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FADS2 (fatty acid desaturase 2)

Identity

Alias_namesLLCDL2
Alias_symbol (synonym)FADSD6
D6D
TU13
DES6
SLL0262
Other alias
HGNC (Hugo) FADS2
LocusID (NCBI) 9415
Atlas_Id 46480
Location 11q12.2  [Link to chromosome band 11q12]
Location_base_pair Starts at 61816203 and ends at 61867354 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BOLA2 (16p11.2) / FADS2 (11q12.2)EZR (6q25.3) / FADS2 (11q12.2)FADS2 (11q12.2) / EZR (6q25.3)
GUK1 (1q42.13) / FADS2 (11q12.2)SAMD11 (1p36.33) / FADS2 (11q12.2)SSRP1 (11q12.1) / FADS2 (11q12.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FADS2   3575
Cards
Entrez_Gene (NCBI)FADS2  9415  fatty acid desaturase 2
AliasesD6D; DES6; FADSD6; LLCDL2; 
SLL0262; TU13
GeneCards (Weizmann)FADS2
Ensembl hg19 (Hinxton)ENSG00000134824 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134824 [Gene_View]  chr11:61816203-61867354 [Contig_View]  FADS2 [Vega]
ICGC DataPortalENSG00000134824
TCGA cBioPortalFADS2
AceView (NCBI)FADS2
Genatlas (Paris)FADS2
WikiGenes9415
SOURCE (Princeton)FADS2
Genetics Home Reference (NIH)FADS2
Genomic and cartography
GoldenPath hg38 (UCSC)FADS2  -     chr11:61816203-61867354 +  11q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FADS2  -     11q12.2   [Description]    (hg19-Feb_2009)
EnsemblFADS2 - 11q12.2 [CytoView hg19]  FADS2 - 11q12.2 [CytoView hg38]
Mapping of homologs : NCBIFADS2 [Mapview hg19]  FADS2 [Mapview hg38]
OMIM606149   
Gene and transcription
Genbank (Entrez)AA665550 AF084559 AF108658 AF126799 AK027459
RefSeq transcript (Entrez)NM_001281501 NM_001281502 NM_004265
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FADS2
Cluster EST : UnigeneHs.502745 [ NCBI ]
CGAP (NCI)Hs.502745
Alternative Splicing GalleryENSG00000134824
Gene ExpressionFADS2 [ NCBI-GEO ]   FADS2 [ EBI - ARRAY_EXPRESS ]   FADS2 [ SEEK ]   FADS2 [ MEM ]
Gene Expression Viewer (FireBrowse)FADS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9415
GTEX Portal (Tissue expression)FADS2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95864   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95864  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95864
Splice isoforms : SwissVarO95864
PhosPhoSitePlusO95864
Domaine pattern : Prosite (Expaxy)CYTOCHROME_B5_2 (PS50255)   
Domains : Interpro (EBI)Cyt_B5-like_heme/steroid-bd    FA_desaturase_dom    Fatty_acid_desaturase   
Domain families : Pfam (Sanger)Cyt-b5 (PF00173)    FA_desaturase (PF00487)   
Domain families : Pfam (NCBI)pfam00173    pfam00487   
Domain families : Smart (EMBL)Cyt-b5 (SM01117)  
Conserved Domain (NCBI)FADS2
DMDM Disease mutations9415
Blocks (Seattle)FADS2
SuperfamilyO95864
Human Protein AtlasENSG00000134824
Peptide AtlasO95864
HPRD05854
IPIIPI00183786   IPI00023484   IPI00867558   IPI00978350   IPI01014345   IPI00974216   IPI00979029   IPI00975943   IPI01010526   IPI00973767   
Protein Interaction databases
DIP (DOE-UCLA)O95864
IntAct (EBI)O95864
FunCoupENSG00000134824
BioGRIDFADS2
STRING (EMBL)FADS2
ZODIACFADS2
Ontologies - Pathways
QuickGOO95864
Ontology : AmiGOstearoyl-CoA 9-desaturase activity  endoplasmic reticulum membrane  integral component of plasma membrane  unsaturated fatty acid biosynthetic process  membrane  linoleoyl-CoA desaturase activity  alpha-linolenic acid metabolic process  linoleic acid metabolic process  oxidation-reduction process  
Ontology : EGO-EBIstearoyl-CoA 9-desaturase activity  endoplasmic reticulum membrane  integral component of plasma membrane  unsaturated fatty acid biosynthetic process  membrane  linoleoyl-CoA desaturase activity  alpha-linolenic acid metabolic process  linoleic acid metabolic process  oxidation-reduction process  
Pathways : KEGGalpha-Linolenic acid metabolism    Biosynthesis of unsaturated fatty acids    PPAR signaling pathway   
NDEx NetworkFADS2
Atlas of Cancer Signalling NetworkFADS2
Wikipedia pathwaysFADS2
Orthology - Evolution
OrthoDB9415
GeneTree (enSembl)ENSG00000134824
Phylogenetic Trees/Animal Genes : TreeFamFADS2
HOVERGENO95864
HOGENOMO95864
Homologs : HomoloGeneFADS2
Homology/Alignments : Family Browser (UCSC)FADS2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFADS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FADS2
dbVarFADS2
ClinVarFADS2
1000_GenomesFADS2 
Exome Variant ServerFADS2
ExAC (Exome Aggregation Consortium)FADS2 (select the gene name)
Genetic variants : HAPMAP9415
Genomic Variants (DGV)FADS2 [DGVbeta]
DECIPHERFADS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFADS2 
Mutations
ICGC Data PortalFADS2 
TCGA Data PortalFADS2 
Broad Tumor PortalFADS2
OASIS PortalFADS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFADS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFADS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FADS2
DgiDB (Drug Gene Interaction Database)FADS2
DoCM (Curated mutations)FADS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FADS2 (select a term)
intoGenFADS2
Cancer3DFADS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606149   
Orphanet
MedgenFADS2
Genetic Testing Registry FADS2
NextProtO95864 [Medical]
TSGene9415
GENETestsFADS2
Target ValidationFADS2
Huge Navigator FADS2 [HugePedia]
snp3D : Map Gene to Disease9415
BioCentury BCIQFADS2
ClinGenFADS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9415
Chemical/Pharm GKB GenePA27974
Clinical trialFADS2
Miscellaneous
canSAR (ICR)FADS2 (select the gene name)
Probes
Litterature
PubMed137 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFADS2
EVEXFADS2
GoPubMedFADS2
iHOPFADS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:33:12 CEST 2017

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