECEPTOR_SIGNALING    KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING    KEGG_ALZHEIMERS_DISEASE    KEGG_PATHWAYS_IN_CANCER   
NDEx NetworkFADD
Atlas of Cancer Signalling NetworkFADD
Wikipedia pathwaysFADD
Orthology - Evolution
OrthoDB8772
GeneTree (enSembl)ENSG00000168040
Phylogenetic Trees/Animal Genes : TreeFamFADD
Homologs : HomoloGeneFADD
Homology/Alignments : Family Browser (UCSC)FADD
Gene fusions - Rearrangements
Fusion : MitelmanARAP1::FADD [11q13.4/11q13.3]  
Fusion : MitelmanIKBKB::FADD [8p11.21/11q13.3]  
Fusion : MitelmanPPP6R3::FADD [11q13.2/11q13.3]  
Fusion : QuiverFADD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFADD [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FADD
dbVarFADD
ClinVarFADD
MonarchFADD
1000_GenomesFADD 
Exome Variant ServerFADD
GNOMAD BrowserENSG00000168040
Varsome BrowserFADD
ACMGFADD variants
VarityQ13158
Genomic Variants (DGV)FADD [DGVbeta]
DECIPHERFADD [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFADD 
Mutations
ICGC Data PortalFADD 
TCGA Data PortalFADD 
Broad Tumor PortalFADD
OASIS PortalFADD [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFADD  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFADD
Mutations and Diseases : HGMDFADD
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFADD
DgiDB (Drug Gene Interaction Database)FADD
DoCM (Curated mutations)FADD
CIViC (Clinical Interpretations of Variants in Cancer)FADD
Cancer3DFADD
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602457    613759   
Orphanet21230    14379   
DisGeNETFADD
MedgenFADD
Genetic Testing Registry FADD
NextProtQ13158 [Medical]
GENETestsFADD
Target ValidationFADD
Huge Navigator FADD [HugePedia]
ClinGenFADD
Clinical trials, drugs, therapy
MyCancerGenomeFADD
Protein Interactions : CTDFADD
Pharm GKB GenePA27972
PharosQ13158
Clinical trialFADD
Miscellaneous
canSAR (ICR)FADD
HarmonizomeFADD
ARCHS4FADD
DataMed IndexFADD
Probes
Litterature
PubMed337 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFADD
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:32:51 CET 2022

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